Page last updated: 2024-11-05

tyramine and Depression, Involutional

tyramine has been researched along with Depression, Involutional in 4 studies

Depression, Involutional: Form of depression in those MIDDLE AGE with feelings of ANXIETY.

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (50.00)29.6817
2010's1 (25.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Aldosary, F1
Norris, S1
Tremblay, P1
James, JS1
Ritchie, JC1
Blier, P2
Wimbiscus, M1
Kostenko, O1
Malone, D1
Debonnel, G1
Saint-André, E1
Hébert, C1
de Montigny, C1
Lavoie, N1
Tobin, M1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effectiveness of the Norepinephrine and Serotonin Reuptake Inhibitor Levomilnacipran in Healthy Males[NCT03249311]Phase 436 participants (Actual)Interventional2018-03-02Active, not recruiting
A Randomized, Single Blind, Controlled, Longitudinal Study of the Effects of Venlafaxine Hydrochloride Capsules on the Language Function of Stroke Patients With Subcortical Aphasia Using fMRI[NCT03588572]43 participants (Actual)Interventional2018-08-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

A Change of Outcome Measure:Picture Naming Test(PNT)

This test mainly assesses the ability of picture name of participants.we used a program for displaying named pictures on a computer screen (60 photos in total, of which 20 were Chinese celebrity faces). Each image was displayed in 3 seconds, and 1 point was correctly named for an image.The faces of celebrities were selected from the picture database of Chinese celebrities in the State Key Laboratory of Cognitive Neuroscience and Learning at Beijing Normal University.Score fluctuation is 0-60 points, the higher the score, the better the ability of picture name. (NCT03588572)
Timeframe: This is an outcome measure to assess the improvement of language function from onset to 3 months after treatment. Thus, participates will undergo this assessment on the first days (V1), 28±3 days (V2), and 90±3 days (V3) after randomization.

,
Interventionscore on a scale (Mean)
Visitation 1Visitation 2Visitation 3
Controlled Group38.3143.3148.31
Venlafaxine Group39.1946.7552.25

A Change of Outcome Measure:Spontaneous Language Frequency Test(SLFT)

This test mainly assesses spontaneous speech fluency of participants.It requires participants name as many food names as possible within one minute, and each correct one to give one point.The higher the score, the better the language function. (NCT03588572)
Timeframe: This is an outcome measure to assess the improvement of language function from onset to 3 months after treatment. Thus, participates will undergo this assessment on the first days (V1), 28±3 days (V2), and 90±3 days (V3) after randomization.

,
Interventionscore on a scale (Mean)
Visitation 1Visitation 2Visitation 3
Controlled Group5.758.1310.81
Venlafaxine Group5.319.3112.69

A Change of Outcome Measure:the Chinese Version of Western Aphasia Battery(WAB)

The main outcome measure for this scale is Aphasia Quotient(AQ) which mainly tests the ability of spontaneous speech, oral comprehension, repetition, and naming, and reflects the severity of aphasia, and can be used as a reliable indicator to evaluate the improvement and deterioration of aphasia. Score fluctuation is 0-100 points, the normal value is 98.4-100 points, AQ<93.8 can be judged as language dysfunction. (NCT03588572)
Timeframe: This is an outcome measure to assess the improvement of language function from onset to 3 months after treatment. Thus, participates will undergo this assessment on the first days (V1), 28±3 days (V2), and 90±3 days (V3) after randomization.

,
Interventionscore on a scale (Mean)
Visitation 1Visitation 2Visitation 3
Controlled Group78.6083.5188.55
Venlafaxine Group78.1688.2494.23

Follow-up Measurement: Hamilton Anxiety Rating Scale (HAMA)

The Hamilton Anxiety Rating Scale (HAMA) is a widely used and well-validated tool for measuring the severity of a patient's anxiety. The HAMA is composed of 14 items and takes 15-20 minutes to complete the interview and score the results. Each item is scored on a 5-point scale, ranging from 0=not present to 4=severe.HAMA Scoring Instructions:0-8=Normal, 8-13= Possible Anxiety, 14-17 = Mild Anxiety, 18-24 = Moderate Anxiety, 25-30 = Severe Anxiety(i.e.,the higher the score, the greater the likelihood of anxiety). (NCT03588572)
Timeframe: We must determine that the participant is not in anxiety at each follow-up. Thus, participates will undergo this assessment on the first days (V1), 28±3 days (V2), and 90±3 days (V3) after randomization.

