tws-119 and Neurodegenerative-Diseases

tws-119 has been researched along with Neurodegenerative-Diseases* in 1 studies

Other Studies

1 other study(ies) available for tws-119 and Neurodegenerative-Diseases

Article	Year
PROTACs suppression of GSK-3β, a crucial kinase in neurodegenerative diseases. European journal of medicinal chemistry, 2021, Jan-15, Volume: 210 Glycogen synthase kinase 3β (GSK-3β) is involved in a variety of diseases such as neurodegenerative diseases, bipolar disorder, and diabetes. In this study, a series of heterobifunctional small molecule proteolysis targeting chimera (PROTAC) were designed and synthesized based on E3 ubiquitin ligase cereblon (CRBN). Most of PROTACs displayed good inhibitory activity, with the IC Topics: Animals; Enzyme Inhibitors; Glycogen Synthase Kinase 3 beta; HT29 Cells; Humans; Models, Molecular; Neurodegenerative Diseases; PC12 Cells; Proteolysis; Rats; Small Molecule Libraries	2021

Article

Year

PROTACs suppression of GSK-3β, a crucial kinase in neurodegenerative diseases.

European journal of medicinal chemistry, 2021, Jan-15, Volume: 210

Glycogen synthase kinase 3β (GSK-3β) is involved in a variety of diseases such as neurodegenerative diseases, bipolar disorder, and diabetes. In this study, a series of heterobifunctional small molecule proteolysis targeting chimera (PROTAC) were designed and synthesized based on E3 ubiquitin ligase cereblon (CRBN). Most of PROTACs displayed good inhibitory activity, with the IC

Topics: Animals; Enzyme Inhibitors; Glycogen Synthase Kinase 3 beta; HT29 Cells; Humans; Models, Molecular; Neurodegenerative Diseases; PC12 Cells; Proteolysis; Rats; Small Molecule Libraries

2021