Compounds > tryptophan

tryptophan and Inflammation

tryptophan has been researched along with Inflammation in 365 studies

Research

Studies (365)

TimeframeStudies, this research(%)All Research%
pre-19908 (2.19)18.7374
1990's10 (2.74)18.2507
2000's29 (7.95)29.6817
2010's184 (50.41)24.3611
2020's134 (36.71)2.80

Authors

AuthorsStudies
Galijasevic, S1
Grondin, JA; Haq, S; Khan, WI1
Chen, W; Fang, J; Feng, C; Han, Y; Hou, P; Liu, Z; Melino, G; Shao, C; Shi, Y; Verkhratsky, A; Wang, Y; Xu, C; Zuo, M1
Cai, J; Chen, X; Gu, K; Jia, G; Liu, G; Tang, J; Tian, G; Wang, F; Wang, J; Wu, C; Zhang, R; Zhao, H1
Kanova, M; Kohout, P1
Ayer, A; Donald, WA; Eaton, P; Guttzeit, S; Kong, SMY; McKinnon, N; Nguyen, GTH; Queiroz, RF; Rajivan, R; Roveri, A; Stanley, CP; Stocker, R; Ursini, F; Winterbourn, CC; Wolhuter, K1
Du, L; Liu, Z; Qi, R; Wang, J; Wu, Z1
Dikmen, M; Kaya-Tilki, E1
Endres, M; Fidzinski, P; Gertz, K; Göttert, R; Holtkamp, M; Kraus, L; Kronenberg, G; Schneider, UC1
Giltay, EJ; Hebbrecht, K; Morrens, M; Sabbe, B; van den Ameele, S; van Nuijs, ALN1
Chang, Y; Han, P; Jia, C; Li, S; Wang, X; Wang, Y; Wei, W; Yang, X; Zhang, B; Zhao, Y1
Anesi, A; Aouizerate, B; Aubert, A; Beau, C; Capuron, L; Cussotto, S; Delgado, I; Dexpert, S; Forestier, D; Ledaguenel, P; Magne, E; Mattivi, F1
Salminen, A2
Gülcemal, S; Hakbilen, S; Körez, MK; Onmaz, DE; Sivrikaya, A; Tezcan, D; Yılmaz, S1
Guarnieri, T1
Berkecz, R; Csont, T; Demján, V; Gáspár, R; Halmi, D; Pipicz, M1
Guillemin, GJ; Mándi, Y; Stone, TW; Vécsei, L; Williams, RO1
Bandodkar, S; Dale, RC; Guillemin, GJ; Han, VX; Heng, B; Yan, J1
Adamski, J; Copetti, M; De Cosmo, S; Mastroianno, M; Menzaghi, C; Prehn, C; Salvemini, L; Scarale, MG; Trischitta, V1
Feng, HY; Guo, ZY; Li, X; Nie, XL; Tan, YQ; Wang, YN; Zhao, YY1
Becker, S; Gao, Z; Khuu, MP; Malinarich, F; Mann, A; Mimmler, M; Paeslack, N; Regen, T; Reinhardt, C1
Bian, X; Chen, Y; Hu, S; Jiang, J; Liu, RH; Liu, Z; Luo, L; Sun, K; Zeng, L; Zhao, S1
Badawy, AA; Bano, S; Dawood, S1
Chen, L; Ji, M; Li, C; Li, M; Liu, W; Liu, Y; Pan, C; Sun, S; Xie, Y; Xu, Z; Yang, Y1
Jiang, H; Jiang, S; Li, L; Li, S; Li, Y; Lu, Y; Lv, J; Lv, L; Shen, J; Wang, Q; Wang, S; Wu, Z; Yan, R; Zhuge, A1
Akdoğan, N; Altıngöz, SM; Balcı, N; Günhan, M; Kurgan, Ş; Önder, C; Serdar, MA1
Cheng, H; Feng, W; Liu, J; Peng, C; Tan, Y; Wang, J; Zhang, D1
Debnath, A; Holloway, AC; Jamshed, L; Jamshed, S; Raine, JC; Thomas, PJ; Tomy, GT; Wish, JV1
Belkhir, L; Bommer, GT; De Greef, J; Dewulf, JP; Gatto, L; Jadoul, M; Laterre, PF; Marie, S; Martin, M; Morelle, J; Oguz, F; Wittebole, X; Yombi, JC1
Bao, L; Chen, L; Duan, S; Feng, L; Fu, Y; Hu, X; Liu, Z; Qiu, M; Wu, K; Zhang, N; Zhao, C; Zhao, Y1
Endres, V; Jones, B; Klemashevich, C; Shankar, S; Sun, Y; Tuchaai, E; Wu, CS1
Cadnapaphornchai, MA; Chonchol, M; Christians, U; Gitomer, BY; Hopp, K; Jackson, MJ; Klawitter, J; Smith, PH1
Aala, WJ; Chen, YF; Chen, YL; Hou, PC; Hsu, CK; Lin, YC; Lu, HC; McGrath, JA; Onoufriadis, A1
Chang, R; Gong, X; Huang, Z; Tan, S; Zou, J1
Du, Y; Gong, M; Ma, X; Ni, P; Ni, R; Wei, J; Yang, X; Zhang, Z; Zhao, L1
Bao, Y; Huang, H; Jiang, P; Li, L; Wu, H; Wu, Q; Yan, T; Zhang, Z1
Garssen, J; Madella, AM; Masereeuw, R; Overbeek, SA; Van Bergenhenegouwen, J1
Chen, S; Chen, Z; Li, Q; Lin, S; Tao, Y; Tong, Y; Wang, P; Wang, T; Xu, Z1
Arunsi, UO; Owumi, SE; Oyelere, AK1
Agista, AZ; Budijanto, S; Komai, M; Koseki, T; Ohsaki, Y; Shirakawa, H; Sultana, H; Tanuseputero, SA; Yang, SC; Yeh, CL1
Agus, A; Arguello, RR; Aucouturier, A; Beaugerie, L; Benech, N; Bermúdez-Humarán, LG; Bourrier, A; Creusot, L; Da Costa, G; Danne, C; Dvorák, Z; Emond, P; Galbert, C; Illes, P; Kirchgesner, J; Landman, C; Langella, P; Lapière, A; Lavelle, A; Lefevre, A; Magniez, A; Mani, S; Michaudel, C; Michel, ML; Moulin, D; Nádvorník, P; Nion-Larmurier, I; Oeuvray, C; Planchais, J; Poirier, M; Richard, ML; Rolhion, N; Seksik, P; Sokol, H; Spatz, M; Wang, Y1
Aragão, C; Azeredo, R; Carvalho, I; Costas, B; Duarte, I; Machado, M; Peixoto, D; Ricardo, A; Santos, P1
Chen, B; Di, Z; Guo, Q; Hu, R; Jiang, S; Liu, J; Ma, R; Shi, M; Song, Z; Sun, S; Wu, X; Xu, H1
Boys, V; Bustamante, S; Chang, J; Leong, RW; Paramsothy, S; Pudipeddi, A; Wasinger, VC; Yau, Y1
Dou, X; Fang, C; Gao, N; Liu, S; Shan, A; Yang, Y; Zhang, L1
Aydin, A; Mat, AF; Ozhan, Y; Sipahi, H1
Augustin, A; Balasubramanian, K; Bjarnason, I; Charlett, A; Chekmeneva, E; DeSouza, N; Dobbs, RJ; Dobbs, SM; Guennec, AL; Hayee, BH; Ibrahim, MAA; Kendler-Rhodes, A; Lewis, M; Ma, Y; Mullish, BH; Ryan, S; Takis, P; Taylor, D; Tucker, RM; Umamahesan, C; Weller, C; Whelan, K1
Ai, C; Shen, C; Song, S; Tong, Y; Wang, L; Wang, S; Yan, C1
Choi, YH; Chun, E; Ji, Y; Jin, M; Jung, HS; Kim, S; Kim, YH; Lee, JE; Lee, WK; Nguyen, TTT; Suh, JH1
Chen, H; Cui, L; Dai, Z; Kou, J; Liu, M; Shi, Y; Song, Q; Sun, S; Wang, B; Wu, Z1
Arslan, AA; Behndig, AF; Brennan, P; Cai, Q; Chen, C; Chen, Y; Fanidi, A; Freedman, ND; Gaziano, JM; Giles, GG; Huang, WY; Johansson, M; Koh, WP; Langhammer, A; Le Marchand, L; Manjer, J; Meyer, K; Midttun, Ø; Prentice, R; Robbins, HA; Sandsveden, M; Sesso, HD; Shu, XO; Stevens, VL; Sørgjerd, EP; Ueland, PM; Ulvik, A; Visvanathan, K; Wang, Y; Weinstein, SJ; Yuan, JM; Zahed, H; Zhang, X; Zheng, W1
Abusoglu, G; Abusoglu, S; Eryavuz Onmaz, D; Humeyra Yerlikaya, F; Kazim Korez, M; Sak, F; Tezcan, D; Unlu, A; Yilmaz, S1
Gao, H; Liu, P; Liu, T; Ning, Z1
Huang, Z; Lai, W; Li, S; Li, XG; Luo, D1
Bjørke-Monsen, AL; Sakkestad, ST; Ueland, PM; Ulvik, A; Varsi, K1
Bertollo, AG; de Oliveira, T; Ignácio, ZM; Mingoti, MED1
Fang, K; Imamura, Y; Kasahara, Y; Konishi, Y; Momono, Y; Murakami, Y; Nishiyama, T; Sakai, D; Yoshida, C1
Cai, Y; Hong, Y; Li, H; Li, P; Li, S; Liao, Q; Liu, D; Shen, B; Xie, Z; Zhang, Q; Zhang, S1
Bagaglia, F; Bianconi, V; Colangelo, C; Cosentini, E; Cucci, A; Fallarino, F; Figorilli, F; Follenzi, A; Franceschini, L; Fuchs, D; Gargaro, M; Giglioni, F; Mannarino, MR; Manni, G; Mencarelli, G; Padiglioni, E; Pieroni, B; Pirro, M; Puccetti, P; Ricciuti, D; Scalisi, G1
Andrews, PI; Antony, J; Ardern-Holmes, S; Bandodkar, S; Chung, J; Dale, RC; Farrar, MA; Gill, D; Guillemin, GJ; Guller, A; Gupta, S; Han, VX; Heng, B; Jones, HF; Kandula, T; Keating, BA; Kothur, K; Menezes, MP; Mohammad, S; Patel, S; Pillai, SC; Sampaio, H; Tantsis, E; Troedson, C; Webster, R; Yan, J1
Abdolghaffari, AH; Hosseini, Y; Lashgari, NA; Momtaz, S; Niazi Shahraki, F; Roudsari, NM; Shayan, M1
Alisjahbana, B; Ardiansyah, E; Avila-Pacheco, J; Bang, ND; Bullock, K; Chau, TTH; Clish, CB; Dian, S; Donovan, J; Estiasari, R; Ganiem, AR; Hai, HT; Hamers, RL; Heemskerk, D; Imran, D; Koeken, VACM; Kumar, V; Maharani, K; Netea, MG; Nhat, LTH; Ruslami, R; Thuong, NTT; Thwaites, G; Tram, TTB; van Crevel, R; van Laarhoven, A; Vinh, DN1
Ai, Z; Chen, L; Li, H; Liu, Y; Song, Y; Su, D; Wang, T; Xu, W; Yang, M; Zhu, G1
Guo, M; Li, S; Liu, M; Wang, Y; Xiang, H; Yao, J1
Stone, TW; Williams, RO1
Cao, K; Chen, C; Li, H; Wang, Q; Zuo, S1
Hu, W; Liu, B; Sun, Y; Wang, S; Zhu, Y1
Bruckner, T; Deisenhammer, EA; Egeter, J; Galffy, M; Giesinger, JM; Gostner, JM; Holzner, B; Hüfner, K; Lehmann, J; Nelles, P; Oberhammer, M; Rockenschaub, J; Sacher, M; Sperner-Unterweger, B; Tymoszuk, P; Vedova, S1
Hemmings, SMJ; Malan-Muller, S; Pretorius, E; Rust, C; Seedat, S; Tonge, D; van den Heuvel, LL1
Akdoğan, N; Balci, N; Günhan, M; Kurgan, Ş; Önder, C; Serdar, CC; Serdar, MA1
Ji, X; Jin, J; Li, J; Wang, Y; Yin, H; Zhao, L; Zhao, M1
Chen, Y; He, H; Peng, M; Sun, H; Zeng, M; Zhou, Y1
Bibb, JA; Chakraborti, A; Funakoshi, H; Kanai, M; Kawahara, Y; Kuroiwa, M; Murakami, Y; Nishi, A; Ohnishi, YN; Shuto, T; Sin, R; Sotogaku, N; Sugiyama, K1
Agulló-Ortuño, MT; Flández, M; Grau, M; López-Martín, JA; Mancebo, E; Núñez Sobrino, JA; Paz-Ares, L1
Guan, C; Mu, G; Tuo, Y; Wang, A; Wang, T1
Jędruchniewicz, K; Sadok, I1
Gan, H; Guo, B; Liao, Y; Lin, R; Liu, M; Lyu, J; Sun, B; Xue, M; Zhang, T; Zheng, P1
Coppens, V; de Boer, P; Fransen, E; Lai, FY; Morrens, M; Sabbe, B; Schuermans, J; Timmers, M; van den Ameele, S; van Diermen, L; van Nuijs, AL; Verkerk, R1
Guo, G; Sun, L; Xu, H; Yang, L1
Gelpi, M; Lebech, AM; Lundgren, J; Midttun, Ø; Mocroft, A; Nielsen, SD; Trøseid, M; Ueland, PM; Ullum, H1
Guaraldi, G; Milic, J1
Coppo, R; Esposito, P; Galli, F; Gregorini, M; Libetta, C; Rampino, T; Sepe, V1
Das, UN1
Deyn, PP; Kema, IP; Naudé, PJW; Nollen, EA; Sorgdrager, FJH1
Erhardt, S; Goiny, M; Imbeault, S; Liu, X1
Hamrick, MW; Kaiser, H; Parker, E1
Bhatti, R; Kaur, J; Kaur, S; Kumari, P; Singh, P1
Clanchy, FI; Huang, YS; Ogbechi, J; Stone, TW; Topping, LM; Williams, RO1
Fluge, Ø; Fosså, A; Kiserud, CE; Loge, JH; Midttun, Ø; Smeland, KH; Tronstad, KJ; Ueland, PM1
Baer, W; Felger, JC; Goldsmith, DR; Haroon, E; Miller, AH; Patel, T; Welle, JR; Woolwine, BJ1
Campiglia, P; Djebali, K; Ganguli, K; Meng, D; Salviati, E; Sommella, E; Walker, WA; Zhu, W1
Fan, W; Hu, Q; Jin, L; Liao, W; Wang, J; Zeng, J; Zhong, S1
Achasova, KM; Babochkina, TI; Borisova, MA; Kozhevnikova, EN; Litvinova, EA; Pindyurin, AV; Snytnikova, OA; Tsentalovich, YP1
Arun, P; Badawy, AA; Ives, JA; Moffett, JR; Namboodiri, AM; Puthillathu, N; Vengilote, R1
Egger, EM; Fuchs, D; Kink, P; Kurz, K; Lanser, L; Weiss, G; Willenbacher, W1
Tanaka, M; Toldi, J; Vécsei, L1
Brollo, M; Devillier, P; Fall, F; Grassin-Delyle, S; Lamy, E; Lenuzza, N; Naline, E; Thévenot, E1
Coimbra, RS; Commodaro, AG; de Paula Guerra, DA; Dos Santos, LM; Kohlhoff, M; Martins-Filho, OA; Rizzo, LV; Serra, HM; Teixeira-Carvalho, A; Vasquez, ARR; Vieira, LQ1
Alvarado, DM; Ciorba, MA1
Kuo, CC; Lee, CM; Liou, JY; Wu, KK; Yet, SF1
Chang, PV; Fu, J; Scott, SA1
Bentley-Hewitt, KL; Butts, CA; Hedderley, DI; Parkar, SG; Perrott, M; Stoklosinski, HM1
Fallarino, F; Fuchs, D; Günther, J; Wirthgen, E1
Baumgartner, R; Berg, M; Forteza, MJ; Hansson, GK; Hedin, U; Hjorth, SA; Ketelhuth, DFJ; Matic, L; Paulsson-Berne, G; Polyzos, KP; Schwartz, TW1
Abadir, PM; Chung, T; de Cabo, R; Ferrucci, L; Hoke, A; Joca, H; Khadeer, M; Le, A; Lovett, J; Moaddel, R; Tian, J; Walston, J; Ward, C; Westbrook, R; Xue, QL; Yang, H1
Bondet, V; Boulet, L; Delage, M; Demangel, C; Di Santo, JP; Doisne, JM; Duchatelet, S; Duffy, D; Goncalves, P; Guenin-Macé, L; Hovnanian, A; Mayau, V; Morel, JD; Nassif, A; Schiavo, A; Ungeheuer, MN1
Bengesser, SA; Birner, A; Dalkner, N; Falzberger, VS; Fellendorf, FT; Hamm, C; Lenger, M; Mangge, H; McIntyre, RS; Pilz, R; Platzer, M; Queissner, R; Reininghaus, B; Reininghaus, E; Rieger, A; Schwalsberger, K; Weiss, EM1
Boeira, SP; Cattelan Souza, L; Giacomeli, R; Jesse, CR; Prigol, M; Silva, MRP; Zarzecki, MS1
Agerer, B; Bergthaler, A; Klavins, K; Kosack, L; Lanz, TV; Lercher, A; Opitz, CA; Platten, M; Popa, AM; Viczenczova, C1
Alcaide, P; Anastasiou, M; Aronovitz, M; Carrillo-Salinas, FJ; Jetton, D; Kaur, K; Ngwenyama, N; Smolgovsky, SA; Tai, A1
Johnston, LJ; Ma, N; Ma, X; Wu, C; Zhang, J; Zhu, S1
Chen, H; Fang, L; Hong, X; Jiang, F; Kong, R; Li, Y; Qian, Z1
Ahmed, T; Alam, MA; Das, S; Fahim, SM; Gazi, MA; Haque, R; Hasan, MM; Hossaini, F; Kabir, MM; Mahfuz, M; Noor, Z; Siddique, MA1
Chamli Hårsmar, S; Lindahl, J; Lindqvist, D; Söderberg, G; Suneson, K1
Anderson, G; Carbone, A; Mazzoccoli, G1
Collier, ME; Giorgini, F; Scrutton, NS; Zhang, S1
Beji, C; Dagenais-Lussier, X; Loucif, H; Routy, JP; Telittchenko, R; van Grevenynghe, J1
Goel, RK; Singh, T1
Apryatin, SA; Balakina, AS; Gmoshinski, IV; Nikityuk, DB; Riger, NA; Shipelin, VA; Shumakova, AA; Trusov, NV1
Kang, WS; Kim, JW; Kim, SA; Park, HJ1
Hu, Y; Ji, X; Lv, H; Peng, B; Wang, J; Wang, S; Yin, J; Yu, Z; Zhang, B1
Bhagavatham, SKS; Dandamudi, RB; Ghaisas, S; Kannan, V; Kunchala, H; Naik, AA; Pargaonkar, A; Pulukool, SK; Saieesh, D; Sharma, A; Sivaramakrishnan, V; Sukumar, P1
Adusumilli, S; Ding, K; Fulzele, S; Hamrick, MW; Hill, WD; Isales, CM; Pacholczyk, R; Patterson, GT; Sahay, B; Smith, K; Wankhade, UD; Yusufu, I1
Coppens, V; De Picker, L; Giltay, EJ; Hebbrecht, K; Morrens, M; Skorobogatov, K1
Bao, CH; Chen, LM; Huang, Y; Liang, SH; Liu, HR; Wang, D; Wu, HG; Wu, LY; Wu, Y1
Abad, C; Horackova, H; Kacerovsky, M; Karahoda, R; Marushka, J; Robles, M; Staud, F; Stranik, J; Tebbens, JD; Vaillancourt, C1
Kopra, E; Mondelli, V; Nikkheslat, N; Pariante, C1
Fu, J; Hu, B; Jiang, YH; Liu, CL; Qin, WH; Wang, HY1
Allers, KA; Beekman, ATF; Giltay, EJ; Keller, S; Milaneschi, Y; Niessen, HG; Penninx, BWJH; Schoevers, RA; Süssmuth, SD1
Clodi, M; Dieplinger, B; Egger, M; Faka, A; Heinzl, M; Klammer, C; Millischer, V; Resl, M; Schwieler, L; Trepci, A1
Alitalo, K; Arasa, J; Beck, A; Cara, LCL; Chalmers, S; Clement, CC; D'Alessandro, A; Demaria, S; Fallarino, F; Fernandez-Rodriguez, R; Formenti, S; Furtado, R; Gadina, M; Galarini, R; Gargaro, M; Gehrke, S; Grohmann, U; Halin, C; Ianni, F; Karaman, S; Lauvau, G; Macchiarulo, A; Manni, G; Mondanelli, G; Moretti, S; Putterman, C; Runge, P; Santambrogio, L; Sardella, R; Skobe, M; Soni, RK; Spada, S; Thangaswamy, S; Tsai, WL; Veldhoen, M1
Bagheri, M; Davis, LK; Ferguson, JF; Gerszten, RE; Hebbring, S; Jarvik, GP; Manouchehri, A; Mosley, JD; Murphy, MB; Murray, KT; Reilly, MP; Shaffer, CM; Shi, M; Singh, K; Stanaway, IB; Wang, C; Wang, TJ1
Gu, Y; Ji, C; Jie, X; Liu, X; Lu, Z; Mo, Y; Wang, L1
An, SY; Bohney, S; Bommi, PV; Calcutt, MW; Chandel, NS; Gao, P; Gibbs, B; Huang, S; Kapitsinou, PP; Kavanaugh, MA; Kerr, EW; Leonardi, R; Rajendran, G; Schonfeld, M; Tiwari, R; Torosyan, R; Truax, AD1
Cisneros, IE; Cunningham, KA1
Miller, BJ; Wang, AK1
Abautret-Daly, Á; Connor, TJ; de Francisco-García, R; Dempsey, E; Harkin, A; Medina, C; Parra-Blanco, A; Riestra, S; Rodrigo, L1
Chen, S; Liu, G; Teng, K; Yin, Y; Zhong, J1
Ablasser, K; Alesutan, I; Belyavskiy, E; Brussee, H; Catena, C; Fahrleitner-Pammer, A; Grübler, MR; Kolesnik, E; Lewinski, DV; März, W; Meinitzer, A; Pieske, B; Pieske-Kraigher, E; Pilz, S; Schwetz, V; Sechi, LA; Tomaschitz, A; Trummer, C; Verheyen, N; Voelkl, J1
Anderson, G1
Chugani, DC; Drewes, JL; Graham, DR; Kannan, S; Lesniak, WG; Nance, E; Rangaramanujam, K; Singh, S; Williams, M; Zhang, Z1
Bakker, SJL; Berger, SP; de Vries, LV; Franssen, CFM; Kema, IP; Minović, I; Navis, G; Sanders, JS; van Faassen, M1
Baydar, T; Girgin, G; Palabiyik, SS; Sipahi, H; Tutkun, E; Yilmaz, OH1
Anderson, G; Carvalho, AF; Duleu, S; Geffard, M; Kanchanatawan, B; Maes, M; Roomruangwong, C; Sirivichayakul, S1
Leonard, BE1
Agudelo, LZ; Cervenka, I; Ruas, JL1
Can, A; Fuchs, D; Groer, M; Krishnamurthy, VB; Millett, CE; Mukherjee, D; Postolache, TT; Reider, A; Saunders, EFH1
Baumgartner, R; Forteza, MJ; Ketelhuth, DFJ1
Khanam, R; Thomas, J; Vohora, D1
Dantzer, R; De Doncker, W; Kuppuswamy, A; Ormstad, H1
Abdullah, NK; Azwa, I; Chong, ML; Crisci, E; Kamarulzaman, A; Larsson, M; Leong, KH; McStea, M; Rajasuriar, R; Takayama, K; Woo, YL; Yap, SH1
D'Agata, A; Duffy, A; Fuchs, D; Groer, M; Louis-Jacques, A; Postolache, TT1
Jeon, SW; Kim, YK1
Czarny, P; Galecki, P; Sliwinski, T; Wigner, P1
Freidin, MB; Livshits, G; Menni, C; Potter, T; Wells, HRR; Williams, FMK1
Maeda, S; Matsuki, N; Sakai, K; Yonezawa, T1
Bieche, I; Castagnet, P; Chemlali, W; Lallemand, F; Meseure, D; Perrot-Applanat, M; Pocard, M; Vacher, S1
Andersen, JR; Christensen, MHE; Fadnes, DJ; Mellgren, G; Midttun, Ø; Nygård, OK; Pedersen, ER; Røst, TH; Ueland, PM; Ulvik, A; Våge, V1
Dey, S; Laury-Kleintop, LD; Mondal, A; Muller, AJ; Prendergast, GC1
Cui, JY; Dempsey, JL; Jeong, H; Kulkarni, S; Lamb, TJ; Mimche, SM; Morgan, ET; Slitt, AL1
Barreto, FS; Chaves Filho, AJM; de Araújo, MCCR; de Lucena, DF; de Moraes, MEA; de Moraes, MO; Macedo, DS; Maes, M1
Alaniz, RC; Choi, M; Ding, Y; Jayaraman, A; Krishnan, S; Lee, K; Saedi, N; Sherr, DH; Sridharan, GV; Yarmush, ML1
Aukrust, P; Gaardbo, JC; Gelpi, M; Gerstoft, J; Hoel, H; Holm, K; Hov, JR; Hove-Skovsgaard, M; Kummen, M; Nielsen, SD; Nwosu, F; Rudi, K; Seljeflot, I; Trøseid, M; Ueland, PM; Ullum, H; Valeur, J1
Alvarez, JI; Antel, J; Ardura-Fabregat, A; Blain, M; Borio, M; Borucki, DM; Chao, CC; de Lima, KA; Dragin, LL; Gutiérrez-Vázquez, C; Healy, L; Hewson, P; Laplaud, DA; Neziraj, T; Prinz, M; Quintana, FJ; Rothhammer, V; Staszewski, O; Takenaka, MC; Tjon, EC; Wheeler, M1
Carvalho, LA; Clarke, G; Díaz, LE; Gómez-Martínez, S; Marcos, A; Michels, N; Olavarria-Ramirez, L; Widhalm, K1
Carvalho, AF; Geffard, M; Kanchanatawan, B; Maes, M; Sirivichayakul, S; Sriswasdi, S; Stoyanov, D; Thika, S1
Bissonnette, M; Ciorba, MA; Guillemin, GJ; Lim, CK; Meckel, K; Pekow, JR; Sofia, MA; Weber, CR1
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Christen, S; Peterhans, E; Stocker, R1
Bowles, CA; Duffy, J; Engel, AG; Gleich, GJ; Lie, JT; Martin, RW; Moyer, TP1
Finn, AF; Gruber, BL; Kaufman, LD; Miller, F; Pampati, J; Peress, NS; Seidman, RJ; Sokoloff, L1
Lallouette, P; Richou, H; Richou, R1
Khrushchov, NG1
Davis, RH; Fisher, JS; McGowan, L1

Reviews

100 review(s) available for tryptophan and Inflammation

ArticleYear
The development of myeloperoxidase inhibitors.
    Bioorganic & medicinal chemistry letters, 2019, 01-01, Volume: 29, Issue:1

    Topics: Animals; Enzyme Inhibitors; Humans; Inflammation; Molecular Structure; Monocytes; Neutrophils; Peroxidase; Structure-Activity Relationship

2019
Tryptophan-derived serotonin-kynurenine balance in immune activation and intestinal inflammation.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021, Volume: 35, Issue:10

    Topics: Animals; Gastrointestinal Microbiome; Humans; Inflammation; Inflammatory Bowel Diseases; Kynurenine; Serotonin; Signal Transduction; Tryptophan

2021
Redressing the interactions between stem cells and immune system in tissue regeneration.
    Biology direct, 2021, 10-20, Volume: 16, Issue:1

    Topics: Animals; Cell Adhesion Molecules; Cell Differentiation; Cell Proliferation; COVID-19; Humans; Immune System; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Insulin-Like Growth Factor II; Interferon-gamma; Kynurenic Acid; Kynurenine; Macrophages; Mice; Muscles; Oxidative Phosphorylation; Receptors, Aryl Hydrocarbon; Regeneration; Stem Cells; Tryptophan; Tumor Necrosis Factor-alpha

2021
Tryptophan: A Unique Role in the Critically Ill.
    International journal of molecular sciences, 2021, Oct-28, Volume: 22, Issue:21

    Topics: Critical Illness; Delirium; Depression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Melatonin; Muscle, Skeletal; Sepsis; Serotonin; Tryptophan

2021
Role of indoleamine 2,3-dioxygenase 1 (IDO1) and kynurenine pathway in the regulation of the aging process.
    Ageing research reviews, 2022, Volume: 75

    Topics: Aging; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Tryptophan

2022
Hypothesis: Emerging Roles for Aryl Hydrocarbon Receptor in Orchestrating CoV-2-Related Inflammation.
    Cells, 2022, 02-13, Volume: 11, Issue:4

    Topics: Adaptive Immunity; Amino Acid Transport Systems, Neutral; Angiotensin-Converting Enzyme 2; Basic Helix-Loop-Helix Transcription Factors; COVID-19; Humans; Immunity, Innate; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Receptors, Aryl Hydrocarbon; SARS-CoV-2; Signal Transduction; Tryptophan

2022
Kynurenine Pathway Metabolites as Potential Clinical Biomarkers in Coronary Artery Disease.
    Frontiers in immunology, 2021, Volume: 12

    Topics: Biomarkers; Coronary Artery Disease; Humans; Inflammation; Kynurenine; Tryptophan

2021
Host/microbiota interactions-derived tryptophan metabolites modulate oxidative stress and inflammation via aryl hydrocarbon receptor signaling.
    Free radical biology & medicine, 2022, 05-01, Volume: 184

    Topics: Gastrointestinal Microbiome; Humans; Inflammation; Ligands; Oxidative Stress; Receptors, Aryl Hydrocarbon; Signal Transduction; Tryptophan

2022
Microbiota-derived tryptophan metabolites in vascular inflammation and cardiovascular disease.
    Amino acids, 2022, Volume: 54, Issue:10

    Topics: Cardiovascular Diseases; Humans; Immunity, Innate; Indoles; Inflammation; Lymphocytes; Microbiota; Tryptophan

2022
An Emerging Cross-Species Marker for Organismal Health: Tryptophan-Kynurenine Pathway.
    International journal of molecular sciences, 2022, Jun-04, Volume: 23, Issue:11

    Topics: Animals; Biomarkers; Ecosystem; Inflammation; Kynurenine; Mammals; Tryptophan

2022
The role and mechanism of tryptophan - kynurenine metabolic pathway in depression.
    Reviews in the neurosciences, 2023, 04-25, Volume: 34, Issue:3

    Topics: Depression; Depressive Disorder, Major; Humans; Inflammation; Kynurenine; Metabolic Networks and Pathways; Tryptophan

2023
Microbial-Derived Tryptophan Catabolites, Kidney Disease and Gut Inflammation.
    Toxins, 2022, 09-18, Volume: 14, Issue:9

    Topics: Fatty Acids, Volatile; Humans; Indican; Inflammation; Prebiotics; Pregnane X Receptor; Receptors, Aryl Hydrocarbon; Renal Insufficiency, Chronic; Tryptophan

2022
The Interrelation between Oxidative Stress, Depression and Inflammation through the Kynurenine Pathway.
    Current topics in medicinal chemistry, 2023, Volume: 23, Issue:6

    Topics: Cytokines; Depression; Humans; Inflammation; Kynurenine; Oxidative Stress; Tryptophan

2023
Activation of aryl hydrocarbon receptor (AhR) in Alzheimer's disease: role of tryptophan metabolites generated by gut host-microbiota.
    Journal of molecular medicine (Berlin, Germany), 2023, Volume: 101, Issue:3

    Topics: Alzheimer Disease; Dysbiosis; Gastrointestinal Microbiome; Humans; Indican; Indoles; Inflammation; Microbiota; Receptors, Aryl Hydrocarbon; Tryptophan

2023
Kynurenine pathway metabolites modulated the comorbidity of IBD and depressive symptoms through the immune response.
    International immunopharmacology, 2023, Volume: 117

    Topics: Colitis, Ulcerative; Comorbidity; Depression; Humans; Inflammation; Kynurenine; Tryptophan

2023
Maternal Inflammation with Elevated Kynurenine Metabolites Is Related to the Risk of Abnormal Brain Development and Behavioral Changes in Autism Spectrum Disorder.
    Cells, 2023, 04-04, Volume: 12, Issue:7

    Topics: Animals; Autism Spectrum Disorder; Brain; Female; Inflammation; Kynurenine; Mammals; Pregnancy; Tryptophan

2023
IDO/Kynurenine; novel insight for treatment of inflammatory diseases.
    Cytokine, 2023, Volume: 166

    Topics: Animals; Cytokines; Diabetes Mellitus, Type 2; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Mammals; Tryptophan; Tumor Necrosis Factor-alpha

2023
Modulation of T cells by tryptophan metabolites in the kynurenine pathway.
    Trends in pharmacological sciences, 2023, Volume: 44, Issue:7

    Topics: Autoimmune Diseases; Humans; Inflammation; Kynurenine; T-Lymphocytes; Tryptophan

2023
Host-Microbiome Interactions: Tryptophan Metabolism and Aromatic Hydrocarbon Receptors after Traumatic Brain Injury.
    International journal of molecular sciences, 2023, Jun-28, Volume: 24, Issue:13

    Topics: Animals; Brain Injuries, Traumatic; Humans; Hydrocarbons, Aromatic; Inflammation; Ligands; Microbiota; Receptors, Aryl Hydrocarbon; Tryptophan

2023
Platelets bridging the gap between gut dysbiosis and neuroinflammation in stress-linked disorders: A narrative review.
    Journal of neuroimmunology, 2023, 09-15, Volume: 382

    Topics: Blood Platelets; Cytokines; Dysbiosis; Humans; Inflammation; Kynurenine; Neuroinflammatory Diseases; Serotonin; Tryptophan

2023
The role of the indoles in microbiota-gut-brain axis and potential therapeutic targets: A focus on human neurological and neuropsychiatric diseases.
    Neuropharmacology, 2023, 11-15, Volume: 239

    Topics: Brain-Gut Axis; Gastrointestinal Microbiome; Humans; Indoles; Inflammation; Tryptophan

2023
Dietary Kynurenine Pathway Metabolites-Source, Fate, and Chromatographic Determinations.
    International journal of molecular sciences, 2023, Nov-14, Volume: 24, Issue:22

    Topics: Animals; Chromatography; Diet; Humans; Inflammation; Kynurenine; Mammals; Tryptophan

2023
Tryptophan Metabolism in Inflammaging: From Biomarker to Therapeutic Target.
    Frontiers in immunology, 2019, Volume: 10

    Topics: Aging; Animals; Biomarkers; Chronic Disease; Disease Susceptibility; Humans; Immunomodulation; Inflammation; Molecular Targeted Therapy; Tryptophan

2019
Kynurenine signaling through the aryl hydrocarbon receptor: Implications for aging and healthspan.
    Experimental gerontology, 2020, Volume: 130

    Topics: Aging; Animals; Basic Helix-Loop-Helix Transcription Factors; Humans; Inflammation; Kynurenine; Longevity; Mice; Reactive Oxygen Species; Receptors, Aryl Hydrocarbon; Signal Transduction; Tryptophan

2020
IDO activation, inflammation and musculoskeletal disease.
    Experimental gerontology, 2020, Volume: 131

    Topics: Animals; Arthritis, Rheumatoid; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Male; Mice; Musculoskeletal Diseases; Osteoporosis; Rats; Tryptophan

2020
Inflammation-Induced Tryptophan Breakdown is Related With Anemia, Fatigue, and Depression in Cancer.
    Frontiers in immunology, 2020, Volume: 11

    Topics: Anemia; Animals; Depression; Fatigue; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Neoplasms; Tryptophan

2020
Exploring the Etiological Links behind Neurodegenerative Diseases: Inflammatory Cytokines and Bioactive Kynurenines.
    International journal of molecular sciences, 2020, Mar-31, Volume: 21, Issue:7

    Topics: Alzheimer Disease; Anti-Inflammatory Agents; Biomarkers; Cytokines; Humans; Huntington Disease; Inflammation; Kynurenine; Neurodegenerative Diseases; Parkinson Disease; Reactive Oxygen Species; Tryptophan

2020
5-methoxytryptophan: an arsenal against vascular injury and inflammation.
    Journal of biomedical science, 2020, Jul-07, Volume: 27, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Humans; Inflammation; Mice; Tryptophan; Vascular System Injuries

2020
Metabolites of microbiota response to tryptophan and intestinal mucosal immunity: A therapeutic target to control intestinal inflammation.
    Medicinal research reviews, 2021, Volume: 41, Issue:2

    Topics: Gastrointestinal Microbiome; Humans; Immunity, Mucosal; Inflammation; Intestinal Mucosa; Microbiota; Tryptophan

2021
Inflammatory Depression-Mechanisms and Non-Pharmacological Interventions.
    International journal of molecular sciences, 2021, Feb-06, Volume: 22, Issue:4

    Topics: C-Reactive Protein; Depression; Depressive Disorder, Major; Dopaminergic Neurons; Dysbiosis; Exercise; Exercise Therapy; Fatty Acids, Omega-3; Gastrointestinal Microbiome; Humans; Inflammation; Probiotics; Synaptic Transmission; Tryptophan

2021
Tryptophan Metabolites and Aryl Hydrocarbon Receptor in Severe Acute Respiratory Syndrome, Coronavirus-2 (SARS-CoV-2) Pathophysiology.
    International journal of molecular sciences, 2021, Feb-05, Volume: 22, Issue:4

    Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; COVID-19; Humans; Inflammation; Receptors, Aryl Hydrocarbon; Respiratory Distress Syndrome; SARS-CoV-2; Tryptophan

2021
Inflammation control and improvement of cognitive function in COVID-19 infections: is there a role for kynurenine 3-monooxygenase inhibition?
    Drug discovery today, 2021, Volume: 26, Issue:6

    Topics: Animals; Cognition; COVID-19; Humans; Inflammation; Kynurenine; Kynurenine 3-Monooxygenase; Neuroprotective Agents; Signal Transduction; Sulfonamides; Thiazoles; Tryptophan

2021
Latest developments in tryptophan metabolism: Understanding its role in B cell immunity.
    Cytokine & growth factor reviews, 2021, Volume: 59

    Topics: B-Lymphocytes; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Tryptophan

2021
Epilepsy Associated Depression: An Update on Current Scenario, Suggested Mechanisms, and Opportunities.
    Neurochemical research, 2021, Volume: 46, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Central Nervous System Agents; Depression; Epilepsy; Humans; Hypothalamo-Hypophyseal System; Inflammation; Neurogenesis; Selective Serotonin Reuptake Inhibitors; Tryptophan

2021
Tryptophan Catabolites in Bipolar Disorder: A Meta-Analysis.
    Frontiers in immunology, 2021, Volume: 12

    Topics: Bipolar Disorder; Depression; Humans; Inflammation; Kynurenic Acid; Kynurenine; Tryptophan

2021
Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease.
    Journal of neuroinflammation, 2021, Jun-14, Volume: 18, Issue:1

    Topics: Animals; Brain-Gut Axis; Depression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Inflammatory Bowel Diseases; Kynurenine; Prognosis; Quality of Life; Quinolinic Acid; Signal Transduction; Tryptophan

2021
Ketamine's effect on inflammation and kynurenine pathway in depression: A systematic review.
    Journal of psychopharmacology (Oxford, England), 2021, Volume: 35, Issue:8

    Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Bipolar Disorder; Cytokines; Depressive Disorder, Major; Humans; Inflammation; Ketamine; Kynurenine; Tryptophan

2021
Covid-19 interface with drug misuse and substance use disorders.
    Neuropharmacology, 2021, 10-15, Volume: 198

    Topics: Adaptation, Psychological; Angiotensin-Converting Enzyme 2; Animals; Axons; Comorbidity; COVID-19; Disease Susceptibility; Drug Misuse; Endothelial Cells; Humans; Immunity, Innate; Inflammation; Kynurenine; Neurons; Neurotransmitter Agents; Olfactory Mucosa; Pandemics; SARS-CoV-2; Social Isolation; Stress, Psychological; Substance-Related Disorders; Tryptophan; Viral Tropism

2021
Meta-analysis of Cerebrospinal Fluid Cytokine and Tryptophan Catabolite Alterations in Psychiatric Patients: Comparisons Between Schizophrenia, Bipolar Disorder, and Depression.
    Schizophrenia bulletin, 2018, 01-13, Volume: 44, Issue:1

    Topics: Bipolar Disorder; Cytokines; Depressive Disorder, Major; Humans; Inflammation; Schizophrenia; Tryptophan

2018
Crosstalk between Tryptophan Metabolism and Cardiovascular Disease, Mechanisms, and Therapeutic Implications.
    Oxidative medicine and cellular longevity, 2017, Volume: 2017

    Topics: Cardiovascular Diseases; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Liver; Signal Transduction; Tryptophan

2017
Linking the biological underpinnings of depression: Role of mitochondria interactions with melatonin, inflammation, sirtuins, tryptophan catabolites, DNA repair and oxidative and nitrosative stress, with consequences for classification and cognition.
    Progress in neuro-psychopharmacology & biological psychiatry, 2018, Jan-03, Volume: 80, Issue:Pt C

    Topics: Cognition; Cognitive Dysfunction; Depressive Disorder, Major; DNA Repair; Humans; Inflammation; Melatonin; Mitochondria; Nitrosative Stress; Oxidative Stress; Sirtuins; Tryptophan

2018
Kynurenines: Tryptophan's metabolites in exercise, inflammation, and mental health.
    Science (New York, N.Y.), 2017, Jul-28, Volume: 357, Issue:6349

    Topics: Brain; Depression; Exercise; Gastrointestinal Microbiome; Gastrointestinal Tract; Humans; Inflammation; Kynurenine; Liver; Mental Disorders; Mental Health; Muscle, Skeletal; Neoplasms; Signal Transduction; Tryptophan

2017
The interplay between cytokines and the Kynurenine pathway in inflammation and atherosclerosis.
    Cytokine, 2019, Volume: 122

    Topics: Adaptive Immunity; Animals; Atherosclerosis; Cardiovascular Diseases; Cytokines; Humans; Immunity, Innate; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Tryptophan

2019
Mechanisms of poststroke fatigue.
    Journal of neurology, neurosurgery, and psychiatry, 2018, Volume: 89, Issue:3

    Topics: Fatigue; Humans; Inflammation; Kynurenine; Signal Transduction; Stroke; Tryptophan

2018
Inflammation-induced depression: Its pathophysiology and therapeutic implications.
    Journal of neuroimmunology, 2017, 12-15, Volume: 313

    Topics: Animals; Depression; Humans; Inflammation; Kynurenine; Serotonin; Tryptophan

2017
Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders.
    Psychiatria Danubina, 2017, Volume: 29, Issue:4

    Topics: Antidepressive Agents; Antioxidants; Biomarkers; Depression; Depressive Disorder; Disease Progression; Humans; Inflammation; Kynurenine; Metabolic Networks and Pathways; Nitric Oxide Synthase; Nitrosative Stress; Oxidative Stress; Quality of Life; Quinolinic Acid; Tryptophan

2017
Inflammatory Reprogramming with IDO1 Inhibitors: Turning Immunologically Unresponsive 'Cold' Tumors 'Hot'.
    Trends in cancer, 2018, Volume: 4, Issue:1

    Topics: Cellular Reprogramming; Humans; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Neoplasms; Small Molecule Libraries; Tryptophan; Tryptophan Oxygenase

2018
Tryptophan catabolites along the indoleamine 2,3-dioxygenase pathway as a biological link between depression and cancer.
    Behavioural pharmacology, 2018, Volume: 29, Issue:2 and 3-Sp

    Topics: Animals; Depression; Depressive Disorder; Humans; Immunity; Indoleamine-Pyrrole 2,3,-Dioxygenase; Indoles; Inflammation; Neoplasms; Oxidative Stress; Serotonin; Signal Transduction; Tryptophan

2018
A new theory of depression based on the serotonin/kynurenine relationship and the hypothalamicpituitary- adrenal axis
    Biomedica : revista del Instituto Nacional de Salud, 2018, 09-01, Volume: 38, Issue:3

    Topics: Animals; Bacterial Infections; Brain; Cytokines; Depression; Humans; Hypothalamo-Hypophyseal System; Illness Behavior; Immunity, Innate; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interleukins; Kynurenine; Models, Neurological; Models, Psychological; Neuroglia; Peripheral Nervous System; Pituitary-Adrenal System; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Serotonin; Social Isolation; Stress, Psychological; Toll-Like Receptor 4; Tryptophan; Vaccines

2018
Probiotics in Autoimmune and Inflammatory Disorders.
    Nutrients, 2018, Oct-18, Volume: 10, Issue:10

    Topics: Animals; Autoimmune Diseases; Fatty Acids, Volatile; Gastrointestinal Microbiome; Humans; Inflammation; Inflammatory Bowel Diseases; Intestines; Nucleosides; Probiotics; Receptors, Aryl Hydrocarbon; Receptors, Histamine H2; Rheumatic Diseases; Tryptophan

2018
RETRACTED: Placental serotonin systems in pregnancy metabolic complications associated with maternal obesity and gestational diabetes mellitus.
    Biochimica et biophysica acta. Molecular basis of disease, 2020, 02-01, Volume: 1866, Issue:2

    Topics: Diabetes, Gestational; Embryonic Development; Female; Fetal Development; Homeostasis; Humans; Inflammation; Kynurenine; Metabolic Networks and Pathways; Obesity, Maternal; Placenta; Pregnancy; Pregnancy Complications; Receptors, Serotonin; Serotonin; Serotonin Plasma Membrane Transport Proteins; Tryptophan

2020
The 'Yin' and the 'Yang' of the kynurenine pathway: excitotoxicity and neuroprotection imbalance in stress-induced disorders.
    Behavioural pharmacology, 2019, Volume: 30, Issue:2 and 3-Sp

