tubastatin-a and Candidiasis

Due to the evolution and development of antifungal drug resistance, limited efficacy of existing drugs has led to high mortality in patients with serious fungal infections. To develop novel antifungal therapeutic strategies, herein a series of carboline fungal histone deacetylase (HDAC) inhibitors were designed and synthesized, which had potent synergistic effects with fluconazole against resistant

Topics: Animals; Azoles; Biofilms; Candida albicans; Candidiasis; Carbolines; Drug Resistance, Fungal; Drug Therapy, Combination; Female; Fluconazole; Fungal Proteins; Fungi; Histone Deacetylase Inhibitors; Humans; Liver; Membrane Transport Proteins; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests