tryptophan and Disease Models, Animal

tryptophan has been researched along with Disease Models, Animal in 385 studies

Research

Studies (385)

Timeframe	Studies, this research(%)	All Research%
pre-1990	44 (11.43)	18.7374
1990's	25 (6.49)	18.2507
2000's	55 (14.29)	29.6817
2010's	179 (46.49)	24.3611
2020's	82 (21.30)	2.80

Authors

Authors	Studies
Braisted, J; Dranchak, P; Earnest, TW; Gu, X; Hoon, MA; Inglese, J; Oliphant, E; Solinski, HJ	1
Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV	1
Cui, YL; Gao, LN; Li, K; Li, KD; Liu, H; Wang, QS; Wang, X; Yan, K; Zhang, Z	1
Coppens, V; De Picker, L; Leboyer, M; Morrens, M; Müller, N; Skorobogatov, K; Verkerk, R	1
Du, Y; Ren, D; Yang, C; Yang, X; Zhao, Y	1
Anderson, S; Arinze, NV; Belghasem, M; Chitalia, VC; Farber, A; Francis, J; Hamburg, NM; Hassan Kamel, M; Lee, N; Lotfollahzadeh, S; Napoleon, MA; Rahimi, N; Ravid, JD; Richards, S; Sherr, D; Siracuse, JJ; Walker, JA; Whelan, SA; Yin, W	1
Chen, L; Gao, M; Guan, F; He, K; Li, J; Liu, M; Lv, Y; Shi, T; Zhang, H; Zhang, M; Zhao, J; Zhao, Y	1
Alavinejad, N; Apetz, N; Drzezga, A; Endepols, H; Neumaier, B; Vus, S; Zischler, J; Zlatopolskiy, BD	1
Barrett, KT; Choudhary, A; Mayengbam, S; Mu, C; Rho, JM; Scantlebury, MH; Shearer, J	1
Burtey, S; Cerini, C; McKay, N; Poitevin, S; Vial, R	1
Ano, Y; Nakayama, H; Ohya, R; Takaichi, Y; Takashima, A; Uchida, K	1
Endres, V; Jones, B; Klemashevich, C; Shankar, S; Sun, Y; Tuchaai, E; Wu, CS	1
Kong, Y; Kumaran Satyanarayanan, S; Liu, J; Su, KP; Sun, J; Ye, T; Yu, Q; Zhang, Y	1
Ge, PY; Guo, R; Ni, SJ; Qi, YY; Qu, SY; Yang, NY; Yao, ZY; Zhang, QC; Zhao, X; Zhu, HX	1
Ejtemaei-Mehr, S; Ghahremani, MH; Ghanbari, A; Ghazi-Khansari, M; Guillemin, GJ; Jand, Y	1
Abraham, SJK; Dedeepiya, VD; Ikewaki, N; Iwasaki, M; Levy, GA; Preethy, S; Raghavan, K; Ranganathan, N; Senthilkumar, R; Srinivasan, S; Yamamoto, N	1
Chen, R; Guo, SN; He, SQ; Huang, JY; Li, SP; Lin, J; Liu, J; Lun, JC; Lv, WJ; Ma, YM	1
Claeys, W; Geerts, A; Ghesquière, B; Lefere, S; Van Hoecke, L; Van Imschoot, G; Van Steenkiste, C; Van Vlierberghe, H; Van Wonterghem, E; Vandenbroucke, RE	1
Chen, J; Huang, S; Liang, J; Luo, X; Pan, Z; Su, Y; Wang, Q; Wang, X; Xie, X; Zhang, M; Zhou, L	1
Chen, B; Di, Z; Guo, Q; Hu, R; Jiang, S; Liu, J; Ma, R; Shi, M; Song, Z; Sun, S; Wu, X; Xu, H	1
Banerjee, J; Chandra, PS; Dey, S; Dixit, AB; Dubey, V; Tripathi, M	1
Cheng, Y; Liu, C; Sun, C	1
Li, T; Niu, P; Ren, D; Shao, H; Yang, X; Zhang, B; Zhao, A; Zhao, Y	1
Han, N; Li, Q; Ren, D; Shi, L; Wang, N; Yan, T; Yang, X; Zhang, B; Zhang, L; Zhang, X; Zhao, Y	1
Chang, Y; Deng, H; Du, B; Feng, J; Huang, H; Li, X; Peng, J; Qiu, M; Wu, J; Wu, P; Xiao, H; Yang, Y	1
Li, T; Liu, L; Niu, P; Ren, D; Shao, H; Yang, W; Yang, X; Zhang, L; Zhang, X; Zhao, Y	1
Abuelezz, SA; Hendawy, N; Salaheldin, TH	1
Amend, L; Bielecka, AA; Boeck, S; Bokemeyer, C; Bröring, TS; Cortesi, F; Gagliani, N; Giannou, AD; Güngör, C; Huber, S; Izbicki, JR; Jung, M; Kimmelman, AC; Konczalla, L; Kylies, D; Lesker, TR; Pelczar, P; Peschka, M; Puelles, VG; Renné, T; Riecken, K; Schönlein, M; Sinn, M; Siveke, JT; Stein, A; Strowig, T; Tintelnot, J; Trajkovic-Arsic, M; Uzunoglu, FG; Xu, Y; Zhang, D	1
Guo, M; Li, S; Liu, M; Wang, Y; Xiang, H; Yao, J	1
Fang, C; Huang, H; Niu, H; Ruan, J; Wei, M; Yin, X; Zhou, Y	1
Cheng, W; Hou, BL; Liang, YN; Wang, T; Wang, Z; Zhu, J	1
Chenaux-Repond, N; Dorochow, E; Geisslinger, G; Gurke, R; Hahnefeld, L; Klein, S; Kolbinger, A; Kraus, N; Ortiz, C; Pierre, S; Scholich, K; Trebicka, J; Welsch, C	1
Appolonova, SA; Bondareva, NE; Brito, A; Kuznetsov, RM; Lubenec, NL; Moskaleva, NE; Samoylov, VM; Savitskii, MV; Sheremet, AB; Soloveva, AV; Tagliaro, F; Zigangirova, NA	1
Geng, F; Gu, JM; Jiang, J; Xue, A; Xue, H; Yang, B; Zhang, N; Zhao, JH	1
Chang, S; Ge, J; Huang, SS; Li, X; Liu, R; Weng, X	1
Chang, Q; Chen, SG; Feng, L; Liu, XM; Tao, X; Wang, LS; Wang, Z; Zhang, MD; Zhou, YF	1
Guo, G; Sun, L; Xu, H; Yang, L	1
Cui, C; Li, W; Liu, S; Sun-Waterhouse, D; Tao, Q; Zhu, X	1
Cui, A; Fan, JG; Gao, J; Han, Y; Hu, Z; Li, Y; Liu, XL; Liu, Y; Liu, Z; Ma, F; Pan, Q; Xin, FZ; Xue, Y; Zhao, ZH; Zhou, D	1
Barcellos, LJG; Bonan, CD; de Abreu, MS; Genario, R; Giacomini, ACVV; Piassetta, AS; Piato, A	1
Bharti, R; Bode, HB; Brandao, I; Deumelandt, K; Epping, L; Falk-Paulsen, M; Grill, A; Keil, M; Kramer, M; Kurschus, FC; Lanz, TV; Meuth, SG; Mishra, N; Mohapatra, SR; Niesler, B; Oezen, I; Okun, JG; Opitz, CA; Platten, M; Rehman, A; Reinhardt, C; Rosenstiel, P; Röth, R; Röwe, J; Sanghvi, K; Sonner, JK; Tang, Y; von Landenberg, A; Wanke, F; Wick, W; Wolf, L; Wolff, H	1
Anegon, I; Frungieri, MB; Gualdoni, GS; Guazzone, VA; Hill, M; Höcht, C; Jacobo, PV; Lustig, L; Matzkin, ME; Pérez, CV; Sobarzo, CM	1
Laury-Kleintop, L; Prendergast, GC; Thomas, S	1
Fu, WW; Li, L; Li, WJ; Song, YH; Wu, RT; Wu, WY; Xie, MY; Yin, SH	1
Assunção Santos, RE; Costa de Santana, BJ; Ferraz-Pereira, KN; Gouveia, HJCB; Lacerda, DC; Manhães-de-Castro, R; Olivier-Coq, J; Toscano, AE; Tourneur, Y	1
Halenova, T; Maximova, T; Pleteneva, T; Syroeshkin, A; Zlatskiy, I	1
Andry, C; Arinze, N; Belghasem, M; Chitalia, VC; Francis, JM; Lee, N; Lyle, C; Napolene, MA; Ravid, K; Richards, S; Roth, D; Spencer, C; Thompson, C; Walker, J; Whelan, SA; Yin, W	1
Jeong, JH; Jung, TW; Kim, HC; Nabeshima, T; Nah, SY; Nguyen, BT; Phan, DH; Saito, K; Sharma, N; Shin, EJ; Tran, HQ	1
Bakhta, O; Beaumont, J; Chao de la Barca, JM; Croyal, M; Dieu, X; Kamel, R; Kouassi Nzoughet, J; Mirebeau-Prunier, D; Pascaud, A; Prunier, F; Reynier, P; Simard, G; Tamareille, S	1
Fan, W; Hu, Q; Jin, L; Liao, W; Wang, J; Zeng, J; Zhong, S	1
Ayers, JI; Borchelt, DR; Brown, H; Cashman, NR; Crown, A; Fagerli, E; Galaleldeen, A; McAlary, L; Yerbury, JJ	1
Carrera Silva, EA; Cerbán, FM; Gea, S; Motran, CC; Stempin, CC; Volpini, X	1
Albini, E; Annunziato, L; Belladonna, ML; Bianchi, R; Boscia, F; Calabresi, P; Carvalho, A; Coletti, A; Cunha, C; Di Filippo, M; Fallarino, F; Gaetani, L; Gargaro, M; Greco, FA; Grohmann, U; Iacono, A; Iamandii, IM; Macchiarulo, A; Maciel, P; Manni, G; Matino, D; Mondanelli, G; Orabona, C; Pallotta, MT; Panfili, E; Peppelenbosch, M; Proietti, E; Puccetti, P; Santambrogio, L; Vacca, C; Volpi, C	1
Achasova, KM; Babochkina, TI; Borisova, MA; Kozhevnikova, EN; Litvinova, EA; Pindyurin, AV; Snytnikova, OA; Tsentalovich, YP	1
Cho, JY; Choi, EY; Jeon, CO; Kim, B; Lee, YK; Morse, HC; Shin, DM; Shin, JH; Shon, WJ	1
Ahmad, FJ; Akhtar, M; Alam, M; Imam, SS; Najmi, AK; Zameer, S	1
Ando, T; Hara, A; Hattori, T; Hirata, A; Hoshi, M; Nakamoto, K; Saito, K; Tashita, C; Tezuka, H; Tomita, H; Yamamoto, Y	1
Cia, F; Francisco, AF; Willcocks, SJ; Wren, BW	1
Guo, Q; Qiu, H; Zhang, J; Zhang, Y; Zhong, X	1
Duarte-Guterman, P; Eid, RS; Galea, LAM; Go, KA; Lamers, Y; Qiu, W	1
Hu, B; Hu, H; Leung, EL; Liu, H; Ye, C; Zhang, Z; Zheng, J; Zhu, L	1
Chen, LW; Chen, PH; Liu, WC	1
Du, L; Duan, Z; Guo, L; Kuang, C; Liang, H; Shi, L; Takikawa, O; Xing, Z; Yang, Q; Zhang, S	1
Li, D; Shao, H; Tan, Z; Xiao, N; Zhang, C	1
Brown, ED; Coombes, BK; De Jong, AM; Dharavath, S; Fiebig-Comyn, AA; French, S; Guo, ABY; Magolan, J; Weber, BS	1
Chang, PV; Fu, J; Scott, SA	1
Hu, X; Liu, S; She, F; Yao, Y; Zhang, W; Zhao, X	1
Abadir, PM; Chung, T; de Cabo, R; Ferrucci, L; Hoke, A; Joca, H; Khadeer, M; Le, A; Lovett, J; Moaddel, R; Tian, J; Walston, J; Ward, C; Westbrook, R; Xue, QL; Yang, H	1
Panda, JJ; Sharma, M; Shukla, S; Tiwari, V	1
Lott, JS	1
Cassard, AM; Ciocan, D; Dupeux, M; Durand, S; Emond, P; Ferrere, G; Houron, C; Hugot, C; Kroemer, G; Lievin-Le Moal, V; Mercier-Nomé, F; Perlemuter, G; Puchois, V; Sokol, H; Spatz, M; Straube, M; Trainel, N; Voican, CS; Wrzosek, L	1
Alcaide, P; Anastasiou, M; Aronovitz, M; Carrillo-Salinas, FJ; Jetton, D; Kaur, K; Ngwenyama, N; Smolgovsky, SA; Tai, A	1
Becker, LB; Choi, J; Choudhary, RC; Hayashida, K; Kim, J; Kim, N; Nishikimi, M; Shoaib, M; Stevens, JF; Yagi, T; Yin, T	1
Bao, X; Jiang, N; Lin, A; Liu, H; Sun, G; Yang, H; Zhang, X; Zheng, J	1
Čepcová, D; Deelman, LE; Kema, IP; Klimas, J; Sandovici, M; Šišková, K; Vavrincová-Yaghi, D; Vavrinec, P	1
Avitabile, T; Choragiewicz, T; Fiedorowicz, M; Grieb, P; Kamińska, A; Kocki, T; Nowakowska, D; Rejdak, R; Toro, MD; Turski, WA; Wertejuk, K; Wełniak-Kaminska, M; Zweifel, S	1
Chen, W; Kong, Q; Li, X; Tian, P; Wang, B; Wang, G; Zhang, H; Zhao, J	1
Bhutia, YD; Ganapathy, V; Ramachandran, S; Sikder, MOF; Sivaprakasam, S; Wachtel, MW	1
Dai, H; Fang, L; Huang, K; Wang, F; Wang, L; Xiang, Q; Yan, J; Yan, X; Yao, H; Zhang, W	1
He, X; Peng, W; Tang, J; Xie, L; Xu, Y; Zhang, W; Zhang, Z; Zhou, J	1
Hasan, M; Jung, BH; Kwon, OS; Lee, G; Lee, SH; Seo, JE	1
Altieri, A; Basu, S; Halayko, AJ; Hemshekhar, M; Krokhin, OV; Lloyd, D; Mookherjee, N; Osawa, N; Piyadasa, H	1
Hsu, WT; Jui, HY; Kuo, CC; Lee, CM; Tseng, YH; Wu, KK	1
Chen, S; Gao, Y; Liu, Y; Tan, J; Wang, Y; Wu, H; Xiao, Z; Yan, H; Yi, S	1
Buckinx, A; De Bundel, D; Gerlach, M; Guenther, E; Kooijman, R; Pierre, A; Smolders, I; Van Den Herrewegen, Y; Van Laethem, G	1
Cao, T; Li, X; Lin, B; Liu, C; Luo, S; Shi, J; Wang, S; Zhang, X; Zheng, T; Zhou, M	1
Cho, JY; Cowling, RT	1
Antonson, AM; Chen, HJ; Galley, JD; Gur, TL	1
Alitalo, K; Arasa, J; Beck, A; Cara, LCL; Chalmers, S; Clement, CC; D'Alessandro, A; Demaria, S; Fallarino, F; Fernandez-Rodriguez, R; Formenti, S; Furtado, R; Gadina, M; Galarini, R; Gargaro, M; Gehrke, S; Grohmann, U; Halin, C; Ianni, F; Karaman, S; Lauvau, G; Macchiarulo, A; Manni, G; Mondanelli, G; Moretti, S; Putterman, C; Runge, P; Santambrogio, L; Sardella, R; Skobe, M; Soni, RK; Spada, S; Thangaswamy, S; Tsai, WL; Veldhoen, M	1
Liu, L; Ren, D; Yang, W; Yang, X; Zhao, Y	1
Alves-Filho, JC; Costa, VV; Cunha, TM; Dantzer, R; Marim, FM; Queiroz-Junior, CM; Teixeira, AL; Teixeira, DC; Teixeira, MM; Valiate, BVS	1
Albini, E; Belladonna, ML; Grohmann, U; Mondanelli, G; Orabona, C; Orecchini, E; Pallotta, MT; Ricci, G	1
Arsenijevic, A; Djonov, V; Dolicanin, Z; Gazdic, M; Lukic, ML; Milosavljevic, N; Nurkovic, J; Simovic Markovic, B; Volarevic, V	1
Chu, M; Feng, H; Ge, X; He, M; Lu, C; Wang, Q; Wu, L; Xia, H	1
Campagnola, G; de Los Santos, T; Diaz-San Segundo, F; Keith, A; Kloc, A; Peersen, O; Rai, DK; Rieder, E; Schafer, EA	1
Alfano, RR; Harvey, G; Harvey, T; Lu, L; Rodríguez-Contreras, A; Shi, L	1
Chen, X; Fu, X; Luo, J; Peng, X; Wang, L; Wang, X; Xiao, Z; Zhou, JX; Zhu, B	1
Parasram, K	1
Han, Y; Kong, L; Liu, L; Liu, Z; Sun, H; Wang, X; Yu, J; Zhang, A	1
Bermudez, I; Csanova, A; Franklin, M; Hlavacova, N; Jezova, D; Li, Y; Sanchez, C	1
Arboleya, S; Buravkov, S; Burokas, A; Clarke, G; Cryan, JF; Dinan, TG; Flynn, I; Gahan, CGM; Golubeva, AV; Hyland, NP; Joyce, SA; Khochanskiy, D; Makarova, O; Moloney, G; Moya-Pérez, A; Murphy, K; Peterson, V; Rea, K; Sherwin, E; Stanton, C	1
Acharjee, A; Cooke, A; Griffin, JL; Koulman, A; Murfitt, SA; Roberts, LD; Sawyer, Y; Wang, X; Zaccone, P	1
Ferraz-Pereira, KN; Lacerda, DC; Manhães-de-Castro, R; Toscano, AE	1
Alm, EJ; Balogh, A; Bartolomaeus, H; Basic, M; Bork, P; Boschmann, M; Côrte-Real, BF; Costea, PI; Dechend, R; Forslund, K; Frätzer, C; Gerlach, RG; Gollasch, M; Grohme, DA; Haase, S; Jantsch, J; Kearney, SM; Kempa, S; Kleiner, FH; Kleinewietfeld, M; Klug, L; Krannich, A; Linker, RA; Mähler, A; Maier, L; Markó, L; Matus, MG; Müller, DN; Neubert, P; Olesen, SW; Rakova, N; Schatz, V; Sunagawa, S; Titze, JM; Tsvetkov, D; Typas, A; Vvedenskaya, O; Wilck, N; Wu, C	1
Arora, D; Basu Mallik, S; Fernandes, J; Mudgal, J; Nampoothiri, M; Pai, KSR; Rao, CM	1
Chen, B; Guo, J; He, S; Hu, J; Hu, L; Huang, X; Li, X; Qi, Y; Shang, D; Wang, J; Wen, Y	1
Suolang, Y; Tang, Y; Zhang, Y; Zhao, L; Zhou, D	1
Aksenova, NA; Dudenkova, VV; Gavrina, AI; Shirmanova, MV; Snopova, LB; Solovieva, AB; Yuzhakova, DV; Zagaynova, EV; Тimashev, PS	1
Chen, L; Chen, Z; Jiang, X; Liu, F; Pang, C; Tang, L; Xu, L; Yu, X; Zhang, J	1
Dong, X; Gong, H; Jiang, CL; Li, JS; Lian, YJ; Liu, LL; Peng, W; Su, WJ; Wang, B; Wang, YX; Zhang, T	1
Broecker, V; Chen, PM; Fang, C; Jane-Wit, D; Kirkiles-Smith, NC; Liu, R; López-Giráldez, F; Manes, TD; Merola, J; Pober, JS; Qin, L; Tietjen, GT; Xie, C	1
Albini, E; Antognelli, C; Belladonna, ML; Berioli, MG; Bianchi, R; Bicciato, S; Cappa, M; Carvalho, A; Ceccarini, G; Chatenoud, L; Cunha, C; De Giorgi, G; Esposito, SM; Fallarino, F; Ferretti, A; Fuchs, D; Grohmann, U; Iacono, A; Lemos, MC; Matino, D; Matteoli, MC; Mondanelli, G; Orabona, C; Pallotta, MT; Pilotte, L; Puccetti, M; Puccetti, P; Romani, L; Scattoni, R; Talesa, VN; Toni, S; Vacca, C; Van den Eynde, B; Verrotti, A; Volpi, C	1
Ahlstedt, J; Ceberg, C; Chakwizira, A; Nittby Redebrandt, H	1
Fischer, CW; Jensen, E; Kousholt, BS; Larsen, ER; Liebenberg, N; Pereira, VS; Wegener, G	1
Alvarez, JI; Antel, J; Ardura-Fabregat, A; Blain, M; Borio, M; Borucki, DM; Chao, CC; de Lima, KA; Dragin, LL; Gutiérrez-Vázquez, C; Healy, L; Hewson, P; Laplaud, DA; Neziraj, T; Prinz, M; Quintana, FJ; Rothhammer, V; Staszewski, O; Takenaka, MC; Tjon, EC; Wheeler, M	1
Besra, G; Blumberg, RS; Collin, F; de Silva, PSA; Gandhi, A; Gensollen, T; Glickman, J; Hauser, R; Iyer, SS; Lavin, R; Llebaria, A; Maxwell, A; Neves, JF; Oh, SF; Sartor, RB; Serra, C	1
Eschenhagen, T; Foo, RS; Geertz, B; Hirt, MN; Höppner, G; Löser, A; Ng, SL; Peters, BS; Reichenspurner, H; Schaefer, A; Schneeberger, Y; Stenzig, J; Tan, W; Wong, E; Zhao, RR	1
Breda, C; Giorgini, F; Sathyasaikumar, KV; Schwarcz, R	1
Deng, YT; Li, XH; Xu, TJ; Zhao, MG	1
Dantzer, R; Garcia, R; Kelley, KW; Lawson, M; McCusker, RH; Nixon, SE; O'Connor, JC; Rodriguez-Zas, SL; Romanova, EV; Southey, BR; Sweedler, JV; Wu, C; Zavala, C	1
Furue, M; Hashimoto-Hachiya, A; Ito, T; Mitoma, C; Tanaka, Y; Tsuji, G; Uchi, H	1
Bosco, DA; Brown, RH; Hetz, C; Martínez Traub, F; Medinas, DB; Rozas, P; Woehlbier, U	1
Bao, Y; Chen, X; Fu, X; Wang, L; Wang, X; Xiao, Z; Zhou, J	1
Chen, JN; Chen, PV; Dou, YX; Huang, T; Qu, C; Su, ZR; Wu, JZ; Xie, Y; Yu, XT; Yuan, ZW; Zeng, HF; Zhang, XJ	1
Barichello, T; Costa, DVDS; da Silva, FER; de Lucena, DF; de Sousa, FCF; de Souza, MRM; Dos Santos, CC; Lima, CNC; Macedo, D; Maes, M; Miyajima, F; Quevedo, J; Rodrigues, FTS; Vasconcelos, SMM	1
Dong, E; Gatta, E; Grayson, DR; Guidotti, A; Locci, V	1
Deng, Z; Egilmez, NK; Haribabu, B; Hsieh, M; Hu, X; Hutchins, E; Jala, VR; Kumar, A; Lei, C; Luo, C; McClain, CJ; Merchant, ML; Miller, DM; Mu, J; Park, JW; Reiman, R; Ren, Y; Sayed, M; Sriwastva, MK; Sundaram, K; Teng, Y; Van Keuren-Jensen, K; Yan, J; Zhang, HG; Zhang, L	1
Gao, J; Li, W; Luo, Y; Sun, J; Sun, L; Wang, G; Yao, X; Yu, J; Zhou, Y; Zhu, Z	1
Ano, Y; Ayabe, T; Furuyashiki, T; Kitaoka, S; Kondo, K; Ohya, R	1
de Jesus Silva, F; Della Lucia, EM; Gouveia Pelúzio, MDC; Natali, AJ; Rezende, RM; Silva Campos Favarato, L; Stampini Duarte Martino, H	1
Ihara, Y; Inai, Y; Ito, Y; Manabe, S; Minakata, S; Sakurai, S	1
Agus, A; Sokol, H	1
Argyopoulos, CP; Bayliss, GP; Cao, G; Chen, DQ; Chen, H; Chen, L; Cheng, XH; Guo, Y; Kang, H; Li, XR; Liu, D; Ma, SX; Mao, JR; Meng, MX; Samuels, DC; Shang, YQ; Su, W; Vaziri, ND; Wang, M; Ye, F; Yu, H; Yu, XY; Zhang, L; Zhang, Y; Zhao, J; Zhao, S; Zhao, YY; Zhuang, S	1
Ait-Belkacem, R; Gomes, B; Marillier, R; Poncelet, L; Stauber, J	1
Chen, X; Geng, F; Lei, X; Li, G; Liu, B; Liu, G; Zhang, N	1
Chang, HS; Hu, KL; Li, LN; Lu, Y; Wang, PP; Yu, X; Zhang, B	1
Ashurov, D; Cunha, C; Mayilvahanan, K; Todorov, G	1
Han, XM; Lu, YN; Qin, YJ; Rang, Y; Wang, NX; Zhai, XJ; Zhang, XL; Zhu, Y	1
Chen, Y; Dai, S; Gordon, J; Kearns, AC; Lehmicke, G; Liu, F; Qin, X; Rappaport, J; Velasquez, S	1
Kasper, S	1
Cai, L; Cong, W; Jin, L; Li, X; Ma, W; Tan, Y; Wang, Y; Zhao, T; Zhu, Z	1
Brzozowska, I; Brzozowski, T; Hess, T; Kania, J; Konturek, PC; Konturek, SJ; Kwiecien, S; Pawlik, M; Reiter, RJ; Targosz, A	1
Leonard, AV; Vink, R	1
Barker, RN; Dahal, LN; Hall, LS; Ward, FJ	1
Chandra, S; Misra-Bhattacharya, S; Rana, AK; Siddiqi, MI	1
Akkerman, S; Blokland, A; Prickaerts, J; Rutten, K; Steinbusch, HW; van Donkelaar, EL	2
Fukuyama, N; Mori, H; Shizuma, T	1
Opitz, C; Platten, M; Wick, W	1
Choi, KM; Jung, ID; Kang, YK; Kim, B; Lee, MG; Park, YM; Yim, HS	1
Dantzer, R; Kelley, KW; Lawson, MA; McCusker, RH; O'Connor, JC; Parrott, JM	1
Ghahary, A; Jalili, RB; Kilani, RT; Li, Y; Rahmani-Neishaboor, E	1
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Kontsevaia, NG	1

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25 review(s) available for tryptophan and Disease Models, Animal

Article	Year
Brain Frontiers in immunology, 2021, Volume: 12 Topics: Animals; Biomarkers; Blood-Brain Barrier; Brain; Disease Models, Animal; Disease Susceptibility; Humans; Kynurenine; Mental Disorders; Metabolic Networks and Pathways; Phenotype; Prognosis; Research; Tryptophan	2021
The tryptophan biosynthetic pathway is essential for Mycobacterium tuberculosis to cause disease. Biochemical Society transactions, 2020, 10-30, Volume: 48, Issue:5 Topics: Allosteric Site; Animals; Anti-Bacterial Agents; Antitubercular Agents; Biosynthetic Pathways; Catalysis; Disease Models, Animal; Drug Resistance, Multiple; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inhibitory Concentration 50; Mice; Mutation; Mycobacterium tuberculosis; Phagocytosis; Phenotype; Tryptophan; Tuberculosis	2020
Phytochemical treatments target kynurenine pathway induced oxidative stress. Redox report : communications in free radical research, 2018, Volume: 23, Issue:1 Topics: Animals; Disease Models, Animal; Glutamic Acid; Humans; Kynurenine; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Phytochemicals; Plant Extracts; Quinolinic Acid; Tryptophan	2018
Implications of tryptophan photoproduct FICZ in oxidative stress and terminal differentiation of keratinocytes. Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 2019, Volume: 154, Issue:1 Topics: Animals; Carbazoles; Cell Differentiation; Disease Models, Animal; Filaggrin Proteins; Humans; Keratinocytes; Mice; Oxidative Stress; Reactive Oxygen Species; Receptors, Aryl Hydrocarbon; Skin Diseases; Tryptophan; Ultraviolet Rays	2019
[Immune modulation by tryptophan metabolism: relevance for autoimmune and tumor diseases]. Deutsche medizinische Wochenschrift (1946), 2013, Volume: 138, Issue:28-29 Topics: Animals; Autoimmune Diseases; Brain; Dietary Supplements; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Immune Tolerance; Immunomodulation; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Mice; Neoplasms; Serotonin; Treatment Outcome; Tryptophan	2013
Targeting classical IL-6 signalling or IL-6 trans-signalling in depression? Expert opinion on therapeutic targets, 2014, Volume: 18, Issue:5 Topics: Acute-Phase Reaction; Animals; Antidepressive Agents; Autoimmunity; Bacterial Translocation; Cytokines; Depression; Depressive Disorder; Disease Models, Animal; Genetic Predisposition to Disease; Humans; Hypothalamo-Hypophyseal System; Inflammation; Interleukin-6; Meta-Analysis as Topic; Molecular Targeted Therapy; Neurodegenerative Diseases; Neuroimmunomodulation; Neurotransmitter Agents; Pituitary-Adrenal System; Receptors, Interleukin-6; Signal Transduction; Stress, Psychological; T-Lymphocyte Subsets; Tryptophan; Zinc	2014
The role of immunomodulators on intestinal barrier homeostasis in experimental models. Clinical nutrition (Edinburgh, Scotland), 2015, Volume: 34, Issue:6 Topics: Animals; Arginine; Bifidobacterium; Citrulline; Disease Models, Animal; Epithelial Cells; Fatty Acids, Omega-3; Glutamine; Homeostasis; Humans; Immunologic Factors; Inflammatory Bowel Diseases; Intestinal Mucosa; Lactobacillus; Linoleic Acids, Conjugated; Permeability; Probiotics; Saccharomyces; Tryptophan	2015
Does serotonin deficit mediate susceptibility to ADHD? Neurochemistry international, 2015, Volume: 82 Topics: Adolescent; Animals; Animals, Newborn; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Child, Preschool; Corpus Striatum; Disease Models, Animal; Dopamine; Gene-Environment Interaction; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Inhibition, Psychological; Mice, Knockout; Multifactorial Inheritance; Nerve Tissue Proteins; Neurotransmitter Transport Proteins; Oxidopamine; Prefrontal Cortex; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Serotonin, 5-HT1B; Selective Serotonin Reuptake Inhibitors; Serotonin; Tryptophan	2015
The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression. Metabolic brain disease, 2009, Volume: 24, Issue:1 Topics: Animals; Biomarkers; Causality; Cytokines; Depressive Disorder; Disease Models, Animal; Encephalitis; Humans; Nerve Degeneration; Oxidative Stress; Stress, Psychological; Tryptophan	2009
Chronic granulomatous disease. Cellular and molecular life sciences : CMLS, 2009, Volume: 66, Issue:4 Topics: Animals; Bacterial Infections; Disease Models, Animal; Enzyme Activation; Granulomatous Disease, Chronic; Humans; Immune System; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Mycoses; NADPH Oxidases; Reactive Oxygen Species; Tryptophan	2009
Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease. Progress in neurobiology, 2010, Feb-09, Volume: 90, Issue:2 Topics: Animals; Disease Models, Animal; Dopamine; Humans; Huntington Disease; Kynurenine; Mice; Mutation; Peptides; Quinolinic Acid; Rats; Receptors, Glutamate; Serotonin Plasma Membrane Transport Proteins; Tryptophan	2010
The new '5-HT' hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to th Progress in neuro-psychopharmacology & biological psychiatry, 2011, Apr-29, Volume: 35, Issue:3 Topics: Animals; Brain; Depression; Disease Models, Animal; Female; Humans; Immunity, Cellular; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Male; Nitrosation; Oxidative Stress; Serotonin; Tryptophan	2011
Lessons learned regarding symptoms of tryptophan deficiency and excess from animal requirement studies. The Journal of nutrition, 2012, Volume: 142, Issue:12 Topics: Animals; Disease Models, Animal; Humans; Nutritional Requirements; Oxidation-Reduction; Swine; Tryptophan	2012
Immunopathogenesis of cerebral malaria. International journal for parasitology, 2006, May-01, Volume: 36, Issue:5 Topics: Animals; Blood-Brain Barrier; Brain; Cytokines; Disease Models, Animal; Host-Parasite Interactions; Humans; Malaria, Cerebral; Mice; Plasmodium falciparum; Signal Transduction; Tryptophan	2006
Integrative hypothesis for Huntington's disease: a brief review of experimental evidence. Physiological research, 2007, Volume: 56, Issue:5 Topics: Animals; Calcium; Cell Death; Disease Models, Animal; Energy Metabolism; Excitatory Amino Acids; Humans; Huntington Disease; Inflammation; Kynurenic Acid; Mice; Mice, Transgenic; Mutation; Neurons; Nitro Compounds; Oxidative Stress; Propionates; Quinolinic Acid; Serotonin Plasma Membrane Transport Proteins; Trinucleotide Repeats; Tryptophan	2007
Adverse effects of excessive consumption of amino acids. Annual review of nutrition, 1984, Volume: 4 Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Animals; Brain; Cattle; Diet; Disease Models, Animal; Ethionine; Fenclonine; Glycine; Growth Disorders; Histidine; Humans; Methionine; Nerve Tissue Proteins; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Pneumonia, Atypical Interstitial, of Cattle; Serine; Stereoisomerism; Sulfhydryl Compounds; Tissue Distribution; Tryptophan; Tyrosine; Vitamin A	1984
The relationship of pellagra to corn and the low availability of niacin in cereals. Experientia. Supplementum, 1983, Volume: 44 Topics: Animals; Biological Assay; Disease Models, Animal; Edible Grain; Europe; Humans; Niacin; Nutritive Value; Pellagra; Poverty; Species Specificity; Tryptophan; United States; Zea mays	1983
Urinary bladder carcinogenesis. Pathobiology annual, 1982, Volume: 12 Topics: Amines; Aniline Compounds; Animals; Carcinogens; Carcinoma; Carcinoma, Squamous Cell; Disease Models, Animal; Dogs; Humans; Mice; Nitroso Compounds; Papilloma; Phenacetin; Rats; Skin Neoplasms; Tryptophan; Urinary Bladder Neoplasms	1982
[Analbuminemic rats (NAR) (author's transl)]. Seikagaku. The Journal of Japanese Biochemical Society, 1981, Volume: 53, Issue:10 Topics: Albumins; Animals; Bilirubin; Blood Proteins; Disease Models, Animal; Female; Male; Mutation; Rats; Rats, Inbred Strains; Serum Albumin; Tryptophan	1981
Vitiligo, psoralen, and melanogenesis: some observations and understanding. Pigment cell research, 1996, Volume: 9, Issue:3 Topics: Animals; Dihydroxyphenylalanine; Disease Models, Animal; Furocoumarins; Humans; Indoles; Lead; Melanins; Skin; Superoxide Dismutase; Tryptophan; Tyrosine; Tyrosine Transaminase; Ultraviolet Rays; Vitiligo	1996
The eosinophilia-myalgia syndrome: what we know, what we think we know, and what we need to know. The Journal of rheumatology. Supplement, 1996, Volume: 46 Topics: Centers for Disease Control and Prevention, U.S.; Congresses as Topic; Disease Models, Animal; Eosinophilia-Myalgia Syndrome; Humans; Population Surveillance; Tryptophan; United States	1996
Animal models of the eosinophilia-myalgia syndrome. The Journal of rheumatology. Supplement, 1996, Volume: 46 Topics: Animals; Disease Models, Animal; Eosinophilia-Myalgia Syndrome; Macaca mulatta; Mice; Rats; Tryptophan	1996
[Current biochemical conceptions of mental disorders. I. Biogenic amines in the pathogenesis of schizophrenia]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1979, Volume: 79, Issue:8 Topics: Animals; Biogenic Amines; Blood Platelets; Brain Chemistry; Catechol O-Methyltransferase; Disease Models, Animal; Dopamine; Dopamine beta-Hydroxylase; Ethylene Glycols; Growth Hormone; Hallucinogens; Homovanillic Acid; Humans; Hydroxydopamines; Monoamine Oxidase; Norepinephrine; Psychoses, Substance-Induced; Receptors, Dopamine; Schizophrenia; Serotonin; Tryptophan; Vanilmandelic Acid	1979
[Catecholamines in the pathochemical structure of depressive conditions (according to material from a biological study)]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1975, Volume: 75, Issue:8 Topics: Adrenal Cortex Hormones; Adrenal Medulla; Animals; Brain; Catecholamines; Cell Nucleus; Depression; Disease Models, Animal; Dopamine; Epinephrine; Humans; Hypothalamus; Male; Norepinephrine; Psychopharmacology; Rats; Reserpine; RNA; Serotonin; Tryptophan	1975
Nutritional disturbances of protein metabolism in the liver. The American journal of pathology, 1976, Volume: 84, Issue:3 Topics: Amino Acids, Essential; Animals; Child, Preschool; Dietary Proteins; Disease Models, Animal; Humans; Kwashiorkor; Liver Circulation; Liver Diseases; Muscles; Nutrition Disorders; Osmolar Concentration; Polyribosomes; Protein Biosynthesis; Protein-Energy Malnutrition; RNA; RNA, Messenger; Threonine; Tryptophan	1976

Trials

1 trial(s) available for tryptophan and Disease Models, Animal

Article	Year
The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Molecular psychiatry, 2013, Volume: 18, Issue:6 Topics: Analysis of Variance; Animals; Body Weight; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Female; Gastrointestinal Tract; Gene Expression Regulation; Hippocampus; Hydroxyindoleacetic Acid; Lipopolysaccharides; Male; Mice; Microbiota; Receptors, Serotonin; Serotonin; Serotonin Plasma Membrane Transport Proteins; Sex Characteristics; Stress, Psychological; Tryptophan; Tryptophan Hydroxylase; Tumor Necrosis Factor-alpha	2013

Article

Year

The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner.

Molecular psychiatry, 2013, Volume: 18, Issue:6

Topics: Analysis of Variance; Animals; Body Weight; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Female; Gastrointestinal Tract; Gene Expression Regulation; Hippocampus; Hydroxyindoleacetic Acid; Lipopolysaccharides; Male; Mice; Microbiota; Receptors, Serotonin; Serotonin; Serotonin Plasma Membrane Transport Proteins; Sex Characteristics; Stress, Psychological; Tryptophan; Tryptophan Hydroxylase; Tumor Necrosis Factor-alpha

2013

Other Studies

359 other study(ies) available for tryptophan and Disease Models, Animal

Article	Year
Inhibition of natriuretic peptide receptor 1 reduces itch in mice. Science translational medicine, 2019, 07-10, Volume: 11, Issue:500 Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries	2019
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49 Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection	2020
Targeting hippocampal phospholipid and tryptophan metabolism for antidepressant-like effects of albiflorin. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2021, Volume: 92 Topics: Animals; Antidepressive Agents; Bridged-Ring Compounds; Depression; Disease Models, Animal; Hippocampus; Mice; Phospholipids; Stress, Psychological; Tryptophan	2021
Gut microbiota-dependent catabolites of tryptophan play a predominant role in the protective effects of turmeric polysaccharides against DSS-induced ulcerative colitis. Food & function, 2021, Oct-19, Volume: 12, Issue:20 Topics: Animals; Colitis, Ulcerative; Curcuma; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Male; Mice; Mice, Inbred C57BL; Polysaccharides; Protective Agents; Tryptophan	2021
Tryptophan metabolites suppress the Wnt pathway and promote adverse limb events in chronic kidney disease. The Journal of clinical investigation, 2022, 01-04, Volume: 132, Issue:1 Topics: Aged; Aged, 80 and over; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Line; Disease Models, Animal; Hindlimb; Humans; Indican; Ischemia; Kynurenine; Mice; Middle Aged; Receptors, Aryl Hydrocarbon; Renal Insufficiency, Chronic; Tryptophan; Wnt Signaling Pathway	2022
Analysis of Serum Metabolomics in Rats with Osteoarthritis by Mass Spectrometry. Molecules (Basel, Switzerland), 2021, Nov-26, Volume: 26, Issue:23 Topics: Animals; Biomarkers; Cartilage, Articular; Chromatography, Liquid; Collagenases; Disease Models, Animal; Fatty Acids; Glutamic Acid; Humans; Mass Spectrometry; Metabolic Networks and Pathways; Metabolome; Metabolomics; Nitrogen; Osteoarthritis; Rats; Spermidine; Tryptophan	2021
Imaging of cerebral tryptophan metabolism using 7-[ NeuroImage, 2022, 02-15, Volume: 247 Topics: Animals; Disease Models, Animal; Fluorine Radioisotopes; Hippocampus; Kynurenine; Male; Melatonin; Oxidopamine; Parkinson Disease; Pineal Gland; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Long-Evans; Serotonin; Tryptophan	2022
Seizure modulation by the gut microbiota and tryptophan-kynurenine metabolism in an animal model of infantile spasms. EBioMedicine, 2022, Volume: 76 Topics: Animals; Disease Models, Animal; Gastrointestinal Microbiome; Humans; Kynurenine; Rats; Seizures; Spasm; Spasms, Infantile; Tryptophan	2022
Tryptophan Metabolites Regulate Neuropentraxin 1 Expression in Endothelial Cells. International journal of molecular sciences, 2022, Feb-21, Volume: 23, Issue:4 Topics: Animals; C-Reactive Protein; Carbazoles; Cells, Cultured; Disease Models, Animal; Human Umbilical Vein Endothelial Cells; Humans; Indican; Indoleacetic Acids; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; Renal Insufficiency, Chronic; Toxins, Biological; Tryptophan; Uremia	2022
Tryptophan-tyrosine dipeptide improves tau-related symptoms in tauopathy mice. Nutritional neuroscience, 2023, Volume: 26, Issue:8 Topics: Alzheimer Disease; Animals; Dipeptides; Disease Models, Animal; Mice; Mice, Transgenic; tau Proteins; Tauopathies; Tryptophan; Tyrosine	2023
Deletion of ghrelin alters tryptophan metabolism and exacerbates experimental ulcerative colitis in aged mice. Experimental biology and medicine (Maywood, N.J.), 2022, Volume: 247, Issue:17 Topics: Animals; Chemotactic Factors; Colitis; Colitis, Ulcerative; Cytokines; Dextran Sulfate; Disease Models, Animal; Fatty Acids, Volatile; Fluorescein-5-isothiocyanate; Gene Deletion; Ghrelin; Inflammation; Interleukin-6; Interleukins; Mice; Mice, Inbred C57BL; Mice, Knockout; Tryptophan; Tumor Necrosis Factor-alpha	2022
Microbiota-derived metabolite Indoles induced aryl hydrocarbon receptor activation and inhibited neuroinflammation in APP/PS1 mice. Brain, behavior, and immunity, 2022, Volume: 106 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Indoles; Inflammasomes; Interleukin-18; Interleukin-6; Male; Mice; Mice, Transgenic; Microbiota; Neuroinflammatory Diseases; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Presenilin-1; Receptors, Aryl Hydrocarbon; Tryptophan; Tumor Necrosis Factor-alpha	2022
Berberine ameliorates depression-like behavior in CUMS mice by activating TPH1 and inhibiting IDO1-associated with tryptophan metabolism. Phytotherapy research : PTR, 2023, Volume: 37, Issue:1 Topics: Animals; Berberine; Chromatography, Liquid; Depression; Disease Models, Animal; Indoleamine-Pyrrole 2,3,-Dioxygenase; Mice; Neurotransmitter Agents; Stress, Psychological; Tandem Mass Spectrometry; Tryptophan; Tryptophan Hydroxylase	2023
Melatonin ameliorates disease severity in a mouse model of multiple sclerosis by modulating the kynurenine pathway. Scientific reports, 2022, 09-24, Volume: 12, Issue:1 Topics: Animals; Biological Factors; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Melatonin; Mice; Mice, Inbred C57BL; Multiple Sclerosis; NAD; Nicotinamide N-Methyltransferase; Receptors, Aryl Hydrocarbon; RNA, Messenger; Severity of Illness Index; Tryptophan	2022
Two unique biological response-modifier glucans beneficially regulating gut microbiota and faecal metabolome in a non-alcoholic steatohepatitis animal model, with potential applications in human health and disease. BMJ open gastroenterology, 2022, Volume: 9, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Firmicutes; Fructose; Gastrointestinal Microbiome; Glucans; Humans; Isoleucine; Leucine; Metabolome; Mice; Non-alcoholic Fatty Liver Disease; Ornithine; RNA, Ribosomal, 16S; Spermidine; Succinic Acid; Telmisartan; Tryptophan; Water	2022
Polysaccharides derived from Shenling Baizhu San improve colitis via modulating tryptophan metabolism in mice. International journal of biological macromolecules, 2022, Dec-01, Volume: 222, Issue:Pt A Topics: Animals; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Drugs, Chinese Herbal; Mice; Mice, Inbred C57BL; Polysaccharides; Tryptophan	2022
A mouse model of hepatic encephalopathy: bile duct ligation induces brain ammonia overload, glial cell activation and neuroinflammation. Scientific reports, 2022, 10-20, Volume: 12, Issue:1 Topics: Ammonia; Animals; Bile Acids and Salts; Bile Ducts; Brain; Choline; Disease Models, Animal; Glutamine; Hepatic Encephalopathy; Hyperammonemia; Kynurenine; Liver Diseases; Mice; Microglia; Neuroinflammatory Diseases; Rats; Taurine; Tryptophan	2022
Gegen Qinlian decoction activates AhR/IL-22 to repair intestinal barrier by modulating gut microbiota-related tryptophan metabolism in ulcerative colitis mice. Journal of ethnopharmacology, 2023, Feb-10, Volume: 302, Issue:Pt B Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Indoles; Interleukin-22; Mice; Mice, Inbred C57BL; Receptors, Aryl Hydrocarbon; Tight Junction Proteins; Tryptophan	2023
Involvement of kynurenine pathway between inflammation and glutamate in the underlying etiopathology of CUMS-induced depression mouse model. BMC neuroscience, 2022, 11-10, Volume: 23, Issue:1 Topics: Animals; Depression; Disease Models, Animal; Glutamic Acid; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Mice; Tryptophan	2022
Differential Levels of Tryptophan-Kynurenine Pathway Metabolites in the Hippocampus, Anterior Temporal Lobe, and Neocortex in an Animal Model of Temporal Lobe Epilepsy. Cells, 2022, 11-10, Volume: 11, Issue:22 Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kynurenic Acid; Kynurenine; Neocortex; Rats; Temporal Lobe; Tryptophan	2022
β-Glucan alleviates mice with ulcerative colitis through interactions between gut microbes and amino acids metabolism. Journal of the science of food and agriculture, 2023, Volume: 103, Issue:8 Topics: Animals; beta-Glucans; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Mice; Mice, Inbred C57BL; Tryptophan	2023
Journal of agricultural and food chemistry, 2022, Dec-28, Volume: 70, Issue:51 Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Mice; Mice, Inbred C57BL; Tryptophan	2022
Gut Bacterial Indole-3-acetic Acid Induced Immune Promotion Mediates Preventive Effects of Fu Brick Tea Polyphenols on Experimental Colitis. Journal of agricultural and food chemistry, 2023, Jan-18, Volume: 71, Issue:2 Topics: Animals; Bacteria; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Mice; Mice, Inbred C57BL; Polyphenols; Tryptophan	2023
Fuc-S-A New Ultrasonic Degraded Sulfated α-l-Fucooligosaccharide-Alleviates DSS-Inflicted Colitis through Reshaping Gut Microbiota and Modulating Host-Microbe Tryptophan Metabolism. Marine drugs, 2022, Dec-25, Volume: 21, Issue:1 Topics: Animals; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Male; Mice; Mice, Inbred C57BL; Oligosaccharides; Sulfates; Tryptophan; Ultrasonics	2022
Theabrownin from Fu Brick Tea Improves Ulcerative Colitis by Shaping the Gut Microbiota and Modulating the Tryptophan Metabolism. Journal of agricultural and food chemistry, 2023, Feb-15, Volume: 71, Issue:6 Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Fluorouracil; Gastrointestinal Microbiome; Mice; Mice, Inbred C57BL; RNA, Ribosomal, 16S; Tea; Tryptophan	2023
PCSK9 Inhibition Reduces Depressive like Behavior in CUMS-Exposed Rats: Highlights on HMGB1/RAGE/TLR4 Pathway, NLRP3 Inflammasome Complex and IDO-1. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2023, Volume: 18, Issue:1-2 Topics: Animals; Antidepressive Agents; Depression; Dioxygenases; Disease Models, Animal; HMGB1 Protein; Inflammasomes; Kynurenine; NLR Family, Pyrin Domain-Containing 3 Protein; Proprotein Convertase 9; Rats; Rats, Wistar; Stress, Psychological; Toll-Like Receptor 4; Tryptophan	2023
Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer. Nature, 2023, Volume: 615, Issue:7950 Topics: Animals; Autophagy; Carcinoma, Pancreatic Ductal; Disease Models, Animal; Fecal Microbiota Transplantation; Germ-Free Life; Glutathione Peroxidase; Humans; Indoleacetic Acids; Metabolomics; Metagenome; Mice; Microbiota; Neutrophils; Pancreatic Neoplasms; Peroxidase; Reactive Oxygen Species; Tryptophan	2023
The Tryptophan Metabolite Indole-3-Carboxaldehyde Alleviates Mice with DSS-Induced Ulcerative Colitis by Balancing Amino Acid Metabolism, Inhibiting Intestinal Inflammation, and Improving Intestinal Barrier Function. Molecules (Basel, Switzerland), 2023, Apr-25, Volume: 28, Issue:9 Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Inflammation; Mice; Mice, Inbred C57BL; NF-kappa B; Quality of Life; Sodium Chloride; Sodium Chloride, Dietary; Toll-Like Receptor 4; Tryptophan	2023
Effects of donepezil treatment on plasma and urine metabolites in amyloid beta-induced Alzheimer's disease rats. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2023, May-30, Volume: 1224 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Donepezil; Fatty Acids; Rats; Tryptophan	2023
[Mechanism of tryptanthrin in treatment of ulcerative colitis in mice based on serum metabolomics]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2023, Volume: 48, Issue:8 Topics: Animals; Arachidonic Acid; Colitis; Colitis, Ulcerative; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Interleukin-6; Metabolomics; Mice; Mice, Inbred C57BL; Purines; Tryptophan; Tumor Necrosis Factor-alpha	2023
Differential Lipidomics, Metabolomics and Immunological Analysis of Alcoholic and Non-Alcoholic Steatohepatitis in Mice. International journal of molecular sciences, 2023, Jun-19, Volume: 24, Issue:12 Topics: Animals; Disease Models, Animal; Fatty Acids; Kynurenine; Lipidomics; Liver; Metabolomics; Mice; Non-alcoholic Fatty Liver Disease; Tryptophan	2023
Pharmacokinetics, quorum-sensing signal molecules and tryptophan-related metabolomics of the novel anti-virulence drug Fluorothiazinon in a Pseudomonas aeruginosa-induced pneumonia murine model. Journal of pharmaceutical and biomedical analysis, 2023, Nov-30, Volume: 236 Topics: Animals; Bacterial Proteins; Disease Models, Animal; Humans; Mice; Pneumonia; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Tryptophan; Virulence	2023
[Serum metabolomics study of Psoraleae Fructus in improving learning and memory ability of APP/PS1 mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2023, Volume: 48, Issue:15 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Arachidonic Acid; Disease Models, Animal; Glycerophospholipids; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Tryptophan	2023
Gut Microbiota-Derived Tryptophan Metabolite Indole-3-aldehyde Ameliorates Aortic Dissection. Nutrients, 2023, Sep-26, Volume: 15, Issue:19 Topics: Aminopropionitrile; Animals; Aortic Aneurysm, Thoracic; Aortic Dissection; Disease Models, Animal; Gastrointestinal Microbiome; Humans; Mice; Tryptophan	2023
Urinary metabolic disturbance in the olfactory bulbectomized rats and the modulatory effects of fluoxetine. Life sciences, 2019, Oct-01, Volume: 234 Topics: Animals; Antidepressive Agents, Second-Generation; Depression; Disease Models, Animal; Fluoxetine; Male; Metabolome; Olfactory Bulb; Prefrontal Cortex; Rats, Sprague-Dawley; Tryptophan	2019
IDO1 depletion induces an anti-inflammatory response in macrophages in mice with chronic viral myocarditis. Cell cycle (Georgetown, Tex.), 2019, Volume: 18, Issue:20 Topics: Animals; Coculture Techniques; Coxsackievirus Infections; Cytokines; Disease Models, Animal; Electrocardiography; Enterovirus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; L-Lactate Dehydrogenase; Macrophages; Male; Malondialdehyde; Mice; Mice, Inbred BALB C; Myocarditis; Myocytes, Cardiac; Signal Transduction; Transfection; Tryptophan; Up-Regulation	2019
γ-[Glu]n-Trp ameliorates anxiety/depression-like behaviors and its anti-inflammatory effect in an animal model of anxiety/depression. Food & function, 2019, Sep-01, Volume: 10, Issue:9 Topics: Animals; Anti-Inflammatory Agents; Anxiety; Behavior, Animal; Depression; Disease Models, Animal; Hippocampus; Humans; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Oligopeptides; Prefrontal Cortex; Tryptophan; Tumor Necrosis Factor-alpha; Whey Proteins	2019
Indole-3-propionic acid inhibits gut dysbiosis and endotoxin leakage to attenuate steatohepatitis in rats. Experimental & molecular medicine, 2019, 09-10, Volume: 51, Issue:9 Topics: Animals; Diet, High-Fat; Disease Models, Animal; Dysbiosis; Endotoxins; Gastrointestinal Microbiome; Gene Expression Regulation; Humans; Indoles; Interleukin-1beta; Interleukin-6; Liver; Macrophages; NF-kappa B; Non-alcoholic Fatty Liver Disease; Occludin; Propionates; Rats; Tryptophan; Tumor Necrosis Factor-alpha; Zonula Occludens-1 Protein	2019
Tryptophan alleviates neuroendocrine and behavioral responses to stress in zebrafish. Behavioural brain research, 2020, 01-27, Volume: 378 Topics: Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Female; Fluoxetine; Hydrocortisone; Male; Serotonin Agents; Stress, Psychological; Tryptophan; Zebrafish	2020
Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology. Nature communications, 2019, 10-25, Volume: 10, Issue:1 Topics: Animals; Autoimmunity; Diet; Dietary Proteins; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Gastrointestinal Microbiome; Mice; Multiple Sclerosis; RNA, Ribosomal, 16S; T-Lymphocytes; Tryptophan	2019
Role of indoleamine 2,3-dioxygenase in testicular immune-privilege. Scientific reports, 2019, 11-04, Volume: 9, Issue:1 Topics: Animals; Autoimmune Diseases; Disease Models, Animal; Epididymis; Immune Privilege; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lymph Nodes; Male; Orchitis; Rats; Rats, Wistar; Sertoli Cells; Severity of Illness Index; Testis; Tryptophan; Tryptophan Oxygenase	2019
Reliable detection of indoleamine 2,3 dioxygenase-1 in murine cells and tissues. Methods in enzymology, 2019, Volume: 629 Topics: Animals; Antibodies, Monoclonal; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique, Indirect; Humans; Hybridomas; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Microscopy, Fluorescence; Neoplasms; Reproducibility of Results; Sensitivity and Specificity; Staining and Labeling; Tryptophan	2019
Protective effect of Ganoderma atrum polysaccharides in acute lung injury rats and its metabolomics. International journal of biological macromolecules, 2020, Jan-01, Volume: 142 Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Biomarkers; Chromatography, High Pressure Liquid; Cytokines; Disease Models, Animal; Fatty Acids, Volatile; Ganoderma; Histidine; Lysophosphatidylcholines; Lysophospholipids; Male; Metabolomics; Polysaccharides; Rats; Rats, Sprague-Dawley; Signal Transduction; Tandem Mass Spectrometry; Taurocholic Acid; Tryptophan	2020
Treatment with the essential amino acid L-tryptophan reduces masticatory impairments in experimental cerebral palsy. Nutritional neuroscience, 2021, Volume: 24, Issue:12 Topics: Animals; Cerebral Palsy; Disease Models, Animal; Eating; Masseter Muscle; Mastication; Phenotype; Rats; Rats, Wistar; Tryptophan; Weight Gain	2021
Deuterium-Depleted Water as Adjuvant Therapeutic Agent for Treatment of Diet-Induced Obesity in Rats. Molecules (Basel, Switzerland), 2019, Dec-19, Volume: 25, Issue:1 Topics: Adjuvants, Pharmaceutic; Animals; Blood Glucose; Brain Chemistry; Cytokines; Deuterium; Diet, High-Fat; Disease Models, Animal; Male; Obesity; Oxidative Stress; Rats; Serotonin; Tryptophan; Water	2019
Metabolites in a mouse cancer model enhance venous thrombogenicity through the aryl hydrocarbon receptor-tissue factor axis. Blood, 2019, 12-26, Volume: 134, Issue:26 Topics: Animals; Colonic Neoplasms; Disease Models, Animal; Female; Humans; Male; Metabolome; Mice; Mice, Nude; Plasminogen Activator Inhibitor 1; Receptors, Aryl Hydrocarbon; Signal Transduction; Thromboplastin; Tryptophan; Venous Thromboembolism; Xenograft Model Antitumor Assays	2019
Lithium attenuates d-amphetamine-induced hyperlocomotor activity in mice via inhibition of interaction between cyclooxygenase-2 and indoleamine-2,3-dioxygenase. Clinical and experimental pharmacology & physiology, 2020, Volume: 47, Issue:5 Topics: Amphetamine; Animals; Antimanic Agents; Behavior, Animal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Indoleamine-Pyrrole 2,3,-Dioxygenase; Lithium Chloride; Locomotion; Male; Mania; Meloxicam; Mice, Inbred C57BL; Prefrontal Cortex; Signal Transduction; Tryptophan	2020
Tryptophane-kynurenine pathway in the remote ischemic conditioning mechanism. Basic research in cardiology, 2020, 01-10, Volume: 115, Issue:2 Topics: Animals; Disease Models, Animal; Ischemic Preconditioning, Myocardial; Kynurenine; Liver; Male; Muscle, Skeletal; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Rats, Wistar; Tryptophan	2020
Tryptophan metabolite-regulated Treg responses contribute to attenuation of airway inflammation during specific immunotherapy in a mouse asthma model. Human vaccines & immunotherapeutics, 2020, 08-02, Volume: 16, Issue:8 Topics: Allergens; Animals; Asthma; Cytokines; Disease Models, Animal; Inflammation; Mice; Mice, Inbred BALB C; Ovalbumin; T-Lymphocytes, Regulatory; Tryptophan	2020
Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection. PloS one, 2020, Volume: 15, Issue:1 Topics: Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Disease Models, Animal; Female; Humans; Male; Mice; Mice, Transgenic; Mutagenesis, Site-Directed; Prions; Protein Aggregation, Pathological; Recombinant Fusion Proteins; Superoxide Dismutase-1; Tryptophan	2020
Signaling pathways that regulate Trypanosoma cruzi infection and immune response. Biochimica et biophysica acta. Molecular basis of disease, 2020, 05-01, Volume: 1866, Issue:5 Topics: Adaptive Immunity; Animals; Antigens, Protozoan; Arginine; Caspase 1; Chagas Disease; Disease Models, Animal; Disease Vectors; Host-Parasite Interactions; Humans; Immunity, Innate; Indoleamine-Pyrrole 2,3,-Dioxygenase; Macrophage Activation; Macrophages; NLR Family, Pyrin Domain-Containing 3 Protein; Receptors, Aryl Hydrocarbon; Signal Transduction; Toll-Like Receptors; Triatoma; Trypanosoma cruzi; Tryptophan	2020
Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation. Proceedings of the National Academy of Sciences of the United States of America, 2020, 02-18, Volume: 117, Issue:7 Topics: Allosteric Regulation; Allosteric Site; Animals; Biocatalysis; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Leukocytes, Mononuclear; Male; Mice, Knockout; Multiple Sclerosis; Serotonin; Tryptophan	2020
Fucose Ameliorates Tryptophan Metabolism and Behavioral Abnormalities in a Mouse Model of Chronic Colitis. Nutrients, 2020, Feb-11, Volume: 12, Issue:2 Topics: Animals; Behavior, Animal; Bifidobacterium; Chronic Disease; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Escherichia coli; Fucose; Gastrointestinal Microbiome; Inflammation; Intestinal Mucosa; Male; Mice, Inbred C57BL; Social Behavior; Tryptophan	2020
Gut microorganisms and their metabolites modulate the severity of acute colitis in a tryptophan metabolism-dependent manner. European journal of nutrition, 2020, Volume: 59, Issue:8 Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Inflammatory Bowel Diseases; Mice; Mice, Inbred C57BL; RNA, Ribosomal, 16S; Tryptophan	2020
Thymoquinone Loaded Solid Lipid Nanoparticles Demonstrated Antidepressant-Like Activity in Rats via Indoleamine 2, 3- Dioxygenase Pathway. Drug research, 2020, Volume: 70, Issue:5 Topics: Animals; Antidepressive Agents; Behavior Observation Techniques; Behavior, Animal; Benzoquinones; Depression; Disease Models, Animal; Drug Carriers; Hippocampus; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lipids; Male; Nanoparticles; Nigella sativa; Rats; Serotonin; Signal Transduction; Tryptophan	2020
Kynurenine plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice. World journal of gastroenterology, 2020, Mar-07, Volume: 26, Issue:9 Topics: Animals; CD4-Positive T-Lymphocytes; Colitis; Colon; Disease Models, Animal; Homeostasis; Immunosuppressive Agents; Kynurenine; Male; Mice; Mice, Inbred C57BL; Sulfates; Trinitrobenzenes; Tryptophan	2020
Revisiting aminocoumarins for the treatment of melioidosis. International journal of antimicrobial agents, 2020, Volume: 56, Issue:1 Topics: Aminocoumarins; Animals; Burkholderia pseudomallei; Disease Models, Animal; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Female; Melioidosis; Mice; Mice, Inbred BALB C; Moths; Novobiocin; Tryptophan	2020
Prunella vulgaris L. attenuates experimental autoimmune thyroiditis by inducing indoleamine 2,3-dioxygenase 1 expression and regulatory T cell expansion. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 128 Topics: Animals; Autoantibodies; Cell Proliferation; Cytokines; Disease Models, Animal; Female; Immunosuppressive Agents; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lymphocyte Activation; Plant Extracts; Prunella; Rats, Inbred Lew; Signal Transduction; T-Lymphocytes, Regulatory; Thyroid Gland; Thyroiditis, Autoimmune; Tryptophan	2020