    Topics: Animals; Brain; Cytokines; Depressive Disorder, Major; Excitatory Amino Acid Agents; Humans; Hypothalamo-Hypophyseal System; Inflammation; Kynurenine; Neurodegenerative Diseases; Neuroprotection; Pituitary-Adrenal System; Tryptophan

2019
The immunometabolic role of indoleamine 2,3-dioxygenase in atherosclerotic cardiovascular disease: immune homeostatic mechanisms in the artery wall.
    Cardiovascular research, 2019, 07-01, Volume: 115, Issue:9

    Topics: Animals; Anti-Inflammatory Agents; Arteries; Atherosclerosis; Energy Metabolism; Humans; Immune System; Immunomodulation; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Plaque, Atherosclerotic; Signal Transduction; Tryptophan; Up-Regulation

2019
Inflammation, serotonin and major depression.
    Current drug targets, 2013, May-01, Volume: 14, Issue:5

    Topics: Animals; Cytokines; Depressive Disorder, Major; Enzyme Activation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Inflammation Mediators; Serotonin; Stress, Psychological; Tryptophan

2013
[Immune modulation by tryptophan metabolism: relevance for autoimmune and tumor diseases].
    Deutsche medizinische Wochenschrift (1946), 2013, Volume: 138, Issue:28-29

    Topics: Animals; Autoimmune Diseases; Brain; Dietary Supplements; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Immune Tolerance; Immunomodulation; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Mice; Neoplasms; Serotonin; Treatment Outcome; Tryptophan

2013
TRYCAT pathways link peripheral inflammation, nicotine, somatization and depression in the etiology and course of Parkinson's disease.
    CNS & neurological disorders drug targets, 2014, Volume: 13, Issue:1

    Topics: Animals; Depression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Nicotine; Parkinson Disease; Signal Transduction; Somatoform Disorders; Tryptophan

2014
Biological phenotypes underpin the physio-somatic symptoms of somatization, depression, and chronic fatigue syndrome.
    Acta psychiatrica Scandinavica, 2014, Volume: 129, Issue:2

    Topics: Autoimmunity; Biomarkers; Depression; Depressive Disorder, Major; Fatigue Syndrome, Chronic; Humans; Immunity, Cellular; Inflammation; Oxidative Stress; Phenotype; Signal Transduction; Somatoform Disorders; Tryptophan

2014
Comparison of in vitro tests for antioxidant and immunomodulatory capacities of compounds.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2014, Jan-15, Volume: 21, Issue:2

    Topics: Anti-Inflammatory Agents; Antioxidants; Humans; Immunologic Factors; Inflammation; Leukocytes, Mononuclear; Lipopolysaccharides; Mitogens; Models, Biological; Neopterin; Oxidative Stress; Plant Extracts; Reactive Oxygen Species; Tryptophan

2014
Role of immune-inflammatory and oxidative and nitrosative stress pathways in the etiology of depression: therapeutic implications.
    CNS drugs, 2014, Volume: 28, Issue:1

    Topics: Animals; Antidepressive Agents; Depression; Humans; Inflammation; Molecular Targeted Therapy; Oxidative Stress; Tryptophan

2014
Targeting classical IL-6 signalling or IL-6 trans-signalling in depression?
    Expert opinion on therapeutic targets, 2014, Volume: 18, Issue:5

    Topics: Acute-Phase Reaction; Animals; Antidepressive Agents; Autoimmunity; Bacterial Translocation; Cytokines; Depression; Depressive Disorder; Disease Models, Animal; Genetic Predisposition to Disease; Humans; Hypothalamo-Hypophyseal System; Inflammation; Interleukin-6; Meta-Analysis as Topic; Molecular Targeted Therapy; Neurodegenerative Diseases; Neuroimmunomodulation; Neurotransmitter Agents; Pituitary-Adrenal System; Receptors, Interleukin-6; Signal Transduction; Stress, Psychological; T-Lymphocyte Subsets; Tryptophan; Zinc

2014
Increased IL-6 trans-signaling in depression: focus on the tryptophan catabolite pathway, melatonin and neuroprogression.
    Pharmacological reports : PR, 2013, Volume: 65, Issue:6

    Topics: Animals; Depression; Humans; Inflammation; Interleukin-6; Receptors, Interleukin-6; Signal Transduction; Tryptophan

2013
5-methoxyindole metabolites of L-tryptophan: control of COX-2 expression, inflammation and tumorigenesis.
    Journal of biomedical science, 2014, Mar-03, Volume: 21

    Topics: Carcinogenesis; Cyclooxygenase 2; Gene Expression Regulation, Neoplastic; Humans; Indoles; Inflammation; Melatonin; Neoplasm Metastasis; Neoplasms; Serotonin; Tryptophan

2014
Disturbed tryptophan metabolism in cardiovascular disease.
    Current medicinal chemistry, 2014, Volume: 21, Issue:17

    Topics: Aging; Animals; Cardiovascular Diseases; Cardiovascular System; Humans; Inflammation; Mood Disorders; Sepsis; Tryptophan

2014
Activated immune system and inflammation in healthy ageing: relevance for tryptophan and neopterin metabolism.
    Current pharmaceutical design, 2014, Volume: 20, Issue:38

    Topics: Aging; Animals; Health Status; Humans; Immunity, Cellular; Inflammation; Neopterin; Oxidative Stress; Reactive Oxygen Species; Tryptophan

2014
The common inflammatory etiology of depression and cognitive impairment: a therapeutic target.
    Journal of neuroinflammation, 2014, Sep-02, Volume: 11

    Topics: Animals; Cognition Disorders; Depression; Humans; Inflammation; Kynurenine; Signal Transduction; Tryptophan

2014
Inflammation, neurotoxins and psychiatric disorders.
    Modern trends in pharmacopsychiatry, 2013, Volume: 28

    Topics: Animals; Humans; Inflammation; Mental Disorders; Neurotoxicity Syndromes; Tryptophan

2013
Bipolar disorder: role of immune-inflammatory cytokines, oxidative and nitrosative stress and tryptophan catabolites.
    Current psychiatry reports, 2015, Volume: 17, Issue:2

    Topics: Bipolar Disorder; Cytokines; Humans; Inflammation; Oxidation-Reduction; Oxidative Stress; Reactive Nitrogen Species; Tryptophan

2015
The potential of targeting indoleamine 2,3-dioxygenase for cancer treatment.
    Expert opinion on therapeutic targets, 2015, Volume: 19, Issue:5

    Topics: Animals; Cell Proliferation; Dendritic Cells; Humans; Immunity, Cellular; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Neoplasms; T-Lymphocytes; Tryptophan

2015
Tryptophan-kynurenine pathway is dysregulated in inflammation, and immune activation.
    Frontiers in bioscience (Landmark edition), 2015, 06-01, Volume: 20, Issue:7

    Topics: Adult; Aged; Animals; Cardiovascular Diseases; Female; Humans; Immune System Diseases; Inflammation; Kidney Diseases; Kynurenine; Male; Mammals; Metabolic Networks and Pathways; Middle Aged; Oxidative Stress; Rabbits; Rats; Tryptophan; Young Adult

2015
Mechanisms underlying neurocognitive dysfunctions in recurrent major depression.
    Medical science monitor : international medical journal of experimental and clinical research, 2015, May-27, Volume: 21

    Topics: Apoptosis; Attention; Circadian Rhythm; Depressive Disorder, Major; Executive Function; Humans; Hypothalamo-Hypophyseal System; Inflammation; Memory; Neurocognitive Disorders; Neurogenesis; Oxidative Stress; Pituitary-Adrenal System; Psychomotor Performance; Reactive Oxygen Species; Tryptophan

2015
Therapeutic targeting of inflammation and tryptophan metabolism in colon and gastrointestinal cancer.
    Translational research : the journal of laboratory and clinical medicine, 2016, Volume: 167, Issue:1

    Topics: Colon; Gastrointestinal Neoplasms; Humans; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Signal Transduction; Tryptophan

2016
Comorbidity between depression and inflammatory bowel disease explained by immune-inflammatory, oxidative, and nitrosative stress; tryptophan catabolite; and gut-brain pathways.
    CNS spectrums, 2016, Volume: 21, Issue:2

    Topics: Brain; Comorbidity; Depression; Depressive Disorder; Gastrointestinal Microbiome; Humans; Inflammation; Inflammatory Bowel Diseases; Intestinal Mucosa; Intestines; Nitrosation; Oxidative Stress; Stress, Physiological; Tryptophan

2016
Current topics in HIV-1 pathogenesis: The emergence of deregulated immuno-metabolism in HIV-infected subjects.
    Cytokine & growth factor reviews, 2015, Volume: 26, Issue:6

    Topics: Adaptive Immunity; Adult; Cytokines; Glucose; HIV Infections; HIV-1; Humans; Immunity, Innate; Inflammation; Lipid Metabolism; Oxidative Stress; T-Lymphocytes; Tryptophan; Viral Proteins

2015
Glioma: Tryptophan Catabolite and Melatoninergic Pathways Link microRNA, 14-3- 3, Chromosome 4q35, Epigenetic Processes and other Glioma Biochemical Changes.
    Current pharmaceutical design, 2016, Volume: 22, Issue:8

    Topics: Animals; Chromosomes, Human, Pair 4; Epigenesis, Genetic; Glioma; Humans; Inflammation; Melatonin; MicroRNAs; Oxidative Stress; Tryptophan

2016
Alterations of amino acid metabolism in osteoarthritis: its implications for nutrition and health.
    Amino acids, 2016, Volume: 48, Issue:4

    Topics: Arginine; Creatinine; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Homoarginine; Humans; Hydroxyproline; Immunologic Factors; Inflammation; Nutritional Requirements; Nutritional Status; Osteoarthritis; Proline; Tryptophan

2016
The Role of the Microbial Metabolites Including Tryptophan Catabolites and Short Chain Fatty Acids in the Pathophysiology of Immune-Inflammatory and Neuroimmune Disease.
    Molecular neurobiology, 2017, Volume: 54, Issue:6

    Topics: Animals; Fatty Acids, Volatile; Humans; Inflammation; Metabolome; Microbiota; Neuroimmunomodulation; Tryptophan

2017
Gut Permeability and Microbiota in Parkinson's Disease: Role of Depression, Tryptophan Catabolites, Oxidative and Nitrosative Stress and Melatonergic Pathways.
    Current pharmaceutical design, 2016, Volume: 22, Issue:40

    Topics: Depression; Gastrointestinal Microbiome; Humans; Inflammation; Intestinal Mucosa; Intestines; Melatonin; Nitrosative Stress; Oxidation-Reduction; Parkinson Disease; Permeability; Tryptophan

2016
Chronic granulomatous disease.
    Cellular and molecular life sciences : CMLS, 2009, Volume: 66, Issue:4

    Topics: Animals; Bacterial Infections; Disease Models, Animal; Enzyme Activation; Granulomatous Disease, Chronic; Humans; Immune System; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Mycoses; NADPH Oxidases; Reactive Oxygen Species; Tryptophan

2009
Inhibitors of indoleamine 2,3-dioxygenase: a review of novel patented lead compounds.
    Expert opinion on therapeutic patents, 2010, Volume: 20, Issue:2

    Topics: Animals; Autoimmunity; Drug Evaluation, Preclinical; Enzyme Inhibitors; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Patents as Topic; Stereoisomerism; T-Lymphocytes; Tryptophan

2010
Tryptophan metabolism, from nutrition to potential therapeutic applications.
    Amino acids, 2011, Volume: 41, Issue:5

    Topics: Animals; Drug Therapy; Humans; Infections; Inflammation; Kynurenine; Nutritional Status; Tryptophan

2011
The new '5-HT' hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to th
    Progress in neuro-psychopharmacology & biological psychiatry, 2011, Apr-29, Volume: 35, Issue:3

    Topics: Animals; Brain; Depression; Disease Models, Animal; Female; Humans; Immunity, Cellular; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Male; Nitrosation; Oxidative Stress; Serotonin; Tryptophan

2011
Kynurenine pathway in schizophrenia: pathophysiological and therapeutic aspects.
    Current pharmaceutical design, 2011, Volume: 17, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Antipsychotic Agents; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenic Acid; Kynurenine; Mice; Molecular Targeted Therapy; Rats; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Synaptic Transmission; Tryptophan

2011
The role of the kynurenine metabolism in major depression.
    Journal of neural transmission (Vienna, Austria : 1996), 2012, Volume: 119, Issue:2

    Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; Humans; Inflammation; Kynurenine; Tryptophan

2012
Biological underpinnings of the commonalities in depression, somatization, and Chronic Fatigue Syndrome.
    Medical hypotheses, 2012, Volume: 78, Issue:6

    Topics: Cytokines; Depression; Fatigue Syndrome, Chronic; Humans; Immunity, Cellular; Inflammation; Models, Biological; Signal Transduction; Somatoform Disorders; Tryptophan

2012
Inflammation-related disorders in the tryptophan catabolite pathway in depression and somatization.
    Advances in protein chemistry and structural biology, 2012, Volume: 88

    Topics: Depression; Humans; Inflammation; Tryptophan

2012
Inflammation in schizophrenia.
    Advances in protein chemistry and structural biology, 2012, Volume: 88

    Topics: Antipsychotic Agents; Brain; Humans; Inflammation; Kynurenine; Macrophages; Microglia; Monocytes; Schizophrenia; Tryptophan

2012
Schizophrenia is primed for an increased expression of depression through activation of immuno-inflammatory, oxidative and nitrosative stress, and tryptophan catabolite pathways.
    Progress in neuro-psychopharmacology & biological psychiatry, 2013, Apr-05, Volume: 42

    Topics: Animals; Comorbidity; Depressive Disorder; Humans; Inflammation; Nitrosation; Oxidative Stress; Schizophrenia; Signal Transduction; Tryptophan

2013
The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations.
    Journal of the neurological sciences, 2012, Dec-15, Volume: 323, Issue:1-2

    Topics: Aging; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Enzyme Inhibitors; Humans; Huntington Disease; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenic Acid; Kynurenine; Microglia; Molecular Targeted Therapy; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Parkinson Disease; Quinolinic Acid; Receptors, G-Protein-Coupled; Receptors, N-Methyl-D-Aspartate; Tryptophan

2012
Indoleamine 2,3-dioxygenase and dendritic cell tolerogenicity.
    Immunological investigations, 2012, Volume: 41, Issue:6-7

    Topics: Animals; Autoimmunity; Cell Lineage; Dendritic Cells; Gene Expression Regulation; Humans; Immune Tolerance; Immunity, Innate; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Mice; Neoplasms; Signal Transduction; Tryptophan

2012
Tryptophan catabolism and T cell responses.
    Advances in experimental medicine and biology, 2003, Volume: 527

    Topics: Animals; Antigen-Presenting Cells; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Lymphocyte Activation; Models, Immunological; Signal Transduction; T-Lymphocytes; Tryptophan; Tryptophan Oxygenase

2003
Crucial role of interferon-gamma and stimulated macrophages in cardiovascular disease.
    Current vascular pharmacology, 2006, Volume: 4, Issue:3

    Topics: Animals; Atherosclerosis; Cardiovascular Diseases; Humans; Inflammation; Interferon-gamma; Macrophage Activation; Macrophages; Neopterin; Oxidative Stress; Reactive Oxygen Species; Tryptophan

2006
Integrative hypothesis for Huntington's disease: a brief review of experimental evidence.
    Physiological research, 2007, Volume: 56, Issue:5

    Topics: Animals; Calcium; Cell Death; Disease Models, Animal; Energy Metabolism; Excitatory Amino Acids; Humans; Huntington Disease; Inflammation; Kynurenic Acid; Mice; Mice, Transgenic; Mutation; Neurons; Nitro Compounds; Oxidative Stress; Propionates; Quinolinic Acid; Serotonin Plasma Membrane Transport Proteins; Trinucleotide Repeats; Tryptophan

2007
Receptors and pathways in innate antifungal immunity: the implication for tolerance and immunity to fungi.
    Advances in experimental medicine and biology, 2007, Volume: 590

    Topics: Animals; Antifungal Agents; Antigens, Fungal; Candidiasis; Cytokines; Dendritic Cells; Humans; Hypersensitivity; Immune Tolerance; Immunity, Innate; Immunotherapy; Inflammation; Lymphocyte Subsets; Mice; Models, Immunological; Mycoses; Phagocytes; Receptors, Pattern Recognition; Tryptophan; Vertebrates

2007
Tryptophan degradation in autoimmune diseases.
    Cellular and molecular life sciences : CMLS, 2007, Volume: 64, Issue:19-20

    Topics: Animals; Autoimmune Diseases; Drug Delivery Systems; Humans; Immunosuppression Therapy; Inflammation; Tryptophan

2007
Controlling pathogenic inflammation to fungi.
    Expert review of anti-infective therapy, 2007, Volume: 5, Issue:6

    Topics: Animals; Fungi; Glucocorticoid-Induced TNFR-Related Protein; Humans; Immune Tolerance; Immunity, Cellular; Immunity, Innate; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interleukin-17; Mycoses; Receptors, Nerve Growth Factor; Receptors, Tumor Necrosis Factor; Signal Transduction; T-Lymphocytes, Regulatory; Tryptophan

2007
Influence of melatonin and its precursor L-tryptophan on Th1 dependent contact hypersensitivity.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2007, Volume: 58 Suppl 6

    Topics: Animals; Dermatitis, Contact; Inflammation; Interferon-gamma; Interleukin-10; Interleukin-12; Interleukin-4; Lymph Nodes; Male; Melatonin; Mice; Mice, Inbred CBA; Th1 Cells; Th2 Cells; Tryptophan

2007
IL-17 and therapeutic kynurenines in pathogenic inflammation to fungi.
    Journal of immunology (Baltimore, Md. : 1950), 2008, Apr-15, Volume: 180, Issue:8

    Topics: Animals; Cytokines; Fungi; Humans; Immune Reconstitution Inflammatory Syndrome; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interleukin-17; Interleukin-23; Kynurenine; Mycoses; T-Lymphocytes, Regulatory; Tryptophan

2008
Utilization of superoxide anion by indoleamine oxygenase-catalyzed tryptophan and indoleamine oxidation.
    Advances in experimental medicine and biology, 1996, Volume: 398

    Topics: Animals; Enzyme Induction; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interferons; Leukocytes; Lymphocytes; Mice; Models, Biological; Oxidation-Reduction; Superoxides; Tryptophan; Tryptophan Oxygenase

1996
Neuroendocrine and immune aspects of fibromyalgia.
    BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, 2001, Volume: 15, Issue:8

    Topics: Animals; Antidepressive Agents, Tricyclic; Fibromyalgia; Humans; Inflammation; Neurosecretory Systems; Serotonin; Tryptophan

2001
Why clinical pharmacology of serotonin?
    Monographs in neural sciences, 1976, Volume: 3

    Topics: Animals; Blood Platelets; Drug Interactions; Emotions; Headache; Humans; Inflammation; Neurons; Pain; Platelet Aggregation; Receptors, Serotonin; Serotonin; Sexual Behavior; Tryptamines; Tryptophan

1976

Trials

8 trial(s) available for tryptophan and Inflammation

ArticleYear
Vitamin e-loaded membrane dialyzers reduce hemodialysis inflammaging.
    BMC nephrology, 2019, 11-15, Volume: 20, Issue:1

    Topics: Bicarbonates; C-Reactive Protein; Cross-Over Studies; Down-Regulation; Female; Hemodiafiltration; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Male; Membranes, Artificial; Middle Aged; Nitric Oxide; Renal Dialysis; Tryptophan; Vitamin E; Vitamins

2019
Elevated dimethylarginine, ATP, cytokines, metabolic remodeling involving tryptophan metabolism and potential microglial inflammation characterize primary open angle glaucoma.
    Scientific reports, 2021, 05-07, Volume: 11, Issue:1

    Topics: Adenosine Triphosphate; Aqueous Humor; Arginine; Cytokines; Female; Glaucoma, Open-Angle; Humans; Inflammation; Male; Microglia; Tryptophan

2021
Intravenous administration of LPS activates the kynurenine pathway in healthy male human subjects: a prospective placebo-controlled cross-over trial.
    Journal of neuroinflammation, 2021, Jul-17, Volume: 18, Issue:1

    Topics: Administration, Intravenous; Adolescent; Adult; C-Reactive Protein; Cross-Over Studies; Humans; Inflammation; Interleukin-6; Kynurenine; Lipopolysaccharides; Male; Placebos; Prospective Studies; Research Subjects; Single-Blind Method; Tryptophan

2021
Low-grade inflammation and tryptophan-kynurenine pathway activation are associated with adverse cardiac remodeling in primary hyperparathyroidism: the EPATH trial.
    Clinical chemistry and laboratory medicine, 2017, Jun-27, Volume: 55, Issue:7

    Topics: Aged; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Echocardiography; Female; Humans; Hyperparathyroidism, Primary; Inflammation; Kynurenine; Male; Quinolinic Acid; Tryptophan; Ventricular Remodeling

2017
Kynurenine metabolism and inflammation-induced depressed mood: A human experimental study.
    Psychoneuroendocrinology, 2019, Volume: 109

    Topics: Adult; Affect; Cytokines; Depression; Endotoxins; Female; Humans; Inflammation; Interleukin-6; Kynurenic Acid; Kynurenine; Male; Middle Aged; Quinolinic Acid; Sex Factors; Tryptophan; Tumor Necrosis Factor-alpha

2019
Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives o
    The Journal of nutrition, 2015, Volume: 145, Issue:1

    Topics: Adult; Biomarkers; Carbon; Contraceptives, Oral, Hormonal; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Metabolome; Pyridoxal Phosphate; Tryptophan; United States; Vitamin B 6; Vitamin B 6 Deficiency

2015
Impact of cholesterol lowering treatment on plasma kynurenine and tryptophan concentrations in chronic kidney disease: relationship with oxidative stress improvement.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2015, Volume: 25, Issue:2

    Topics: Aged; Allantoin; Anticholesteremic Agents; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Dose-Response Relationship, Drug; Ezetimibe; Female; Healthy Volunteers; Humans; Inflammation; Kynurenine; Male; Malondialdehyde; Middle Aged; NF-kappa B; Oxidative Stress; Renal Insufficiency, Chronic; Simvastatin; Taurine; Triglycerides; Tryptophan; Uric Acid

2015
Depressive and anxiety symptoms in the early puerperium are related to increased degradation of tryptophan into kynurenine, a phenomenon which is related to immune activation.
    Life sciences, 2002, Sep-06, Volume: 71, Issue:16

    Topics: Adult; Anxiety; Depression; Female; Humans; Immunity; Inflammation; Interleukin-6; Interleukin-8; Kynurenine; Leukemia Inhibitory Factor Receptor alpha Subunit; Menstrual Cycle; Postpartum Period; Pregnancy; Psychiatric Status Rating Scales; Receptors, Cytokine; Receptors, OSM-LIF; Tryptophan

2002

Other Studies

257 other study(ies) available for tryptophan and Inflammation

ArticleYear
Tryptophan Ameliorates Barrier Integrity and Alleviates the Inflammatory Response to Enterotoxigenic
    Frontiers in immunology, 2021, Volume: 12

    Topics: Animals; Antigens, Bacterial; Cell Line; Enterotoxigenic Escherichia coli; Epithelial Cells; Escherichia coli Proteins; Fimbriae Proteins; Inflammation; Intestinal Mucosa; Naphthalenes; Phospholipase C gamma; rac1 GTP-Binding Protein; Receptors, Calcium-Sensing; RNA Interference; RNA, Small Interfering; Signal Transduction; Swine; Tryptophan

2021
Hydrogen peroxide signaling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation.
    Nature communications, 2021, 11-16, Volume: 12, Issue:1

    Topics: Animals; Cyclic GMP-Dependent Protein Kinase Type I; Endothelial Cells; Homeodomain Proteins; Hydrogen Peroxide; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Male; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Peroxidases; Peroxiredoxins; Signal Transduction; Tryptophan

2021
Indole-3-Propionic Acid, a Functional Metabolite of
    International journal of molecular sciences, 2021, Nov-18, Volume: 22, Issue:22

    Topics: 3' Untranslated Regions; Animals; Cell Line; Clostridium; Gastrointestinal Microbiome; Gene Expression Profiling; Gene Expression Regulation, Developmental; Indoles; Inflammation; Interleukin-1beta; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Muscle Cells; Muscle Development; Muscle, Skeletal; Pregnane X Receptor; Probiotics; Propionates; Signal Transduction; Transcriptome; Tryptophan

2021
Neuroprotective effects of some epigenetic modifying drugs' on Chlamydia pneumoniae-induced neuroinflammation: A novel model.
    PloS one, 2021, Volume: 16, Issue:11

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Carbamates; Chlamydophila Infections; Chlamydophila pneumoniae; Epigenesis, Genetic; Humans; Hydroxamic Acids; Inflammation; Neuroprotective Agents; Peptide Fragments; Phthalimides; THP-1 Cells; Tryptophan

2021
Lithium inhibits tryptophan catabolism via the inflammation-induced kynurenine pathway in human microglia.
    Glia, 2022, Volume: 70, Issue:3

    Topics: Glycogen Synthase Kinase 3; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Induced Pluripotent Stem Cells; Inflammation; Kynurenine; Lithium; Microglia; Tryptophan

2022
The Role of Kynurenines in Cognitive Dysfunction in Bipolar Disorder.
    Neuropsychobiology, 2022, Volume: 81, Issue:3

    Topics: Bipolar Disorder; Cognitive Dysfunction; Humans; Inflammation; Kynurenic Acid; Kynurenine; Tryptophan

2022
Tryptophan 2,3-dioxygenase 2 plays a key role in regulating the activation of fibroblast-like synoviocytes in autoimmune arthritis.
    British journal of pharmacology, 2022, Volume: 179, Issue:12

    Topics: Animals; Arthritis, Rheumatoid; Cell Movement; Cells, Cultured; Dioxygenases; Fibroblasts; Inflammation; Kynurenine; Rats; Synovial Membrane; Synoviocytes; Tryptophan; Tryptophan Oxygenase

2022
Association between the indole pathway of tryptophan metabolism and subclinical depressive symptoms in obesity: a preliminary study.
    International journal of obesity (2005), 2022, Volume: 46, Issue:4

    Topics: C-Reactive Protein; Depression; Humans; Indoles; Inflammation; Kynurenine; Obesity; Tryptophan

2022
Kynurenine pathway of tryptophan metabolism in patients with familial Mediterranean fever.
    Modern rheumatology, 2023, Mar-02, Volume: 33, Issue:2

    Topics: Case-Control Studies; Familial Mediterranean Fever; Humans; Inflammation; Kynurenine; Tryptophan

2023
Editorial: Multiple Implications of the Kynurenine Pathway in Inflammatory Diseases: Diagnostic and Therapeutic Applications.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Tryptophan

2022
Development of a translational inflammation panel for the quantification of cerebrospinal fluid Pterin, Tryptophan-Kynurenine and Nitric oxide pathway metabolites.
    EBioMedicine, 2022, Volume: 77

    Topics: Chromatography, Liquid; Humans; Inflammation; Kynurenine; Nitric Oxide; Pilot Projects; Pterins; Tandem Mass Spectrometry; Tryptophan

2022
Circulating Metabolites Associate With and Improve the Prediction of All-Cause Mortality in Type 2 Diabetes.
    Diabetes, 2022, 06-01, Volume: 71, Issue:6

    Topics: Biomarkers; Diabetes Mellitus, Type 2; Humans; Inflammation; Kynurenine; Tryptophan

2022
Pu-erh Tea Restored Circadian Rhythm Disruption by Regulating Tryptophan Metabolism.
    Journal of agricultural and food chemistry, 2022, May-11, Volume: 70, Issue:18

    Topics: Animals; Chronobiology Disorders; Circadian Rhythm; Gastrointestinal Microbiome; Inflammation; Mice; Serotonin; Tea; Tryptophan

2022
Inflammation and serotonin deficiency in major depressive disorder: molecular docking of antidepressant and anti-inflammatory drugs to tryptophan and indoleamine 2,3-dioxygenases.
    Bioscience reports, 2022, 05-27, Volume: 42, Issue:5

    Topics: Anti-Inflammatory Agents; Antidepressive Agents; Depressive Disorder, Major; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Molecular Docking Simulation; Salicylates; Serotonin; Tryptophan

2022
Indolepropionic acid reduces obesity-induced metabolic dysfunction through colonic barrier restoration mediated via tuft cell-derived IL-25.
    The FEBS journal, 2022, Volume: 289, Issue:19

    Topics: Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Fatty Acids, Nonesterified; Glucose; Indoles; Inflammation; Interleukin-17; Mice; Mice, Inbred C57BL; Obesity; Tight Junction Proteins; Tryptophan

2022
Identification of a protective Bacteroides strain of alcoholic liver disease and its synergistic effect with pectin.
    Applied microbiology and biotechnology, 2022, Volume: 106, Issue:9-10

    Topics: Animals; Bacteroides; Ethanol; Inflammation; Liver; Liver Diseases, Alcoholic; Mice; Mice, Inbred C57BL; Pectins; Tryptophan

2022
Influence of periodontal inflammation on tryptophan-kynurenine metabolism: a cross-sectional study.
    Clinical oral investigations, 2022, Volume: 26, Issue:9

    Topics: Cross-Sectional Studies; Humans; Inflammation; Interleukin-6; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan

2022
Ginsenoside Rg1 Alleviates Acute Ulcerative Colitis by Modulating Gut Microbiota and Microbial Tryptophan Metabolism.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Animals; Colitis; Colitis, Ulcerative; Dextran Sulfate; Gastrointestinal Microbiome; Ginsenosides; Inflammation; Mice; Mice, Inbred C57BL; RNA, Ribosomal, 16S; Tryptophan

2022
Urine metabolomics links dysregulation of the tryptophan-kynurenine pathway to inflammation and severity of COVID-19.
    Scientific reports, 2022, 06-15, Volume: 12, Issue:1

    Topics: Biomarkers; Chromatography, Liquid; COVID-19; Humans; Inflammation; Kynurenine; Metabolomics; SARS-CoV-2; Tandem Mass Spectrometry; Tryptophan

2022
Dietary Tryptophan-Mediated Aryl Hydrocarbon Receptor Activation by the Gut Microbiota Alleviates Escherichia coli-Induced Endometritis in Mice.
    Microbiology spectrum, 2022, 08-31, Volume: 10, Issue:4

    Topics: Animals; Dysbiosis; Endometritis; Escherichia coli; Female; Gastrointestinal Microbiome; Humans; Inflammation; Ligands; Limosilactobacillus reuteri; Mice; Receptors, Aryl Hydrocarbon; Tryptophan

2022
Deletion of ghrelin alters tryptophan metabolism and exacerbates experimental ulcerative colitis in aged mice.
    Experimental biology and medicine (Maywood, N.J.), 2022, Volume: 247, Issue:17

    Topics: Animals; Chemotactic Factors; Colitis; Colitis, Ulcerative; Cytokines; Dextran Sulfate; Disease Models, Animal; Fatty Acids, Volatile; Fluorescein-5-isothiocyanate; Gene Deletion; Ghrelin; Inflammation; Interleukin-6; Interleukins; Mice; Mice, Inbred C57BL; Mice, Knockout; Tryptophan; Tumor Necrosis Factor-alpha

2022
Kynurenines in polycystic kidney disease.
    Journal of nephrology, 2023, Volume: 36, Issue:1

    Topics: Adult; Child; Disease Progression; Glomerular Filtration Rate; Humans; Inflammation; Kidney; Kynurenine; Polycystic Kidney, Autosomal Dominant; Tryptophan

2023
Plasma metabolomic profiling reflects the malnourished and chronic inflammatory state in recessive dystrophic epidermolysis bullosa.
    Journal of dermatological science, 2022, Volume: 107, Issue:2

    Topics: Chromatography, Liquid; Epidermolysis Bullosa Dystrophica; Fibrosis; Glutamates; Glutamine; Humans; Inflammation; Kynurenine; Malnutrition; Phenylalanine; Succinates; Tandem Mass Spectrometry; Tryptophan; Tyrosine

2022
A combination of neuroimaging and plasma metabolomic analysis suggests inflammation is associated with white matter structural connectivity in major depressive disorder.
    Journal of affective disorders, 2022, 12-01, Volume: 318

    Topics: Brain; Depressive Disorder, Major; Humans; Inflammation; Kynurenine; Lysophosphatidylcholines; Magnetic Resonance Imaging; Neuroimaging; Tryptophan; White Matter

2022
PAH-induced metabolic changes related to inflammation in childhood asthma.
    Environmental science and pollution research international, 2023, Volume: 30, Issue:5

    Topics: Animals; Asthma; Immunoglobulin E; Inflammation; Interleukin-17; Mice; Tryptophan

2023
Detection of the role of intestinal flora and tryptophan metabolism involved in antidepressant-like actions of crocetin based on a multi-omics approach.
    Psychopharmacology, 2022, Volume: 239, Issue:11

    Topics: Animals; Antidepressive Agents; Arachidonic Acid; Arginine; Cytokines; Depression; Gastrointestinal Microbiome; Hippocampus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenic Acid; Mice; Mitogen-Activated Protein Kinases; Occludin; Receptors, Aryl Hydrocarbon; Serotonin; Serotonin Plasma Membrane Transport Proteins; Stress, Psychological; Tryptophan

2022
The protective effect of 3-indolepropanoic acid on aflatoxin B1-induced systemic perturbation of the liver and kidney function in rats.
    Fundamental & clinical pharmacology, 2023, Volume: 37, Issue:2

    Topics: Aflatoxin B1; Animals; Biomarkers; DNA Adducts; Glutathione; Inflammation; Kidney; Liver; Male; Oxidative Stress; Rats; Tryptophan

2023
Tryptamine, a Microbial Metabolite in Fermented Rice Bran Suppressed Lipopolysaccharide-Induced Inflammation in a Murine Macrophage Model.
    International journal of molecular sciences, 2022, Sep-23, Volume: 23, Issue:19

    Topics: Animals; Anti-Inflammatory Agents; Cytokines; Ethanol; Inflammation; Lipopolysaccharides; Macrophages; Mice; Oryza; Receptors, Aryl Hydrocarbon; Solvents; Tryptamines; Tryptophan; Water

2022
Rewiring the altered tryptophan metabolism as a novel therapeutic strategy in inflammatory bowel diseases.
    Gut, 2023, Volume: 72, Issue:7

    Topics: Animals; Colitis; Humans; Inflammation; Inflammatory Bowel Diseases; Intestines; Mice; Tryptophan

2023
Tryptophan Modulatory Role in European Seabass (
    International journal of molecular sciences, 2022, Oct-18, Volume: 23, Issue:20

    Topics: Animal Feed; Animals; Bass; Disease Resistance; Hydrocortisone; Inflammation; Kynurenine; Membrane Glycoproteins; Tryptophan

2022
Involvement of kynurenine pathway between inflammation and glutamate in the underlying etiopathology of CUMS-induced depression mouse model.
    BMC neuroscience, 2022, 11-10, Volume: 23, Issue:1

    Topics: Animals; Depression; Disease Models, Animal; Glutamic Acid; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Mice; Tryptophan

2022
Tryptophan Metabolism 'Hub' Gene Expression Associates with Increased Inflammation and Severe Disease Outcomes in COVID-19 Infection and Inflammatory Bowel Disease.
    International journal of molecular sciences, 2022, Nov-26, Volume: 23, Issue:23

    Topics: COVID-19; Humans; Inflammation; Inflammatory Bowel Diseases; Proteomics; Transcriptome; Tryptophan

2022
Gut-Derived Metabolites from Dietary Tryptophan Supplementation Quench Intestinal Inflammation through the AMPK-SIRT1-Autophagy Pathway.
    Journal of agricultural and food chemistry, 2022, Dec-28, Volume: 70, Issue:51

    Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Dietary Supplements; Inflammation; Lipopolysaccharides; Mice; Sirtuin 1; Swine; Tryptophan

2022
Faecal metabolite deficit, gut inflammation and diet in Parkinson's disease: Integrative analysis indicates inflammatory response syndrome.
    Clinical and translational medicine, 2023, Volume: 13, Issue:1

    Topics: Benzoates; Diet; Humans; Inflammation; Leukocyte L1 Antigen Complex; Maltose; Parkinson Disease; Tryptophan

2023
    Food & function, 2023, Jan-23, Volume: 14, Issue:2

    Topics: Animals; Ascophyllum; Betaine; Carnitine; Fatty Acids, Volatile; Gastrointestinal Microbiome; Inflammation; Mice; Polysaccharides; RNA, Transfer; Tryptophan

2023
Tryptophan-dependent and -independent secretions of tryptophanyl- tRNA synthetase mediate innate inflammatory responses.
    Cell reports, 2023, 01-31, Volume: 42, Issue:1

    Topics: Humans; Inflammation; Tryptophan; Tryptophan-tRNA Ligase

2023
Excessive dietary L-tryptophan regulated amino acids metabolism and serotonin signaling in the colon of weaning piglets with acetate-induced gut inflammation.
    Amino acids, 2023, Volume: 55, Issue:3

    Topics: Animal Feed; Animals; Colon; Diet; Dietary Supplements; Inflammation; Serotonin; Swine; Tryptophan; Weaning

2023
A cross-sectional study of inflammatory markers as determinants of circulating kynurenines in the Lung Cancer Cohort Consortium.
    Scientific reports, 2023, 01-18, Volume: 13, Issue:1

    Topics: Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Humans; Inflammation; Interferon-gamma; Kynurenine; Lung Neoplasms; NAD; Neopterin; Tryptophan

2023
Impaired kynurenine metabolism in patients with primary Sjögren's syndrome.
    Clinical biochemistry, 2023, Volume: 114

    Topics: Chromatography, Liquid; Humans; Inflammation; Kynurenine; Sjogren's Syndrome; Tandem Mass Spectrometry; Tryptophan

2023
Cassane diterpenoid ameliorates dextran sulfate sodium-induced experimental colitis by regulating gut microbiota and suppressing tryptophan metabolism.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Animals; Colitis; Colitis, Ulcerative; Dextran Sulfate; Diterpenes; Gastrointestinal Microbiome; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Mice; RNA, Ribosomal, 16S; Tryptophan

2022
A Vegetarian Diet Significantly Changes Plasma Kynurenine Concentrations.
    Biomolecules, 2023, 02-18, Volume: 13, Issue:2

    Topics: Biomarkers; Diet, Vegetarian; Female; Humans; Inflammation; Kynurenine; Riboflavin; Tryptophan

2023
Stress and Kynurenine-Inflammation Pathway in Major Depressive Disorder.
    Advances in experimental medicine and biology, 2023, Volume: 1411

    Topics: Depressive Disorder, Major; Dioxygenases; Humans; Inflammation; Kynurenine; Quality of Life; Tryptophan

2023
Indoleacrylic acid produced by Parabacteroides distasonis alleviates type 2 diabetes via activation of AhR to repair intestinal barrier.
    BMC biology, 2023, 04-18, Volume: 21, Issue:1

    Topics: Animals; Bacteroidetes; Diabetes Mellitus, Type 2; Indoles; Inflammation; Rats; Receptors, Aryl Hydrocarbon; Tryptophan

2023
A tryptophan metabolite prevents depletion of circulating endothelial progenitor cells in systemic low-grade inflammation.
    Frontiers in immunology, 2023, Volume: 14

    Topics: Animals; C-Reactive Protein; Endothelial Progenitor Cells; Inflammation; Kynurenine; Lipopolysaccharides; Mice; Tryptophan

2023
CSF neopterin, quinolinic acid and kynurenine/tryptophan ratio are biomarkers of active neuroinflammation.
    EBioMedicine, 2023, Volume: 91

    Topics: Adolescent; Biomarkers; Child; Child, Preschool; Humans; Infant; Inflammation; Kynurenine; Leukocytosis; Male; Neopterin; Nervous System Diseases; Neuroinflammatory Diseases; Quinolinic Acid; Tryptophan

2023
Tryptophan metabolism determines outcome in tuberculous meningitis: a targeted metabolomic analysis.
    eLife, 2023, 05-09, Volume: 12

    Topics: Adult; HIV Infections; Humans; Inflammation; Kynurenine; Meningitis, Cryptococcal; Tryptophan; Tuberculosis, Meningeal

2023
Pulsatilla chinensis saponins ameliorated murine depression by inhibiting intestinal inflammation mediated IDO1 overexpression and rebalancing tryptophan metabolism.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2023, Jul-25, Volume: 116

    Topics: Animals; Antidepressive Agents; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Inflammatory Bowel Diseases; Interferon-gamma; Mice; Pulsatilla; Saponins; Tryptophan

2023
The Tryptophan Metabolite Indole-3-Carboxaldehyde Alleviates Mice with DSS-Induced Ulcerative Colitis by Balancing Amino Acid Metabolism, Inhibiting Intestinal Inflammation, and Improving Intestinal Barrier Function.
    Molecules (Basel, Switzerland), 2023, Apr-25, Volume: 28, Issue:9

    Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Inflammation; Mice; Mice, Inbred C57BL; NF-kappa B; Quality of Life; Sodium Chloride; Sodium Chloride, Dietary; Toll-Like Receptor 4; Tryptophan

2023
Integrative analysis of the gut microbiota and faecal and serum short-chain fatty acids and tryptophan metabolites in patients with cirrhosis and hepatic encephalopathy.
    Journal of translational medicine, 2023, 06-17, Volume: 21, Issue:1

    Topics: Fatty Acids, Volatile; Feces; Fibrosis; Gastrointestinal Microbiome; Hepatic Encephalopathy; Humans; Inflammation; Liver Cirrhosis; RNA, Ribosomal, 16S; Tryptophan

2023
The effect of inflammation, SARS-CoV-2 infection, age and mental health on serotonin, and kynurenine and catecholamine pathway metabolites.
    Psychoneuroendocrinology, 2023, Volume: 156

    Topics: COVID-19; Cross-Sectional Studies; Dopamine; Humans; Inflammation; Kynurenine; Mental Health; Phenylalanine; SARS-CoV-2; Serotonin; Tryptophan; Tyrosine

2023
Does smoking influence tryptophan metabolism in periodontal inflammation? A cross-sectional study.
    Journal of periodontal research, 2023, Volume: 58, Issue:5

    Topics: Biomarkers; Cross-Sectional Studies; Humans; Inflammation; Interleukin-6; Kynurenine; Periodontal Diseases; Smoking; Tryptophan

2023
Modulation of tryptophan metabolism via AHR-IL22 pathway mediates the alleviation of DSS-induced colitis by chitooligosaccharides with different degrees of polymerization.
    Carbohydrate polymers, 2023, Nov-01, Volume: 319

    Topics: Animals; Colitis; Inflammation; Interleukin-22; Mice; Polymerization; Tryptophan

2023
Inhibition of STAT-mediated cytokine responses to chemically-induced colitis prevents inflammation-associated neurobehavioral impairments.
    Brain, behavior, and immunity, 2023, Volume: 114

    Topics: Animals; Colitis; Cytokines; Dextran Sulfate; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Male; Mice; Tryptophan

2023
Tryptophan Modulation in Cancer-Associated Cachexia Mouse Models.
    International journal of molecular sciences, 2023, Aug-21, Volume: 24, Issue:16

    Topics: Adenocarcinoma; Animals; Cachexia; Inflammation; Mice; Muscular Atrophy; Pancreatic Neoplasms; Quality of Life; Tryptophan

2023
Indole-3-Lactic Acid, a Tryptophan Metabolite of
    Journal of agricultural and food chemistry, 2023, Dec-06, Volume: 71, Issue:48

    Topics: Animals; Inflammation; Intestinal Mucosa; Mice; NF-E2-Related Factor 2; Signal Transduction; Tight Junction Proteins; Tryptophan

2023
Correlation between immune-related Tryptophan-Kynurenine pathway and severity of severe pneumonia and inflammation-related polyunsaturated fatty acids.
    Immunity, inflammation and disease, 2023, Volume: 11, Issue:11

    Topics: Arachidonic Acid; Fatty Acids, Omega-3; Fatty Acids, Unsaturated; Humans; Hydroxyeicosatetraenoic Acids; Inflammation; Kynurenine; Linolenic Acids; Pneumonia; Tryptophan

2023
A mood state-specific interaction between kynurenine metabolism and inflammation is present in bipolar disorder.
    Bipolar disorders, 2020, Volume: 22, Issue:1

    Topics: Adult; Affect; Biomarkers; Bipolar Disorder; C-Reactive Protein; Depression; Female; Humans; Inflammation; Kynurenine; Male; Middle Aged; Symptom Assessment; Tryptophan

2020
IDO1 depletion induces an anti-inflammatory response in macrophages in mice with chronic viral myocarditis.
    Cell cycle (Georgetown, Tex.), 2019, Volume: 18, Issue:20

    Topics: Animals; Coculture Techniques; Coxsackievirus Infections; Cytokines; Disease Models, Animal; Electrocardiography; Enterovirus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; L-Lactate Dehydrogenase; Macrophages; Male; Malondialdehyde; Mice; Mice, Inbred BALB C; Myocarditis; Myocytes, Cardiac; Signal Transduction; Transfection; Tryptophan; Up-Regulation

2019
Abdominal Adipose Tissue Is Associated With Alterations in Tryptophan-Kynurenine Metabolism and Markers of Systemic Inflammation in People With Human Immunodeficiency Virus.
    The Journal of infectious diseases, 2020, 01-14, Volume: 221, Issue:3

    Topics: Abdominal Fat; Aged; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Female; HIV; HIV Infections; Humans; Inflammation; Kynurenic Acid; Kynurenine; Longitudinal Studies; Male; Middle Aged; Neopterin; Quinolinic Acid; Tryptophan; Waist-Hip Ratio

2020
Why Am I Getting Fat? Exploring Immune-Metabolic Pathways to Central Fat Accumulation in Persons With HIV.
    The Journal of infectious diseases, 2020, 01-14, Volume: 221, Issue:3

    Topics: Abdominal Fat; HIV; HIV Infections; Humans; Inflammation; Kynurenine; Metabolic Networks and Pathways; Tryptophan

2020
Bioactive lipids as modulators of immune check point inhibitors.
    Medical hypotheses, 2020, Volume: 135

    Topics: Animals; Arachidonic Acid; Fatty Acids, Unsaturated; Humans; Immune Checkpoint Inhibitors; Immune System; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Killer Cells, Natural; Lipids; Lymphocytes, Tumor-Infiltrating; Macrophages; Neoplasms; T-Lymphocytes; Tryptophan

