tug-891 has been researched along with Diabetes-Mellitus--Type-2* in 1 studies
1 other study(ies) available for tug-891 and Diabetes-Mellitus--Type-2
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Discovery of a potent and selective GPR120 agonist.
GPR120 is a receptor of unsaturated long-chain fatty acids reported to mediate GLP-1 secretion, insulin sensitization, anti-inflammatory, and anti-obesity effects and is therefore emerging as a new potential target for treatment of type 2 diabetes and metabolic diseases. Further investigation is however hindered by the lack of suitable receptor modulators. Screening of FFA1 ligands provided a lead with moderate activity on GPR120 and moderate selectivity over FFA1. Optimization led to the discovery of the first potent and selective GPR120 agonist. Topics: Biphenyl Compounds; Cell Survival; Cinnamates; Diabetes Mellitus, Type 2; Glucagon-Like Peptide 1; HEK293 Cells; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Phenylpropionates; Receptors, G-Protein-Coupled; Structure-Activity Relationship | 2012 |