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tyramine and Hypotension, Orthostatic

tyramine has been researched along with Hypotension, Orthostatic in 38 studies

Hypotension, Orthostatic: A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure 3 minutes after the person has risen from supine to standing. Symptoms generally include DIZZINESS, blurred vision, and SYNCOPE.

Research Excerpts

ExcerptRelevanceReference
" Patients with PD+NOH had normal bradycardia responses to edrophonium and normal epinephrine responses to glucagon."3.74Generalized and neurotransmitter-selective noradrenergic denervation in Parkinson's disease with orthostatic hypotension. ( Goldstein, DS; Holmes, C; Imrich, R; Pechnik, S; Sharabi, Y, 2008)
"These data suggest that the etiology of orthostatic hypotension and presyncope after spaceflight includes low alpha(1)-adrenergic receptor responsiveness before flight and a remodeling of the central nervous system during spaceflight such that sympathetic responses to baroreceptor input become impaired."2.71Mechanisms of postspaceflight orthostatic hypotension: low alpha1-adrenergic receptor responses before flight and central autonomic dysregulation postflight. ( deBlock, HF; Huang, PL; Meck, JV; Mills, PJ; Robertson, D; Waters, WW; Ziegler, MG, 2004)
"Diseases characterized by neurogenic orthostatic hypotension (NOH), such as Parkinson disease (PD) and pure autonomic failure (PAF), are associated with cardiac sympathetic denervation, as reflected by low myocardial concentrations of 6-[(18)F]fluorodopamine-derived radioactivity."1.35Functional effects of cardiac sympathetic denervation in neurogenic orthostatic hypotension. ( Bentho, O; Eldadah, BA; Goldstein, DS; Grossman, E; Holmes, C; Imrich, R; Pechnik, S; Sharabi, Y, 2009)
"The clinical diagnosis of orthostatic hypotension (OH) is straightforward and usually does not require extensive laboratory testing."1.27Orthostatic hypotension. II. Clinical diagnosis, testing, and treatment. ( Schatz, IJ, 1984)
"A patient with severe orthostatic hypotension due to dopamine-beta-hydroxylase deficiency was treated with the unnatural aminoacid D,L-threo-3,4-dihydroxyphenylserine (DOPS) in the hope that it would serve as a substrate of aromatic-L-aminoacid decarboxylase to produce (-)-noradrenaline."1.27Effect of unnatural noradrenaline precursor on sympathetic control and orthostatic hypotension in dopamine-beta-hydroxylase deficiency. ( Boomsma, F; Man in 't Veld, AJ; Schalekamp, MA; van den Meiracker, AH, 1987)
"Patients in whom orthostatic hypotension is attended by tachycardia are subsensitive to administered catecholamines, and may suffer from deficient effector organ responsivity."1.26Pharmacologic distinction of different orthostatic hypotension syndromes. ( Ebert, MH; Kopin, IJ; Polinsky, RJ; Weise, V, 1981)
"Six patients with neurogenic orthostatic hypotension were treated with a chemical preparation of tyramine and tranylcypromine ("Parnate"), a monoamine oxidase inhibitor (M."1.26Treatment of neurogenic orthostatic hypotension with a monoamine oxidase inhibitor and tyramine. ( Johnson, RH; Keogh, HJ; Nanda, RN, 1976)
"A patient is described who had severe orthostatic hypotension."1.26Severe orthostatic hypotension associated with carcinoma of the bronchus. ( Breckenridge, AM; Green, CJ; Wright, FK, 1979)
"Five patients with idiopathic orthostatic hypotension and defective vasoconstrictor responses to the Valsalva maneuver and to application of ice to the forehead were found to have absent vasoconstriction in the forearm in response to intra-arterial administration of tyramine and enhanced vasoconstrictor responses in response to intra-arterial administration of norepinephrine."1.25Norepinephrine depletion in idiopathic orthostatic hypotension. ( Kontos, HA; Norvell, JE; Richardson, DW, 1975)

