tylophorine-b and Lung-Neoplasms

tylophorine-b has been researched along with Lung-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for tylophorine-b and Lung-Neoplasms

ArticleYear
Design, synthesis, and evaluation of a water-soluble antofine analogue with high antiproliferative and antitumor activity.
    Bioorganic & medicinal chemistry, 2013, Feb-15, Volume: 21, Issue:4

    New water soluble antofine C-13a analogues were designed, synthesized, and evaluated for antiproliferative activity against cancer cells. Particularly, (-)-(R)-13a-hydroxymethylantofine ((-)-(R)-4b) demonstrated notable growth inhibition against a panel of human cancer cell lines. This growth inhibition was associated with the arrest of the cell cycle in the G0/G1 phases and suppression of mTOR signaling in human lung A549 cancer cells. Compound (-)-(R)-4b also overcame paclitaxel-resistance in human lung cancer cells (A549-Pa) by suppressing P-glycoprotein expression. Furthermore, compound (-)-(R)-4b significantly inhibited the tumor growth of A549 and A549-Pa xenografts in a nude mouse model, which suggests it is a promising novel antitumor agent with sufficient aqueous solubility.

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; G1 Phase Cell Cycle Checkpoints; HCT116 Cells; HEK293 Cells; Humans; Indoles; Lung Neoplasms; Mice; Mice, Nude; Phenanthrolines; Signal Transduction; Stereoisomerism; TOR Serine-Threonine Kinases; Transplantation, Heterologous; Water

2013
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