Postpartum fluoxetine increased maternal inflammatory signalling and decreased tryptophan metabolism: Clues for efficacy. Neuropharmacology, 2020, 09-15, Volume: 175 Topics: Animals; Depression, Postpartum; Disease Models, Animal; Female; Fluoxetine; Frontal Lobe; Hippocampus; Inflammation Mediators; Postpartum Period; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Signal Transduction; Tryptophan	2020
Bletilla striata oligosaccharides improve metabolic syndrome through modulation of gut microbiota and intestinal metabolites in high fat diet-fed mice. Pharmacological research, 2020, Volume: 159 Topics: Animals; Bacteria; Bile Acids and Salts; Colon; Diet, High-Fat; Disease Models, Animal; Dysbiosis; Fatty Acids, Volatile; Fecal Microbiota Transplantation; Gastrointestinal Microbiome; Male; Metabolic Syndrome; Mice, Inbred C57BL; Oligosaccharides; Orchidaceae; Plant Extracts; Tryptophan	2020
Supplementation of endogenous Ahr ligands reverses insulin resistance and associated inflammation in an insulin-dependent diabetic mouse model. The Journal of nutritional biochemistry, 2020, Volume: 83 Topics: Animals; Cell Adhesion Molecules; Diabetes Mellitus; Dietary Supplements; Disease Models, Animal; Humans; Indoles; Insulin Resistance; Kupffer Cells; Ligands; Male; Mice; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; NF-kappa B; Oxygenases; Receptors, Aryl Hydrocarbon; Tryptophan	2020
Amyloid β neurotoxicity is IDO1-Kyn-AhR dependent and blocked by IDO1 inhibitor. Signal transduction and targeted therapy, 2020, 06-12, Volume: 5, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Basic Helix-Loop-Helix Transcription Factors; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Neurons; Rats; Receptors, Aryl Hydrocarbon; Tryptophan	2020
Role of tryptophan-metabolizing microbiota in mice diarrhea caused by Folium sennae extracts. BMC microbiology, 2020, 06-29, Volume: 20, Issue:1 Topics: Animals; Bacteria; Cassia; Cytochrome P-450 Enzyme System; Diarrhea; Disease Models, Animal; DNA, Bacterial; DNA, Ribosomal; Female; Gene Expression Regulation; Male; Mice; Microbiota; Phylogeny; Plant Extracts; Plant Leaves; Protein Interaction Maps; RNA, Ribosomal, 16S; Sequence Analysis, DNA; Signal Transduction; Tryptophan	2020
Genetic and Chemical Screening in Human Blood Serum Reveals Unique Antibacterial Targets and Compounds against Klebsiella pneumoniae. Cell reports, 2020, 07-21, Volume: 32, Issue:3 Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; DNA Damage; Drug Approval; Female; Genetic Testing; Humans; Hydrolysis; Indoles; Iron; Klebsiella Infections; Klebsiella pneumoniae; Phenotype; Rats, Wistar; Ruthenium Red; Serum; Small Molecule Libraries; Tryptophan; Uracil	2020
Microbial tryptophan metabolites regulate gut barrier function via the aryl hydrocarbon receptor. Proceedings of the National Academy of Sciences of the United States of America, 2020, 08-11, Volume: 117, Issue:32 Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Caco-2 Cells; Colitis, Ulcerative; Cytoskeletal Proteins; Disease Models, Animal; Gastrointestinal Microbiome; Humans; Inflammation; Intestinal Mucosa; Mice; Mice, Knockout; Nonmuscle Myosin Type IIA; Permeability; Receptors, Aryl Hydrocarbon; Tryptophan	2020
Tryptophan decreases the intensity of lipopolysaccharide-induced acute lung injury in a rat model. Amino acids, 2020, Volume: 52, Issue:8 Topics: Acute Lung Injury; Animals; Disease Models, Animal; Interleukin-8; Lipid Peroxidation; Lipopolysaccharides; Lung; Lymphocytes; Macrophage Migration-Inhibitory Factors; Male; Neutrophils; Peroxidase; Rats; Rats, Wistar; Tryptophan; Tumor Necrosis Factor-alpha	2020
Kynurenines link chronic inflammation to functional decline and physical frailty. JCI insight, 2020, 08-20, Volume: 5, Issue:16 Topics: Adult; Aged; Aged, 80 and over; Animals; Arginine; Chronic Disease; Cytokines; Disease Models, Animal; Female; Frail Elderly; Humans; Inflammation; Interleukin-10; Kynurenine; Male; Mice, Inbred C57BL; Middle Aged; Neuromuscular Junction; Serotonin; Tryptophan; Walking Speed; Young Adult	2020
Fluorescent Dopamine-Tryptophan Nanocomposites as Dual-Imaging and Antiaggregation Agents: New Generation of Amyloid Theranostics with Trimeric Effects. ACS applied materials & interfaces, 2020, Sep-30, Volume: 12, Issue:39 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Line, Tumor; Disease Models, Animal; Dopamine; Fluorescent Dyes; Humans; Male; Maze Learning; Nanocomposites; Neuroprotective Agents; Particle Size; Protein Aggregates; Rats; Rats, Sprague-Dawley; Streptozocin; Surface Properties; Theranostic Nanomedicine; Tryptophan	2020
Microbiota tryptophan metabolism induces aryl hydrocarbon receptor activation and improves alcohol-induced liver injury. Gut, 2021, Volume: 70, Issue:7 Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Carbazoles; Disease Models, Animal; Fecal Microbiota Transplantation; Feces; Female; Humans; Intestines; Liver Diseases, Alcoholic; Metabolome; Mice; Mice, Knockout; Microbiota; Pectins; Prebiotics; Receptors, Aryl Hydrocarbon; Tryptophan	2021
Gut dysbiosis induced by cardiac pressure overload enhances adverse cardiac remodeling in a T cell-dependent manner. Gut microbes, 2020, 11-09, Volume: 12, Issue:1 Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Disease Models, Animal; Dysbiosis; Endomyocardial Fibrosis; Fatty Acids, Volatile; Gastrointestinal Microbiome; Heart Failure; Hypertrophy, Left Ventricular; Hypertrophy, Right Ventricular; Inflammation; Lymphocyte Activation; Lymphocyte Depletion; Male; Mice; Mice, Inbred C57BL; Receptors, Aryl Hydrocarbon; T-Lymphocytes; Tryptophan; Ventricular Pressure; Ventricular Remodeling	2020
Plasma metabolomics supports the use of long-duration cardiac arrest rodent model to study human disease by demonstrating similar metabolic alterations. Scientific reports, 2020, 11-12, Volume: 10, Issue:1 Topics: Animals; Biomarkers; Cardiopulmonary Resuscitation; Carnitine; Disease Models, Animal; Fatty Acids; Heart Arrest; Humans; Kynurenic Acid; Male; Metabolomics; Phospholipids; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Tryptophan	2020
Chitosan oligosaccharides attenuate loperamide-induced constipation through regulation of gut microbiota in mice. Carbohydrate polymers, 2021, Feb-01, Volume: 253 Topics: Animals; Antidiarrheals; Base Sequence; Bile Acids and Salts; Chitosan; Constipation; Disease Models, Animal; DNA, Ribosomal; Fatty Acids, Volatile; Feces; Gastrointestinal Microbiome; Gastrointestinal Motility; Intestinal Mucosa; Loperamide; Male; Mice; Mice, Inbred BALB C; Oligosaccharides; Sequence Analysis, DNA; Signal Transduction; Tryptophan	2021
The protective effect of 1-methyltryptophan isomers in renal ischemia-reperfusion injury is not exclusively dependent on indolamine 2,3-dioxygenase inhibition. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 135 Topics: Animals; Coculture Techniques; Dendritic Cells; Disease Models, Animal; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; Fibrosis; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kidney; Kidney Diseases; Lectins, C-Type; Mice; NIH 3T3 Cells; NK Cell Lectin-Like Receptor Subfamily K; Reperfusion Injury; Signal Transduction; T-Lymphocytes; THP-1 Cells; Toll-Like Receptor 4; Transforming Growth Factor beta; Tryptophan	2021
Tryptophan Pathway Abnormalities in a Murine Model of Hereditary Glaucoma. International journal of molecular sciences, 2021, Jan-21, Volume: 22, Issue:3 Topics: Animals; Biomarkers; Disease Models, Animal; Disease Susceptibility; Genetic Diseases, Inborn; Glaucoma; Kynurenic Acid; Kynurenine; Magnetic Resonance Imaging; Metabolic Networks and Pathways; Mice; Retina; Species Specificity; Tryptophan	2021
Daily intake of Lactobacillus alleviates autistic-like behaviors by ameliorating the 5-hydroxytryptamine metabolic disorder in VPA-treated rats during weaning and sexual maturation. Food & function, 2021, Mar-21, Volume: 12, Issue:6 Topics: Animals; Autistic Disorder; Behavior, Animal; Butyric Acid; Disease Models, Animal; Fatty Acids, Volatile; Gastrointestinal Microbiome; Lactobacillus; Probiotics; Rats; Serotonin; Sexual Maturation; Tryptophan; Valproic Acid; Weaning	2021
α-Methyl-l-tryptophan as a weight-loss agent in multiple models of obesity in mice. The Biochemical journal, 2021, 04-16, Volume: 478, Issue:7 Topics: Amino Acid Transport Systems; Animals; Anti-Obesity Agents; Diet, High-Fat; Disease Models, Animal; Female; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Obese; Non-alcoholic Fatty Liver Disease; Obesity; Tryptophan	2021
Fructooligosaccharides protect against OVA-induced food allergy in mice by regulating the Th17/Treg cell balance using tryptophan metabolites. Food & function, 2021, Apr-07, Volume: 12, Issue:7 Topics: Animals; Disease Models, Animal; Food Hypersensitivity; Male; Mice; Mice, Inbred BALB C; Oligosaccharides; Ovalbumin; T-Lymphocytes, Regulatory; Th17 Cells; Tryptophan	2021
Frontiers in immunology, 2021, Volume: 12 Topics: Animals; Anti-Inflammatory Agents; Basidiomycota; Bile Acids and Salts; Colitis; Dextran Sulfate; Disease Models, Animal; Female; Forkhead Transcription Factors; Fungal Polysaccharides; Gastrointestinal Microbiome; Gram-Negative Bacteria; Gram-Positive Bacteria; Mice; Mice, Inbred C57BL; Molecular Weight; Protective Agents; RNA, Ribosomal, 16S; Signal Transduction; T-Lymphocytes, Regulatory; Treatment Outcome; Tryptophan; Tyrosine	2021
Employing metabolomic approaches to determine the influence of age on experimental autoimmune encephalomyelitis (EAE). Molecular immunology, 2021, Volume: 135 Topics: Age Factors; Aging; Animals; Autoimmunity; Brain; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Fatty Acids, Unsaturated; Female; Interleukin-6; Metabolome; Metabolomics; Mice; Mice, Inbred C57BL; NADPH Oxidases; Risk Factors; Sphingolipids; Spinal Cord; Tryptophan; Tyrosine	2021
Disrupting Tryptophan in the Central Hydrophobic Region Selectively Mitigates Immunomodulatory Activities of the Innate Defence Regulator Peptide IDR-1002. Journal of medicinal chemistry, 2021, 05-27, Volume: 64, Issue:10 Topics: Amino Acid Substitution; Animals; Anti-Inflammatory Agents; Antimicrobial Cationic Peptides; Asthma; Disease Models, Animal; Epithelial Cells; Female; Humans; Hydrophobic and Hydrophilic Interactions; Immunomodulation; Interleukin 1 Receptor Antagonist Protein; Interleukin-33; Mice; Mice, Inbred BALB C; Neutrophil Infiltration; Principal Component Analysis; Protein Structure, Secondary; Pyroglyphidae; Tryptophan	2021
5-Methoxytryptophan attenuates postinfarct cardiac injury by controlling oxidative stress and immune activation. Journal of molecular and cellular cardiology, 2021, Volume: 158 Topics: Animals; Apoptosis; Cell Line, Transformed; Disease Models, Animal; Female; Human Umbilical Vein Endothelial Cells; Humans; Hydrogen Peroxide; Immunity; Myocardial Infarction; Myocarditis; Myocardium; Myocytes, Cardiac; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Treatment Outcome; Tryptophan; Ventricular Function, Left; Ventricular Remodeling	2021
Tryptophan in the diet ameliorates motor deficits in a rotenone-induced rat Parkinson's disease model via activating the aromatic hydrocarbon receptor pathway. Brain and behavior, 2021, Volume: 11, Issue:8 Topics: Animals; Diet; Disease Models, Animal; Hydrocarbons, Aromatic; Neuroprotective Agents; Parkinson Disease; Rats; Rotenone; Tryptophan	2021
Translational potential of the ghrelin receptor agonist macimorelin for seizure suppression in pharmacoresistant epilepsy. European journal of neurology, 2021, Volume: 28, Issue:9 Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Humans; Indoles; Mice; Mice, Inbred C57BL; Receptors, Ghrelin; Seizures; Status Epilepticus; Tryptophan	2021
STING agonist and IDO inhibitor combination therapy inhibits tumor progression in murine models of colorectal cancer. Cellular immunology, 2021, Volume: 366 Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Carcinogenesis; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Disease Models, Animal; Disease Progression; Female; Humans; Immune Checkpoint Inhibitors; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Membrane Proteins; Mice; Mice, Inbred C57BL; Myeloid-Derived Suppressor Cells; Neoplasm Transplantation; Programmed Cell Death 1 Receptor; Tryptophan	2021
5-Methoxytryptophan: A game changer in the management of post-myocardial infarction? Journal of molecular and cellular cardiology, 2021, Volume: 160 Topics: Animals; Anti-Inflammatory Agents; Cardiotonic Agents; Disease Models, Animal; Humans; Myocardial Infarction; Myocardial Revascularization; Treatment Outcome; Tryptophan	2021
Prenatal stress-induced disruptions in microbial and host tryptophan metabolism and transport. Behavioural brain research, 2021, 09-24, Volume: 414 Topics: Age Factors; Animals; Disease Models, Animal; Female; Gastrointestinal Microbiome; Mice; Mice, Inbred C57BL; Pregnancy; Prenatal Exposure Delayed Effects; Stress, Psychological; Tryptophan	2021
3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine. Nature communications, 2021, 07-21, Volume: 12, Issue:1 Topics: Animals; Biogenic Amines; Cell Line, Tumor; Dendritic Cells; Disease Models, Animal; Endothelial Cells; Humans; Immunomodulation; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interferon-gamma; Kynurenine; Mice; Nephritis; NF-kappa B; Psoriasis; Tryptophan	2021
Fuzhuan Brick Tea Polysaccharide Improved Ulcerative Colitis in Association with Gut Microbiota-Derived Tryptophan Metabolism. Journal of agricultural and food chemistry, 2021, Aug-04, Volume: 69, Issue:30 Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Mice; Mice, Inbred C57BL; Polysaccharides; Tea; Tryptophan	2021
Inhibition of Tryptophan Catabolism Is Associated With Neuroprotection During Frontiers in immunology, 2021, Volume: 12 Topics: Animals; Brain; Cells, Cultured; Disease Models, Animal; Mice; Mice, Inbred C57BL; Microcephaly; Nervous System Diseases; Neuroinflammatory Diseases; Neurons; Neuroprotection; Neuroprotective Agents; Tryptophan; Zika Virus; Zika Virus Infection	2021
Pathogenetic Interplay Between IL-6 and Tryptophan Metabolism in an Experimental Model of Obesity. Frontiers in immunology, 2021, Volume: 12 Topics: Adipose Tissue; Animals; Biomarkers; Cytokines; Diet, High-Fat; Disease Models, Animal; Disease Susceptibility; Energy Metabolism; Hepatocytes; Indoleamine-Pyrrole 2,3,-Dioxygenase; Insulin; Interleukin-6; Kynurenine; Male; Mice; Obesity; Receptors, Interleukin-6; Tryptophan	2021
Mesenchymal stem cells attenuate acute liver injury by altering ratio between interleukin 17 producing and regulatory natural killer T cells. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2017, Volume: 23, Issue:8 Topics: Animals; Carbon Tetrachloride; CD8-Positive T-Lymphocytes; Cells, Cultured; Coculture Techniques; Disease Models, Animal; Forkhead Transcription Factors; Galactosylceramides; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-17; Liver Failure, Acute; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Natural Killer T-Cells; Neutrophils; T-Lymphocytes, Regulatory; Th17 Cells; Tryptophan	2017
Effects of breviscapine on amyloid beta 1-42 induced Alzheimer's disease mice: A HPLC-QTOF-MS based plasma metabonomics study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2017, Jul-01, Volume: 1057 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Biomarkers; Cholesterol; Chromatography, High Pressure Liquid; Disease Models, Animal; Flavonoids; Male; Maze Learning; Metabolic Networks and Pathways; Metabolomics; Mice; Mice, Inbred ICR; Mice, Transgenic; Neuroprotective Agents; Peptide Fragments; Phospholipids; Serotonin; Tandem Mass Spectrometry; Tryptophan	2017
Attenuation of Foot-and-Mouth Disease Virus by Engineered Viral Polymerase Fidelity. Journal of virology, 2017, 08-01, Volume: 91, Issue:15 Topics: Amino Acid Substitution; Animals; Antigens, Viral; Antiviral Agents; Cells, Cultured; Cricetinae; Disease Models, Animal; DNA Mutational Analysis; Drug Resistance, Viral; Fluorouracil; Foot-and-Mouth Disease; Foot-and-Mouth Disease Virus; Mice; Mutagenesis, Site-Directed; Point Mutation; Protein Engineering; Ribavirin; Swine; Tryptophan; Viral Nonstructural Proteins; Viral Plaque Assay	2017
Label-Free Fluorescence Spectroscopy for Detecting Key Biomolecules in Brain Tissue from a Mouse Model of Alzheimer's Disease. Scientific reports, 2017, 06-01, Volume: 7, Issue:1 Topics: Alzheimer Disease; Animals; Brain; Disease Models, Animal; Early Diagnosis; Flavin-Adenine Dinucleotide; Humans; Mice; Mice, Transgenic; NAD; Spectrometry, Fluorescence; Tryptophan	2017
Association of RASgrf1 methylation with epileptic seizures. Oncotarget, 2017, Jul-11, Volume: 8, Issue:28 Topics: Animals; Brain; Disease Models, Animal; DNA Methylation; Epilepsy; Gene Expression; Genetic Association Studies; Genetic Predisposition to Disease; Male; Mice; Mice, Knockout; Phthalimides; Pyramidal Cells; ras-GRF1; Seizures; Tryptophan	2017
High-Throughput Metabolomics for Discovering Potential Metabolite Biomarkers and Metabolic Mechanism from the APPswe/PS1dE9 Transgenic Model of Alzheimer's Disease. Journal of proteome research, 2017, 09-01, Volume: 16, Issue:9 Topics: Alzheimer Disease; Animals; Arginine; Biomarkers; Chromatography, High Pressure Liquid; Cognitive Dysfunction; Dicarboxylic Acids; Disease Models, Animal; Early Diagnosis; Glucuronic Acid; Glyoxylates; Humans; Male; Metabolome; Metabolomics; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multivariate Analysis; Pentoses; Proline; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Starch; Sucrose; Tryptophan	2017
Contrasting effects of vortioxetine and paroxetine on pineal gland biochemistry in a tryptophan-depletion model of depression in female rats. Progress in neuro-psychopharmacology & biological psychiatry, 2017, 10-03, Volume: 79, Issue:Pt B Topics: Administration, Oral; Animals; Antidepressive Agents, Second-Generation; Depressive Disorder; Disease Models, Animal; Female; Glutamic Acid; Melatonin; Norepinephrine; Paroxetine; Pineal Gland; Piperazines; Random Allocation; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA-Binding Proteins; Selective Serotonin Reuptake Inhibitors; Serotonin; Sulfides; Tryptophan; Vortioxetine	2017
Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism. EBioMedicine, 2017, Volume: 24 Topics: Animals; Autism Spectrum Disorder; Bacteria; Bifidobacterium; Bile Acids and Salts; Disease Models, Animal; Gastrointestinal Diseases; Gastrointestinal Tract; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Male; Mice; Microbiota; Tryptophan	2017
Metabolomics and Lipidomics Study of Mouse Models of Type 1 Diabetes Highlights Divergent Metabolism in Purine and Tryptophan Metabolism Prior to Disease Onset. Journal of proteome research, 2018, 03-02, Volume: 17, Issue:3 Topics: Animals; Autoimmunity; Chromatography, Liquid; Diabetes Mellitus, Type 1; Discriminant Analysis; Disease Models, Animal; Female; Gas Chromatography-Mass Spectrometry; Gene Expression; Histocompatibility Antigens Class II; Islets of Langerhans; Kynurenic Acid; Lipid Metabolism; Lysophospholipids; Metabolomics; Mice; Mice, Inbred NOD; Mice, SCID; Mice, Transgenic; Prediabetic State; Principal Component Analysis; Protein Multimerization; Purines; Tryptophan	2018
Does l-Tryptophan supplementation reduce chewing deficits in an experimental model of cerebral palsy? Nutritional neuroscience, 2019, Volume: 22, Issue:5 Topics: Animals; Cerebral Palsy; Dietary Supplements; Disease Models, Animal; Humans; Mastication; Treatment Outcome; Tryptophan	2019
Salt-responsive gut commensal modulates T Nature, 2017, 11-30, Volume: 551, Issue:7682 Topics: Animals; Autoimmunity; Blood Pressure; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Feces; Gastrointestinal Microbiome; Humans; Hypertension; Indoleacetic Acids; Indoles; Intestines; Lactobacillus; Lymphocyte Activation; Lymphocyte Count; Male; Mice; Pilot Projects; Sodium Chloride; Symbiosis; Th17 Cells; Tryptophan	2017
N-acetyl-L-tryptophan, a substance-P receptor antagonist attenuates aluminum-induced spatial memory deficit in rats. Toxicology mechanisms and methods, 2018, Volume: 28, Issue:5 Topics: Acetylcholinesterase; Aluminum Chloride; Aluminum Compounds; Animals; Apoptosis; Behavior, Animal; Brain; Chlorides; Disease Models, Animal; Glutathione; GPI-Linked Proteins; Male; Maze Learning; Memory Disorders; Neurokinin-1 Receptor Antagonists; Neuroprotective Agents; Oxidative Stress; Rats, Wistar; Spatial Memory; Time Factors; Tryptophan	2018
Regulation of the kynurenine metabolism pathway by Xiaoyao San and the underlying effect in the hippocampus of the depressed rat. Journal of ethnopharmacology, 2018, Mar-25, Volume: 214 Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Hippocampus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Kynurenine 3-Monooxygenase; Locomotion; Male; Neural Cell Adhesion Molecules; Quinolinic Acid; Rats, Sprague-Dawley; Signal Transduction; Tryptophan	2018
Bifidobacteria alleviate experimentally induced colitis by upregulating indoleamine 2, 3-dioxygenase expression. Microbiology and immunology, 2018, Volume: 62, Issue:2 Topics: Animals; Bifidobacterium; Colitis; Colonic Diseases; Disease Models, Animal; Female; Forkhead Transcription Factors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammatory Bowel Diseases; Interleukin-17; Mice; Mice, Inbred BALB C; Probiotics; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid; Tryptophan; Up-Regulation	2018
Photodynamic therapy of mouse tumor model using chlorin e6- polyvinyl alcohol complex. Journal of photochemistry and photobiology. B, Biology, 2018, Volume: 178 Topics: Animals; Cell Line, Tumor; Cell Survival; Chlorophyllides; Disease Models, Animal; Mice; Mice, Inbred BALB C; Microscopy, Atomic Force; Microscopy, Confocal; Neoplasms; Oxidation-Reduction; Photochemotherapy; Photosensitizing Agents; Polyvinyl Alcohol; Porphyrins; Reactive Oxygen Species; Spectrometry, Fluorescence; Transplantation, Homologous; Tryptophan; Whole Body Imaging	2018
Role of the indoleamine-2,3-dioxygenase/kynurenine pathway of tryptophan metabolism in behavioral alterations in a hepatic encephalopathy rat model. Journal of neuroinflammation, 2018, Jan-04, Volume: 15, Issue:1 Topics: Animals; Bile Ducts; Disease Models, Animal; Hepatic Encephalopathy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation Mediators; Kynurenine; Ligation; Male; Rats; Rats, Wistar; Signal Transduction; Tryptophan	2018
Glycyrrhizic acid ameliorates the kynurenine pathway in association with its antidepressant effect. Behavioural brain research, 2018, 11-01, Volume: 353 Topics: Animals; Antidepressive Agents; Depressive Disorder; Disease Models, Animal; Glycyrrhizic Acid; HMGB1 Protein; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Mice, Inbred BALB C; Random Allocation; Stress, Psychological; Tissue Culture Techniques; Tryptophan	2018