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-199028 (73.68)18.7374
1990's5 (13.16)18.2507
2000's4 (10.53)29.6817
2010's1 (2.63)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Imrich, R2
Eldadah, BA2
Bentho, O1
Pechnik, S3
Sharabi, Y3
Holmes, C3
Grossman, E1
Goldstein, DS3
Meck, JV1
Waters, WW1
Ziegler, MG1
deBlock, HF1
Mills, PJ1
Robertson, D3
Huang, PL1
Moak, JP1
Saleem, A1
Schatz, IJ3
Murphy, DL1
Sunderland, T1
Cohen, RM1
Guillevin, L2
Dumas, P2
Bletry, O2
Serdaru, M1
Brunet, P2
Godeau, P2
Polinsky, RJ1
Kopin, IJ1
Ebert, MH1
Weise, V1
Taylor, D1
Reveley, A1
Faivre, F1
Karet, FE1
Dickerson, JE1
Brown, J1
Brown, MJ1
Jacob, G1
Shannon, JR1
Costa, F1
Furlan, R1
Biaggioni, I1
Mosqueda-Garcia, R1
Robertson, RM2
Nanda, RN3
Johnson, RH3
Keogh, HJ2
Davies, B1
Bannister, R1
Sever, P1
Trust, PM1
Burks, TF1
Loo, TL1
Grubb, MN1
Green, CJ1
Breckenridge, AM1
Wright, FK1
Röckel, A1
Hennemann, H1
Richwien, D1
Heidland, A1
Kontos, HA2
Richardson, DW2
Norvell, JE2
Demanet, JC1
Ibrahim, MM1
Koegh, HJ1
Cortelli, P1
Parchi, P1
Contin, M1
Sforza, E1
Lugaresi, A1
Pasquali, R1
Lugaresi, E1
Pourrias, B1
Marie, C1
Man in 't Veld, AJ1
Boomsma, F1
van den Meiracker, AH1
Schalekamp, MA1
Goldberg, MR1
Onrot, J1
Hollister, AS1
Wiley, R1
Thompson, JG1
Bodemer, C1
Zisook, S1
Wood, CA1
Riddle, J1
Reed, R1
Paul, C1
Christlieb, AR1
Munichoodappa, C1
Braaten, JT1
Hillestad, L1
Lewis, RK1
Hazelrig, CG1
Fricke, FJ1
Russell, RO1
Diamond, MA1
Murray, RH1
Schmid, PG1
Forette, B1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Identifying the Pathophysiology of Neurogenic Orthostatic Hypotension and the Effects of Melatonin on Reducing Supine Hypertension in Peripherally Intact Versus Denervated Post-ganglionic Sympathetic Nerves[NCT02963181]Early Phase 110 participants (Actual)Interventional2018-03-01Terminated (stopped due to PI leaving)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for tyramine and Hypotension, Orthostatic

ArticleYear
Monoamine oxidase-inhibiting antidepressants. A clinical update.
    The Psychiatric clinics of North America, 1984, Volume: 7, Issue:3

    Topics: Antidepressive Agents, Tricyclic; Anxiety Disorders; Depressive Disorder; Diet; Drug Interactions; D

1984
A clinical overview of monoamine oxidase inhibitors.
    Psychosomatics, 1985, Volume: 26, Issue:3

    Topics: Antidepressive Agents, Tricyclic; Anxiety Disorders; Body Weight; Depressive Disorder; Dose-Response

1985
[Arterial hypotension--etiology and therapy. A review].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1973, Mar-20, Volume: 93, Issue:8

    Topics: Adrenal Cortex Hormones; Amphetamine; Diet Therapy; Female; Humans; Hypotension, Orthostatic; Male;

1973

Trials

2 trials available for tyramine and Hypotension, Orthostatic

ArticleYear
Mechanisms of postspaceflight orthostatic hypotension: low alpha1-adrenergic receptor responses before flight and central autonomic dysregulation postflight.
    American journal of physiology. Heart and circulatory physiology, 2004, Volume: 286, Issue:4

    Topics: Adrenergic alpha-Agonists; Adult; Arginine Vasopressin; Autonomic Nervous System; Baroreflex; Blood

2004
Abnormal norepinephrine clearance and adrenergic receptor sensitivity in idiopathic orthostatic intolerance.
    Circulation, 1999, Apr-06, Volume: 99, Issue:13

    Topics: Adult; Autonomic Nervous System; Female; Humans; Hypotension, Orthostatic; Isoproterenol; Male; Nitr

1999

Other Studies

33 other studies available for tyramine and Hypotension, Orthostatic

ArticleYear
Smile and Say "Cheese".
    JAMA, 2019, 07-23, Volume: 322, Issue:4

    Topics: Cheese; Food-Drug Interactions; History, 20th Century; Humans; Hypotension, Orthostatic; Monoamine O

2019
Functional effects of cardiac sympathetic denervation in neurogenic orthostatic hypotension.
    Parkinsonism & related disorders, 2009, Volume: 15, Issue:2

    Topics: Adrenergic beta-Agonists; Aged; Autonomic Nervous System Diseases; Blood Pressure; Dopamine; Female;

2009
Generalized and neurotransmitter-selective noradrenergic denervation in Parkinson's disease with orthostatic hypotension.
    Movement disorders : official journal of the Movement Disorder Society, 2008, Sep-15, Volume: 23, Issue:12