2020
Effects of IDO1 and TDO2 inhibition on cognitive deficits and anxiety following LPS-induced neuroinflammation.
    Acta neuropsychiatrica, 2020, Volume: 32, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Brain; Cognitive Dysfunction; Enzyme Inhibitors; Indoles; Inflammation; Kynurenine; Lipopolysaccharides; Male; Mice; Tryptophan

2020
Modification of the lead molecule: Tryptophan and piperidine appended triazines reversing inflammation and hyeperalgesia in rats.
    Bioorganic & medicinal chemistry, 2020, 01-15, Volume: 28, Issue:2

    Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Formaldehyde; Humans; Hyperalgesia; Inflammation; Molecular Docking Simulation; Molecular Structure; Piperidines; Rats; Rats, Wistar; Structure-Activity Relationship; Triazines; Tryptophan

2020
Metabolic analysis of amino acids and vitamin B6 pathways in lymphoma survivors with cancer related chronic fatigue.
    PloS one, 2020, Volume: 15, Issue:1

    Topics: Adolescent; Adult; Aged; Amino Acids; Cancer Survivors; Child; Fatigue Syndrome, Chronic; Female; Humans; Inflammation; Lymphoma; Male; Middle Aged; Surveys and Questionnaires; Tryptophan; Vitamin B 6; Young Adult

2020
Associations among peripheral and central kynurenine pathway metabolites and inflammation in depression.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2020, Volume: 45, Issue:6

    Topics: Depression; Humans; Inflammation; Kynurenic Acid; Kynurenine; Tryptophan

2020
Indole-3-lactic acid, a metabolite of tryptophan, secreted by Bifidobacterium longum subspecies infantis is anti-inflammatory in the immature intestine.
    Pediatric research, 2020, Volume: 88, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Bifidobacterium longum; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cytokines; Enterocolitis, Necrotizing; Enterocytes; Humans; Hydrocortisone; Indoles; Infant, Newborn; Inflammation; Interleukin-1beta; Interleukin-8; Intestines; Male; Mice; Mice, Inbred C57BL; Milk, Human; Organ Culture Techniques; Probiotics; Receptors, Aryl Hydrocarbon; Tandem Mass Spectrometry; Tryptophan

2020
Tryptophan metabolite-regulated Treg responses contribute to attenuation of airway inflammation during specific immunotherapy in a mouse asthma model.
    Human vaccines & immunotherapeutics, 2020, 08-02, Volume: 16, Issue:8

    Topics: Allergens; Animals; Asthma; Cytokines; Disease Models, Animal; Inflammation; Mice; Mice, Inbred BALB C; Ovalbumin; T-Lymphocytes, Regulatory; Tryptophan

2020
Fucose Ameliorates Tryptophan Metabolism and Behavioral Abnormalities in a Mouse Model of Chronic Colitis.
    Nutrients, 2020, Feb-11, Volume: 12, Issue:2

    Topics: Animals; Behavior, Animal; Bifidobacterium; Chronic Disease; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Escherichia coli; Fucose; Gastrointestinal Microbiome; Inflammation; Intestinal Mucosa; Male; Mice, Inbred C57BL; Social Behavior; Tryptophan

2020
Quinolinate as a Marker for Kynurenine Metabolite Formation and the Unresolved Question of NAD
    Frontiers in immunology, 2020, Volume: 11

    Topics: Animals; Biomarkers; Cell Movement; Gerbillinae; Hippocampus; HSP90 Heat-Shock Proteins; Immunity; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; NAD; Pokeweed Mitogens; Poly(ADP-ribose) Polymerases; Quinolinic Acid; Rats; Spleen; Tryptophan

2020
Metabolic reprograming of LPS-stimulated human lung macrophages involves tryptophan metabolism and the aspartate-arginosuccinate shunt.
    PloS one, 2020, Volume: 15, Issue:4

    Topics: Aged; Argininosuccinic Acid; Aspartic Acid; Cells, Cultured; Female; Humans; Inflammation; Lipopolysaccharides; Macrophage Activation; Macrophages, Alveolar; Male; Middle Aged; Signal Transduction; Tryptophan

2020
Intestinal microbiota regulates tryptophan metabolism following oral infection with Toxoplasma gondii.
    Parasite immunology, 2020, Volume: 42, Issue:9

    Topics: Animals; Female; Gastrointestinal Microbiome; Inflammation; Mice; Mice, Inbred C57BL; Toxoplasma; Toxoplasmosis; Tryptophan

2020
Serotonin Receptors Regulate Inflammatory Response in Experimental Colitis.
    The Journal of nutrition, 2020, 07-01, Volume: 150, Issue:7

    Topics: Animals; Colitis; Dextran Sulfate; Inflammation; Mice; Receptors, Serotonin; Tryptophan

2020
Microbial tryptophan metabolites regulate gut barrier function via the aryl hydrocarbon receptor.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 08-11, Volume: 117, Issue:32

    Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Caco-2 Cells; Colitis, Ulcerative; Cytoskeletal Proteins; Disease Models, Animal; Gastrointestinal Microbiome; Humans; Inflammation; Intestinal Mucosa; Mice; Mice, Knockout; Nonmuscle Myosin Type IIA; Permeability; Receptors, Aryl Hydrocarbon; Tryptophan

2020
Influence of kiwifruit on gastric and duodenal inflammation-related gene expression in aspirin-induced gastric mucosal damage in rats.
    Scientific reports, 2020, 08-03, Volume: 10, Issue:1

    Topics: Actinidia; Animals; Aspirin; CLOCK Proteins; Duodenum; Fruit; Gastric Mucosa; Gene Expression Regulation; Inflammation; Male; Plant Extracts; Principal Component Analysis; Rats, Sprague-Dawley; Stomach; Stomach Ulcer; Tight Junction Proteins; Tryptophan

2020
Editorial: Immunomodulatory Roles of Tryptophan Metabolites in Inflammation and Cancer.
    Frontiers in immunology, 2020, Volume: 11

    Topics: Animals; Humans; Immunity; Immunomodulation; Inflammation; Neoplasms; Tryptophan

2020
Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans.
    Journal of internal medicine, 2021, Volume: 289, Issue:1

    Topics: Carotid Artery Diseases; Down-Regulation; Humans; Inflammation; Kynurenic Acid; Kynurenine; Macrophages; Plaque, Atherosclerotic; Tryptophan; Up-Regulation

2021
Kynurenines link chronic inflammation to functional decline and physical frailty.
    JCI insight, 2020, 08-20, Volume: 5, Issue:16

    Topics: Adult; Aged; Aged, 80 and over; Animals; Arginine; Chronic Disease; Cytokines; Disease Models, Animal; Female; Frail Elderly; Humans; Inflammation; Interleukin-10; Kynurenine; Male; Mice, Inbred C57BL; Middle Aged; Neuromuscular Junction; Serotonin; Tryptophan; Walking Speed; Young Adult

2020
Dysregulation of tryptophan catabolism at the host-skin microbiota interface in hidradenitis suppurativa.
    JCI insight, 2020, 10-15, Volume: 5, Issue:20

    Topics: Adult; Axilla; Female; Fibroblasts; Hidradenitis Suppurativa; Host Microbial Interactions; Humans; Inflammation; Kynurenine; Male; Metabolism; Middle Aged; Receptors, Aryl Hydrocarbon; Skin; Tryptophan

2020
C-Reactive Protein as a Possible Predictor of Trail-Making Performance in Individuals with Psychiatric Disorders.
    Nutrients, 2020, Oct-02, Volume: 12, Issue:10

    Topics: Adult; Aged; Biomarkers; C-Reactive Protein; Cognitive Dysfunction; Female; Humans; Inflammation; Inflammation Mediators; Kynurenine; Linear Models; Male; Mental Disorders; Middle Aged; Neuropsychological Tests; Predictive Value of Tests; Psychomotor Performance; Reaction Time; Stroop Test; Trail Making Test; Tryptophan; Young Adult

2020
Involvement of Indoleamine-2,3-Dioxygenase and Kynurenine Pathway in Experimental Autoimmune Encephalomyelitis in Mice.
    Neurochemical research, 2020, Volume: 45, Issue:12

    Topics: Animals; Body Weight; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Female; Gene Expression; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Kynurenine 3-Monooxygenase; Mice, Inbred C57BL; Myelin-Oligodendrocyte Glycoprotein; Oximes; Peptide Fragments; Quinolinic Acid; Sulfonamides; Tryptophan

2020
Hepatocyte-intrinsic type I interferon signaling reprograms metabolism and reveals a novel compensatory mechanism of the tryptophan-kynurenine pathway in viral hepatitis.
    PLoS pathogens, 2020, Volume: 16, Issue:10

    Topics: Animals; Antiviral Agents; Female; Hepatitis Viruses; Hepatitis, Viral, Animal; Hepatocytes; Humans; Immunity, Innate; Inflammation; Interferon Regulatory Factor-7; Kynurenine; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, Interferon alpha-beta; STAT1 Transcription Factor; Tryptophan; Tryptophan Oxygenase

2020
Gut dysbiosis induced by cardiac pressure overload enhances adverse cardiac remodeling in a T cell-dependent manner.
    Gut microbes, 2020, 11-09, Volume: 12, Issue:1

    Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Disease Models, Animal; Dysbiosis; Endomyocardial Fibrosis; Fatty Acids, Volatile; Gastrointestinal Microbiome; Heart Failure; Hypertrophy, Left Ventricular; Hypertrophy, Right Ventricular; Inflammation; Lymphocyte Activation; Lymphocyte Depletion; Male; Mice; Mice, Inbred C57BL; Receptors, Aryl Hydrocarbon; T-Lymphocytes; Tryptophan; Ventricular Pressure; Ventricular Remodeling

2020
Treatment with 5-methoxytryptophan attenuates microglia-induced neuroinflammation in spinal cord trauma.
    International immunopharmacology, 2020, Volume: 88

    Topics: Animals; Cell Line; Female; Humans; Inflammation; Mice; Mice, Inbred C57BL; Microglia; Spinal Cord Injuries; Tryptophan

2020
Plasma Kynurenine to Tryptophan Ratio Is Negatively Associated with Linear Growth of Children Living in a Slum of Bangladesh: Results from a Community-Based Intervention Study.
    The American journal of tropical medicine and hygiene, 2020, 11-23, Volume: 104, Issue:2

    Topics: Bangladesh; Biomarkers; Chromatography, Liquid; Cohort Studies; Female; Growth and Development; Growth Disorders; Humans; Infant; Inflammation; Kynurenine; Male; Plasma; Poverty Areas; Tryptophan

2020
Effects of Tyrosine and Tryptophan in Rats with Diet-Induced Obesity.
    International journal of molecular sciences, 2021, Feb-28, Volume: 22, Issue:5

    Topics: Animals; Body Weight; Cytokines; Diet; Energy Metabolism; Feeding Behavior; Inflammation; Liver; Male; Memory; Obesity; Rats; Rats, Wistar; Triglycerides; Tryptophan; Tyrosine

2021
Early-Life Stress Modulates Gut Microbiota and Peripheral and Central Inflammation in a Sex-Dependent Manner.
    International journal of molecular sciences, 2021, Feb-14, Volume: 22, Issue:4

    Topics: Animals; Animals, Newborn; Cytokines; Female; Gastrointestinal Microbiome; Hippocampus; Inflammation; Kynurenine; Male; Maternal Deprivation; Population Dynamics; Rats, Sprague-Dawley; RNA, Ribosomal, 16S; Sex Factors; Staphylococcus; Streptococcus; Stress, Psychological; Tryptophan

2021
Ameliorative Effect of Dietary Tryptophan on Neurodegeneration and Inflammation in d-Galactose-Induced Aging Mice with the Potential Mechanism Relying on AMPK/SIRT1/PGC-1α Pathway and Gut Microbiota.
    Journal of agricultural and food chemistry, 2021, Apr-28, Volume: 69, Issue:16

    Topics: Aging; AMP-Activated Protein Kinases; Animals; Diet; Galactose; Gastrointestinal Microbiome; Inflammation; Mice; Neurodegenerative Diseases; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Sirtuin 1; Tryptophan

2021
A Tryptophan-Deficient Diet Induces Gut Microbiota Dysbiosis and Increases Systemic Inflammation in Aged Mice.
    International journal of molecular sciences, 2021, May-08, Volume: 22, Issue:9

    Topics: Aging; Animals; Bacteria; Biodiversity; Cytokines; Diet; Feces; Gastrointestinal Microbiome; Inflammation; Male; Mice; Mice, Inbred C57BL; Phylogeny; Tryptophan

2021
Prenatal inflammation as a link between placental expression signature of tryptophan metabolism and preterm birth.
    Human molecular genetics, 2021, 11-01, Volume: 30, Issue:22

    Topics: Biomarkers; Computational Biology; Disease Susceptibility; Female; Gene Expression Profiling; Gene Expression Regulation; Humans; Inflammation; Metabolic Networks and Pathways; Placenta; Pregnancy; Pregnancy Outcome; Premature Birth; Risk Factors; Transcriptome; Tryptophan

2021
Gut ACE2 Expression, Tryptophan Deficiency, and Inflammatory Responses The Potential Connection That Should Not Be Ignored During SARS-CoV-2 Infection.
    Cellular and molecular gastroenterology and hepatology, 2021, Volume: 12, Issue:4

    Topics: Angiotensin-Converting Enzyme 2; Animals; COVID-19; Cytokines; Epithelial Cells; Inflammation; Intestinal Mucosa; Intestines; Kynurenine; Lipopolysaccharides; Mice; Mice, Knockout; Phenotype; Recombinant Proteins; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Tryptophan

2021
The association between plasma tryptophan catabolites and depression: The role of symptom profiles and inflammation.
    Brain, behavior, and immunity, 2021, Volume: 97

    Topics: Depression; Depressive Disorder, Major; Humans; Inflammation; Kynurenic Acid; Kynurenine; Tryptophan

2021
3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine.
    Nature communications, 2021, 07-21, Volume: 12, Issue:1

    Topics: Animals; Biogenic Amines; Cell Line, Tumor; Dendritic Cells; Disease Models, Animal; Endothelial Cells; Humans; Immunomodulation; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interferon-gamma; Kynurenine; Mice; Nephritis; NF-kappa B; Psoriasis; Tryptophan

2021
The genetic architecture of plasma kynurenine includes cardiometabolic disease mechanisms associated with the SH2B3 gene.
    Scientific reports, 2021, 08-02, Volume: 11, Issue:1

    Topics: Animals; Biomarkers; C-Reactive Protein; Inflammation; Kynurenine; Male; Mice; Polymorphism, Single Nucleotide; Tryptophan

2021
Bupi Yishen formula attenuates kidney injury in 5/6 nephrectomized rats via the tryptophan-kynurenic acid-aryl hydrocarbon receptor pathway.
    BMC complementary medicine and therapies, 2021, Aug-10, Volume: 21, Issue:1

    Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Drugs, Chinese Herbal; Inflammation; Kidney; Kynurenic Acid; Medicine, Chinese Traditional; Metabolome; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon; Renal Insufficiency, Chronic; Tryptophan

2021
Hypoxic preconditioning protects against ischemic kidney injury through the IDO1/kynurenine pathway.
    Cell reports, 2021, 08-17, Volume: 36, Issue:7

    Topics: Animals; Hypoxia; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Ischemia; Kidney; Kynurenine; Metabolome; Mice, Inbred C57BL; Mice, Knockout; NAD; Procollagen-Proline Dioxygenase; Protective Agents; Tryptophan

2021
Association between psychological measures with inflammatory anddisease-related markers of inflammatory bowel disease.
    International journal of psychiatry in clinical practice, 2017, Volume: 21, Issue:3

    Topics: Adult; Aged; Anxiety; Biomarkers; C-Reactive Protein; Case-Control Studies; Colon; Depression; Female; Gene Expression; Humans; Inflammation; Inflammatory Bowel Diseases; Interferon-gamma; Interleukin-1beta; Interleukin-6; Kynurenine; Male; Matrix Metalloproteinase 9; Middle Aged; Quality of Life; Tryptophan

2017
Maternal Inflammation Results in Altered Tryptophan Metabolism in Rabbit Placenta and Fetal Brain.
    Developmental neuroscience, 2017, Volume: 39, Issue:5

    Topics: Animals; Brain; Female; Indoles; Inflammation; Placenta; Pregnancy; Quinolinic Acid; Rabbits; Serotonin; Tryptophan

2017
The tryptophan/kynurenine pathway, systemic inflammation, and long-term outcome after kidney transplantation.
    American journal of physiology. Renal physiology, 2017, 08-01, Volume: 313, Issue:2

    Topics: Adult; Biomarkers; Chromatography, Liquid; Female; Graft Rejection; Graft Survival; Humans; Inflammation; Inflammation Mediators; Kidney Transplantation; Kynurenine; Longitudinal Studies; Male; Middle Aged; Predictive Value of Tests; Prospective Studies; Risk Factors; Tandem Mass Spectrometry; Time Factors; Treatment Outcome; Tryptophan; Vascular Diseases

2017
Possible changes of New-Generation inflammation markers with occupational lead exposure.
    Journal of occupational health, 2017, Jul-27, Volume: 59, Issue:4

    Topics: Adult; Biomarkers; Chromatography, High Pressure Liquid; Hospitals; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Lead; Male; Middle Aged; Neopterin; Occupational Exposure; Tryptophan; Turkey

2017
IgM-mediated autoimmune responses to oxidative specific epitopes, but not nitrosylated adducts, are significantly decreased in pregnancy: association with bacterial translocation, perinatal and lifetime major depression and the tryptophan catabolite (TRYC
    Metabolic brain disease, 2017, Volume: 32, Issue:5

    Topics: Adult; Autoimmunity; Bacterial Translocation; Biomarkers; Cytokines; Depression, Postpartum; Depressive Disorder, Major; Epitopes; Female; Gram-Negative Bacteria; Humans; Immunoglobulin M; Inflammation; Kynurenine; Metabolic Networks and Pathways; Nitric Oxide; Pregnancy; Tryptophan; Young Adult

2017
Major Depression as a Neuroprogressive Prelude to Dementia: What Is the Evidence?
    Modern trends in pharmacopsychiatry, 2017, Volume: 31

    Topics: Brain; Cytokines; Dementia; Depressive Disorder, Major; Humans; Inflammation; Kynurenine; Oxidative Stress; Quinolinic Acid; Tryptophan

2017
Total sleep time and kynurenine metabolism associated with mood symptom severity in bipolar disorder.
    Bipolar disorders, 2018, Volume: 20, Issue:1

    Topics: Adult; Affect; Biomarkers; Bipolar Disorder; Depression; Female; Humans; Inflammation; Kynurenine; Male; Middle Aged; Neopterin; Outcome Assessment, Health Care; Serotonin; Sleep; Sleep Initiation and Maintenance Disorders; Tryptophan

2018
Activation of indoleamine 2, 3- dioxygenase pathway by olanzapine augments antidepressant effects of venlafaxine in mice.
    Psychiatry research, 2017, Volume: 258

    Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Benzodiazepines; Depression; Depressive Disorder, Treatment-Resistant; Female; Hippocampus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interleukin-1beta; Interleukin-6; Kynurenine; Male; Mice; Olanzapine; Serotonin; Stress, Psychological; Swimming; Tryptophan; Venlafaxine Hydrochloride

2017
HIV/Human herpesvirus co-infections: Impact on tryptophan-kynurenine pathway and immune reconstitution.
    PloS one, 2017, Volume: 12, Issue:10

    Topics: Adult; Antibodies, Viral; Antiretroviral Therapy, Highly Active; CD4-Positive T-Lymphocytes; Coinfection; Female; Herpes Simplex; Herpesvirus 1, Human; HIV Infections; Humans; Immune Reconstitution Inflammatory Syndrome; Inflammation; Kynurenine; Male; Metabolic Networks and Pathways; Seroepidemiologic Studies; Tryptophan

2017
Associations Among Obesity, Inflammation, and Tryptophan Catabolism in Pregnancy.
    Biological research for nursing, 2018, Volume: 20, Issue:3

    Topics: Adult; Biomarkers; Body Mass Index; Cross-Sectional Studies; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Male; Neopterin; Obesity; Pregnancy; Pregnancy Complications; Tryptophan

2018
Metabolomic markers of fatigue: Association between circulating metabolome and fatigue in women with chronic widespread pain.
    Biochimica et biophysica acta. Molecular basis of disease, 2018, Volume: 1864, Issue:2

    Topics: Adult; Aged; Area Under Curve; Biomarkers; C-Reactive Protein; Chronic Pain; Cohort Studies; Diseases in Twins; Eicosapentaenoic Acid; Fatigue; Fatty Acids, Omega-3; Female; Furans; Glycosylation; Humans; Inflammation; Linear Models; Metabolome; Middle Aged; Musculoskeletal Pain; Propionates; Risk Factors; ROC Curve; Tryptophan; United Kingdom

2018
Decreased plasma amino acid concentrations in cats with chronic gastrointestinal diseases and their possible contribution in the inflammatory response.
    Veterinary immunology and immunopathology, 2018, Volume: 195

    Topics: Amino Acids; Animals; Cat Diseases; Cats; Chronic Disease; Female; Gastrointestinal Diseases; Histidine; Inflammation; Interleukin-8; Macrophages; Male; Tryptophan

2018
High AHR expression in breast tumors correlates with expression of genes from several signaling pathways namely inflammation and endogenous tryptophan metabolism.
    PloS one, 2018, Volume: 13, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Cell Line, Tumor; Estrogen Receptor alpha; Female; Humans; Inflammation; Middle Aged; Real-Time Polymerase Chain Reaction; Receptors, Aryl Hydrocarbon; RNA, Messenger; Signal Transduction; Tryptophan

2018
Inflammatory markers, the tryptophan-kynurenine pathway, and vitamin B status after bariatric surgery.
    PloS one, 2018, Volume: 13, Issue:2

    Topics: Adult; Bariatric Surgery; Biomarkers; C-Reactive Protein; Female; Glycated Hemoglobin; Humans; Inflammation; Kynurenine; Male; Middle Aged; Obesity; Tryptophan; Vitamin B Complex

2018
Physiological Regulation of Drug Metabolism and Transport: Pregnancy, Microbiome, Inflammation, Infection, and Fasting.
    Drug metabolism and disposition: the biological fate of chemicals, 2018, Volume: 46, Issue:5

    Topics: Animals; Antioxidant Response Elements; Biological Transport; Cytochrome P-450 CYP2D6; Fasting; Female; Gastrointestinal Microbiome; Hepatocyte Nuclear Factor 4; Humans; Inactivation, Metabolic; Inflammation; Liver; Malaria; Male; Membrane Transport Proteins; Metabolic Clearance Rate; Mice; Mice, Transgenic; Microbiota; Plasmodium chabaudi; Pregnancy; Schistosomiasis mansoni; Tryptophan

2018
Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages.
    Cell reports, 2018, 04-24, Volume: 23, Issue:4

    Topics: Animals; Cytokines; Dietary Fats; Fatty Acid Synthase, Type I; Gastrointestinal Microbiome; Hep G2 Cells; Hepatocytes; Humans; Indoleacetic Acids; Inflammation; Macrophages; Male; Mice; RAW 264.7 Cells; Receptors, Aryl Hydrocarbon; Sterol Regulatory Element Binding Protein 1; Tryptamines; Tryptophan

2018
Impact of HIV and Type 2 diabetes on Gut Microbiota Diversity, Tryptophan Catabolism and Endothelial Dysfunction.
    Scientific reports, 2018, 04-30, Volume: 8, Issue:1