Interferon-γ converts human microvascular pericytes into negative regulators of alloimmunity through induction of indoleamine 2,3-dioxygenase 1. JCI insight, 2018, 03-08, Volume: 3, Issue:5 Topics: Allografts; Animals; Antigen Presentation; Cell Communication; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Female; Graft Rejection; Healthy Volunteers; Human Umbilical Vein Endothelial Cells; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Isoantigens; Mice, SCID; Microvessels; Pericytes; Primary Cell Culture; RNA, Small Interfering; Skin; Skin Transplantation; T-Lymphocytes, Cytotoxic; Transplantation Chimera; Transplantation, Homologous; Tryptophan	2018
Deficiency of immunoregulatory indoleamine 2,3-dioxygenase 1in juvenile diabetes. JCI insight, 2018, 03-22, Volume: 3, Issue:6 Topics: Animals; Antibodies, Monoclonal, Humanized; Child; Cytokines; Diabetes Mellitus, Type 1; Disease Models, Animal; Female; Gene Expression Regulation, Enzymologic; Genetic Association Studies; Humans; Immune Tolerance; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Leukocytes, Mononuclear; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Multivariate Analysis; Polymorphism, Single Nucleotide; Receptors, Interleukin-6; Tryptophan	2018
Mathematical modelling of the synergistic combination of radiotherapy and indoleamine-2,3-dioxygenase (IDO) inhibitory immunotherapy against glioblastoma. The British journal of radiology, 2018, Volume: 91, Issue:1087 Topics: Animals; Combined Modality Therapy; Disease Models, Animal; Dose Fractionation, Radiation; Glioblastoma; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Models, Theoretical; Rats; Rats, Inbred F344; Tryptophan	2018
A Preclinical Study of Casein Glycomacropeptide as a Dietary Intervention for Acute Mania. The international journal of neuropsychopharmacology, 2018, 05-01, Volume: 21, Issue:5 Topics: Acute Disease; Amino Acids, Branched-Chain; Animals; Behavior, Animal; Bipolar Disorder; Caseins; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Dopamine; Male; Peptide Fragments; Rats; Rats, Sprague-Dawley; Serotonin; Tryptophan; Tyrosine	2018
Microglial control of astrocytes in response to microbial metabolites. Nature, 2018, Volume: 557, Issue:7707 Topics: Animals; Astrocytes; Cells, Cultured; Central Nervous System; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; ErbB Receptors; Female; Humans; Inflammation; Lipopolysaccharide Receptors; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Receptors, Aryl Hydrocarbon; Symbiosis; Transforming Growth Factor alpha; Tryptophan; Vascular Endothelial Growth Factor B; Vascular Endothelial Growth Factor Receptor-1	2018
Dietary and Microbial Oxazoles Induce Intestinal Inflammation by Modulating Aryl Hydrocarbon Receptor Responses. Cell, 2018, 05-17, Volume: 173, Issue:5 Topics: Animals; Antigens, CD1d; Colitis; Diet; Disease Models, Animal; Epithelial Cells; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-10; Intestines; Mice; Mice, Inbred C57BL; Mice, Knockout; Natural Killer T-Cells; Oxazoles; Receptors, Aryl Hydrocarbon; RNA Interference; RNA, Small Interfering; Signal Transduction; Tryptophan	2018
Pharmacological inhibition of DNA methylation attenuates pressure overload-induced cardiac hypertrophy in rats. Journal of molecular and cellular cardiology, 2018, Volume: 120 Topics: Analysis of Variance; Animals; Cardiomegaly; CpG Islands; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Fibrosis; Gene Expression Regulation; Heart Failure; Magnetic Resonance Imaging; Male; Myocardium; Myocytes, Cardiac; Phthalimides; Rats; Rats, Wistar; Sequence Analysis, RNA; Thoracic Arteries; Tryptophan; Ventricular Function	2018
Assessing and Modulating Kynurenine Pathway Dynamics in Huntington's Disease: Focus on Kynurenine 3-Monooxygenase. Methods in molecular biology (Clifton, N.J.), 2018, Volume: 1780 Topics: Aged; Animals; Brain; Disease Models, Animal; Enzyme Inhibitors; Female; Humans; Huntingtin Protein; Huntington Disease; Kynurenine; Kynurenine 3-Monooxygenase; Male; Metabolic Networks and Pathways; Middle Aged; Neuroprotective Agents; Tryptophan	2018
Gentiopicroside abrogates lipopolysaccharide-induced depressive-like behavior in mice through tryptophan-degrading pathway. Metabolic brain disease, 2018, Volume: 33, Issue:5 Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Hindlimb Suspension; Inflammation Mediators; Iridoid Glucosides; Lipopolysaccharides; Male; Mice; Motor Activity; Signal Transduction; Swimming; Tryptophan	2018
Disruption of microglia histone acetylation and protein pathways in mice exhibiting inflammation-associated depression-like symptoms. Psychoneuroendocrinology, 2018, Volume: 97 Topics: Acetylation; Animals; Depression; Disease Models, Animal; Histones; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Male; Mice; Mice, Inbred C57BL; Microglia; Protein Processing, Post-Translational; Serotonin; Tryptophan	2018
Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences of the United States of America, 2018, 08-07, Volume: 115, Issue:32 Topics: Adult; Aged; Aged, 80 and over; Aging; Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Brain; Cell Line; Disease Models, Animal; Endoplasmic Reticulum Stress; Female; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Motor Neurons; Mutation; Oxidation-Reduction; Protein Aggregation, Pathological; Protein Folding; Proteostasis; Spinal Cord; Superoxide Dismutase-1; Tryptophan; Tunicamycin; Unfolded Protein Response	2018
RASgrf1, a Potential Methylatic Mediator of Anti-epileptogenesis? Neurochemical research, 2018, Volume: 43, Issue:10 Topics: Animals; Disease Models, Animal; DNA Methylation; Electroencephalography; Gene Expression; Hippocampus; Kainic Acid; Male; Mice, Inbred C57BL; Phthalimides; Promoter Regions, Genetic; ras-GRF1; Status Epilepticus; Tryptophan	2018
Palmatine ameliorated murine colitis by suppressing tryptophan metabolism and regulating gut microbiota. Pharmacological research, 2018, Volume: 137 Topics: Animals; Anti-Inflammatory Agents; Berberine Alkaloids; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Male; Mice, Inbred BALB C; Mucins; Tight Junction Proteins; Tryptophan	2018
Major depression model induced by repeated and intermittent lipopolysaccharide administration: Long-lasting behavioral, neuroimmune and neuroprogressive alterations. Journal of psychiatric research, 2018, Volume: 107 Topics: Animals; Behavior, Animal; Depressive Disorder, Major; Disease Models, Animal; Female; Fluoxetine; Lipopolysaccharides; Mice; Selective Serotonin Reuptake Inhibitors; Serotonin; Tryptophan	2018
Molecular pharmacology, 2019, Volume: 95, Issue:1 Topics: Animals; Antipsychotic Agents; Brain; Brain-Derived Neurotrophic Factor; Cell Adhesion Molecules, Neuronal; Chromatin; Chromatin Assembly and Disassembly; Clozapine; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Extracellular Matrix Proteins; Female; Glutamate Decarboxylase; Male; Mental Disorders; Mice; Nerve Tissue Proteins; Phthalimides; Pregnancy; Prenatal Exposure Delayed Effects; Promoter Regions, Genetic; Reelin Protein; Serine Endopeptidases; Tryptophan	2019
Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota. Cell host & microbe, 2018, 11-14, Volume: 24, Issue:5 Topics: Animals; Bacterial Proteins; Colitis; Disease Models, Animal; Disease Susceptibility; Exosome Multienzyme Ribonuclease Complex; Female; Food; Gastrointestinal Microbiome; Germ-Free Life; Host-Pathogen Interactions; Immunity, Mucosal; Indoles; Interleukin-22; Interleukins; Intestines; Lacticaseibacillus rhamnosus; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Plants; Receptors, Aryl Hydrocarbon; RNA, Ribosomal, 16S; Serine Endopeptidases; Tryptophan	2018
A tryptophan metabolite of the skin microbiota attenuates inflammation in patients with atopic dermatitis through the aryl hydrocarbon receptor. The Journal of allergy and clinical immunology, 2019, Volume: 143, Issue:6 Topics: Animals; Calcitriol; Cells, Cultured; Cytokines; Dermatitis, Atopic; Disease Models, Animal; Humans; Indoles; Keratinocytes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Microbiota; Receptors, Aryl Hydrocarbon; Skin; Thymic Stromal Lymphopoietin; Tryptophan; Up-Regulation	2019
Tryptophan-Tyrosine Dipeptide, the Core Sequence of β-Lactolin, Improves Memory by Modulating the Dopamine System. Nutrients, 2019, Feb-06, Volume: 11, Issue:2 Topics: Amnesia; Animals; Dipeptides; Disease Models, Animal; Dopamine; Frontal Lobe; Hippocampus; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Scopolamine; Tryptophan; Tyrosine	2019
Does aerobic exercise associated with tryptophan supplementation attenuates hyperalgesia and inflammation in female rats with experimental fibromyalgia? PloS one, 2019, Volume: 14, Issue:2 Topics: Animals; Disease Models, Animal; Female; Fibromyalgia; Hyperalgesia; Inflammation; Interleukin-6; Physical Conditioning, Animal; Rats; Rats, Wistar; Tryptophan; Tumor Necrosis Factor-alpha	2019
A novel assay for detection and quantification of C-mannosyl tryptophan in normal or diabetic mice. Scientific reports, 2019, 03-18, Volume: 9, Issue:1 Topics: Animals; Biomarkers; Chromatography, Liquid; Diabetes Mellitus; Disease Models, Animal; Female; Fluorescence; Humans; Kidney; Mice; Mice, Mutant Strains; Ovary; Tryptophan; Uterus	2019
[Tryptophan and metabolic syndrome, a new challenge for health]. Medecine sciences : M/S, 2019, Volume: 35, Issue:3 Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Membrane Permeability; Disease Models, Animal; Gastrointestinal Microbiome; Humans; Inflammation; Intestinal Mucosa; Metabolic Networks and Pathways; Metabolic Syndrome; Mice; Receptors, Aryl Hydrocarbon; Tryptophan	2019
Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan. Nature communications, 2019, 04-01, Volume: 10, Issue:1 Topics: Acetylcarnitine; Animals; Canavanine; Carnitine; Case-Control Studies; Disease Models, Animal; Disease Progression; Fibrosis; Gene Knock-In Techniques; Gene Knockdown Techniques; Humans; I-kappa B Proteins; Inflammation; Kelch-Like ECH-Associated Protein 1; Kidney; Metabolomics; Mice; NF-E2-Related Factor 2; NF-kappa B; Renal Insufficiency, Chronic; Severity of Illness Index; Signal Transduction; Taurine; Tryptophan; Tryptophan Hydroxylase; Ureteral Obstruction	2019
Target exposure and pharmacodynamics study of the indoleamine 2,3-dioxygenase-1 (IDO-1) inhibitor epacadostat in the CT26 mouse tumor model. Journal of pharmaceutical and biomedical analysis, 2019, Jun-05, Volume: 170 Topics: Animals; Chromatography, Liquid; Disease Models, Animal; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Mice, Inbred BALB C; Neoplasms; Oximes; Sulfonamides; Tandem Mass Spectrometry; Tryptophan	2019
High-throughput metabolomics and ingenuity pathway approach reveals the pharmacological effect and targets of Ginsenoside Rg1 in Alzheimer's disease mice. Scientific reports, 2019, 05-07, Volume: 9, Issue:1 Topics: Alzheimer Disease; Animals; Biomarkers, Pharmacological; Chromatography, High Pressure Liquid; Disease Models, Animal; Ginsenosides; High-Throughput Screening Assays; Hippocampus; Male; Mass Spectrometry; Metabolic Networks and Pathways; Metabolomics; Mice, Transgenic; Neuroprotective Agents; Panax; Proteomics; Sphingolipids; Tryptophan	2019
Antidepressant-Like Effect and Mechanism of Action of Honokiol on the Mouse Lipopolysaccharide (LPS) Depression Model. Molecules (Basel, Switzerland), 2019, May-28, Volume: 24, Issue:11 Topics: Animals; Antidepressive Agents; Autonomic Nervous System; Biphenyl Compounds; Brain; Calcium; Cytokines; Depression; Disease Models, Animal; Hindlimb Suspension; Immobilization; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation Mediators; Kynurenine; Lignans; Lipopolysaccharides; Mice, Inbred ICR; NF-kappa B; RNA, Messenger; Swimming; Tryptophan	2019
Amelioration of obsessive-compulsive disorder in three mouse models treated with one epigenetic drug: unraveling the underlying mechanism. Scientific reports, 2019, 06-19, Volume: 9, Issue:1 Topics: Animals; Compulsive Behavior; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Female; Humans; Male; Mice; Obsessive-Compulsive Disorder; Phthalimides; Tryptophan	2019
Development of an underivatized LC-MS/MS method for quantitation of 14 neurotransmitters in rat hippocampus, plasma and urine: Application to CUMS induced depression rats. Journal of pharmaceutical and biomedical analysis, 2019, Sep-10, Volume: 174 Topics: Animals; Blood Chemical Analysis; Chromatography, Liquid; Depression; Disease Models, Animal; Glutamic Acid; Hippocampus; Kynurenic Acid; Kynurenine; Limit of Detection; Linear Models; Male; Neurotransmitter Agents; Phenylalanine; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tandem Mass Spectrometry; Tryptophan; Urinalysis	2019
Elevated indoleamine-2,3-dioxygenase enzyme activity in a novel mouse model of HIV-associated atherosclerosis. AIDS (London, England), 2019, 08-01, Volume: 33, Issue:10 Topics: Animals; Aorta; Aortic Diseases; Atherosclerosis; Cytokines; Diet, High-Fat; Disease Models, Animal; HIV Infections; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice, Transgenic; Tryptophan	2019
Editorial. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2019, Volume: 20, Issue:5 Topics: Animals; Antisocial Personality Disorder; Biological Psychiatry; Biomarkers; Bipolar Disorder; Cognition; Depression; Disease Models, Animal; Histocompatibility Antigens Class II; Humans; Mice; Tryptophan	2019
Metallothionein prevents diabetes-induced cardiac pathological changes, likely via the inhibition of succinyl-CoA:3-ketoacid coenzyme A transferase-1 nitration at Trp(374). American journal of physiology. Endocrinology and metabolism, 2013, Apr-15, Volume: 304, Issue:8 Topics: Animals; Coenzyme A-Transferases; Diabetes Mellitus, Experimental; Disease Models, Animal; Energy Metabolism; Heart Diseases; Male; Metallothionein; Mice; Mice, Inbred Strains; Mice, Transgenic; Myocardium; Nitrogen; Protein Structure, Tertiary; Superoxides; Tryptophan; Tyrosine	2013
Esophagoprotection mediated by exogenous and endogenous melatonin in an experimental model of reflux esophagitis. Journal of pineal research, 2013, Volume: 55, Issue:1 Topics: Analysis of Variance; Animals; Arginine; Capsaicin; Digestive System Surgical Procedures; Disease Models, Animal; Esophagitis, Peptic; Esophagus; Male; Melatonin; Mucous Membrane; Nitric Oxide; Pineal Gland; Protective Agents; Rats; Rats, Wistar; Tryptophan	2013
The effect of an NK1 receptor antagonist on blood spinal cord barrier permeability following balloon compression-induced spinal cord injury. Acta neurochirurgica. Supplement, 2013, Volume: 118 Topics: Albumins; Animals; Balloon Occlusion; Blood-Brain Barrier; Brain; Capillary Permeability; Disease Models, Animal; Edema; Evans Blue; Male; Rabbits; Receptors, Tachykinin; Spinal Cord Injuries; Time Factors; Tryptophan	2013
Indoleamine 2,3 dioxygenase contributes to transferable tolerance in rat red blood cell inducible model of experimental autoimmune haemolytic anaemia. Clinical and experimental immunology, 2013, Volume: 173, Issue:1 Topics: Abatacept; Adoptive Transfer; Anemia, Hemolytic, Autoimmune; Animals; Antibodies, Monoclonal; Autoantibodies; CTLA-4 Antigen; Disease Models, Animal; Erythrocytes; Immunization; Immunoconjugates; Indoleamine-Pyrrole 2,3,-Dioxygenase; Isoantibodies; Mice; Mice, Inbred BALB C; Rats; Rats, Sprague-Dawley; Self Tolerance; Species Specificity; Spleen; Tryptophan	2013
Molecular characterization of an rsmD-like rRNA methyltransferase from the Wolbachia endosymbiont of Brugia malayi and antifilarial activity of specific inhibitors of the enzyme. Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:8 Topics: Animals; Brugia malayi; Cloning, Molecular; Culicidae; Disease Models, Animal; Drug Evaluation, Preclinical; Enzyme Inhibitors; Female; Filaricides; Genes, Bacterial; Gerbillinae; Inhibitory Concentration 50; Male; Methyltransferases; Murinae; Substrate Specificity; Symbiosis; Tryptophan; Wolbachia	2013
No effect of acute tryptophan depletion on phosphodiesterase inhibition--related improvements of short-term object memory in male Wistar rats. Acta psychiatrica Scandinavica, 2013, Volume: 128, Issue:2 Topics: Animals; Behavior, Animal; Diet Therapy; Disease Models, Animal; Dose-Response Relationship, Drug; Hippocampus; Imidazoles; Male; Memory Disorders; Memory, Short-Term; Phosphodiesterase 5 Inhibitors; Piperazines; Rats; Rats, Wistar; Recognition, Psychology; Serotonin; Sulfones; Synaptic Transmission; Triazines; Tryptophan; Vardenafil Dihydrochloride	2013
Protective effect of tryptophan against dextran sulfate sodium- induced experimental colitis. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2013, Volume: 24, Issue:1 Topics: Animal Feed; Animals; Antidepressive Agents, Second-Generation; Body Weight; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal; Female; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Nitric Oxide; Oxidative Stress; Random Allocation; Tryptophan; Tyrosine	2013
Effect of 1-methyl-D-tryptophan and adoptive transfer of dendritic cells on polymicrobial sepsis induced by cecal content injection. Microbiology and immunology, 2013, Volume: 57, Issue:9 Topics: Adoptive Transfer; Animals; Cecum; Cells, Cultured; Dendritic Cells; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred ICR; Sepsis; Tryptophan	2013
Intracerebroventricular administration of lipopolysaccharide induces indoleamine-2,3-dioxygenase-dependent depression-like behaviors. Journal of neuroinflammation, 2013, Jul-18, Volume: 10 Topics: Animals; Antidepressive Agents; Brain; Depression; Disease Models, Animal; Exploratory Behavior; Food Preferences; Indoleamine-Pyrrole 2,3,-Dioxygenase; Injections, Intraventricular; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Sucrose; Time Factors; Tryptophan; Up-Regulation	2013
Kynurenine increases matrix metalloproteinase-1 and -3 expression in cultured dermal fibroblasts and improves scarring in vivo. The Journal of investigative dermatology, 2014, Volume: 134, Issue:3 Topics: Animals; Cells, Cultured; Cicatrix, Hypertrophic; Dermatologic Agents; Dermis; Disease Models, Animal; Ear, External; Female; Fibroblasts; Foreskin; Gene Expression Regulation, Enzymologic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; MAP Kinase Signaling System; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Rabbits; Tryptophan	2014
Mouse genetics and proteomic analyses demonstrate a critical role for complement in a model of DHRD/ML, an inherited macular degeneration. Human molecular genetics, 2014, Jan-01, Volume: 23, Issue:1 Topics: Animals; Arginine; Bruch Membrane; Cell Adhesion; Complement C3; Complement System Proteins; Corneal Dystrophies, Hereditary; Disease Models, Animal; Extracellular Matrix Proteins; Gene Knock-In Techniques; Humans; Mice; Mice, Transgenic; Optic Disk Drusen; Point Mutation; Proteomics; Reproducibility of Results; Retinal Drusen; Tryptophan	2014
In vitro structure-activity relationships of aplysinopsin analogs and their in vivo evaluation in the chick anxiety-depression model. Bioorganic & medicinal chemistry, 2013, Nov-15, Volume: 21, Issue:22 Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Chickens; Depression; Disease Models, Animal; Humans; Monoamine Oxidase; Protein Binding; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Structure-Activity Relationship; Tryptophan	2013
Autistic-like behavioural and neurochemical changes in a mouse model of food allergy. Behavioural brain research, 2014, Mar-15, Volume: 261 Topics: Age Factors; Animals; Autistic Disorder; Biogenic Monoamines; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Food Hypersensitivity; Grooming; Homovanillic Acid; Interpersonal Relations; Male; Maze Learning; Mice; Mice, Inbred C3H; Milk; Proto-Oncogene Proteins c-fos; Statistics, Nonparametric; Tryptophan	2014
Evaluation of kynurenine pathway metabolism in Toxoplasma gondii-infected mice: implications for schizophrenia. Schizophrenia research, 2014, Volume: 152, Issue:1 Topics: Animals; Anti-Infective Agents; Brain; Disease Models, Animal; Drug Combinations; Female; Kynurenic Acid; Kynurenine; Mice; Mice, Inbred C57BL; Neuroglia; Pyrimethamine; Quinolinic Acid; RNA, Messenger; Signal Transduction; Sulfadiazine; Time Factors; Toxoplasmosis; Tryptophan	2014
Eimeria falciformis infection of the mouse caecum identifies opposing roles of IFNγ-regulated host pathways for the parasite development. Mucosal immunology, 2014, Volume: 7, Issue:4 Topics: Animals; Cecum; Cluster Analysis; Coccidiosis; Disease Models, Animal; Eimeria; Gene Expression Profiling; Gene Expression Regulation; Host-Parasite Interactions; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon gamma Receptor; Interferon-gamma; Mice; Mice, Knockout; Models, Biological; Monomeric GTP-Binding Proteins; Receptors, CXCR3; Receptors, Interferon; Signal Transduction; Tryptophan	2014
Insights into the mechanisms of macular degeneration associated with the R172W mutation in RDS. Human molecular genetics, 2014, Jun-15, Volume: 23, Issue:12 Topics: Amino Acid Substitution; Animals; Arginine; Basic-Leucine Zipper Transcription Factors; Disease Models, Animal; Eye Proteins; Fundus Oculi; Humans; Macular Degeneration; Membrane Proteins; Mice; Mice, Transgenic; Peripherins; Retinal Cone Photoreceptor Cells; Tetraspanins; Tryptophan	2014
Inhibition of stress-induced hepatic tryptophan 2,3-dioxygenase exhibits antidepressant activity in an animal model of depressive behaviour. The international journal of neuropsychopharmacology, 2014, Volume: 17, Issue:6 Topics: Allopurinol; Animals; Antidepressive Agents; Cerebral Cortex; Chronic Disease; Corticosterone; Depressive Disorder; Disease Models, Animal; Enzyme Inhibitors; Kynurenine; Liver; Male; Neuropsychological Tests; Rats, Sprague-Dawley; Restraint, Physical; RNA, Messenger; Stress, Psychological; Tryptophan; Tryptophan Oxygenase; Weight Gain	2014
Pantothenic acid deficiency may increase the urinary excretion of 2-oxo acids and nicotinamide catabolites in rats. Journal of nutritional science and vitaminology, 2013, Volume: 59, Issue:6 Topics: Adipates; Animals; Disease Models, Animal; Ketoglutaric Acids; Male; Niacinamide; Oxaloacetic Acid; Pantothenic Acid; Pyruvic Acid; Rats; Rats, Wistar; Tryptophan	2013
Lipopolysaccharide-induced brain activation of the indoleamine 2,3-dioxygenase and depressive-like behavior are impaired in a mouse model of metabolic syndrome. Psychoneuroendocrinology, 2014, Volume: 40 Topics: Animals; Behavior, Animal; Brain; Depression; Disease Models, Animal; Enzyme Activation; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lipopolysaccharides; Male; Metabolic Syndrome; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Transgenic; Receptors, Leptin; Tryptophan	2014
