tski-vi and Encephalitis

N,N'-bis(methylisatin-beta-thiosemicarbazone)-2-methylpiperazine (TSKI-VI) proved to be significantly effective against lethal vaccinia, pseudorabies and Mengo virus-induced encephalitis in different strains of mice when administered subcutaneously (s.c.) in doses of 20 mg/kg body weight, twice daily, for a period of five days. The strongest effects occurred in vaccinia virus-infected mice, and the degree of protection was both dose- and virus-dependent. Titres of vaccinia virus in brains of infected mice were slightly lower in TSKI-VI or methisazone-treated mice as compared to virus controls.

Topics: Animals; Dose-Response Relationship, Drug; Encephalitis; Enterovirus Infections; Female; Male; Mengovirus; Methisazone; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Piperazines; Pseudorabies; Thiosemicarbazones; Vaccinia