    Topics: Arginine; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Endothelium; Feces; Female; Gastrointestinal Microbiome; HIV Infections; Humans; Inflammation; Kynurenine; Male; Metabolism; Middle Aged; Neopterin; Risk Factors; RNA, Ribosomal, 16S; Tryptophan

2018
Microglial control of astrocytes in response to microbial metabolites.
    Nature, 2018, Volume: 557, Issue:7707

    Topics: Animals; Astrocytes; Cells, Cultured; Central Nervous System; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; ErbB Receptors; Female; Humans; Inflammation; Lipopolysaccharide Receptors; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Receptors, Aryl Hydrocarbon; Symbiosis; Transforming Growth Factor alpha; Tryptophan; Vascular Endothelial Growth Factor B; Vascular Endothelial Growth Factor Receptor-1

2018
Psychosocial stress and inflammation driving tryptophan breakdown in children and adolescents: A cross-sectional analysis of two cohorts.
    Psychoneuroendocrinology, 2018, Volume: 94

    Topics: Adolescent; C-Reactive Protein; Child; Cohort Studies; Cross-Sectional Studies; Cytokines; Depression; Depressive Disorder; Female; Humans; Inflammation; Interferon-gamma; Interleukin-6; Kynurenic Acid; Kynurenine; Male; Stress, Psychological; Tryptophan; Tumor Necrosis Factor-alpha

2018
Towards a new classification of stable phase schizophrenia into major and simple neuro-cognitive psychosis: Results of unsupervised machine learning analysis.
    Journal of evaluation in clinical practice, 2018, Volume: 24, Issue:4

    Topics: Adult; Behavioral Symptoms; Cognitive Reserve; Cytokines; Female; Humans; Inflammation; Male; Middle Aged; Neurocognitive Disorders; Neuroimmunomodulation; Patient Acuity; Psychiatric Status Rating Scales; Psychotic Disorders; Quality of Life; Schizophrenia; Schizophrenic Psychology; Tryptophan; Unsupervised Machine Learning

2018
Tryptophan Metabolism through the Kynurenine Pathway is Associated with Endoscopic Inflammation in Ulcerative Colitis.
    Inflammatory bowel diseases, 2018, 06-08, Volume: 24, Issue:7

    Topics: Adolescent; Adult; Aged; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Colitis, Ulcerative; Colonoscopy; Female; Gas Chromatography-Mass Spectrometry; Humans; Inflammation; Kynurenine; Logistic Models; Male; Metabolic Networks and Pathways; Middle Aged; Multivariate Analysis; Sensitivity and Specificity; Tryptophan; Young Adult

2018
Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health.
    Nature medicine, 2018, Volume: 24, Issue:8

    Topics: Animals; Diabetes Mellitus, Type 2; Fatty Liver; Gastrointestinal Microbiome; Health; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Insulin Resistance; Interleukin-22; Interleukins; Intestines; Kynurenine; Lipopolysaccharides; Male; Mice, Inbred C57BL; Obesity; Principal Component Analysis; Tryptophan

2018
Disruption of microglia histone acetylation and protein pathways in mice exhibiting inflammation-associated depression-like symptoms.
    Psychoneuroendocrinology, 2018, Volume: 97

    Topics: Acetylation; Animals; Depression; Disease Models, Animal; Histones; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Male; Mice; Mice, Inbred C57BL; Microglia; Protein Processing, Post-Translational; Serotonin; Tryptophan

2018
Naringenin protects against oxido-inflammatory aberrations and altered tryptophan metabolism in olfactory bulbectomized-mice model of depression.
    Toxicology and applied pharmacology, 2018, 09-15, Volume: 355

    Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Behavior, Animal; Brain Chemistry; Cytokines; Depression; Estrogen Antagonists; Flavanones; Fluoxetine; Inflammation; Kynurenine; Male; Metabolic Networks and Pathways; Mice; Mice, Inbred BALB C; Motor Activity; Olfactory Bulb; Oxidative Stress; Tryptophan

2018
Hypothesis kynurenic and quinolinic acids: The main players of the kynurenine pathway and opponents in inflammatory disease.
    Medical hypotheses, 2018, Volume: 118

    Topics: Animals; Anti-Inflammatory Agents; Humans; Immunosuppressive Agents; Inflammation; Kynurenic Acid; Kynurenine; Male; Models, Theoretical; ortho-Aminobenzoates; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Wistar; Tryptophan

2018
A step ahead: Exploring the gut microbiota in inpatients with bipolar disorder during a depressive episode.
    Bipolar disorders, 2019, Volume: 21, Issue:1

    Topics: Biomarkers; Bipolar Disorder; Case-Control Studies; Cross-Sectional Studies; Depression; Depressive Disorder; Gastrointestinal Microbiome; Humans; Inflammation; Inpatients; Kynurenine; Male; Tryptophan

2019
Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins.
    Scientific reports, 2018, 07-27, Volume: 8, Issue:1

    Topics: Animals; Anthocyanins; Anti-Inflammatory Agents; Bacteria; Diet, High-Fat; Dysbiosis; Feces; Gastrointestinal Microbiome; Genes, Bacterial; Inflammation; Male; Metabolome; Neuroprotection; Neuroprotective Agents; Phylogeny; Plant Extracts; Rats, Wistar; Rubus; Tryptophan

2018
Effects of 1-Methyltryptophan on Immune Responses and the Kynurenine Pathway after Lipopolysaccharide Challenge in Pigs.
    International journal of molecular sciences, 2018, Oct-02, Volume: 19, Issue:10

    Topics: Animals; Cytokines; Fibroblasts; Immunity; Inflammation; Kynurenine; Lipopolysaccharides; Lung; Metabolic Networks and Pathways; Metabolome; RNA, Messenger; Swine; Tryptophan

2018
Involvement of calcium-sensing receptor activation in the alleviation of intestinal inflammation in a piglet model by dietary aromatic amino acid supplementation.
    The British journal of nutrition, 2018, Volume: 120, Issue:12

    Topics: Amino Acids, Aromatic; Animals; Colon; Cytokines; Diet; Dietary Supplements; Epithelial Cells; Female; I-kappa B Kinase; Inflammation; Intestines; Jejunum; Lipopolysaccharides; NF-kappa B; Peroxidase; Phenylalanine; Phosphorylation; Random Allocation; Receptors, Calcium-Sensing; RNA, Messenger; Signal Transduction; Sus scrofa; Swine; Tryptophan; Tumor Necrosis Factor-alpha; Tyrosine

2018
Macrophage de novo NAD
    Nature immunology, 2019, Volume: 20, Issue:1

    Topics: Aging; Animals; Cells, Cultured; Homeostasis; Immunity, Innate; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; NAD; Oxidative Phosphorylation; Pentosyltransferases; Phagocytosis; Signal Transduction; Tryptophan

2019
The treatment value of IL-1β monoclonal antibody under the targeting location of alpha-methyl-L-tryptophan and superparamagnetic iron oxide nanoparticles in an acute temporal lobe epilepsy model.
    Journal of translational medicine, 2018, 12-04, Volume: 16, Issue:1

    Topics: Acute Disease; Animals; Antibodies, Monoclonal; Epilepsy, Temporal Lobe; Glial Fibrillary Acidic Protein; Inflammation; Interleukin-1beta; Magnetic Resonance Imaging; Magnetite Nanoparticles; Male; Rats, Sprague-Dawley; Transcription Factor RelA; Tryptophan

2018
Orchestration of Tryptophan-Kynurenine Pathway, Acute Decompensation, and Acute-on-Chronic Liver Failure in Cirrhosis.
    Hepatology (Baltimore, Md.), 2019, Volume: 69, Issue:4

    Topics: Acute-On-Chronic Liver Failure; Aged; Bacterial Infections; Case-Control Studies; Europe; Female; Hepatic Encephalopathy; Humans; Inflammation; Kynurenine; Liver Cirrhosis; Male; Middle Aged; Prospective Studies; Renal Insufficiency; Tryptophan

2019
Association of Age-related Macular Degeneration With Mortality in Patients With Acquired Immunodeficiency Syndrome; Role of Systemic Inflammation.
    American journal of ophthalmology, 2019, Volume: 199

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antigens, CD; Biomarkers; C-Reactive Protein; Case-Control Studies; Chemokine CXCL10; Female; Humans; Inflammation; Interleukin-6; Kynurenine; Longitudinal Studies; Macular Degeneration; Male; Middle Aged; Proportional Hazards Models; Prospective Studies; Risk Factors; Tryptophan

2019
Exploratory metabolomics of nascent metabolic syndrome.
    Journal of diabetes and its complications, 2019, Volume: 33, Issue:3

    Topics: Adult; Aged; Biomarkers; Blood Glucose; Blood Pressure; Cardiovascular Diseases; Female; gamma-Aminobutyric Acid; Humans; Inflammation; Male; Metabolic Syndrome; Metabolomics; Middle Aged; Pyrrolidonecarboxylic Acid; Triglycerides; Tryptophan; Waist Circumference

2019
The kynurenine pathway and cognitive performance in community-dwelling older adults. The Hordaland Health Study.
    Brain, behavior, and immunity, 2019, Volume: 75

    Topics: Aged; Biomarkers; Body Mass Index; C-Reactive Protein; Cognition; Cross-Sectional Studies; Female; Humans; Independent Living; Inflammation; Kynurenine; Male; Neopterin; Neuropsychological Tests; Signal Transduction; Tryptophan

2019
Kynurenine Is a Cerebrospinal Fluid Biomarker for Bacterial and Viral Central Nervous System Infections.
    The Journal of infectious diseases, 2019, 06-05, Volume: 220, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Autoimmune Diseases; Biomarkers; Central Nervous System Infections; Cerebrospinal Fluid; Female; Humans; Inflammation; Kynurenine; Lactic Acid; Leukocyte Count; Male; Middle Aged; Tryptophan; Young Adult

2019
Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation.
    Nature, 2019, Volume: 566, Issue:7745

    Topics: Animals; Blood Pressure; Cell Line; Cyclic GMP-Dependent Protein Kinase Type I; Cysteine; Enzyme Activation; Female; Humans; Hydrogen Peroxide; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Male; Oxidation-Reduction; Rats; Signal Transduction; Singlet Oxygen; Tryptophan; Vasodilator Agents

2019
Does aerobic exercise associated with tryptophan supplementation attenuates hyperalgesia and inflammation in female rats with experimental fibromyalgia?
    PloS one, 2019, Volume: 14, Issue:2

    Topics: Animals; Disease Models, Animal; Female; Fibromyalgia; Hyperalgesia; Inflammation; Interleukin-6; Physical Conditioning, Animal; Rats; Rats, Wistar; Tryptophan; Tumor Necrosis Factor-alpha

2019
[Tryptophan and metabolic syndrome, a new challenge for health].
    Medecine sciences : M/S, 2019, Volume: 35, Issue:3

    Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Membrane Permeability; Disease Models, Animal; Gastrointestinal Microbiome; Humans; Inflammation; Intestinal Mucosa; Metabolic Networks and Pathways; Metabolic Syndrome; Mice; Receptors, Aryl Hydrocarbon; Tryptophan

2019
Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan.
    Nature communications, 2019, 04-01, Volume: 10, Issue:1

    Topics: Acetylcarnitine; Animals; Canavanine; Carnitine; Case-Control Studies; Disease Models, Animal; Disease Progression; Fibrosis; Gene Knock-In Techniques; Gene Knockdown Techniques; Humans; I-kappa B Proteins; Inflammation; Kelch-Like ECH-Associated Protein 1; Kidney; Metabolomics; Mice; NF-E2-Related Factor 2; NF-kappa B; Renal Insufficiency, Chronic; Severity of Illness Index; Signal Transduction; Taurine; Tryptophan; Tryptophan Hydroxylase; Ureteral Obstruction

2019
How acute and chronic physical disease may influence mental health - An Analysis of neurotransmitter precursor amino acid levels.
    Psychoneuroendocrinology, 2019, Volume: 106

    Topics: Acute Disease; Adult; Aged; Amino Acids; Anxiety Disorders; C-Reactive Protein; Chronic Disease; Depression; Depressive Disorder; Female; Humans; Inflammation; Kynurenine; Male; Mental Disorders; Mental Health; Middle Aged; Neurotransmitter Agents; Phenylalanine; Prospective Studies; Tryptophan; Tyrosine

2019
Soluble CD83 Triggers Resolution of Arthritis and Sustained Inflammation Control in IDO Dependent Manner.
    Frontiers in immunology, 2019, Volume: 10

    Topics: Animals; Antibodies, Blocking; Antigens, CD; Arthritis, Experimental; CD83 Antigen; Cytokines; Female; Immunoglobulins; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Joints; Membrane Glycoproteins; Mice; Signal Transduction; Solubility; T-Lymphocytes, Regulatory; Transforming Growth Factor beta; Tryptophan

2019
Dietary tryptophan deficiency and its supplementation compromises inflammatory mechanisms and disease resistance in a teleost fish.
    Scientific reports, 2019, 05-22, Volume: 9, Issue:1

    Topics: Animal Feed; Animals; Bass; Blood Bactericidal Activity; Blood Cell Count; Body Weight; Complement Pathway, Alternative; Disease Resistance; Dose-Response Relationship, Drug; Erythrocyte Indices; Fish Diseases; Gene Expression Profiling; Gram-Negative Bacterial Infections; Hemoglobins; Hydrocortisone; Immunity, Humoral; Inflammation; Muramidase; Neuroimmunomodulation; Nutritional Requirements; Peroxidases; Photobacterium; Tryptophan

2019
Changes in tryptophan metabolism during pregnancy and postpartum periods: Potential involvement in postpartum depressive symptoms.
    Journal of affective disorders, 2019, 08-01, Volume: 255

    Topics: Adult; Depression; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Postpartum Period; Pregnancy; Psychiatric Status Rating Scales; Tryptophan

2019
The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs.
    Science translational medicine, 2019, 06-12, Volume: 11, Issue:496

    Topics: Adipocytes; Animals; Energy Metabolism; Gastrointestinal Microbiome; Inflammation; Insulin Resistance; Male; Mice; MicroRNAs; Obesity; Tryptophan

2019
Circulating markers of cellular immune activation in prediagnostic blood sample and lung cancer risk in the Lung Cancer Cohort Consortium (LC3).
    International journal of cancer, 2020, 05-01, Volume: 146, Issue:9

    Topics: Adenocarcinoma of Lung; Adult; Aged; Biomarkers, Tumor; Carcinoma, Large Cell; Carcinoma, Squamous Cell; Case-Control Studies; Female; Follow-Up Studies; Humans; Inflammation; Kynurenine; Lung Neoplasms; Male; Middle Aged; Neopterin; Prognosis; Prospective Studies; Risk Factors; Small Cell Lung Carcinoma; Tryptophan

2020
Aging leads to prolonged duration of inflammation-induced depression-like behavior caused by Bacillus Calmette-Guérin.
    Brain, behavior, and immunity, 2013, Volume: 32

    Topics: Aging; Anhedonia; Animals; Behavior, Animal; Body Weight; Chronic Disease; Depression; Hindlimb Suspension; Illness Behavior; Inflammation; Kynurenine; Lung; Mice; Mice, Inbred BALB C; Motor Activity; Mycobacterium bovis; Mycobacterium Infections; Spleen; Tryptophan

2013
A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study.
    Clinical and experimental immunology, 2013, Volume: 173, Issue:1

    Topics: 3-Hydroxyanthranilic Acid; Aged; Aging; Biomarkers; Body Mass Index; Creatinine; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Male; Middle Aged; Motor Activity; Neopterin; Norway; ortho-Aminobenzoates; Reference Values; Smoking; Tryptophan; Xanthurenates

2013
C-reactive protein predicts fatigue independently of depression in breast cancer patients prior to chemotherapy.
    Brain, behavior, and immunity, 2013, Volume: 34

    Topics: Biomarkers; Breast Neoplasms; C-Reactive Protein; Cytokines; Depression; Fatigue; Female; Humans; Inflammation; Kynurenine; Middle Aged; Tryptophan

2013
Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women.
    The Journal of nutrition, 2013, Volume: 143, Issue:11

    Topics: Adult; Biomarkers; Creatine; Cystathionine; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Male; Multivariate Analysis; Postprandial Period; Pyridoxal Phosphate; Serine; Tryptophan; Vitamin B 6; Vitamin B 6 Deficiency; Young Adult

2013
Inflammation-induced catabolism of tryptophan and tyrosine in acute ischemic stroke.
    Journal of molecular neuroscience : MN, 2013, Volume: 51, Issue:3

    Topics: Aged; Brain Ischemia; C-Reactive Protein; Case-Control Studies; Catecholamines; Cytokines; Female; Glucose; Humans; Inflammation; Male; Middle Aged; Stroke; Tryptophan; Tyrosine

2013
Specific in situ detection of murine indoleamine 2, 3-dioxygenase.
    Journal of cellular biochemistry, 2014, Volume: 115, Issue:2

    Topics: Animals; Antibodies, Monoclonal; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Mice; Tissue Distribution; Tryptophan

2014
Quiescent and proliferative fibroblasts exhibit differential p300 HAT activation through control of 5-methoxytryptophan production.
    PloS one, 2014, Volume: 9, Issue:2

    Topics: Anti-Inflammatory Agents; Cell Differentiation; Cell Proliferation; Chromatography, High Pressure Liquid; Cyclooxygenase 2; Fibroblasts; Gene Silencing; Humans; Immunoenzyme Techniques; Inflammation; Mass Spectrometry; p300-CBP Transcription Factors; Promoter Regions, Genetic; RNA, Small Interfering; Sepharose; Streptavidin; Tryptophan

2014
Interferon (IFN)-γ-mediated inflammation and the kynurenine pathway in relation to bone mineral density: the Hordaland Health Study.
    Clinical and experimental immunology, 2014, Volume: 176, Issue:3

    Topics: Aged; Biomarkers; Bone Density; Female; Humans; Inflammation; Inflammation Mediators; Interferon-gamma; Kynurenine; Male; Metabolic Networks and Pathways; Metabolome; Middle Aged; Neopterin; Risk Factors; Tryptophan

2014
1-Methyl-tryptophan synergizes with methotrexate to alleviate arthritis in a mouse model of arthritis.
    Autoimmunity, 2014, Volume: 47, Issue:6

    Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Autoimmunity; Cytokines; Disease Models, Animal; Drug Synergism; Inflammation; Methotrexate; Mice; Tryptophan; Tryptophan Oxygenase

2014
Drug analog inhibition of indoleamine 2,3-dioxygenase (IDO) activity modifies pattern recognition receptor expression and proinflammatory cytokine responses early during influenza virus infection.
    Journal of leukocyte biology, 2014, Volume: 96, Issue:3

    Topics: Animals; Cell Line; Cytokines; Enzyme Induction; Enzyme Inhibitors; Female; Gene Expression Regulation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Influenza A Virus, H3N2 Subtype; Lung; Macrophage Activation; Macrophages, Alveolar; Mice; Mice, Inbred C57BL; Nuclear Proteins; Orthomyxoviridae Infections; Receptors, Pattern Recognition; Time Factors; Tryptophan; Ubiquitin-Protein Ligases

2014
Evidence for increased catabolism of vitamin B-6 during systemic inflammation.
    The American journal of clinical nutrition, 2014, Volume: 100, Issue:1

    Topics: Aged; Biomarkers; Body Mass Index; C-Reactive Protein; Cross-Sectional Studies; Dietary Supplements; Female; Humans; Inflammation; Kynurenine; Linear Models; Longitudinal Studies; Male; Middle Aged; Neopterin; Norway; Oxidative Stress; Pyridoxal; Pyridoxal Phosphate; Pyridoxic Acid; ROC Curve; Tryptophan; Vitamin B 6

2014
Importance of tryptophan nitration of carbonic anhydrase III for the morbidity of atopic dermatitis.
    Free radical biology & medicine, 2014, Volume: 73

    Topics: Animals; Carbonic Anhydrase III; Cell Line; Dermatitis, Atopic; Disease Models, Animal; Humans; Immunohistochemistry; Inflammation; Keratin-2; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Peroxynitrous Acid; Phosphopyruvate Hydratase; Rats; Reactive Nitrogen Species; Skin; Tryptophan

2014
Does tryptophan degradation along the kynurenine pathway mediate the association between pro-inflammatory immune activity and depressive symptoms?
    Psychoneuroendocrinology, 2014, Volume: 45

    Topics: Adolescent; Adult; Aged; Case-Control Studies; Depression; Depressive Disorder, Major; Female; Humans; Immune System; Inflammation; Inflammation Mediators; Kynurenine; Male; Metabolic Networks and Pathways; Middle Aged; Netherlands; Proteolysis; Tryptophan; Young Adult

2014
NK1 receptor blockade is ineffective in improving outcome following a balloon compression model of spinal cord injury.
    PloS one, 2014, Volume: 9, Issue:5

    Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Inflammation; Neurokinin-1 Receptor Antagonists; Protease Inhibitors; Rabbits; Receptors, Neurokinin-1; Spinal Cord Compression; Substance P; Tryptophan

2014
Interferon-γ-induced inflammatory markers and the risk of cancer: the Hordaland Health Study.
    Cancer, 2014, Nov-01, Volume: 120, Issue:21

    Topics: Adult; Aged; Biomarkers, Tumor; C-Reactive Protein; Female; Follow-Up Studies; Humans; Inflammation; Interferon-gamma; Kaplan-Meier Estimate; Kynurenine; Male; Middle Aged; Neoplasms; Neopterin; Proportional Hazards Models; Prospective Studies; Risk Factors; Tryptophan

2014
Tryptophan catabolism is unaffected in chronic granulomatous disease.
    Nature, 2014, Oct-23, Volume: 514, Issue:7523

    Topics: Animals; Granulomatous Disease, Chronic; Inflammation; Kynurenine; Tryptophan

2014
Romani & Puccetti reply.
    Nature, 2014, Oct-23, Volume: 514, Issue:7523

    Topics: Animals; Granulomatous Disease, Chronic; Inflammation; Kynurenine; Tryptophan

2014
The tryptophan kynurenine pathway, neopterin and IL-6 during vulvectomy and abdominal hysterectomy.
    Journal of biomedical science, 2014, Dec-20, Volume: 21

    Topics: Adult; Aged; Biomarkers; Female; Humans; Hysterectomy; Inflammation; Interleukin-6; Kynurenine; Middle Aged; Neopterin; Prospective Studies; Tryptophan; Vulva

2014
Prevention of postoperative fatigue syndrome in rat model by ginsenoside Rb1 via down-regulation of inflammation along the NMDA receptor pathway in the hippocampus.
    Biological & pharmaceutical bulletin, 2015, Volume: 38, Issue:2

    Topics: Animals; Cytokines; Down-Regulation; Fatigue; Ginsenosides; Hippocampus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Intestine, Small; Male; Neurons; Postoperative Complications; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Syndrome; Tryptophan

2015
Inhibition of indoleamine 2,3-dioxygenase promotes vascular inflammation and increases atherosclerosis in Apoe-/- mice.
    Cardiovascular research, 2015, May-01, Volume: 106, Issue:2

    Topics: Animals; Apolipoproteins E; Atherosclerosis; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Mice, Knockout; Tryptophan; Tunica Media; Vascular Cell Adhesion Molecule-1

2015
Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behaviour responses to systemic poly I:C.
    Brain, behavior, and immunity, 2015, Volume: 48

