tubulysin-a and Glioblastoma

tubulysin-a has been researched along with Glioblastoma* in 1 studies

Other Studies

1 other study(ies) available for tubulysin-a and Glioblastoma

Article	Year
Structure-activity and high-content imaging analyses of novel tubulysins. Chemical biology & drug design, 2007, Volume: 70, Issue:2 The synthesis and biological evaluation of three tubulysin analogs provides the first structure-activity relationship in this family of potent cytotoxic myxobacteria metabolites. Most importantly, the labile N,O-acetal at N(14) is not essential for biological activity. Further, structural simplifications are possible without abolishing biological activities. The N-terminal amino acid can be replaced with N-methylsarcosine, and the configuration at the acetoxy-bearing stereocenter at C(11) is important but not critical for almost all aspects of the biological profile. Our data encourage further development of these compounds as potential therapeutic agents in cancer treatment. Topics: Animals; Cattle; Cell Line, Tumor; Depsipeptides; Glioblastoma; HeLa Cells; Humans; Mitosis; Oligopeptides; Structure-Activity Relationship; Thiazoles; Tubulin; Tubulin Modulators; Vinblastine	2007

Article

Year

Structure-activity and high-content imaging analyses of novel tubulysins.

Chemical biology & drug design, 2007, Volume: 70, Issue:2

The synthesis and biological evaluation of three tubulysin analogs provides the first structure-activity relationship in this family of potent cytotoxic myxobacteria metabolites. Most importantly, the labile N,O-acetal at N(14) is not essential for biological activity. Further, structural simplifications are possible without abolishing biological activities. The N-terminal amino acid can be replaced with N-methylsarcosine, and the configuration at the acetoxy-bearing stereocenter at C(11) is important but not critical for almost all aspects of the biological profile. Our data encourage further development of these compounds as potential therapeutic agents in cancer treatment.

Topics: Animals; Cattle; Cell Line, Tumor; Depsipeptides; Glioblastoma; HeLa Cells; Humans; Mitosis; Oligopeptides; Structure-Activity Relationship; Thiazoles; Tubulin; Tubulin Modulators; Vinblastine

2007