ts-011 and Kidney-Diseases

ts-011 has been researched along with Kidney-Diseases* in 1 studies

Other Studies

1 other study(ies) available for ts-011 and Kidney-Diseases

Article	Year
Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice. Biochimica et biophysica acta. Molecular basis of disease, 2018, Volume: 1864, Issue:3 Angiotensin II (AngII) plays an important role in the pathogenesis of hypertension and associated renal injuries. To elucidate the molecular mechanism by which AngII induces renal damage, we found that AngII infusion significantly induced CYP4A14 expression in renal proximal tubule cells (RPTCs) with marked increases in blood pressure and proteinuria. Renal production of the major CYP4A metabolite, 20-HETE, was also significantly increased in the AngII-treated mice. Compared to wild-type (WT) mice, CYP4A14 knockout (CYP4A14 Topics: Angiotensin II; Animals; Cytochrome P450 Family 4; Enzyme Induction; Fibrosis; Formamides; Kidney; Kidney Diseases; Kidney Tubules, Proximal; Male; Mice; Mice, Knockout; Morpholines	2018

Article

Year

Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice.

Biochimica et biophysica acta. Molecular basis of disease, 2018, Volume: 1864, Issue:3

Angiotensin II (AngII) plays an important role in the pathogenesis of hypertension and associated renal injuries. To elucidate the molecular mechanism by which AngII induces renal damage, we found that AngII infusion significantly induced CYP4A14 expression in renal proximal tubule cells (RPTCs) with marked increases in blood pressure and proteinuria. Renal production of the major CYP4A metabolite, 20-HETE, was also significantly increased in the AngII-treated mice. Compared to wild-type (WT) mice, CYP4A14 knockout (CYP4A14

Topics: Angiotensin II; Animals; Cytochrome P450 Family 4; Enzyme Induction; Fibrosis; Formamides; Kidney; Kidney Diseases; Kidney Tubules, Proximal; Male; Mice; Mice, Knockout; Morpholines

2018