Suppression of experimental autoimmune glomerulonephritis by tryptophan. Journal of nephrology, 2014, Volume: 27, Issue:1 Topics: 3-Hydroxyanthranilic Acid; Animals; Anti-Glomerular Basement Membrane Disease; Apoptosis; CD4-Positive T-Lymphocytes; Cell Proliferation; Cells, Cultured; Cytokines; Disease Models, Animal; Female; Free Radical Scavengers; Glomerular Filtration Rate; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Macrophages; Proteinuria; Rats; Rats, Inbred WKY; Th1 Cells; Th2 Cells; Tryptophan	2014
Activation of brain indoleamine 2,3-dioxygenase contributes to epilepsy-associated depressive-like behavior in rats with chronic temporal lobe epilepsy. Journal of neuroinflammation, 2014, Mar-04, Volume: 11 Topics: Animals; Chromatography, Liquid; Cytokines; Depression; Disease Models, Animal; Epilepsy, Temporal Lobe; Food Preferences; Gene Expression Regulation; Hippocampus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Lithium Chloride; Male; Mass Spectrometry; Minocycline; Rats; Rats, Wistar; Statistics, Nonparametric; Time Factors; Tryptophan	2014
Anti-scarring properties of different tryptophan derivatives. PloS one, 2014, Volume: 9, Issue:3 Topics: Administration, Cutaneous; Animals; Cell Movement; Cell Proliferation; Cell Survival; Cicatrix, Hypertrophic; Collagen Type I; Disease Models, Animal; Enzyme Activation; Female; Fibroblasts; Fibronectins; Gene Expression Regulation; Humans; Kynurenine; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Rabbits; Tryptophan; Wound Healing	2014
Effect of tryptophan supplementation on diet-induced non-alcoholic fatty liver disease in mice. The British journal of nutrition, 2014, Jul-14, Volume: 112, Issue:1 Topics: Animals; Biological Transport; Dietary Supplements; Disease Models, Animal; Duodenum; Enzyme Induction; Fatty Liver; Gastrointestinal Motility; Intestinal Mucosa; Lipopolysaccharides; Liver; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Occludin; Organ Size; Serotonin; Serotonin Plasma Membrane Transport Proteins; Specific Pathogen-Free Organisms; Tight Junctions; Triglycerides; Tryptophan; Tryptophan Hydroxylase	2014
Indoleamine 2,3-dioxygenase inhibition alters the non-coding RNA transcriptome following renal ischemia-reperfusion injury. Transplant immunology, 2014, Volume: 30, Issue:4 Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Graft Rejection; Graft Survival; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kidney; Kidney Transplantation; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Untranslated; Transcriptome; Tryptophan	2014
The murine serotonin syndrome - evaluation of responses to 5-HT-enhancing drugs in NMRI mice. Behavioural brain research, 2015, Jan-15, Volume: 277 Topics: Animals; Behavior, Animal; Disease Models, Animal; Fluoxetine; Male; Mice; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Syndrome; Tryptophan	2015
1-Methyl-tryptophan synergizes with methotrexate to alleviate arthritis in a mouse model of arthritis. Autoimmunity, 2014, Volume: 47, Issue:6 Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Autoimmunity; Cytokines; Disease Models, Animal; Drug Synergism; Inflammation; Methotrexate; Mice; Tryptophan; Tryptophan Oxygenase	2014
Importance of tryptophan nitration of carbonic anhydrase III for the morbidity of atopic dermatitis. Free radical biology & medicine, 2014, Volume: 73 Topics: Animals; Carbonic Anhydrase III; Cell Line; Dermatitis, Atopic; Disease Models, Animal; Humans; Immunohistochemistry; Inflammation; Keratin-2; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Peroxynitrous Acid; Phosphopyruvate Hydratase; Rats; Reactive Nitrogen Species; Skin; Tryptophan	2014
The kynurenine pathway contributes to long-term neuropsychological changes in experimental pneumococcal meningitis. Behavioural brain research, 2014, Aug-15, Volume: 270 Topics: Animals; Anti-Bacterial Agents; Ceftriaxone; Cognition; Disease Models, Animal; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Meningitis, Pneumococcal; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Neuropsychological Tests; Tryptophan	2014
NK1 receptor blockade is ineffective in improving outcome following a balloon compression model of spinal cord injury. PloS one, 2014, Volume: 9, Issue:5 Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Inflammation; Neurokinin-1 Receptor Antagonists; Protease Inhibitors; Rabbits; Receptors, Neurokinin-1; Spinal Cord Compression; Substance P; Tryptophan	2014
Characterization of the mitofusin 2 R94W mutation in a knock-in mouse model. Journal of the peripheral nervous system : JPNS, 2014, Volume: 19, Issue:2 Topics: Animals; Animals, Newborn; Arginine; Cells, Cultured; Charcot-Marie-Tooth Disease; Disease Models, Animal; Escape Reaction; Exploratory Behavior; Fibroblasts; GTP Phosphohydrolases; Humans; In Vitro Techniques; Mice; Mice, Transgenic; Mitochondria; Mitochondrial Proteins; Motor Activity; Muscle Strength; Oxygen Consumption; Point Mutation; Psychomotor Performance; Tryptophan	2014
Effect of maternal immune activation on the kynurenine pathway in preadolescent rat offspring and on MK801-induced hyperlocomotion in adulthood: amelioration by COX-2 inhibition. Brain, behavior, and immunity, 2014, Volume: 41 Topics: Animals; Brain; Celecoxib; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dizocilpine Maleate; Female; Gestational Age; Hyperkinesis; Kynurenic Acid; Kynurenine; Male; Picolinic Acids; Poly I-C; Pregnancy; Prenatal Exposure Delayed Effects; Pyrazoles; Quinolinic Acid; Random Allocation; Rats; Rats, Wistar; Schizophrenia; Sexual Maturation; Sulfonamides; Tryptophan	2014
Orally administered whole egg demonstrates antidepressant-like effects in the forced swimming test on rats. Acta neuropsychiatrica, 2014, Volume: 26, Issue:4 Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Eggs; Male; Motor Activity; Prefrontal Cortex; Rats; Rats, Inbred WKY; Rats, Wistar; Serotonin; Stress, Psychological; Swimming; Tryptophan	2014
Lipopolysaccharide repeated challenge followed by chronic mild stress protocol introduces a combined model of depression in rats: reversibility by imipramine and pentoxifylline. Pharmacology, biochemistry, and behavior, 2014, Volume: 126 Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Gene Expression; Hippocampus; Imipramine; Kynurenine; Lipopolysaccharides; Male; Pentoxifylline; Rats; Stress, Psychological; Tryptophan; Tumor Necrosis Factor-alpha	2014
LPS-conditioned dendritic cells confer endotoxin tolerance contingent on tryptophan catabolism. Immunobiology, 2015, Volume: 220, Issue:2 Topics: Adoptive Transfer; Animals; Cytokines; Dendritic Cells; Disease Models, Animal; Endotoxins; Gene Expression; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation Mediators; Lipopolysaccharides; Lung; Male; Mice; Mice, Knockout; Models, Biological; Shock, Septic; Tryptophan	2015
Biochemical, histopathological and morphological profiling of a rat model of early immune stimulation: relation to psychopathology. PloS one, 2015, Volume: 10, Issue:1 Topics: Animals; Astrocytes; Biogenic Monoamines; Body Weight; Brain; Disease Models, Animal; Kynurenine; Male; Mental Disorders; Metabolic Networks and Pathways; Metabolome; Microglia; Neuroimmunomodulation; Neurotransmitter Agents; Psychopathology; Rats; Tryptophan	2015
Expression of hippocampal serotonin receptors 5-HT2C and 5-HT5A in a rat model of diet-induced obesity supplemented with tryptophan. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2015, Volume: 42 Topics: Analysis of Variance; Animals; Body Weight; Dietary Supplements; Disease Models, Animal; Drinking; Eating; Gene Expression Regulation; Hippocampus; Male; Obesity; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Time Factors; Tryptophan	2015
DNA methylation in the medial prefrontal cortex regulates alcohol-induced behavior and plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, Apr-15, Volume: 35, Issue:15 Topics: Alcoholism; Animals; Choice Behavior; Conditioning, Operant; Disease Models, Animal; DNA Methylation; Enzyme Inhibitors; Ethanol; Gene Expression Profiling; Male; Methyltransferases; Nerve Tissue Proteins; Neuronal Plasticity; Phthalimides; Prefrontal Cortex; Rats; Rats, Wistar; Self Administration; Statistics, Nonparametric; Synaptotagmin II; Transduction, Genetic; Tryptophan	2015
LX0702, a novel snake venom peptide derivative, inhibits thrombus formation via affecting the binding of fibrinogen with GPIIb/IIIa. Journal of pharmacological sciences, 2015, Volume: 127, Issue:4 Topics: Animals; Bleeding Time; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Enzyme-Linked Immunosorbent Assay; Female; Fibrinogen; Fibrinolytic Agents; Male; Mice, Inbred ICR; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Rabbits; Rats, Sprague-Dawley; Snake Venoms; Sulfonamides; Thrombosis; Tryptophan	2015
Absence of aryl hydrocarbon receptors increases endogenous kynurenic acid levels and protects mouse brain against excitotoxic insult and oxidative stress. Journal of neuroscience research, 2015, Volume: 93, Issue:9 Topics: Acetyltransferases; Animals; Basic Helix-Loop-Helix Transcription Factors; Brain; Disease Models, Animal; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamate Decarboxylase; Kynurenic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Neurotoxicity Syndromes; Oxidative Stress; Quinolinic Acid; Receptors, Aryl Hydrocarbon; Tryptophan	2015
Western diet-induced anxiolytic effects in mice are associated with alterations in tryptophan metabolism. Nutritional neuroscience, 2016, Volume: 19, Issue:8 Topics: Animals; Anxiety; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cytokines; Diet, Western; Disease Models, Animal; Exploratory Behavior; Gene Expression Regulation, Enzymologic; Indoleamine-Pyrrole 2,3,-Dioxygenase; Intestinal Mucosa; Intestine, Small; Liver; Male; Metabolic Diseases; Mice, 129 Strain; Nerve Tissue Proteins; Neurons; Prosencephalon; Specific Pathogen-Free Organisms; Tryptophan; Tryptophan Hydroxylase	2016
Pineal Melatonin in a Sub-chronic Tryptophan Depletion Female Rat Model of Treatment-resistant Depression. Pharmacopsychiatry, 2015, Volume: 48, Issue:4-5 Topics: Aldosterone; Animals; Corticosterone; Depressive Disorder, Treatment-Resistant; Disease Models, Animal; Female; Melatonin; Norepinephrine; Pineal Gland; Rats; Serotonin; Tryptophan	2015
Intravenous tryptophan administration attenuates cortisol secretion induced by intracerebroventricular injection of noradrenaline. Animal science journal = Nihon chikusan Gakkaiho, 2016, Volume: 87, Issue:2 Topics: Animals; Cattle; Disease Models, Animal; Dose-Response Relationship, Drug; Hydrocortisone; Injections, Intravenous; Injections, Intraventricular; Male; Norepinephrine; Stress, Psychological; Tryptophan	2016
The role of branched chain amino acid and tryptophan metabolism in rat's behavioral diversity: Intertwined peripheral and brain effects. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2015, Volume: 25, Issue:10 Topics: Amino Acids, Branched-Chain; Animals; Anxiety; Blood Glucose; Disease Models, Animal; Exploratory Behavior; Insulin; Kynurenine; Large Neutral Amino Acid-Transporter 1; Male; Maze Learning; Plicamycin; Prefrontal Cortex; Protein Synthesis Inhibitors; Random Allocation; Rats, Wistar; RNA, Messenger; Serotonin; Stress, Psychological; Tryptophan	2015
Antihypertensive and cardioprotective effects of the dipeptide isoleucine-tryptophan and whey protein hydrolysate. Acta physiologica (Oxford, England), 2015, Volume: 215, Issue:4 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Captopril; Cardiotonic Agents; Dipeptides; Disease Models, Animal; Humans; Hypertension; Isoleucine; Male; Protein Hydrolysates; Rats; Rats, Inbred SHR; Renin-Angiotensin System; Tryptophan; Whey	2015
Quantitative analysis of phenylalanine, tyrosine, tryptophan and kynurenine in rat model for tauopathies by ultra-high performance liquid chromatography with fluorescence and mass spectrometry detection. Journal of pharmaceutical and biomedical analysis, 2016, Jan-05, Volume: 117 Topics: Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Humans; Kynurenine; Phenylalanine; Rats; Rats, Inbred SHR; Rats, Transgenic; Tandem Mass Spectrometry; Tauopathies; Tryptophan; Tyrosine	2016
Disrupted Tryptophan Metabolism Induced Cognitive Impairment in a Mouse Model of Sepsis-associated Encephalopathy. Inflammation, 2016, Volume: 39, Issue:2 Topics: Animals; Cecum; Cognitive Dysfunction; Disease Models, Animal; Enzyme Activation; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Mice; Mice, Inbred C57BL; Sepsis; Sepsis-Associated Encephalopathy; Tryptophan	2016
Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis. Nature medicine, 2016, Volume: 22, Issue:2 Topics: Acute Disease; Animals; Benzoxazoles; Chromatography, Liquid; Crystallography, X-Ray; Disease Models, Animal; HEK293 Cells; Hepatocytes; Humans; In Vitro Techniques; Kidney; Kynurenine 3-Monooxygenase; Lung; Mice; Mice, Knockout; Multiple Organ Failure; Oxazolidinones; Pancreas; Pancreatitis; Propionates; Rats; RNA, Messenger; Tandem Mass Spectrometry; Tryptophan	2016
Multiprobe molecular imaging of an NMDA receptor hypofunction rat model for glutamatergic dysfunction. Psychiatry research. Neuroimaging, 2016, Feb-28, Volume: 248 Topics: Animals; Brain; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Kynurenine; Male; Molecular Imaging; Positron-Emission Tomography; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Tryptophan	2016
Naphthoquinone-Tryptophan Hybrid Inhibits Aggregation of the Tau-Derived Peptide PHF6 and Reduces Neurotoxicity. Journal of Alzheimer's disease : JAD, 2016, Volume: 51, Issue:1 Topics: Animals; Carrier Proteins; Disease Models, Animal; Drosophila; Drosophila Proteins; Eye; Female; Humans; Immunoprecipitation; In Vitro Techniques; Larva; Locomotion; Mice, Transgenic; Microscopy, Electron, Scanning; Naphthoquinones; Neurotoxicity Syndromes; Oligopeptides; Protein Aggregates; Retinal Pigments; tau Proteins; Tryptophan	2016
Indoleamine-2,3-dioxygenase mediates neurobehavioral alterations induced by an intracerebroventricular injection of amyloid-β1-42 peptide in mice. Brain, behavior, and immunity, 2016, Volume: 56 Topics: Amyloid beta-Peptides; Animals; Anxiety; Behavior, Animal; Depression; Disease Models, Animal; Hippocampus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Injections, Intraventricular; Kynurenine; Memory Disorders; Mice; Nerve Growth Factors; Peptide Fragments; Prefrontal Cortex; Recognition, Psychology; Tryptophan	2016
A Novel Protective Function of 5-Methoxytryptophan in Vascular Injury. Scientific reports, 2016, 05-05, Volume: 6 Topics: Aged; Animals; Arteries; Cells, Cultured; Coronary Artery Disease; Disease Models, Animal; Female; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Male; MAP Kinase Signaling System; Mice; Middle Aged; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neointima; Tryptophan; Vascular System Injuries	2016
Vascular Alterations in a Murine Model of Acute Graft-Versus-Host Disease Are Associated with Decreased Serum Levels of Adiponectin and an Increased Activity and Vascular Expression of Indoleamine 2,3-Dioxygenase. Cell transplantation, 2016, Volume: 25, Issue:11 Topics: Acetylcholine; Adiponectin; Animals; Body Weight; Bone Marrow Transplantation; Cytokines; Disease Models, Animal; Female; Graft vs Host Disease; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mesenteric Arteries; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Transplantation, Homologous; Tryptophan; Whole-Body Irradiation	2016
Female Flinders Sensitive Line rats show estrous cycle-independent depression-like behavior and altered tryptophan metabolism. Neuroscience, 2016, 08-04, Volume: 329 Topics: 5-Hydroxytryptophan; Animals; Anxiety; Brain; Depressive Disorder; Disease Models, Animal; Estrous Cycle; Female; Kynurenine; Male; Motor Activity; ortho-Aminobenzoates; Quinolinic Acid; Rats; Resilience, Psychological; Sex Characteristics; Tryptophan	2016
β1-C121W Is Down But Not Out: Epilepsy-Associated Scn1b-C121W Results in a Deleterious Gain-of-Function. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, 06-08, Volume: 36, Issue:23 Topics: Animals; Animals, Newborn; Biotinylation; Cells, Cultured; Cerebral Cortex; Cysteine; Disease Models, Animal; Epilepsy; Fever; Gene Expression Regulation, Developmental; Immunoprecipitation; Mice; Mice, Transgenic; Neurons; Polymorphism, Single Nucleotide; Statistics, Nonparametric; Tryptophan; Voltage-Gated Sodium Channel beta-1 Subunit	2016
Dynamic DNA Methylation Regulates Levodopa-Induced Dyskinesia. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, 06-15, Volume: 36, Issue:24 Topics: Analysis of Variance; Animals; Antiparkinson Agents; Corpus Striatum; Dioxygenases; Disease Models, Animal; DNA Methylation; Dopamine; Dyskinesia, Drug-Induced; Enzyme Inhibitors; GADD45 Proteins; Gene Expression Regulation; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; Levodopa; Male; Medial Forebrain Bundle; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Phthalimides; Rats; Rats, Sprague-Dawley; Tryptophan	2016
Anticonvulsant effect of a ghrelin receptor agonist in 6Hz corneally kindled mice. Epilepsia, 2016, Volume: 57, Issue:9 Topics: Animals; Anticonvulsants; Cornea; Disease Models, Animal; Electric Stimulation; Glycine; Indoles; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oligopeptides; Receptors, Ghrelin; Status Epilepticus; Triazoles; Tryptophan	2016
Tryptophan catabolism in Pseudomonas aeruginosa and potential for inter-kingdom relationship. BMC microbiology, 2016, 07-08, Volume: 16, Issue:1 Topics: Acute Lung Injury; Animals; Disease Models, Animal; Host-Pathogen Interactions; Immunity, Innate; Kynurenic Acid; Kynurenine; Metabolic Networks and Pathways; Mice; Murinae; ortho-Aminobenzoates; Pseudomonas aeruginosa; Pseudomonas Infections; Transaminases; Tryptophan	2016
Decreased levels of kynurenic acid in prefrontal cortex in a genetic animal model of depression. Acta neuropsychiatrica, 2017, Volume: 29, Issue:1 Topics: Animals; Cerebellum; Chromatography, Liquid; Corpus Striatum; Depressive Disorder; Disease Models, Animal; Hippocampus; Kynurenic Acid; Kynurenine; Prefrontal Cortex; Rats; Tryptophan	2017
[STUDYING SOME PHARMACOLOGICAL EFFECTS OF NEW 3-HYDROXYPYRIDINE DERIVATIVE]. Eksperimental'naia i klinicheskaia farmakologiia, 2016, Volume: 79, Issue:2 Topics: Adamantane; Amnesia; Animals; Animals, Outbred Strains; Anticonvulsants; Benzimidazoles; Brain Ischemia; Disease Models, Animal; Exercise Test; Gluconeogenesis; Male; Mice; Neuroprotective Agents; Nootropic Agents; Physical Conditioning, Animal; Picolines; Piracetam; Rats; Swimming; Tryptophan	2016
Serotonin biosynthesis as a predictive marker of serotonin pharmacodynamics and disease-induced dysregulation. Scientific reports, 2016, 07-21, Volume: 6 Topics: Animals; Disease Models, Animal; Fibrosis; Isotope Labeling; Lung Diseases, Interstitial; Rats; Serotonin; Serotonin Receptor Agonists; Tryptophan; Tryptophan Hydroxylase	2016
Advanced age negatively impacts survival in an experimental brain tumor model. Neuroscience letters, 2016, Sep-06, Volume: 630 Topics: Aging; Animals; Brain Neoplasms; Cell Line, Tumor; Disease Models, Animal; Glioblastoma; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lymphocytes, Tumor-Infiltrating; Mice; Mice, Inbred C57BL; Survival Analysis; Tryptophan	2016
Acute single dose of ketamine relieves mechanical allodynia and consequent depression-like behaviors in a rat model. Neuroscience letters, 2016, Sep-19, Volume: 631 Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Freund's Adjuvant; Hippocampus; Hyperalgesia; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interleukin-1beta; Interleukin-6; Ketamine; Kynurenine; Male; Nociception; Rats; Rats, Sprague-Dawley; Serotonin; Tryptophan	2016
Comparison of fluoxetine and 1-methyl-L-tryptophan in treatment of depression-like illness in Bacillus Calmette-Guerin-induced inflammatory model of depression in mice. Journal of basic and clinical physiology and pharmacology, 2016, Nov-01, Volume: 27, Issue:6 Topics: Animals; Antidepressive Agents; BCG Vaccine; Depression; Disease Models, Animal; Fluoxetine; Inflammation; Male; Mice; Mice, Inbred C57BL; Random Allocation; Treatment Outcome; Tryptophan	2016
Omics to Explore Amyotrophic Lateral Sclerosis Evolution: the Central Role of Arginine and Proline Metabolism. Molecular neurobiology, 2017, Volume: 54, Issue:7 Topics: Amyotrophic Lateral Sclerosis; Animals; Arginine; Disease Models, Animal; Female; Humans; Longitudinal Studies; Male; Metabolomics; Mice, Transgenic; Motor Neurons; Proline; Superoxide Dismutase; Tryptophan	2017
Kynurenine 3-monooxygenase is implicated in antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions. Behavioural brain research, 2017, 01-15, Volume: 317 Topics: Animals; Antidepressive Agents; Biogenic Monoamines; Depressive Disorder, Major; Disease Models, Animal; Exploratory Behavior; Food Preferences; Hippocampus; Imipramine; Kynurenine; Kynurenine 3-Monooxygenase; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Sertraline; Sucrose; Swimming; Tryptophan	2017
Reversal of schizophrenia-like symptoms and immune alterations in mice by immunomodulatory drugs. Journal of psychiatric research, 2017, Volume: 84 Topics: Animals; Antipsychotic Agents; Brain; Disease Models, Animal; Immunologic Factors; Immunomodulation; Interleukin-4; Interleukin-6; Ketamine; Male; Melatonin; Mice; Neuroimmunomodulation; Random Allocation; Risperidone; Schizophrenia; Schizophrenic Psychology; Tryptophan	2017
Cl-NQTrp Alleviates Tauopathy Symptoms in a Model Organism through the Inhibition of Tau Aggregation-Engendered Toxicity. Neuro-degenerative diseases, 2017, Volume: 17, Issue:2-3 Topics: Alzheimer Disease; Animals; Animals, Genetically Modified; Disease Models, Animal; Drosophila melanogaster; Eye; Naphthalenes; Neuroprotective Agents; Peptide Fragments; tau Proteins; Tauopathies; Tryptophan	2017
Modulation of a Circulating Uremic Solute via Rational Genetic Manipulation of the Gut Microbiota. Cell host & microbe, 2016, Dec-14, Volume: 20, Issue:6 Topics: Animal Feed; Animals; Bacteria; Bacteroides; Diet; Disease Models, Animal; Disease Progression; Gastrointestinal Microbiome; Gastrointestinal Tract; Genetic Engineering; Germ-Free Life; Humans; Indican; Indoles; Metagenome; Mice; Microbiota; Renal Insufficiency, Chronic; Toxins, Biological; Tryptophan; Tryptophanase	2016
Tryptophan metabolite activation of the aryl hydrocarbon receptor regulates IL-10 receptor expression on intestinal epithelia. Mucosal immunology, 2017, Volume: 10, Issue:5 Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Gene Expression Regulation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Interleukin-10; Interleukin-10 Receptor alpha Subunit; Intestinal Mucosa; Kynurenine; Mice; Mice, Inbred C57BL; Mice, Knockout; Promoter Regions, Genetic; Receptors, Aryl Hydrocarbon; Signal Transduction; Tryptophan; Wound Healing	2017