    Topics: Animals; Brain; Illness Behavior; Immunity, Innate; Inflammation; Interferon Type I; Interleukin-1beta; Interleukin-6; Kynurenine; Mice; Mice, Knockout; Motor Activity; Poly I-C; Receptors, Interferon; Tryptophan; Tumor Necrosis Factor-alpha

2015
Increased Plasma Levels of Xanthurenic and Kynurenic Acids in Type 2 Diabetes.
    Molecular neurobiology, 2015, Volume: 52, Issue:2

    Topics: 3-Hydroxyanthranilic Acid; Adult; Aged; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenic Acid; Kynurenine; Male; Metformin; Middle Aged; Prediabetic State; Pyridoxal Phosphate; Stress, Physiological; Tryptophan; Tryptophan Oxygenase; Xanthurenates

2015
The kynurenine pathway activities in a sub-Saharan HIV/AIDS population.
    BMC infectious diseases, 2015, Aug-19, Volume: 15

    Topics: Acquired Immunodeficiency Syndrome; Adult; Africa South of the Sahara; Antiretroviral Therapy, Highly Active; Case-Control Studies; CD4 Lymphocyte Count; Cross-Sectional Studies; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Gas Chromatography-Mass Spectrometry; HIV Infections; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interferon-gamma; Interleukin-6; Kynurenine; Male; Middle Aged; Neopterin; Niacinamide; Pentosyltransferases; Poverty; Quinolinic Acid; South Africa; Tryptophan

2015
ω-6 (18:2) and ω-3 (18:3) fatty acids in reconstituted high-density lipoproteins show different functionality of anti-atherosclerotic properties and embryo toxicity.
    The Journal of nutritional biochemistry, 2015, Volume: 26, Issue:12

    Topics: alpha-Linolenic Acid; Animals; Antioxidants; Apolipoprotein A-I; Atherosclerosis; Cellular Senescence; Circular Dichroism; Fibroblasts; Gene Expression Regulation, Developmental; Humans; Inflammation; Linoleic Acid; Lipids; Lipoproteins, HDL; Lipoproteins, LDL; Macrophages; Oxygen; Phagocytosis; Reactive Oxygen Species; Tryptophan; Zebrafish

2015
Influence of Hepatitis C Virus Sustained Virological Response on Immunosuppressive Tryptophan Catabolism in ART-Treated HIV/HCV Coinfected Patients.
    Journal of acquired immune deficiency syndromes (1999), 2016, Mar-01, Volume: 71, Issue:3

    Topics: Adult; Anti-HIV Agents; Biomarkers; Coinfection; Disease Progression; Female; Hepacivirus; Hepatitis C; HIV Infections; Humans; Inflammation; Insulin; Kynurenine; Male; Middle Aged; Tryptophan

2016
Central kynurenine pathway shift with age in women.
    Journal of neurochemistry, 2016, Volume: 136, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aging; Brain; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Middle Aged; Neopterin; Neurotoxins; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase; Young Adult

2016
The tryptophan metabolism enzyme L-kynureninase is a novel inflammatory factor in psoriasis and other inflammatory diseases.
    The Journal of allergy and clinical immunology, 2016, Volume: 137, Issue:6

    Topics: Biopsy; Cells, Cultured; Dermatitis, Atopic; Female; Gene Expression Profiling; Humans; Hydrolases; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Inflammation Mediators; Male; Metabolic Networks and Pathways; Myeloid Cells; Psoriasis; Skin; Tryptophan

2016
Mast cells' involvement in inflammation pathways linked to depression: evidence in mastocytosis.
    Molecular psychiatry, 2016, Volume: 21, Issue:11

    Topics: Depression; Depressive Disorder, Major; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenic Acid; Kynurenine; Male; Mast Cells; Mastocytosis; Middle Aged; Psychiatric Status Rating Scales; Serotonin; Stress, Psychological; Tryptophan

2016
Plasma Biomarkers of Inflammation, the Kynurenine Pathway, and Risks of All-Cause, Cancer, and Cardiovascular Disease Mortality: The Hordaland Health Study.
    American journal of epidemiology, 2016, Feb-15, Volume: 183, Issue:4

    Topics: Aged; Biomarkers; C-Reactive Protein; Female; Humans; Inflammation; Kynurenine; Longitudinal Studies; Male; Middle Aged; Mortality; Neopterin; Norway; Tryptophan

2016
Indoleamine-2,3-dioxygenase mediates neurobehavioral alterations induced by an intracerebroventricular injection of amyloid-β1-42 peptide in mice.
    Brain, behavior, and immunity, 2016, Volume: 56

    Topics: Amyloid beta-Peptides; Animals; Anxiety; Behavior, Animal; Depression; Disease Models, Animal; Hippocampus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Injections, Intraventricular; Kynurenine; Memory Disorders; Mice; Nerve Growth Factors; Peptide Fragments; Prefrontal Cortex; Recognition, Psychology; Tryptophan

2016
Endothelium-Derived 5-Methoxytryptophan Protects Endothelial Barrier Function by Blocking p38 MAPK Activation.
    PloS one, 2016, Volume: 11, Issue:3

    Topics: Animals; Antigens, CD; Cadherins; Capillary Permeability; Cells, Cultured; Culture Media, Conditioned; Down-Regulation; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Male; Mice; Mice, Inbred C57BL; p38 Mitogen-Activated Protein Kinases; Protective Agents; Tryptophan

2016
Endothelium-Derived 5-Methoxytryptophan Is a Circulating Anti-Inflammatory Molecule That Blocks Systemic Inflammation.
    Circulation research, 2016, 07-08, Volume: 119, Issue:2

    Topics: Aged; Aged, 80 and over; Animals; Anti-Inflammatory Agents; Endothelium, Vascular; Endotoxemia; Female; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Male; Mice; Mice, Inbred C57BL; Middle Aged; Tryptophan

2016
Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor.
    Nature medicine, 2016, Volume: 22, Issue:6

    Topics: Animals; Astrocytes; Case-Control Studies; Cell Proliferation; Central Nervous System; Chemokine CCL2; Chromatin Immunoprecipitation; Chromatography, High Pressure Liquid; Encephalomyelitis, Autoimmune, Experimental; Fluorescent Antibody Technique; Gastrointestinal Microbiome; Gene Expression Profiling; Gene Knockdown Techniques; Glial Fibrillary Acidic Protein; Humans; Immunoblotting; Indican; Indoles; Inflammation; Interferon Type I; Interferon-beta; Limosilactobacillus reuteri; Mice; Mice, Knockout; Multiple Sclerosis; Myxovirus Resistance Proteins; Nitric Oxide Synthase Type II; Optical Imaging; Polymerase Chain Reaction; Receptor, Interferon alpha-beta; Receptors, Aryl Hydrocarbon; Serotonin; STAT1 Transcription Factor; Suppressor of Cytokine Signaling Proteins; T-Lymphocytes; Tryptophan; Tryptophanase

2016
Peroxynitrite-induced structural perturbations in human IgG: A physicochemical study.
    Archives of biochemistry and biophysics, 2016, 08-01, Volume: 603

    Topics: Arthritis, Rheumatoid; Calorimetry, Differential Scanning; Circular Dichroism; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Humans; Immunoglobulin G; Inflammation; Light; Microscopy, Fluorescence; Oxygen; Peroxynitrous Acid; Protein Structure, Secondary; Scattering, Radiation; Sepharose; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Temperature; Tryptophan; Tyrosine

2016
Glia: An astrocytic axis.
    Nature reviews. Neuroscience, 2016, Volume: 17, Issue:7

    Topics: Astrocytes; Humans; Inflammation; Interferon Type I; Neuroglia; Receptors, Aryl Hydrocarbon; Tryptophan

2016
Tryptophan, kynurenine, and kynurenine metabolites: Relationship to lifetime aggression and inflammatory markers in human subjects.
    Psychoneuroendocrinology, 2016, Volume: 71

    Topics: Adult; Aggression; Biomarkers; C-Reactive Protein; Female; Humans; Inflammation; Interleukin-6; Kynurenic Acid; Kynurenine; Male; Picolinic Acids; Quinolinic Acid; Tryptophan

2016
Immunomodulatory Effects of the Mycosporine-Like Amino Acids Shinorine and Porphyra-334.
    Marine drugs, 2016, Jun-21, Volume: 14, Issue:6

    Topics: Amino Acids; Cell Line, Tumor; Cyclohexanones; Cyclohexylamines; Glycine; Humans; Immunologic Factors; Inflammation; NF-kappa B; Porphyra; Rhodophyta; Tryptophan

2016
Body image dissatisfaction in pregnant and non-pregnant females is strongly predicted by immune activation and mucosa-derived activation of the tryptophan catabolite (TRYCAT) pathway.
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2018, Volume: 19, Issue:3

    Topics: Adult; Body Image; Depression; Female; Humans; Immunoglobulin A; Immunoglobulin M; Inflammation; Metabolic Networks and Pathways; Mucous Membrane; Personal Satisfaction; Postpartum Period; Pregnancy; Pregnancy Complications; Prospective Studies; Tryptophan

2018
Serum Immune System Biomarkers Neopterin and Interleukin-10 Are Strongly Related to Tryptophan Metabolism in Healthy Young Adults.
    The Journal of nutrition, 2016, Volume: 146, Issue:9

    Topics: 3-Hydroxyanthranilic Acid; Adolescent; Adult; Biomarkers; Body Mass Index; C-Reactive Protein; Cross-Sectional Studies; Female; Humans; Inflammation; Interleukin-10; Kynurenine; Linear Models; Male; Neopterin; ortho-Aminobenzoates; Pyridoxal Phosphate; Surveys and Questionnaires; Tryptophan; Vitamin B 6; Young Adult

2016
Acute single dose of ketamine relieves mechanical allodynia and consequent depression-like behaviors in a rat model.
    Neuroscience letters, 2016, Sep-19, Volume: 631

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Freund's Adjuvant; Hippocampus; Hyperalgesia; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interleukin-1beta; Interleukin-6; Ketamine; Kynurenine; Male; Nociception; Rats; Rats, Sprague-Dawley; Serotonin; Tryptophan

2016
Plasma Tryptophan and the Kynurenine-Tryptophan Ratio are Associated with the Acquisition of Statural Growth Deficits and Oral Vaccine Underperformance in Populations with Environmental Enteropathy.
    The American journal of tropical medicine and hygiene, 2016, Oct-05, Volume: 95, Issue:4

    Topics: Anthropometry; Antibodies; Antibodies, Viral; Child Development; Child, Preschool; Citrulline; Cohort Studies; Cytokines; Enteritis; Female; Growth Disorders; Humans; Infant; Inflammation; Kynurenine; Linear Models; Male; Peru; Poliovirus Vaccine, Oral; Tanzania; Tetanus Toxoid; Tryptophan

2016
Comparison of fluoxetine and 1-methyl-L-tryptophan in treatment of depression-like illness in Bacillus Calmette-Guerin-induced inflammatory model of depression in mice.
    Journal of basic and clinical physiology and pharmacology, 2016, Nov-01, Volume: 27, Issue:6

    Topics: Animals; Antidepressive Agents; BCG Vaccine; Depression; Disease Models, Animal; Fluoxetine; Inflammation; Male; Mice; Mice, Inbred C57BL; Random Allocation; Treatment Outcome; Tryptophan

2016
Inflammatory, endocrine and metabolic correlates of fatigue in obese children.
    Psychoneuroendocrinology, 2016, Volume: 74

    Topics: Adolescent; Anhedonia; Apathy; Body Mass Index; C-Reactive Protein; Child; Fatigue; Female; Humans; Inflammation; Insulin; Insulin Resistance; Kynurenine; Male; Mental Fatigue; Pediatric Obesity; Tryptophan

2016
Tryptophan metabolism, its relation to inflammation and stress markers and association with psychological and cognitive functioning: Tasmanian Chronic Kidney Disease pilot study.
    BMC nephrology, 2016, 11-10, Volume: 17, Issue:1

    Topics: Aged; Aged, 80 and over; Anxiety; Biomarkers; Cognition; Cross-Sectional Studies; Depression; Female; Glomerular Filtration Rate; Humans; Hydrocortisone; Indican; Indoleacetic Acids; Inflammation; Kynurenic Acid; Male; Middle Aged; Neopterin; Oxidative Stress; Pilot Projects; Prospective Studies; Renal Insufficiency, Chronic; Surveys and Questionnaires; Tasmania; Tryptophan

2016
Kynurenine Pathway Activation in Human African Trypanosomiasis.
    The Journal of infectious diseases, 2017, 03-01, Volume: 215, Issue:5

    Topics: Adolescent; Adult; Aged; Biomarkers; Central Nervous System; Female; Humans; Inflammation; Interferon-gamma; Interleukin-10; Interleukin-6; Kynurenine; Kynurenine 3-Monooxygenase; Male; Middle Aged; Retrospective Studies; Transaminases; Trypanosoma brucei rhodesiense; Trypanosomiasis, African; Tryptophan; Young Adult

2017
Increased breakdown of kynurenine towards its neurotoxic branch in bipolar disorder.
    PloS one, 2017, Volume: 12, Issue:2

    Topics: Adult; Bipolar Disorder; Brain; Case-Control Studies; Cognition; Depression; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Male; Middle Aged; Multivariate Analysis; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan

2017
Relationships between body temperatures and inflammation indicators under physiological and pathophysiological conditions in pigs exposed to systemic lipopolysaccharide and dietary deoxynivalenol.
    Journal of animal physiology and animal nutrition, 2018, Volume: 102, Issue:1

    Topics: Animal Feed; Animals; Biomarkers; Body Temperature; Inflammation; Kynurenine; Lipopolysaccharides; Swine; Trichothecenes; Tryptophan

2018
NO scavenging by 3-hydroxyanthranilic acid and 3-hydroxykynurenine: N-nitrosation leads via oxadiazoles to o-quinone diazides.
    Nitric oxide : biology and chemistry, 2008, Volume: 19, Issue:3

    Topics: 3-Hydroxyanthranilic Acid; Acetylcysteine; Aminophenols; Chromatography, Thin Layer; Diazonium Compounds; Free Radical Scavengers; Hydrazines; Inflammation; Kynurenine; Magnetic Resonance Imaging; Mass Spectrometry; Nitric Oxide; Nitrites; Nitrosation; Nuclear Magnetic Resonance, Biomolecular; ortho-Aminobenzoates; Oxadiazoles; Quinones; Tryptophan

2008
The kynurenines are associated with oxidative stress, inflammation and the prevalence of cardiovascular disease in patients with end-stage renal disease.
    Atherosclerosis, 2009, Volume: 204, Issue:1

    Topics: Adult; Age Factors; Aged; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Case-Control Studies; Cross-Sectional Studies; Diabetes Complications; Female; Humans; Inflammation; Kidney Failure, Chronic; Kynurenine; Logistic Models; Male; Middle Aged; Oxidative Stress; Peroxides; Prevalence; Risk Assessment; Risk Factors; Sex Factors; Superoxide Dismutase; Tryptophan

2009
Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2009, Volume: 24, Issue:6

    Topics: 5-Hydroxytryptophan; Adult; Aged; C-Reactive Protein; Case-Control Studies; Creatinine; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Inflammation Mediators; Kidney Failure, Chronic; Kynurenic Acid; Kynurenine; Male; Middle Aged; Prognosis; Prospective Studies; Quinolinic Acid; Receptors, Tumor Necrosis Factor, Type I; Renal Dialysis; Renal Insufficiency, Chronic; Serotonin; Tryptophan; Uremia

2009
Quantitative profiling of biomarkers related to B-vitamin status, tryptophan metabolism and inflammation in human plasma by liquid chromatography/tandem mass spectrometry.
    Rapid communications in mass spectrometry : RCM, 2009, Volume: 23, Issue:9

    Topics: Biomarkers; Chromatography, Liquid; Cotinine; Cystathionine; Humans; Inflammation; Neopterin; Riboflavin; Sensitivity and Specificity; Tandem Mass Spectrometry; Tryptophan; Vitamin B 6

2009
l-Tryptophan exhibits therapeutic function in a porcine model of dextran sodium sulfate (DSS)-induced colitis.
    The Journal of nutritional biochemistry, 2010, Volume: 21, Issue:6

    Topics: Animal Nutrition Sciences; Animals; Apoptosis; Body Weight; Colitis; Dextrans; Disease Models, Animal; Inflammation; Interleukin-6; Mannitol; Permeability; Sulfates; Swine; Tryptophan; Tumor Necrosis Factor-alpha

2010
Function of the tryptophan metabolite, L-kynurenine, in human corneal endothelial cells.
    Molecular vision, 2009, Jul-08, Volume: 15

    Topics: Apoptosis; Cell Line; Cell Proliferation; Culture Media, Conditioned; Cytokines; Endothelium, Corneal; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Enzymologic; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Large Neutral Amino Acid-Transporter 1; Oligonucleotide Array Sequence Analysis; Subcellular Fractions; T-Lymphocytes; Tissue Culture Techniques; Transforming Growth Factor beta2; Tryptophan; Up-Regulation

2009
Synthesis and evaluation of l-5-(2-[(18)F]fluoroethoxy)tryptophan as a new PET tracer.
    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2010, Volume: 68, Issue:2

    Topics: Animals; Brain Neoplasms; Image Enhancement; Inflammation; Isotope Labeling; Metabolic Clearance Rate; Mice; Organ Specificity; Positron-Emission Tomography; Radiopharmaceuticals; Tissue Distribution; Tryptophan

2010
The kynurenine pathway and inflammation in amyotrophic lateral sclerosis.
    Neurotoxicity research, 2010, Volume: 18, Issue:2

    Topics: Adult; Amyotrophic Lateral Sclerosis; Brain; Female; HLA-DR Antigens; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Male; Middle Aged; Picolinic Acids; Quinolinic Acid; Signal Transduction; Spinal Cord; Tryptophan

2010
AHR activation by tryptophan--pathogenic hallmark of Th17-mediated inflammation in eosinophilic fasciitis, eosinophilia-myalgia-syndrome and toxic oil syndrome?
    Immunology letters, 2010, Feb-16, Volume: 128, Issue:2

    Topics: Brassica; Eosinophilia; Eosinophilia-Myalgia Syndrome; Fasciitis; Fatty Acids, Monounsaturated; Humans; Inflammation; Interleukin-17; Plant Oils; Rapeseed Oil; Receptors, Aryl Hydrocarbon; Syndrome; T-Lymphocytes, Helper-Inducer; Tryptophan

2010
Metabolomic analysis identifies inflammatory and noninflammatory metabolic effects of genetic modification in a mouse model of Crohn's disease.
    Journal of proteome research, 2010, Apr-05, Volume: 9, Issue:4

    Topics: Animals; Chromatography, Liquid; Cluster Analysis; Crohn Disease; Disease Models, Animal; Germ-Free Life; Inflammation; Interleukin-10; Kynurenine; Male; Mass Spectrometry; Metabolome; Metabolomics; Mice; Mice, Transgenic; Principal Component Analysis; Tryptophan; Urine

2010
Kynurenine is an endothelium-derived relaxing factor produced during inflammation.
    Nature medicine, 2010, Volume: 16, Issue:3

    Topics: Adenylyl Cyclases; Animals; Blood Pressure; Coronary Vessels; Dose-Response Relationship, Drug; Endothelium-Dependent Relaxing Factors; Endothelium, Vascular; Endotoxemia; Enzyme Activation; Guanylate Cyclase; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interferon-gamma; Kynurenine; Malaria; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Plasmodium berghei; Rats; Rats, Inbred SHR; Tryptophan

2010
Ido brings down the pressure in systemic inflammation.
    Nature medicine, 2010, Volume: 16, Issue:3

    Topics: Animals; Blood Pressure; Coronary Vessels; Endothelium-Dependent Relaxing Factors; Endothelium, Vascular; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Mice; Muscle, Smooth, Vascular; Rats; Rats, Inbred SHR; Tryptophan

2010
Insights into therapy: tryptophan oxidation and HIV infection.
    Science translational medicine, 2010, May-19, Volume: 2, Issue:32

    Topics: 3-Hydroxyanthranilic Acid; Anti-Inflammatory Agents; Antiviral Agents; Dendritic Cells; Disease Progression; Enzyme Inhibitors; HIV Infections; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Inflammation Mediators; Interleukin-17; Kynurenine; Oxidation-Reduction; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Tryptophan; Viral Load

2010
Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease.
    Science translational medicine, 2010, May-19, Volume: 2, Issue:32

    Topics: 3-Hydroxyanthranilic Acid; Biopsy; CD4 Lymphocyte Count; CD4-CD8 Ratio; Cells, Cultured; Colon, Sigmoid; Dendritic Cells; Disease Progression; HIV Infections; HIV Seropositivity; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Inflammation Mediators; Interferon-gamma; Interleukin-17; Kynurenine; Lipopolysaccharides; Lymph Nodes; Prospective Studies; Rectum; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Time Factors; Tryptophan; Up-Regulation; Viral Load

2010
The role of tryptophan catabolism along the kynurenine pathway in acute ischemic stroke.
    Neurochemical research, 2010, Volume: 35, Issue:9

    Topics: 3-Hydroxyanthranilic Acid; Aged; Aged, 80 and over; Brain Ischemia; Free Radical Scavengers; Humans; Inflammation; Kynurenine; Male; Stroke; Tryptophan

2010
Beyond immunosuppression: reconsidering indoleamine 2,3-dioxygenase as a pathogenic element of chronic inflammation.
    Immunotherapy, 2010, Volume: 2, Issue:3

    Topics: Arthritis, Rheumatoid; Autoimmunity; Chronic Disease; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Lupus Erythematosus, Systemic; Tryptophan

2010
Vagus nerve stimulation in refractory epilepsy: effects on pro- and anti-inflammatory cytokines in peripheral blood.
    Neuroimmunomodulation, 2011, Volume: 18, Issue:1

    Topics: Adolescent; Adult; Brain; Child; Cytokines; Epilepsy; Female; Humans; Inflammation; Inflammation Mediators; Male; Middle Aged; Neuroimmunomodulation; Signal Transduction; Tryptophan; Up-Regulation; Vagus Nerve Stimulation; Young Adult

2011
In vitro testing for anti-inflammatory properties of compounds employing peripheral blood mononuclear cells freshly isolated from healthy donors.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2011, Volume: 60, Issue:2

    Topics: Anti-Inflammatory Agents; Humans; Inflammation; Interferon-gamma; Interleukin-2 Receptor alpha Subunit; Isoprostanes; Leukocytes, Mononuclear; Mitogens; Neopterin; Receptors, Tumor Necrosis Factor, Type II; Tryptophan; Tumor Necrosis Factor-alpha

2011
Spinal cord mechanisms mediating behavioral hyperalgesia induced by neurokinin-1 tachykinin receptor activation in the rostral ventromedial medulla.
    Neuroscience, 2010, Dec-29, Volume: 171, Issue:4

    Topics: Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Excitatory Amino Acid Antagonists; Freund's Adjuvant; GABA Agents; Hyperalgesia; In Vitro Techniques; Inflammation; Male; Medulla Oblongata; Membrane Potentials; Microinjections; Muscimol; Ondansetron; Oxazines; Pain Measurement; Pain Threshold; Posterior Horn Cells; Pyridazines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-1; Serotonin Antagonists; Spinal Cord; Substance P; Tryptophan; Up-Regulation