,
Interventionscore on a scale (Mean)
Visitation 1Visitation 2Visitation 3
Controlled Group4.634.003.25
Venlafaxine Group4.884.133.56

Follow-up Measurement: Hamilton Depression Rating Scale (HAMD)

The Hamilton Depression Rating Scale (HAMD) has proven useful for many years as a way of determining a patient's level of depression before, during, and after treatment. It generally takes 15-20 minutes to complete the interview and score the results. Eight items are scored on a 5-point scale, ranging from 0 = not present to 4 = severe. Nine items are scored from 0-2. HAMD Scoring Instructions:0-7=Normal, 8-13 = Mild Depression, 14-18 = Moderate Depression, 19-22 = Severe Depression, ≥ 23 = Very Severe Depression(i.e.,Minimum 0 points and maximum 50 points, the higher the score, the greater the likelihood of depression). (NCT03588572)
Timeframe: We must determine that the participant is not in depression at each follow-up. Thus, participates will undergo this assessment on the first days (V1), 28±3 days (V2), and 90±3 days (V3) after randomization.

,
Interventionscore on a scale (Mean)
Visitation 1Visitation 2Visitation 3
Controlled Group5.254.633.88
Venlafaxine Group5.634.944.06

Follow-up Measurement: Mini-Mental State Examination (MMSE)

The Mini-Mental State Examination (MMSE) is a 30-point questionnaire that is used extensively in clinical and research settings to measure cognitive impairment. Administration of the test takes between 5 and 10 minutes. The MMSE test includes simple questions and problems in a number of areas: the time and place of the test, repeating lists of words, arithmetic such as the serial sevens, language use and comprehension, and basic motor skills. Any score greater than or equal to 24 points (out of 30) indicates a normal cognition. Below this, scores can indicate severe (≤9 points), moderate (10-18 points) or mild (19-23 points) cognitive impairment.The raw score may also need to be corrected for educational attainment and age. (NCT03588572)
Timeframe: We must determine that the participant is not in moderate or more cognitive impairment at each follow-up. Thus, participates will undergo this assessment on the first days (V1), 28±3 days (V2), and 90±3 days (V3) after randomization.

,
Interventionscore on a scale (Mean)
Visitation 1Visitation 2Visitation 3
Controlled Group23.8825.0026.19
Venlafaxine Group23.8125.3826.38

Reviews

1 review available for tyramine and Depression, Involutional

ArticleYear
MAO inhibitors: risks, benefits, and lore.
    Cleveland Clinic journal of medicine, 2010, Volume: 77, Issue:12

    Topics: Administration, Cutaneous; Antidepressive Agents; Blood Pressure; Cheese; Depressive Disorder, Major

2010

Trials

1 trial available for tyramine and Depression, Involutional

ArticleYear
Differential physiological effects of a low dose and high doses of venlafaxine in major depression.
    The international journal of neuropsychopharmacology, 2007, Volume: 10, Issue:1

    Topics: Adrenergic Uptake Inhibitors; Adult; Antidepressive Agents, Second-Generation; Blood Platelets; Bloo

2007
Differential physiological effects of a low dose and high doses of venlafaxine in major depression.
    The international journal of neuropsychopharmacology, 2007, Volume: 10, Issue:1

    Topics: Adrenergic Uptake Inhibitors; Adult; Antidepressive Agents, Second-Generation; Blood Platelets; Bloo

2007
Differential physiological effects of a low dose and high doses of venlafaxine in major depression.
    The international journal of neuropsychopharmacology, 2007, Volume: 10, Issue:1

    Topics: Adrenergic Uptake Inhibitors; Adult; Antidepressive Agents, Second-Generation; Blood Platelets; Bloo

2007
Differential physiological effects of a low dose and high doses of venlafaxine in major depression.
    The international journal of neuropsychopharmacology, 2007, Volume: 10, Issue:1

    Topics: Adrenergic Uptake Inhibitors; Adult; Antidepressive Agents, Second-Generation; Blood Platelets; Bloo

2007

Other Studies

2 other studies available for tyramine and Depression, Involutional

ArticleYear
Differential Potency of Venlafaxine, Paroxetine, and Atomoxetine to Inhibit Serotonin and Norepinephrine Reuptake in Patients With Major Depressive Disorder.
    The international journal of neuropsychopharmacology, 2022, 04-19, Volume: 25, Issue:4

    Topics: Antidepressive Agents, Second-Generation; Atomoxetine Hydrochloride; Cyclohexanols; Depressive Disor

2022
Psychopharmacology column: why choose selegiline transdermal system for refractory depression?
    Issues in mental health nursing, 2007, Volume: 28, Issue:2

    Topics: Administration, Cutaneous; Antidepressive Agents; Depressive Disorder, Major; Drug Interactions; Hum

2007