tyramine has been researched along with Huntington Disease in 2 studies
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In patients with Huntington's disease, there is a mutation in the gene encoding the protein huntingtin, which results in an expanded polyglutamine sequence leading to degeneration of the basal ganglia." | 1.33 | Enhanced toxicity to the catecholamine tyramine in polyglutamine transfected SH-SY5Y cells. ( Dimayuga, ER; Keller, JN; Maragos, WF; Smith, RR, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Smith, RR | 1 |
| Dimayuga, ER | 1 |
| Keller, JN | 1 |
| Maragos, WF | 1 |
| Dill, RE | 1 |
| Dorris, RL | 1 |
| Phillips-Thonnard, I | 1 |
2 other studies available for tyramine and Huntington Disease
| Article | Year |
|---|---|
Enhanced toxicity to the catecholamine tyramine in polyglutamine transfected SH-SY5Y cells.
Topics: Catalase; Cell Line; Deferoxamine; DNA; Dopamine; Humans; Huntington Disease; Hydrogen Peroxide; Iro | 2005 |
A pharmacologic model of Huntington's chorea.
Topics: Animals; Carbachol; Catheterization; Clozapine; Corpus Striatum; Disease Models, Animal; Dyskinesia, | 1976 |