Intracerebroventricular Administration of Streptozotocin as an Experimental Approach to Depression: Evidence for the Involvement of Proinflammatory Cytokines and Indoleamine-2,3-Dioxygenase. Neurotoxicity research, 2017, Volume: 31, Issue:4 Topics: Animals; Blood Glucose; Cytokines; Depression; Disease Models, Animal; Grooming; Hippocampus; Hydroxyindoleacetic Acid; Immobility Response, Tonic; Indoleamine-Pyrrole 2,3,-Dioxygenase; Infusions, Intraventricular; Kynurenine; Male; Mice; Minocycline; Serotonin; Streptozocin; Tryptophan	2017
The activation of the kynurenine pathway in a rat model with renovascular hypertension. Experimental biology and medicine (Maywood, N.J.), 2017, Volume: 242, Issue:7 Topics: Angiotensin II; Animals; Blood Pressure; Chromatography, High Pressure Liquid; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Hypertension, Renovascular; Kynurenine; Male; Metabolic Networks and Pathways; Rats; Rats, Wistar; Tryptophan	2017
Loss of Tryptophan Fluorescence Correlates With Mechanical Stiffness Following Photo-Crosslinking Treatment of Rabbit Cornea. Investigative ophthalmology & visual science, 2017, 02-01, Volume: 58, Issue:2 Topics: Animals; Biomechanical Phenomena; Cornea; Cross-Linking Reagents; Disease Models, Animal; Fluorescence; Keratoconus; Male; Photochemotherapy; Photosensitizing Agents; Rabbits; Spectrometry, Fluorescence; Tryptophan	2017
n-Butylidenephthalide exhibits protection against neurotoxicity through regulation of tryptophan 2, 3 dioxygenase in spinocerebellar ataxia type 3. Neuropharmacology, 2017, 05-01, Volume: 117 Topics: Animals; Ataxin-3; Calcium; Calpain; Cerebellum; Disease Models, Animal; HEK293 Cells; Humans; Machado-Joseph Disease; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Neuroprotective Agents; Phthalic Anhydrides; Quinolinic Acid; Ryanodine Receptor Calcium Release Channel; Tryptophan; Tryptophan Oxygenase	2017
Targeting the Microbiota-Gut-Brain Axis: Prebiotics Have Anxiolytic and Antidepressant-like Effects and Reverse the Impact of Chronic Stress in Mice. Biological psychiatry, 2017, Oct-01, Volume: 82, Issue:7 Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Brain; Corticosterone; Depression; Disease Models, Animal; Gastrointestinal Microbiome; Gastrointestinal Tract; Gene Expression; Locomotion; Male; Mice; Mice, Inbred C57BL; Neurotransmitter Agents; Nociception; Oligosaccharides; Prebiotics; Stress, Psychological; Tryptophan	2017
Tryptophan depletion affects compulsive behaviour in rats: strain dependent effects and associated neuromechanisms. Psychopharmacology, 2017, Volume: 234, Issue:8 Topics: Amygdala; Analysis of Variance; Animals; Behavior, Animal; Brain; Compulsive Behavior; Diet; Disease Models, Animal; Dopamine; Drinking; Hippocampus; Male; Neostriatum; Polydipsia; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Serotonin; Tryptophan	2017
Acute citalopram has different effects on regional 5-HT synthesis in FSL, FRL, and SDP rats: an autoradiographic evaluation. Brain research bulletin, 2008, Oct-22, Volume: 77, Issue:4 Topics: Animals; Antidepressive Agents, Second-Generation; Autoradiography; Brain; Citalopram; Depressive Disorder; Disease Models, Animal; Male; Random Allocation; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; Serotonin; Species Specificity; Tryptophan	2008
Phosphodiesterase 2 and 5 inhibition attenuates the object memory deficit induced by acute tryptophan depletion. European journal of pharmacology, 2008, Dec-14, Volume: 600, Issue:1-3 Topics: Animals; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Imidazoles; Male; Memory; Memory Disorders; Nitric Oxide; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Rats; Rats, Wistar; Serotonin; Sulfones; Triazines; Tryptophan; Vardenafil Dihydrochloride	2008
Chronic voluntary ethanol intake hypersensitizes 5-HT(1A) autoreceptors in C57BL/6J mice. Journal of neurochemistry, 2008, Volume: 107, Issue:6 Topics: 5-Hydroxytryptophan; Action Potentials; Alcohol Drinking; Alcoholism; Animals; Behavior, Animal; Body Temperature; Disease Models, Animal; Food Preferences; Guanosine 5'-O-(3-Thiotriphosphate); Hydroxyindoleacetic Acid; Hypothermia; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Neurons; Protein Binding; Pyrimidines; Raphe Nuclei; Receptor, Serotonin, 5-HT1A; Serotonin; Serotonin Receptor Agonists; Tryptophan	2008
St. John's Wort modulates brain regional serotonin metabolism in swim stressed rats. Pakistan journal of pharmaceutical sciences, 2009, Volume: 22, Issue:1 Topics: Amygdala; Animals; Anti-Anxiety Agents; Behavior, Animal; Brain; Corticosterone; Disease Models, Animal; Hippocampus; Hydroxyindoleacetic Acid; Hypericum; Hypothalamo-Hypophyseal System; Hypothalamus; Male; Pituitary-Adrenal System; Plant Preparations; Rats; Rats, Wistar; Serotonin; Stress, Psychological; Swimming; Tryptophan	2009
Bronchoconstriction induced by hyperventilation with humidified hot air: role of TRPV1-expressing airway afferents. Journal of applied physiology (Bethesda, Md. : 1985), 2009, Volume: 106, Issue:6 Topics: Airway Resistance; Animals; Atropine; Benzamides; Bronchoconstriction; Bronchodilator Agents; Capsaicin; Disease Models, Animal; Drug Combinations; Ethanolamines; Formoterol Fumarate; Guinea Pigs; Hot Temperature; Humidity; Hyperthermia, Induced; Hyperventilation; Male; Neurons, Afferent; Piperidines; Receptors, Tachykinin; Specific Pathogen-Free Organisms; TRPV Cation Channels; Tryptophan	2009
Repeated administration of Nigella sativa decreases 5-HT turnover and produces anxiolytic effects in rats. Pakistan journal of pharmaceutical sciences, 2009, Volume: 22, Issue:2 Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Brain; Disease Models, Animal; Drug Administration Schedule; Exploratory Behavior; Hydroxyindoleacetic Acid; Motor Activity; Plant Oils; Rats; Rats, Wistar; Serotonin; Tryptophan	2009
l-Tryptophan exhibits therapeutic function in a porcine model of dextran sodium sulfate (DSS)-induced colitis. The Journal of nutritional biochemistry, 2010, Volume: 21, Issue:6 Topics: Animal Nutrition Sciences; Animals; Apoptosis; Body Weight; Colitis; Dextrans; Disease Models, Animal; Inflammation; Interleukin-6; Mannitol; Permeability; Sulfates; Swine; Tryptophan; Tumor Necrosis Factor-alpha	2010
Substance P is associated with the development of brain edema and functional deficits after traumatic brain injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2009, Volume: 29, Issue:8 Topics: Animals; Brain Edema; Brain Injuries; Capillary Permeability; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Magnetic Resonance Imaging; Male; Microscopy, Confocal; Microscopy, Immunoelectron; Motor Activity; Neurokinin-1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Substance P; Tryptophan	2009
Origins and functional basis of regulatory CD11c+CD8+ T cells. European journal of immunology, 2009, Volume: 39, Issue:6 Topics: Animals; CD11c Antigen; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Differentiation; Cell Lineage; Colitis; Dendritic Cells; Disease Models, Animal; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Ovalbumin; Peptide Fragments; Protein Serine-Threonine Kinases; Receptors, Antigen, T-Cell; Spleen; T-Lymphocyte Subsets; T-Lymphocytes, Regulatory; Transcription Factor CHOP; Tryptophan; Tumor Necrosis Factor Receptor Superfamily, Member 9	2009
Acute tryptophan depletion in C57BL/6 mice does not induce central serotonin reduction or affective behavioural changes. Neurochemistry international, 2010, Volume: 56, Issue:1 Topics: Acute Disease; Affect; Animals; Anxiety Disorders; Behavior, Animal; Brain; Brain Chemistry; Depressive Disorder; Disease Models, Animal; Food, Formulated; Hippocampus; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mood Disorders; Serotonin; Synaptic Transmission; Tryptophan	2010
Antioxidant activity of tryptophan in rats under experimental endotoxic shock. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2010, Volume: 64, Issue:1 Topics: Animals; Animals, Suckling; Antioxidants; Cytokines; Dietary Supplements; Disease Models, Animal; Female; Lipopolysaccharides; Lung; Melatonin; Pregnancy; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Shock, Septic; Tryptophan	2010
Acute tryptophan depletion potentiates 3,4-methylenedioxymethamphetamine-induced cerebrovascular hyperperfusion in adult male Wistar rats. Journal of neuroscience research, 2010, May-15, Volume: 88, Issue:7 Topics: Animals; Binding, Competitive; Brain; Cerebral Arteries; Cerebrovascular Circulation; Cerebrovascular Disorders; Depressive Disorder; Disease Models, Animal; Hyperemia; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Rats; Rats, Wistar; Serotonin; Serotonin Agents; Serotonin Plasma Membrane Transport Proteins; Tryptophan; Vasodilation	2010
Tryptophan depletion impairs object-recognition memory in the rat: reversal by risperidone. Behavioural brain research, 2010, Apr-02, Volume: 208, Issue:2 Topics: Animals; Brain; Chromatography; Diet; Disease Models, Animal; Hydroxyindoleacetic Acid; Male; Memory Disorders; Motor Activity; Rats; Recognition, Psychology; Risperidone; Serotonin; Serotonin Antagonists; Tryptophan	2010
NK-1 receptor is involved in the decreased movement in a rat chronic acid reflux oesophagitis model. Neurogastroenterology and motility, 2010, Volume: 22, Issue:5 Topics: Animals; Blotting, Western; Disease Models, Animal; Esophagitis, Peptic; Esophagus; Male; Motor Activity; Movement; Neurokinin-1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Neurokinin-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tachykinins; Tryptophan	2010
Metabolomic analysis identifies inflammatory and noninflammatory metabolic effects of genetic modification in a mouse model of Crohn's disease. Journal of proteome research, 2010, Apr-05, Volume: 9, Issue:4 Topics: Animals; Chromatography, Liquid; Cluster Analysis; Crohn Disease; Disease Models, Animal; Germ-Free Life; Inflammation; Interleukin-10; Kynurenine; Male; Mass Spectrometry; Metabolome; Metabolomics; Mice; Mice, Transgenic; Principal Component Analysis; Tryptophan; Urine	2010
Peripheral and cerebral metabolic abnormalities of the tryptophan-kynurenine pathway in a murine model of major depression. Behavioural brain research, 2010, Jun-26, Volume: 210, Issue:1 Topics: Animals; Brain; Chronic Disease; Depressive Disorder, Major; Disease Models, Animal; Hydroxyindoleacetic Acid; Kynurenine; Lung; Male; Metabolic Networks and Pathways; Mice; Mice, Inbred BALB C; Serotonin; Stress, Psychological; Tryptophan	2010
Dysfunctional kynurenine pathway metabolism in the R6/2 mouse model of Huntington's disease. Journal of neurochemistry, 2010, Volume: 113, Issue:6 Topics: Age Factors; Animals; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Female; Huntingtin Protein; Huntington Disease; Kynurenine; Metabolic Diseases; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Nuclear Proteins; Time Factors; Tritium; Tryptophan	2010
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression. Neuroscience, 2010, Nov-10, Volume: 170, Issue:4 Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Citalopram; Concanavalin A; Corticosterone; Corticotropin-Releasing Hormone; Cytokines; Depression; Disease Models, Animal; Female; Lipopolysaccharides; Maternal Deprivation; Probiotics; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stress, Psychological; Tryptophan	2010
Spinal cord mechanisms mediating behavioral hyperalgesia induced by neurokinin-1 tachykinin receptor activation in the rostral ventromedial medulla. Neuroscience, 2010, Dec-29, Volume: 171, Issue:4 Topics: Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Excitatory Amino Acid Antagonists; Freund's Adjuvant; GABA Agents; Hyperalgesia; In Vitro Techniques; Inflammation; Male; Medulla Oblongata; Membrane Potentials; Microinjections; Muscimol; Ondansetron; Oxazines; Pain Measurement; Pain Threshold; Posterior Horn Cells; Pyridazines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-1; Serotonin Antagonists; Spinal Cord; Substance P; Tryptophan; Up-Regulation	2010
Effects of maternal L-tryptophan depletion and corticosterone administration on neurobehavioral adjustments in mouse dams and their adolescent and adult daughters. Progress in neuro-psychopharmacology & biological psychiatry, 2011, Aug-01, Volume: 35, Issue:6 Topics: Age Factors; Animals; Animals, Newborn; Animals, Outbred Strains; Brain; Brain-Derived Neurotrophic Factor; Conditioning, Operant; Corticosterone; Depressive Disorder, Major; Disease Models, Animal; Exploratory Behavior; Female; Hypothalamic Diseases; Male; Maternal Behavior; Maze Learning; Mice; Pregnancy; Stress, Psychological; Tryptophan	2011
Vascular expression, activity and function of indoleamine 2,3-dioxygenase-1 following cerebral ischaemia-reperfusion in mice. Naunyn-Schmiedeberg's archives of pharmacology, 2011, Volume: 383, Issue:5 Topics: Animals; Arterioles; Cerebral Cortex; Disease Models, Animal; Enzyme Inhibitors; Guanidines; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Ischemic Attack, Transient; Kynurenine; Mice; Mice, Knockout; Motor Activity; Nitric Oxide Synthase Type II; Reperfusion Injury; Tryptophan	2011
A substance P antagonist improves outcome when administered 4 h after onset of ischaemic stroke. Brain research, 2011, Jun-01, Volume: 1393 Topics: Animals; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Disease Models, Animal; Drug Administration Schedule; Infarction, Middle Cerebral Artery; Male; Neurokinin-1 Receptor Antagonists; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Recovery of Function; Substance P; Time Factors; Tryptophan	2011
The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease. Current biology : CB, 2011, Jun-07, Volume: 21, Issue:11 Topics: Animals; Animals, Genetically Modified; Disease Models, Animal; Drosophila melanogaster; Huntington Disease; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Nerve Degeneration; Neuroprotective Agents; Tryptophan; Tryptophan Oxygenase	2011
UPLC-MS-based urine metabolomics reveals indole-3-lactic acid and phenyllactic acid as conserved biomarkers for alcohol-induced liver disease in the Ppara-null mouse model. Journal of proteome research, 2011, Sep-02, Volume: 10, Issue:9 Topics: Alcohols; Analysis of Variance; Animals; Biomarkers; Chromatography, High Pressure Liquid; Disease Models, Animal; Indoles; Lactates; Liver Diseases, Alcoholic; Male; Mass Spectrometry; Metabolic Networks and Pathways; Metabolomics; Mice; Mice, Knockout; Phenylalanine; PPAR alpha; Principal Component Analysis; Taurine; Tryptophan	2011
Substance P induces adverse myocardial remodelling via a mechanism involving cardiac mast cells. Cardiovascular research, 2011, Dec-01, Volume: 92, Issue:3 Topics: Animals; Apoptosis; Cell Degranulation; Collagen; Disease Models, Animal; Heart Failure; In Situ Nick-End Labeling; Male; Mast Cells; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Neurokinin A; Neurokinin-1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Time Factors; Tryptophan; Tumor Necrosis Factor-alpha; Ultrasonography; Ventricular Remodeling	2011
Effects of fenfluramine, 8-OH-DPAT, and tryptophan-enriched diet on the high-ethanol intake by rats bred for susceptibility to stress. Alcohol (Fayetteville, N.Y.), 2011, Volume: 45, Issue:8 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alcohol Drinking; Animals; Antidepressive Agents, Second-Generation; Breeding; Diet; Disease Models, Animal; Eating; Escape Reaction; Ethanol; Fenfluramine; Male; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists; Stress, Psychological; Swimming; Tryptophan	2011
Fatal pancreatitis in simian immunodeficiency virus SIV(mac251)-infected macaques treated with 2',3'-dideoxyinosine and stavudine following cytotoxic-T-lymphocyte-associated antigen 4 and indoleamine 2,3-dioxygenase blockade. Journal of virology, 2012, Volume: 86, Issue:1 Topics: AIDS Vaccines; Animals; Anti-HIV Agents; CTLA-4 Antigen; Didanosine; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; HIV Infections; HIV-1; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Macaca mulatta; Pancreatitis; Simian Immunodeficiency Virus; Stavudine; Tryptophan	2012
Sub-chronic dietary tryptophan depletion--an animal model of depression with improved face and good construct validity. Journal of psychiatric research, 2012, Volume: 46, Issue:2 Topics: Aldosterone; Analysis of Variance; Animals; Body Weight; Brain; Calcium-Binding Proteins; Catecholamines; Chromatography, High Pressure Liquid; Corticosterone; Depression; Diet; Disease Models, Animal; DNA-Binding Proteins; Kynurenic Acid; Kynurenine; Male; Nerve Tissue Proteins; Nucleobindins; Paroxetine; Protein Binding; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Selective Serotonin Reuptake Inhibitors; Swimming; Time Factors; Tritium; Tryptophan	2012
Epigenetic regulation of motor neuron cell death through DNA methylation. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Nov-16, Volume: 31, Issue:46 Topics: 5-Methylcytosine; Age Factors; Amyloid Precursor Protein Secretases; Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Aspartic Acid Endopeptidases; Camptothecin; Caspase 3; Cell Line, Transformed; Central Nervous System; Cytosine; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Enzyme Inhibitors; Epigenomics; Gene Expression Regulation, Developmental; Green Fluorescent Proteins; Humans; Indoles; Mice; Mice, Transgenic; Motor Neurons; Mutation; Phthalimides; Propionates; RNA, Small Interfering; Sciatic Neuropathy; Superoxide Dismutase; Transfection; Tryptophan; Up-Regulation	2011
The role of indoleamine 2,3-dioxygenase in a mouse model of neuroinflammation-induced depression. Journal of Alzheimer's disease : JAD, 2012, Volume: 28, Issue:4 Topics: Animals; Depression; Disease Models, Animal; Encephalitis; Indoleamine-Pyrrole 2,3,-Dioxygenase; Male; Maze Learning; Mice; Mice, Inbred C57BL; Tryptophan	2012
Metabonomic study on the anti-osteoporosis effect of Rhizoma Drynariae and its action mechanism using ultra-performance liquid chromatography-tandem mass spectrometry. Journal of ethnopharmacology, 2012, Jan-06, Volume: 139, Issue:1 Topics: Alkaline Phosphatase; Animals; Biomarkers; Bone Density; Bone Density Conservation Agents; Chromatography, Liquid; Disease Models, Animal; Drugs, Chinese Herbal; Femur; Lysophosphatidylcholines; Metabolomics; Osteocalcin; Osteoporosis; Phenylalanine; Polypodiaceae; Prednisolone; Protein Carbonylation; Rats; Rats, Wistar; Rhizome; Tandem Mass Spectrometry; Tibia; Tryptophan	2012
Pharmacological activity of a Bv8 analogue modified in position 24. British journal of pharmacology, 2012, Volume: 166, Issue:3 Topics: Alanine; Amino Acid Substitution; Amphibian Proteins; Analgesics; Animals; Chemotaxis; CHO Cells; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Hyperalgesia; Ligands; Macrophages; Male; Mice; Neuropeptides; Pain, Postoperative; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Peptide; Structure-Activity Relationship; Transfection; Tryptophan	2012
Reduction of serotonergic neurons in the dorsal raphe due to chronic prenatal administration of a tryptophan-free diet. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2012, Volume: 30, Issue:2 Topics: Animals; Animals, Newborn; Chronic Disease; Disease Models, Animal; Female; Fetal Nutrition Disorders; Food, Formulated; Male; Nervous System Malformations; Neural Inhibition; Pregnancy; Raphe Nuclei; Rats; Rats, Wistar; Serotonin; Tryptophan	2012
Metabolic differences underlying two distinct rat urinary phenotypes, a suggested role for gut microbial metabolism of phenylalanine and a possible connection to autism. FEBS letters, 2012, Apr-05, Volume: 586, Issue:7 Topics: Animals; Autistic Disorder; Bacterial Proteins; Biomarkers; Chlorogenic Acid; Clostridium; Disease Models, Animal; Fungal Proteins; Glycine; Hippurates; Humans; Intestines; Phenylalanine; Phenylalanine Ammonia-Lyase; Rats; Stereoisomerism; Systems Biology; Tryptophan; Tyrosine; Yeasts	2012
Blood pressure reducing effects of Phalaris canariensis in normotensive and spontaneously hypertensive rats. Canadian journal of physiology and pharmacology, 2012, Volume: 90, Issue:2 Topics: Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension; Kynurenine; Male; Phalaris; Plant Extracts; Prehypertension; Rats; Rats, Inbred SHR; Rats, Wistar; Sympathetic Nervous System; Time Factors; Tryptophan	2012
Anxiety-like behavior and cognitive flexibility in adult rats perinatally exposed to increased serotonin concentrations. Behavioural brain research, 2012, Apr-21, Volume: 230, Issue:1 Topics: 5-Hydroxytryptophan; Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Anxiety Disorders; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Male; Maze Learning; Monoamine Oxidase Inhibitors; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Serotonin; Sex Factors; Tranylcypromine; Tryptophan	2012
Essential role of excessive tryptophan and its neurometabolites in fatigue. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2012, Volume: 39, Issue:1 Topics: Acetylglucosaminidase; Amino Acids, Branched-Chain; Analysis of Variance; Animals; Corpus Striatum; Disease Models, Animal; Exercise Test; Exploratory Behavior; Fatigue; Female; Fluoxetine; Hydroxyindoleacetic Acid; Kynurenic Acid; Locomotion; Maze Learning; Microdialysis; Quinolinic Acid; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Stereotyped Behavior; Synaptosomes; Time Factors; Tryptophan	2012
FICZ, a tryptophan photoproduct, suppresses pulmonary eosinophilia and Th2-type cytokine production in a mouse model of ovalbumin-induced allergic asthma. International immunopharmacology, 2012, Volume: 13, Issue:4 Topics: Animals; Anti-Allergic Agents; Asthma; Carbazoles; Cells, Cultured; Cytokines; Disease Models, Animal; GATA3 Transcription Factor; Gene Expression Regulation; Humans; Immunosuppression Therapy; Ligands; Mice; Mice, Inbred BALB C; Ovalbumin; Pulmonary Eosinophilia; Receptors, Aryl Hydrocarbon; Th2 Cells; Tryptophan	2012
A substance P antagonist improves outcome in female Sprague Dawley rats following diffuse traumatic brain injury. CNS neuroscience & therapeutics, 2012, Volume: 18, Issue:6 Topics: Animals; Brain Injuries; Disease Models, Animal; Female; Motor Activity; Rats; Rats, Sprague-Dawley; Substance P; Tryptophan	2012
High tryptophan diet reduces CA1 intraneuronal β-amyloid in the triple transgenic mouse model of Alzheimer's disease. Aging cell, 2012, Volume: 11, Issue:5 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; CA1 Region, Hippocampal; Disease Models, Animal; Female; Male; Mice; Mice, Transgenic; Neurons; Serotonin; Serotonin Plasma Membrane Transport Proteins; Tryptophan	2012