    Topics: Aged; Blood Pressure; Bradycardia; Cholinesterase Inhibitors; Edrophonium; Epinephrine; Female; Gluc

2008
Supine low-frequency power of heart rate variability reflects baroreflex function, not cardiac sympathetic innervation.
    Heart rhythm, 2007, Volume: 4, Issue:12

    Topics: Adrenergic alpha-Antagonists; Adrenergic Fibers; Autonomic Nervous System Diseases; Baroreflex; Hear

2007
Orthostatic hypotension. II. Clinical diagnosis, testing, and treatment.
    Archives of internal medicine, 1984, Volume: 144, Issue:5

    Topics: Adrenergic beta-Antagonists; Afferent Pathways; Drug Therapy, Combination; Efferent Pathways; Fludro

1984
Orthostatic hypotension: diagnosis and treatment.
    Hospital practice (Office ed.), 1984, Volume: 19, Issue:4

    Topics: Blood Pressure; Diagnosis, Differential; Dizziness; Female; Fludrocortisone; Humans; Hypotension, Or

1984
[Treatment of neurogenic orthostatic hypotension by an association of tyramine and a monoamine oxidase inhibitor (author's transl)].
    Annales de medecine interne, 1980, Volume: 131, Issue:8

    Topics: Aged; Aldosterone; Catecholamines; Drug Therapy, Combination; Female; Humans; Hypotension, Orthostat

1980
Pharmacologic distinction of different orthostatic hypotension syndromes.
    Neurology, 1981, Volume: 31, Issue:1

    Topics: Adult; Aged; Angiotensin II; Autonomic Nervous System Diseases; Blood Pressure; Epinephrine; Female;

1981
Current management concepts in orthostatic hypotension.
    Archives of internal medicine, 1980, Volume: 140, Issue:9

    Topics: Fludrocortisone; Humans; Hypotension, Orthostatic; Indomethacin; Monoamine Oxidase Inhibitors; Propr

1980
Clozapine-induced hypotension treated with moclobemide and Bovril.
    The British journal of psychiatry : the journal of mental science, 1995, Volume: 167, Issue:3

    Topics: Adult; Antipsychotic Agents; Benzamides; Clozapine; Dose-Response Relationship, Drug; Drug Administr

1995
Bovril and moclobemide: a novel therapeutic strategy for central autonomic failure.
    Lancet (London, England), 1994, Nov-05, Volume: 344, Issue:8932

    Topics: Activities of Daily Living; Autonomic Nervous System Diseases; Benzamides; Blood Pressure; Blood Pre

1994
Treatment of neurogenic orthostatic hypotension with a monoamine oxidase inhibitor and tyramine.
    Lancet (London, England), 1976, Nov-27, Volume: 2, Issue:7996

    Topics: Administration, Oral; Adult; Aged; Autonomic Nervous System; Blood Pressure; Drug Evaluation; Drug T

1976
Pressor amines and monoamine-oxidase inhibitors for treatment of postural hypotension in autonomic failure. Limitations and hazards.
    Lancet (London, England), 1978, Jan-28, Volume: 1, Issue:8057

    Topics: Aged; Blood Pressure; Drug Evaluation; Drug Therapy, Combination; Efferent Pathways; Ephedrine; Fema

1978
Tyramine and M.A.O. inhibitors in postural hypotension.
    Lancet (London, England), 1978, Feb-18, Volume: 1, Issue:8060

    Topics: Drug Therapy, Combination; Humans; Hypotension, Orthostatic; Tranylcypromine; Tyramine

1978
Mechanism of the cardiovascular actions of cyclocytidine.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1978, Volume: 159, Issue:3

    Topics: Adrenergic Fibers; Ancitabine; Animals; Blood Pressure; Cats; Cytarabine; Dogs; Drug Tolerance; Hypo

1978
Severe orthostatic hypotension associated with carcinoma of the bronchus.
    Postgraduate medical journal, 1979, Volume: 55, Issue:644

    Topics: Aged; Bronchial Neoplasms; Carcinoma, Small Cell; Humans; Hypotension, Orthostatic; Male; Tranylcypr

1979
[Pupillary reaction on tyramine- a parameter of uremic sympathicopathy (author's transl)].
    Klinische Wochenschrift, 1976, May-15, Volume: 54, Issue:10

    Topics: Adult; Aged; Autonomic Nervous System; Diabetes Mellitus; Dilatation; Electrocardiography; Humans; H

1976
Mechanisms of circulatory dysfunction in orthostatic hypotension.
    Transactions of the American Clinical and Climatological Association, 1976, Volume: 87

    Topics: Blood Circulation; Blood Flow Velocity; Humans; Hypotension, Orthostatic; Ice; Norepinephrine; Syndr