2010
G-protein coupled receptor 35 (GPR35) activation and inflammatory pain: Studies on the antinociceptive effects of kynurenic acid and zaprinast.
    Neuropharmacology, 2011, Volume: 60, Issue:7-8

    Topics: Analgesics; Animals; Antidepressive Agents, Second-Generation; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Ganglia, Spinal; Gene Expression; Inflammation; Kynurenic Acid; Kynurenine; Male; Mice; Neuroglia; Pain; Pain Measurement; Phosphodiesterase Inhibitors; Probenecid; Purinones; Receptors, G-Protein-Coupled; Spinal Cord; Tryptophan

2011
Deficient tryptophan catabolism along the kynurenine pathway reveals that the epididymis is in a unique tolerogenic state.
    The Journal of biological chemistry, 2011, Mar-11, Volume: 286, Issue:10

    Topics: Animals; Epididymis; Gene Expression Regulation, Enzymologic; Indoleamine-Pyrrole 2,3,-Dioxygenase; Infertility, Male; Inflammation; Kynurenine; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Organ Specificity; Spermatozoa; Tryptophan; Ubiquitination

2011
Myeloperoxidase-catalyzed oxidative inactivation of human kininogens: the impairment of kinin-precursor and prekallikrein-binding functions.
    Biological chemistry, 2011, Volume: 392, Issue:3

    Topics: Amino Acid Sequence; Bradykinin; Humans; Inflammation; Kininogens; Kinins; Methionine; Molecular Sequence Data; Peroxidase; Phagocytes; Prekallikrein; Reactive Oxygen Species; Tryptophan

2011
Chronic low-grade inflammation in elderly persons is associated with altered tryptophan and tyrosine metabolism: role in neuropsychiatric symptoms.
    Biological psychiatry, 2011, Jul-15, Volume: 70, Issue:2

    Topics: Aged; Aged, 80 and over; C-Reactive Protein; Chronic Disease; Enzyme-Linked Immunosorbent Assay; Fasting; Fatigue; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interleukin-6; Male; Mental Disorders; Movement Disorders; Neopterin; Nitrites; Psychiatric Status Rating Scales; Sleep Wake Disorders; Tryptophan; Tyrosine

2011
Plasma kynurenine levels are elevated in suicide attempters with major depressive disorder.
    Brain, behavior, and immunity, 2011, Volume: 25, Issue:6

    Topics: Adolescent; Adult; Aged; Antidepressive Agents; Cytokines; Depressive Disorder, Major; Duloxetine Hydrochloride; Female; Humans; Hypericum; Impulsive Behavior; Inflammation; Kynurenine; Male; Middle Aged; Neopterin; Phytotherapy; Recurrence; Serotonin; Smoking; Suicide, Attempted; Thiophenes; Tryptophan; Young Adult

2011
Protective effects of tryptophan on neuro-inflammation in rats after administering lipopolysaccharide.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2011, Volume: 65, Issue:3

    Topics: Animals; Antioxidants; Cerebral Cortex; Drug Interactions; Female; Free Radical Scavengers; Hippocampus; Inflammation; Interferon-gamma; Lactation; Lipid Peroxidation; Lipopolysaccharides; Neuroprotective Agents; Nitrates; Nitrites; Pregnancy; Rats; Rats, Sprague-Dawley; Shock, Septic; Tryptophan

2011
Homology modeling, docking, molecular dynamics simulation, and structural analyses of coxsakievirus B3 2A protease: an enzyme involved in the pathogenesis of inflammatory myocarditis.
    International journal of biological macromolecules, 2011, Nov-01, Volume: 49, Issue:4

    Topics: Catalytic Domain; Cysteine Endopeptidases; Enterovirus B, Human; HeLa Cells; Humans; Inflammation; Molecular Dynamics Simulation; Myocarditis; Protein Denaturation; Protein Structure, Secondary; Structural Homology, Protein; Temperature; Tryptophan; Viral Proteins

2011
Depression symptoms, low-grade inflammatory activity, and new targets for clinical intervention.
    Biological psychiatry, 2011, Jul-15, Volume: 70, Issue:2

    Topics: Female; Humans; Inflammation; Male; Mental Disorders; Tryptophan; Tyrosine

2011
Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis.
    Critical care medicine, 2011, Volume: 39, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Hypotension; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Male; Middle Aged; Parenteral Nutrition, Total; Prospective Studies; Shock, Septic; Tryptophan; Young Adult

2011
Kynurenine metabolism predicts cognitive function in patients following cardiac bypass and thoracic surgery.
    Journal of neurochemistry, 2011, Volume: 119, Issue:1

    Topics: Adult; Aged; Biomarkers; Chromatography, High Pressure Liquid; Cognition; Coronary Artery Bypass; Enzyme-Linked Immunosorbent Assay; Extracorporeal Circulation; Female; Humans; Inflammation; Kynurenine; Lipid Peroxidation; Male; Middle Aged; Neopterin; Nerve Growth Factors; Neuropsychological Tests; Postoperative Complications; Predictive Value of Tests; Psychomotor Performance; Reproducibility of Results; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Stroop Test; Thoracic Surgical Procedures; Trail Making Test; Tryptophan; Tumor Necrosis Factor-alpha; Verbal Learning

2011
Activation-dependent adsorption of cytokines and toxins related to liver failure to carbon beads.
    Biomacromolecules, 2011, Oct-10, Volume: 12, Issue:10

    Topics: Adsorption; Bilirubin; Carbon; Cholates; Humans; Inflammation; Interleukin-6; Liver Failure, Acute; Particle Size; Phenol; Plasmapheresis; Porosity; Tryptophan; Tumor Necrosis Factor-alpha

2011
Pharmacological characteristics of endokinin C/D-derived peptides in nociceptive and inflammatory processing in rats.
    Peptides, 2011, Volume: 32, Issue:12

    Topics: Amino Acid Sequence; Amino Acids; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Formaldehyde; Humans; Hyperalgesia; Immunohistochemistry; Inflammation; Injections, Subcutaneous; Male; Nociceptive Pain; Pain Measurement; Peptide Fragments; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Substance P; Tachykinins; Time Factors; Tryptophan

2011
Pharmacological characterization of the ghrelin receptor mediating its inhibitory action on inflammatory pain in rats.
    Amino acids, 2012, Volume: 43, Issue:4

    Topics: Animals; Carrageenan; Edema; Ghrelin; Hyperalgesia; Indoles; Inflammation; Injections, Intraperitoneal; Injections, Intravenous; Male; Oligopeptides; Pain; Protein Isoforms; Rats; Rats, Sprague-Dawley; Receptors, Ghrelin; Tryptophan

2012
Treatment with a substance P receptor antagonist is neuroprotective in the intrastriatal 6-hydroxydopamine model of early Parkinson's disease.
    PloS one, 2012, Volume: 7, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Blood-Brain Barrier; Cells; Dopaminergic Neurons; Inflammation; Male; Motor Activity; Neurokinin-1 Receptor Antagonists; Neuroprotective Agents; Oxidopamine; Parkinson Disease, Secondary; Piperidines; Rats; Rats, Sprague-Dawley; Rotarod Performance Test; Substance P; Substantia Nigra; Tryptophan

2012
Inhibition of increased indoleamine 2,3-dioxygenase activity attenuates Toxoplasma gondii replication in the lung during acute infection.
    Cytokine, 2012, Volume: 59, Issue:2

    Topics: Acute Disease; Animals; Antibodies, Protozoan; Antigens, Protozoan; Enzyme Inhibitors; Gene Expression Regulation; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Life Cycle Stages; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Protozoan Proteins; RNA, Messenger; Toxoplasma; Toxoplasmosis; Tryptophan

2012
Fatigue in patients with lung cancer is related with accelerated tryptophan breakdown.
    PloS one, 2012, Volume: 7, Issue:5

    Topics: Anemia; Biomarkers, Tumor; Fatigue; Female; Humans; Inflammation; Lung Neoplasms; Male; Neoplasm Staging; Psychological Tests; Quality of Life; Tryptophan

2012
Vitamin B6 status and interferon-γ-mediated immune activation in primary hyperparathyroidism.
    Journal of internal medicine, 2012, Volume: 272, Issue:6

    Topics: Aged; Biomarkers; Cardiovascular Diseases; Female; Humans; Hyperparathyroidism, Primary; Immunity, Cellular; Immunologic Factors; Inflammation; Interferon-gamma; Kynurenine; Longitudinal Studies; Male; Middle Aged; Monitoring, Immunologic; Neopterin; ortho-Aminobenzoates; Parathyroidectomy; Postoperative Care; Risk Factors; Tryptophan; Vitamin B 6

2012
Modulatory effects of acupuncture on murine depression-like behavior following chronic systemic inflammation.
    Brain research, 2012, Sep-07, Volume: 1472

    Topics: Acupuncture Therapy; Animals; Behavior, Animal; Brain; Chromatography, High Pressure Liquid; Chronic Disease; Depression; Dopamine; Inflammation; Kynurenine; Male; Mice; Mice, Inbred BALB C; Motor Activity; Tryptophan

2012
Tryptophan hydroxylase-1 regulates immune tolerance and inflammation.
    The Journal of experimental medicine, 2012, Oct-22, Volume: 209, Issue:11

    Topics: Animals; CD4-Positive T-Lymphocytes; Cell Line, Tumor; Cells, Cultured; Encephalomyelitis, Autoimmune, Experimental; Female; Flow Cytometry; Gene Expression; Immune Tolerance; Inflammation; Male; Mast Cells; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Neoplasms, Experimental; Reverse Transcriptase Polymerase Chain Reaction; Skin Transplantation; TOR Serine-Threonine Kinases; Transplantation, Homologous; Tryptophan; Tryptophan Hydroxylase

2012
An exploratory study of the interplay between decreased concentration of tryptophan, accumulation of kynurenines, and inflammatory arthritis.
    IUBMB life, 2012, Volume: 64, Issue:12

    Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; 3-Hydroxyanthranilic Acid; Animals; Arthritis, Experimental; Gene Expression Regulation; Hydrolases; Inflammation; Kynurenine; Kynurenine 3-Monooxygenase; Lymph Nodes; Mice; Mice, Inbred DBA; Organ Specificity; ortho-Aminobenzoates; RNA, Messenger; Signal Transduction; Spleen; Tryptophan

2012
Inflammation in aspergillosis: the good, the bad, and the therapeutic.
    Annals of the New York Academy of Sciences, 2012, Volume: 1273

    Topics: Aspergillosis; Aspergillus; Humans; Immunity, Innate; Inflammation; T-Lymphocytes, Helper-Inducer; Tryptophan

2012
Effects of systemic and central nervous system localized inflammation on the contributions of metabolic precursors to the L-kynurenine and quinolinic acid pools in brain.
    Journal of neurochemistry, 2002, Volume: 82, Issue:2

    Topics: Animals; Body Fluid Compartments; Brain; Corpus Striatum; Encephalitis; Female; Gerbillinae; Inflammation; Injections, Subcutaneous; Kidney; Kynurenine; Lipopolysaccharides; Liver; Lung; Mass Spectrometry; Models, Biological; Protein Binding; Quinolinic Acid; Serum Albumin; Tissue Distribution; Tritium; Tryptophan

2002
Oxidative damage and cytogenic analysis in leukocytes of Parkinson's disease patients.
    Neurology, 2003, Feb-25, Volume: 60, Issue:4

    Topics: Cytogenetic Analysis; Homocysteine; Humans; Inflammation; Interferon-gamma; Leukocytes; Macrophages; Neopterin; Oxidative Stress; Parkinson Disease; T-Lymphocytes; Tryptophan

2003
[THE ANTIEDEMA-ANTIINFLAMMATORY ACTION OF AESCIN AND ITS RELATIONS TO THE ADRENO-HYPOPHYSIAL AXIS].
    Folia endocrinologica, 1964, Volume: 17

    Topics: Adrenal Cortex Hormones; Adrenal Glands; Adrenalectomy; Aesculus; Animals; Anti-Inflammatory Agents; Ascorbic Acid; Biomedical Research; Cholesterol; Edema; Escin; Guinea Pigs; Hypophysectomy; Inflammation; Lipid Metabolism; Metabolism; Pharmacology; Pituitary Gland; Rats; Research; Saponins; Tryptophan

1964
Oxidative cross-linking of tryptophan to glycine restrains matrix metalloproteinase activity: specific structural motifs control protein oxidation.
    The Journal of biological chemistry, 2004, Feb-20, Volume: 279, Issue:8

    Topics: Amino Acid Motifs; Catalytic Domain; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Deuterium; Glycine; Hydrogen; Hypochlorous Acid; Inflammation; Kinetics; Magnetic Resonance Spectroscopy; Mass Spectrometry; Matrix Metalloproteinase 7; Models, Chemical; Models, Molecular; Oxygen; Peptide Library; Peptides; Phagocytes; Spectrometry, Mass, Electrospray Ionization; Temperature; Tryptophan; Ultraviolet Rays

2004
Antithrombin reduces the ischemia/reperfusion-induced spinal cord injury in rats by attenuating inflammatory responses.
    Thrombosis and haemostasis, 2004, Volume: 91, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Antithrombins; Coloring Agents; Disease Models, Animal; Epoprostenol; Factor Xa; Humans; Inflammation; Interleukin-8; Ischemia; Male; Peroxidase; Rats; Rats, Wistar; Reperfusion Injury; Spinal Cord; Spinal Cord Injuries; Tetrazolium Salts; Time Factors; Tryptophan; Tumor Necrosis Factor-alpha

2004
Possible role of cytokine-induced tryptophan degradation in anaemia of inflammation.
    European journal of haematology, 2004, Volume: 72, Issue:2

    Topics: Aged; Aged, 80 and over; Anemia; Chronic Disease; Cytokines; Female; Humans; Inflammation; Male; Reference Values; Th1 Cells; Tryptophan

2004
Modulation of human dendritic-cell function following transduction with viral vectors: implications for gene therapy.
    Blood, 2005, May-15, Volume: 105, Issue:10

    Topics: Adenoviridae; Cells, Cultured; Cytokines; Dendritic Cells; Genetic Therapy; Genetic Vectors; Humans; Inflammation; Interferons; Lentivirus; Lymphocyte Culture Test, Mixed; Phenotype; Signal Transduction; Th1 Cells; Transduction, Genetic; Tryptophan; Up-Regulation

2005
[Missing granulocytic infiltrate in pityriasis versicolor--indication of specific anti-inflammatory activity of the pathogen?].
    Mycoses, 2005, Volume: 48 Suppl 1

    Topics: Colony Count, Microbial; Granulocytes; Humans; Inflammation; Leukocyte Count; Malassezia; Spores, Fungal; Tinea Versicolor; Tryptophan

2005
Kynurenine--an old pathway retraced.
    Journal of clinical psychopharmacology, 2006, Volume: 26, Issue:4

    Topics: Animals; Depressive Disorder, Major; Humans; Hydrolases; Inflammation; Interferons; Kynurenine; ortho-Aminobenzoates; Rats; Review Literature as Topic; Tryptophan

2006
The activity of the immunoregulatory enzyme indoleamine 2,3-dioxygenase is decreased in smokers.
    Clinical and experimental immunology, 2006, Volume: 145, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Chromatography, High Pressure Liquid; Cohort Studies; Cotinine; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Male; Middle Aged; Smoking; Statistics, Nonparametric; T-Lymphocytes; Tryptophan

2006
Gamma interferon confers resistance to infection with Staphylococcus aureus in human vascular endothelial cells by cooperative proinflammatory and enhanced intrinsic antibacterial activities.
    Infection and immunity, 2007, Volume: 75, Issue:12

    Topics: Animals; Cattle; Dose-Response Relationship, Immunologic; Endocytosis; Endothelial Cells; Ferric Compounds; Humans; Inflammation; Interferon-gamma; Iron; Recombinant Proteins; Staphylococcal Infections; Staphylococcus aureus; Tryptophan

2007
The immune effects of TRYCATs (tryptophan catabolites along the IDO pathway): relevance for depression - and other conditions characterized by tryptophan depletion induced by inflammation.
    Neuro endocrinology letters, 2007, Volume: 28, Issue:6

    Topics: Adult; Anti-Inflammatory Agents; Cytokines; Depressive Disorder; Female; Gene Expression Regulation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interferon-gamma; Interleukin-10; Kynurenic Acid; Kynurenine; Lipopolysaccharides; Male; Quinolinic Acid; Reference Values; Tryptophan; Tumor Necrosis Factor-alpha; Xanthurenates

2007
Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease.
    Nature, 2008, Jan-10, Volume: 451, Issue:7175

    Topics: Animals; Aspergillosis; Aspergillus fumigatus; Chronic Disease; Disease Models, Animal; Granulomatous Disease, Chronic; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interferon-gamma; Interleukin-17; Kynurenine; Lung; Lung Diseases, Fungal; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases; Reactive Oxygen Species; Receptors, Antigen, T-Cell, gamma-delta; Superoxides; T-Lymphocytes; Tryptophan

2008
Anti-inflammatory effect of tryptophan in Selye pouch.
    Journal of the American Podiatry Association, 1981, Volume: 71, Issue:12

    Topics: Animals; Anti-Inflammatory Agents; Croton Oil; Inflammation; Male; Mice; Tryptophan

1981
Relationships between lower plasma L-tryptophan levels and immune-inflammatory variables in depression.
    Psychiatry research, 1993, Volume: 49, Issue:2

    Topics: Adult; Age Factors; Amino Acids; Depressive Disorder; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Female; Haptoglobins; Humans; Immunity; Inflammation; Interleukin-6; Male; Middle Aged; Sex Factors; Transferrin; Tryptophan

1993
Pathological and immunological effects of ingesting L-tryptophan and 1,1'-ethylidenebis (L-tryptophan) in Lewis rats.
    The Journal of clinical investigation, 1993, Volume: 91, Issue:3

    Topics: Animals; Antibodies, Monoclonal; Antigens, Surface; Female; Immunophenotyping; Inflammation; Leukocyte Count; Macrophages; Monocytes; Muscles; Necrosis; Pancreas; Rats; Rats, Inbred Lew; Receptors, Interleukin-2; Tryptophan

1993
The inflammatory response system and the availability of plasma tryptophan in patients with primary sleep disorders and major depression.
    Journal of affective disorders, 1998, Volume: 49, Issue:3

    Topics: Adult; Cytokines; Depressive Disorder; Dinoprostone; Female; Humans; Immunity, Cellular; Inflammation; Male; Middle Aged; Mitogens; Sleep Wake Disorders; Tryptophan

1998
Serotonin-immune interactions in detoxified chronic alcoholic patients without apparent liver disease: activation of the inflammatory response system and lower plasma total tryptophan.
    Psychiatry research, 1998, May-08, Volume: 78, Issue:3

    Topics: Adult; Alcoholism; Antigens, CD; Cytokine Receptor gp130; Female; Humans; Inflammation; Interleukin 1 Receptor Antagonist Protein; Interleukin-6; Interleukin-8; Lipopolysaccharide Receptors; Male; Membrane Glycoproteins; Proteins; Receptors, Interleukin-6; Serotonin; Sialoglycoproteins; Tryptophan; Uteroglobin

1998
Oxidative damage in rat tissue following excessive L-tryptophan and atherogenic diets.
    Advances in experimental medicine and biology, 1999, Volume: 467

    Topics: Animals; Diet, Atherogenic; Female; Inflammation; Lipid Peroxidation; Liver; Muscle, Skeletal; Rats; Tryptophan

1999
Prevention of T cell-driven complement activation and inflammation by tryptophan catabolism during pregnancy.
    Nature immunology, 2001, Volume: 2, Issue:1

    Topics: Animals; Complement Activation; Decidua; Enzyme Inhibitors; Female; Fetus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Male; Maternal-Fetal Exchange; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Mice, Transgenic; Pregnancy; Skin Transplantation; T-Lymphocytes; Transplantation, Homologous; Transplantation, Isogeneic; Tryptophan; Tryptophan Oxygenase

2001
Inhibition of inflammation with certain amino acids.
    Journal of the American Podiatry Association, 1978, Volume: 68, Issue:1

    Topics: Amino Acids; Animals; Anti-Inflammatory Agents; Edema; Hindlimb; Inflammation; Male; Phenylalanine; Rats; Tryptophan

1978
Anti-inflammatory activity of L-tryptophan and DL-tryptophan.
    The Indian journal of medical research, 1978, Volume: 68

    Topics: Animals; Anti-Inflammatory Agents; Female; Inflammation; Male; Rats; Tryptophan

1978
Oxidative tryptophan metabolism in renal allograft recipients: increased kynurenine synthesis is associated with inflammation and OKT3 therapy.
    Cytokine, 1992, Volume: 4, Issue:3

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Biomarkers; Creatinine; Female; Graft Rejection; Gram-Negative Bacterial Infections; Humans; Inflammation; Interferon-gamma; Kidney Transplantation; Kynurenine; Male; Middle Aged; Muromonab-CD3; Oxidation-Reduction; Postoperative Complications; Predictive Value of Tests; Retrospective Studies; Tryptophan; Tryptophan Oxygenase; Virus Diseases

1992
Antioxidant activities of some tryptophan metabolites: possible implication for inflammatory diseases.
    Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:7

    Topics: Animals; Antioxidants; Female; Free Radicals; Inflammation; Kinetics; Kynurenine; Liposomes; Lung; Mice; Mice, Inbred ICR; Orthomyxoviridae Infections; Peroxides; Tryptophan

1990
The clinical spectrum of the eosinophilia-myalgia syndrome associated with L-tryptophan ingestion. Clinical features in 20 patients and aspects of pathophysiology.
    Annals of internal medicine, 1990, Jul-15, Volume: 113, Issue:2

    Topics: Adult; Aged; Eosinophilia; Fasciitis; Female; Humans; Hypertension, Pulmonary; Inflammation; Male; Middle Aged; Muscular Diseases; Myocarditis; Nervous System Diseases; Pain; Pain Management; Pulmonary Fibrosis; Tryptophan

1990
Eosinophilic neuritis, perimyositis, and vasculitis associated with ingestion of L-tryptophan.
    The Journal of rheumatology, 1990, Volume: 17, Issue:6

    Topics: Administration, Oral; Adult; Aged; Blood Vessels; Connective Tissue Diseases; Eosinophilia; Female; Humans; Inflammation; Male; Middle Aged; Neuritis; Tryptophan; Vasculitis

1990
[Contribution to the study of the modifications of inflammatory reactions, induced by abrine, in guinea pigs immunized with ana-abrine].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1966, Jul-18, Volume: 263, Issue:3

    Topics: Animals; Guinea Pigs; Inflammation; Toxins, Biological; Toxoids; Tryptophan

1966
[Radioautographic study of the inclusion of H3-tryptophan into porous connective tissue cells].
    Doklady Akademii nauk SSSR, 1971, Apr-21, Volume: 197, Issue:6

    Topics: Adipose Tissue; Animals; Autoradiography; Connective Tissue; Connective Tissue Cells; Fibroblasts; Inflammation; Macrophages; Mice; Tritium; Tryptophan

1971
Local antiphlogistic activity of L-phenylalanine and L-tryptophane.
    The Journal of endocrinology, 1968, Volume: 41, Issue:4

    Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents; Cortisone; Depression, Chemical; Gelatin; Inflammation; Leukocyte Count; Leukocytes; Male; Neutrophils; Phenylalanine; Rats; Stereoisomerism; Tryptophan

1968