1976
Usefulness of noradrenaline and tyramine infusion tests in the diagnosis of orthostatic hypotension.
    Cardiology, 1976, Volume: 61 suppl 1

    Topics: Adult; Aged; Blood Pressure; Female; Heart Rate; Humans; Hypotension, Orthostatic; Male; Middle Aged

1976
Treatment of neurogenic orthostatic hypotension with a monoamine oxidase inhibitor and tyramine.
    Acta neurologica Belgica, 1976, Volume: 76, Issue:5-6

    Topics: Blood Pressure; Drug Therapy, Combination; Heart Rate; Humans; Hypotension, Orthostatic; Monoamine O

1976
Norepinephrine depletion in idiopathic orthostatic hypotension.
    Annals of internal medicine, 1975, Volume: 82, Issue:3

    Topics: Fluorescence; Heart Rate; Humans; Hypotension, Orthostatic; Ice; Nerve Endings; Neurons, Efferent; N

1975
Localization of lesion in patients with idiopathic orthostatic hypotension.
    British heart journal, 1975, Volume: 37, Issue:8

    Topics: Aged; Atropine; Blood Pressure; Cold Temperature; Electrocardiography; Female; Heart Rate; Humans; H

1975
Letter: Drugs for rare diseases.
    British medical journal, 1975, Nov-15, Volume: 4, Issue:5993

    Topics: Cheese; Humans; Hypotension, Orthostatic; Tyramine

1975
Isolated failure of noradrenergic transmission in a case with orthostatic hypotension and hyperactivity of gastro-colic reflex.
    Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 1992, Volume: 2, Issue:3

    Topics: Adult; Atropine; Autonomic Nervous System Diseases; Blood Pressure; Clonidine; Colon; Defecation; Ed

1992
Effects of tilting in the anaesthetized and mechanically ventilated rat: a model of orthostatic hypotension.
    Fundamental & clinical pharmacology, 1992, Volume: 6, Issue:1

    Topics: Anesthesia; Animals; Blood Pressure; Catecholamines; Disease Models, Animal; Heart Rate; Hypotension

1992
Effect of unnatural noradrenaline precursor on sympathetic control and orthostatic hypotension in dopamine-beta-hydroxylase deficiency.
    Lancet (London, England), 1987, Nov-21, Volume: 2, Issue:8569

    Topics: Aromatic-L-Amino-Acid Decarboxylases; Dopamine; Dopamine beta-Hydroxylase; Dose-Response Relationshi

1987
Isolated failure of autonomic noradrenergic neurotransmission. Evidence for impaired beta-hydroxylation of dopamine.
    The New England journal of medicine, 1986, Jun-05, Volume: 314, Issue:23

    Topics: Adrenergic Fibers; Adult; Autonomic Nervous System Diseases; Blood Pressure; Clonidine; Dopamine; Fe

1986
[Amyloidosis and orthostatic hypotension. Physiopathology, therapeutic attempts. Apropos of 5 cases].
    Annales de medecine interne, 1987, Volume: 138, Issue:8

    Topics: Adult; Aged; Amyloidosis; Female; Humans; Hypotension, Orthostatic; Male; Middle Aged; Tranylcypromi

1987
Quadriplegia, orthostatic hypotension, and phenelzine with tyramine.
    Annals of internal medicine, 1985, Volume: 103, Issue:5

    Topics: Aged; Drug Therapy, Combination; Humans; Hypotension, Orthostatic; Male; Phenelzine; Quadriplegia; T

1985
Decreased response of plasma renin activity to orthostasis in diabetic patients with orthostatic hypotension.
    Diabetes, 1974, Volume: 23, Issue:10

    Topics: Adult; Aldosterone; Amyloidosis; Angiotensin II; Animals; Blood Pressure; Cattle; Diabetes Complicat

1974
Therapy of idiopathic postural hypotension.
    Archives of internal medicine, 1972, Volume: 129, Issue:6

    Topics: Adult; Aged; Amines; Amphetamine; Blood Pressure; Blood Volume; Cheese; Dextroamphetamine; Female; F

1972
Idiopathic postural hypotension: physiologic observations and report of a new mode of therapy.
    The Journal of clinical investigation, 1970, Volume: 49, Issue:7

    Topics: Blood Pressure; Blood Pressure Determination; Cheese; Diet Therapy; Fecal Incontinence; Heart Rate;

1970
[Diagnosis of pheochromocytomas].
    La Presse medicale, 1968, Dec-07, Volume: 76, Issue:48

    Topics: Angiography; Catecholamines; Diabetes Complications; Glucagon; Histamine; Humans; Hypertension; Hype

1968