Combined tissue plasminogen activator and an NK1 tachykinin receptor antagonist: an effective treatment for reperfusion injury following acute ischemic stroke in rats. Neuroscience, 2012, Sep-18, Volume: 220 Topics: Animals; Blood-Brain Barrier; Capillary Permeability; Disease Models, Animal; Fibrinolytic Agents; Male; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Recovery of Function; Reperfusion Injury; Stroke; Tissue Plasminogen Activator; Tryptophan	2012
A rodent model of premenstrual dysphoria: progesterone withdrawal induces depression-like behavior that is differentially sensitive to classes of antidepressants. Behavioural brain research, 2012, Oct-01, Volume: 234, Issue:2 Topics: Analysis of Variance; Animals; Antidepressive Agents; Autoradiography; Chromatography, High Pressure Liquid; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Estradiol; Female; Food Preferences; Hormones; Mood Disorders; Motor Activity; Nociception; Ovariectomy; Premenstrual Syndrome; Progesterone; Rats; Rats, Long-Evans; Serotonin; Serotonin Plasma Membrane Transport Proteins; Social Behavior; Substance Withdrawal Syndrome; Swimming; Tryptophan	2012
Citalopram decreases tryptophan 2,3-dioxygenase activity and brain 5-HT turnover in swim stressed rats. Pharmacological reports : PR, 2012, Volume: 64, Issue:3 Topics: Amygdala; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Citalopram; Corticosterone; Disease Models, Animal; Hippocampus; Hypothalamus; Liver; Male; Rats; Rats, Wistar; Serotonin; Stress, Psychological; Swimming; Tryptophan; Tryptophan Oxygenase	2012
The Fgfr2 W290R mouse model of Crouzon syndrome. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2012, Volume: 28, Issue:9 Topics: Animals; Arginine; Bone and Bones; Cartilage; Cranial Sutures; Craniofacial Dysostosis; Disease Models, Animal; Humans; Mice; Mutation; Phenotype; Receptor, Fibroblast Growth Factor, Type 2; Tryptophan	2012
Preclinical evaluation of HIV eradication strategies in the simian immunodeficiency virus-infected rhesus macaque: a pilot study testing inhibition of indoleamine 2,3-dioxygenase. AIDS research and human retroviruses, 2013, Volume: 29, Issue:2 Topics: Administration, Oral; Animals; Disease Models, Animal; DNA, Viral; Enzyme Inhibitors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Macaca mulatta; Pilot Projects; Plasma; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Treatment Outcome; Tryptophan; Viral Load	2013
Lactobacillus johnsonii inhibits indoleamine 2,3-dioxygenase and alters tryptophan metabolite levels in BioBreeding rats. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2013, Volume: 27, Issue:4 Topics: Animals; Cells, Cultured; Disease Models, Animal; Hydrogen Peroxide; Indoleamine-Pyrrole 2,3,-Dioxygenase; Indoles; Kynurenine; Lactobacillus; Rats; Rats, Inbred BB; Serotonin; Tryptophan	2013
Effect of indoleamine 2,3-dioxygenase on induction of experimental autoimmune encephalomyelitis. Journal of neuroimmunology, 2002, Volume: 129, Issue:1-2 Topics: Animals; Axons; Cell Division; Cytokines; Disease Models, Animal; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Interleukin-10; Interleukin-4; Kinetics; Kynurenine; Lymph Nodes; Mice; RNA, Messenger; Spinal Cord; T-Lymphocytes; Treatment Outcome; Tryptophan; Tryptophan Oxygenase	2002
Lack of effects by tricyclic antidepressant and serotonin inhibitors on anorexia in MCG 101 tumor-bearing mice with eicosanoid-related cachexia. Nutrition (Burbank, Los Angeles County, Calif.), 2003, Volume: 19, Issue:1 Topics: Animals; Anorexia; Antidepressive Agents, Tricyclic; Body Weight; Brain; Cachexia; Dinoprostone; Disease Models, Animal; Eating; Eicosanoids; Female; Injections, Intraperitoneal; Interleukin-6; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Nitric Oxide; Selective Serotonin Reuptake Inhibitors; Serotonin; Tryptophan	2003
Transgenic rat model of Huntington's disease. Human molecular genetics, 2003, Mar-15, Volume: 12, Issue:6 Topics: Animals; Animals, Genetically Modified; Cell Nucleus; Disease Models, Animal; Disease Progression; DNA, Complementary; Glucose; Huntingtin Protein; Huntington Disease; Immunohistochemistry; Magnetic Resonance Imaging; Models, Genetic; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Phenotype; Promoter Regions, Genetic; Rats; Time Factors; Tissue Distribution; Tomography, Emission-Computed; Transgenes; Trinucleotide Repeat Expansion; Tryptophan	2003
Regional brain serotonin synthesis is increased in the olfactory bulbectomy rat model of depression: an autoradiographic study. Journal of neurochemistry, 2003, Volume: 85, Issue:2 Topics: Animals; Autoradiography; Brain; Depression; Disease Models, Animal; Male; Olfactory Bulb; Rats; Rats, Sprague-Dawley; Serotonin; Tryptophan	2003
Tryptophan metabolism via serotonin in rats with hexachlorobenzene experimental porphyria. Biochemical pharmacology, 2003, Jul-01, Volume: 66, Issue:1 Topics: 5-Hydroxytryptophan; Animals; Brain; Chromatography, High Pressure Liquid; Digestive System; Disease Models, Animal; Fungicides, Industrial; Hexachlorobenzene; Humans; Liver; Porphyria Cutanea Tarda; Porphyrias; Rats; Rats, Wistar; Serotonin; Tryptophan; Tryptophan Hydroxylase	2003
Antithrombin reduces the ischemia/reperfusion-induced spinal cord injury in rats by attenuating inflammatory responses. Thrombosis and haemostasis, 2004, Volume: 91, Issue:1 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Antithrombins; Coloring Agents; Disease Models, Animal; Epoprostenol; Factor Xa; Humans; Inflammation; Interleukin-8; Ischemia; Male; Peroxidase; Rats; Rats, Wistar; Reperfusion Injury; Spinal Cord; Spinal Cord Injuries; Tetrazolium Salts; Time Factors; Tryptophan; Tumor Necrosis Factor-alpha	2004
Detection of murine intestinal adenomas using targeted molecular autofluorescence. Digestive diseases and sciences, 2004, Volume: 49, Issue:1 Topics: Adenomatous Polyps; Animals; Colonic Polyps; Disease Models, Animal; Intestinal Polyps; Intestine, Small; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Pilot Projects; Precancerous Conditions; Predictive Value of Tests; Sensitivity and Specificity; Tryptophan	2004
Tryptophan reduces creatine kinase activity in the brain cortex of rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2004, Volume: 22, Issue:2 Topics: Amino Acid Metabolism, Inborn Errors; Animals; Brain Diseases, Metabolic, Inborn; Cerebral Cortex; Creatine Kinase; Disease Models, Animal; Down-Regulation; Energy Metabolism; Glutathione; Oxidative Stress; Rats; Rats, Wistar; Tryptophan	2004
Inhibition of indoleamine 2,3-dioxygenase (IDO) enhances elimination of virus-infected macrophages in an animal model of HIV-1 encephalitis. Blood, 2005, Oct-01, Volume: 106, Issue:7 Topics: Animals; Basal Ganglia; Blotting, Western; Brain; CD3 Complex; CD8 Antigens; CD8-Positive T-Lymphocytes; Cell Separation; Disease Models, Animal; Encephalitis, Viral; Flow Cytometry; HIV Infections; Humans; Image Processing, Computer-Assisted; Indoleamine-Pyrrole 2,3,-Dioxygenase; Lymphocytes; Macrophages; Male; Mice; Mice, Inbred NOD; Mice, SCID; Monocytes; T-Lymphocytes, Cytotoxic; Time Factors; Tryptophan; Up-Regulation	2005
Reduced serotonin and 3-hydroxyanthranilic acid levels in serum of cystatin B-deficient mice, a model system for progressive myoclonus epilepsy. Epilepsia, 2005, Volume: 46 Suppl 5 Topics: 3-Hydroxyanthranilic Acid; Adult; Animals; Chromatography, High Pressure Liquid; Cystatin B; Cystatins; Disease Models, Animal; Female; Humans; Kynurenine; Male; Mice; Myoclonic Epilepsies, Progressive; Serotonin; Tryptophan	2005
Pathologic and immunohistochemical findings in hypothalamic and mesencephalic regions in the pah(enu2) mouse model for phenylketonuria. Pediatric research, 2005, Volume: 58, Issue:2 Topics: Animals; Catecholamines; CD11b Antigen; Disease Models, Animal; Dopamine; Female; Gene Transfer Techniques; Genotype; Heterozygote; Homozygote; Hypothalamus; Immunohistochemistry; Macrophages; Male; Mesencephalon; Mice; Mice, Mutant Strains; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phenylketonurias; Substantia Nigra; Time Factors; Tryptophan; Tyrosine	2005
Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite. Science (New York, N.Y.), 2005, Nov-04, Volume: 310, Issue:5749 Topics: Adoptive Transfer; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigen-Presenting Cells; Brain; Cell Line; Cytokines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Histocompatibility Antigens Class II; Immune Tolerance; Immunosuppressive Agents; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Lymphocyte Activation; Mice; Mice, Transgenic; Microglia; Multiple Sclerosis; Myelin Proteins; ortho-Aminobenzoates; Signal Transduction; Spinal Cord; T-Lymphocytes; Th1 Cells; Th2 Cells; Tryptophan	2005
Increases in brain tryptophan concentration in stressed rats following ethanol administration. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2005, Volume: 15, Issue:11 Topics: Animals; Brain; Central Nervous System Depressants; Disease Models, Animal; Ethanol; Hindlimb Suspension; Male; Rats; Rats, Wistar; Stress, Psychological; Tryptophan	2005
Influenza-induced expression of indoleamine 2,3-dioxygenase enhances interleukin-10 production and bacterial outgrowth during secondary pneumococcal pneumonia. The Journal of infectious diseases, 2006, Jan-15, Volume: 193, Issue:2 Topics: Animals; Bronchoalveolar Lavage Fluid; Delayed-Action Preparations; Disease Models, Animal; Enzyme Inhibitors; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Influenza A virus; Interleukin-10; Lung; Mice; Mice, Inbred C57BL; Orthomyxoviridae Infections; Pneumonia, Pneumococcal; Streptococcus pneumoniae; Survival Analysis; Tryptophan; Tumor Necrosis Factor-alpha	2006
Tryptophan metabolite improves symptoms in MS model. The Lancet. Neurology, 2006, Volume: 5, Issue:1 Topics: Animals; Disease Models, Animal; Kynurenine; Mice; Multiple Sclerosis, Relapsing-Remitting; Neuritis, Autoimmune, Experimental; Tryptophan	2006
Brain 5-HT synthesis in the Flinders Sensitive Line rat model of depression: an autoradiographic study. Neurochemistry international, 2006, Volume: 48, Issue:5 Topics: Animals; Autoradiography; Brain Chemistry; Carbon Radioisotopes; Depressive Disorder; Disease Models, Animal; Down-Regulation; Genetic Predisposition to Disease; Limbic System; Neural Pathways; Neurons; Prosencephalon; Radioligand Assay; Raphe Nuclei; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Synaptic Transmission; Tryptophan	2006
Promotion of oxidative stress by L-tryptophan in cerebral cortex of rats. Neurochemistry international, 2006, Volume: 49, Issue:1 Topics: Amino Acid Metabolism, Inborn Errors; Animals; Antioxidants; Catalase; Cerebral Cortex; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Free Radicals; Glutathione; Lipid Peroxidation; Luminescence; Male; Nerve Degeneration; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Tryptophan	2006
Chronic buspirone treatment normalizes regional serotonin synthesis in the olfactory bulbectomized rat brain: an autoradiographic study. Brain research bulletin, 2006, Mar-31, Volume: 69, Issue:2 Topics: Animals; Autoradiography; Brain; Buspirone; Carbon Radioisotopes; Denervation; Depressive Disorder; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Drug Administration Schedule; Male; Olfactory Bulb; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Sensory Deprivation; Serotonin; Serotonin Receptor Agonists; Tryptophan	2006
Augmented cocaine-induced accumbal dopamine efflux, motor activity and place preference in rats fed with a tryptophan-deficient diet. Neuroscience letters, 2006, Jun-19, Volume: 401, Issue:1-2 Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine; Environment, Controlled; Exploratory Behavior; Extracellular Fluid; Food, Formulated; Hydroxyindoleacetic Acid; Hyperkinesis; Male; Motor Activity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Serotonin; Tryptophan	2006
Tryptophan-deficient diet increases the neurochemical and behavioral response to amphetamine. Brain research, 2006, Jun-13, Volume: 1094, Issue:1 Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Brain; Brain Chemistry; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Extracellular Fluid; Food, Formulated; Hydroxyindoleacetic Acid; Male; Microdialysis; Motor Activity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Reward; Serotonin; Tryptophan	2006
Rats subjected to extended L-tryptophan restriction during early postnatal stage exhibit anxious-depressive features and structural changes. Journal of neuropathology and experimental neurology, 2006, Volume: 65, Issue:6 Topics: Age Factors; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Brain; Bromodeoxyuridine; Cell Count; Depression; Diet, Protein-Restricted; Disease Models, Animal; Immunohistochemistry; Male; Maze Learning; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Serotonin; Silver Staining; Swimming; Tryptophan; Tryptophan Hydroxylase	2006
Altered tryptophan metabolism in the brain of cystatin B-deficient mice: a model system for progressive myoclonus epilepsy. Epilepsia, 2006, Volume: 47, Issue:10 Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Chromatography, High Pressure Liquid; Cystatin B; Cystatins; Disease Models, Animal; Female; Hydroxyindoleacetic Acid; Kynurenine; Male; Mice; Mutation; Phenotype; Serotonin; Synaptic Transmission; Tryptophan; Unverricht-Lundborg Syndrome	2006
Oral treatment with live Lactobacillus reuteri inhibits the allergic airway response in mice. American journal of respiratory and critical care medicine, 2007, Mar-15, Volume: 175, Issue:6 Topics: Administration, Oral; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cytokines; Disease Models, Animal; DNA, Bacterial; Eosinophils; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Limosilactobacillus reuteri; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Probiotics; Toll-Like Receptor 9; Tryptophan	2007
Tryptophan 32 potentiates aggregation and cytotoxicity of a copper/zinc superoxide dismutase mutant associated with familial amyotrophic lateral sclerosis. The Journal of biological chemistry, 2007, Jun-01, Volume: 282, Issue:22 Topics: Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Erythrocytes; Humans; Inclusion Bodies; Mice; Mice, Transgenic; Motor Neurons; Mutation, Missense; Oxidation-Reduction; Protein Processing, Post-Translational; Rabbits; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Tryptophan	2007
The guinea-pig is a poor animal model for studies of niacin deficiency and presents challenges in any study using purified diets. The British journal of nutrition, 2007, Volume: 98, Issue:1 Topics: Animals; Bone Marrow; Caseins; Dietary Supplements; Disease Models, Animal; Gelatin; Guinea Pigs; Humans; Male; NAD; Niacin; Survival Analysis; Tryptophan; Weight Gain	2007
Formation and progression of sub-retinal pigment epithelium deposits in Efemp1 mutation knock-in mice: a model for the early pathogenic course of macular degeneration. Human molecular genetics, 2007, Oct-15, Volume: 16, Issue:20 Topics: Animals; Arginine; Bruch Membrane; Disease Models, Animal; Disease Progression; Extracellular Matrix Proteins; Female; Humans; Macular Degeneration; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Mutagenesis, Site-Directed; Optic Nerve; Pigment Epithelium of Eye; Point Mutation; Retina; Time Factors; Tryptophan	2007
Mechanism of age-dependent susceptibility and novel treatment strategy in glutaric acidemia type I. The Journal of clinical investigation, 2007, Volume: 117, Issue:11 Topics: Aging; Amino Acid Metabolism, Inborn Errors; Animals; Brain Diseases, Metabolic, Inborn; Child; Diet; Disease Models, Animal; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Glucose; Glutamic Acid; Glutarates; Glutaryl-CoA Dehydrogenase; Homoarginine; Humans; Lysine; Mice; Mice, Knockout; Mitochondria; Neurons; Nuclear Magnetic Resonance, Biomolecular; Tryptophan	2007
Serotonergic mediation effects of St John's wort in rats subjected to swim stress. Pakistan journal of pharmaceutical sciences, 2008, Volume: 21, Issue:1 Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Depression; Disease Models, Animal; Hydroxyindoleacetic Acid; Hypericum; Injections, Intraperitoneal; Male; Motor Activity; Plant Extracts; Rats; Rats, Wistar; Serotonin; Stress, Psychological; Swimming; Tryptophan; Tryptophan Oxygenase	2008
Indoleamine 2,3-dioxygenase-dependent tryptophan metabolites contribute to tolerance induction during allergen immunotherapy in a mouse model. The Journal of allergy and clinical immunology, 2008, Volume: 121, Issue:4 Topics: Animals; Bronchoalveolar Lavage Fluid; Cytokines; Desensitization, Immunologic; Disease Models, Animal; Eosinophilia; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Male; Mice; Mice, Inbred BALB C; Respiratory Hypersensitivity; Th2 Cells; Tryptophan	2008
Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease. Nature, 2008, Jan-10, Volume: 451, Issue:7175 Topics: Animals; Aspergillosis; Aspergillus fumigatus; Chronic Disease; Disease Models, Animal; Granulomatous Disease, Chronic; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interferon-gamma; Interleukin-17; Kynurenine; Lung; Lung Diseases, Fungal; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases; Reactive Oxygen Species; Receptors, Antigen, T-Cell, gamma-delta; Superoxides; T-Lymphocytes; Tryptophan	2008
Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice. Molecular psychiatry, 2009, Volume: 14, Issue:5 Topics: Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Cytokinins; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Hindlimb Suspension; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lipopolysaccharides; Male; Mice; Mice, Inbred ICR; Minocycline; Motor Activity; Swimming; Time Factors; Tryptophan	2009
Mouse model for allogeneic immune reaction against fetus recapitulates human pre-eclampsia. The journal of obstetrics and gynaecology research, 2008, Volume: 34, Issue:1 Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Female; Fetus; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Placenta; Pre-Eclampsia; Pregnancy; Tryptophan	2008
Glial activation precedes seizures and hippocampal neurodegeneration in measles virus-infected mice. Epilepsia, 2008, Volume: 49 Suppl 2 Topics: Animals; Animals, Newborn; Astrocytes; Behavior, Animal; Cell Count; Coloring Agents; Cricetinae; Disease Models, Animal; Electroencephalography; Encephalitis, Viral; Hippocampus; Kynurenine; Measles virus; Mice; Mice, Inbred BALB C; Microglia; Monitoring, Physiologic; Nerve Degeneration; Neuroglia; Pyramidal Cells; Quinolinic Acid; Seizures; Tryptophan	2008
Tryptophan administration induces oxidative stress in brain cortex of rats. Metabolic brain disease, 2008, Volume: 23, Issue:2 Topics: alpha-Tocopherol; Amino Acid Metabolism, Inborn Errors; Animals; Antioxidants; Brain Diseases, Metabolic; Catalase; Cell Death; Cerebral Cortex; Disease Models, Animal; Glutathione; Glutathione Peroxidase; Male; Nerve Degeneration; Neurons; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Superoxide Dismutase-1; Taurine; Thiobarbituric Acid Reactive Substances; Tryptophan	2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat. Journal of psychiatric research, 2008, Volume: 43, Issue:2 Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chromatography, High Pressure Liquid; Corticosterone; Corticotropin-Releasing Hormone; Cytokines; Depression; Disease Models, Animal; Flow Cytometry; Hypothalamus; Immunoenzyme Techniques; Intestines; Kynurenic Acid; Male; Polymerase Chain Reaction; Probiotics; Rats; Rats, Sprague-Dawley; Stress, Psychological; Tryptophan; Vasopressins	2008
Regulation of hepatic tyrosine aminotransferase in genetically obese rats. Biochimica et biophysica acta, 1983, Apr-20, Volume: 756, Issue:3 Topics: Adrenalectomy; Aging; Amino Acids; Animals; Corticosterone; Diet; Disease Models, Animal; Enzyme Activation; Insulin; Liver; Obesity; Rats; Tryptophan; Tyrosine; Tyrosine Transaminase	1983
Ontogeny of the levels of serotonin in various parts of the brain in severely protein malnourished rats. Brain research, 1984, Jun-11, Volume: 303, Issue:1 Topics: Animals; Blood Proteins; Brain Chemistry; Disease Models, Animal; Fatty Acids, Nonesterified; Female; Humans; Hydroxyindoleacetic Acid; Infant, Newborn; Infant, Small for Gestational Age; Male; Pregnancy; Protein Deficiency; Rats; Serotonin; Tryptophan	1984
Portacaval anastomosis: brain and plasma metabolite abnormalities and the effect of nutritional therapy. Journal of neurochemistry, 1984, Volume: 43, Issue:3 Topics: Amino Acids; Animals; Brain; Disease Models, Animal; Glucagon; Insulin; Liver Diseases; Male; Nutritional Physiological Phenomena; Portacaval Shunt, Surgical; Rats; Rats, Inbred Strains; Species Specificity; Tryptophan	1984
Disturbances of amino acid transport in rats with experimental hyperphenylalaninaemia. Journal of inherited metabolic disease, 1981, Volume: 4, Issue:2 Topics: Amino Acids; Animals; Cerebral Cortex; Disease Models, Animal; Fenclonine; Glycine; Humans; Leucine; Liver; Phenylalanine; Phenylketonurias; Rats; Tryptophan	1981
Increased tryptophan uptake into the brain in hyperammonemia. Life sciences, 1983, Dec-12, Volume: 33, Issue:24 Topics: Amino Acids; Ammonia; Animals; Brain; Brain Stem; Disease Models, Animal; Indoles; Male; Probenecid; Rats; Rats, Inbred Strains; Tryptophan; Urease	1983
A new model for reducing ethanol toxicity. Advances in experimental medicine and biology, 1980, Volume: 126 Topics: Alcoholic Intoxication; Amino Acids; Animals; Blood Glucose; Blood Urea Nitrogen; Disease Models, Animal; Ethanol; Hepatectomy; Humans; Intestinal Absorption; Lactates; Lysine; Pyruvates; Rats; Tryptophan	1980
[Biochemical study of the animal model depression induced by tetrabenazine (author's transl)]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 1980, Volume: 82, Issue:4 Topics: Animals; Behavior; Brain; Corticosterone; Depressive Disorder; Disease Models, Animal; Humans; Male; Rats; Serotonin; Tetrabenazine; Tryptophan	1980
Studies on the mechanism of shock. Central serotoninergic neuron activity after trauma in the rat. British journal of experimental pathology, 1980, Volume: 61, Issue:1 Topics: 5,6-Dihydroxytryptamine; Animals; Brain; Burns; Disease Models, Animal; Hindlimb; Hypothalamus; Ischemia; Neurons; Rats; Serotonin; Shock, Traumatic; Tryptophan; Tryptophan Hydroxylase	1980
Neocortical dialysate monoamines of rats after acute, subacute, and chronic liver shunt. Journal of neurochemistry, 1995, Volume: 64, Issue:3 Topics: 3,4-Dihydroxyphenylacetic Acid; Acute Disease; Amino Acids; Ammonia; Animals; Biogenic Monoamines; Body Weight; Cerebral Cortex; Chronic Disease; Dialysis; Disease Models, Animal; Dopamine; Extracellular Space; Hepatic Encephalopathy; Hydroxyindoleacetic Acid; Male; Norepinephrine; Phenylalanine; Rats; Rats, Wistar; Serotonin; Tryptophan; Tyrosine	1995
Tryptophan deficiency and alcohol consumption in rats as a model for disadvantaged human populations: a preliminary study. Medical anthropology, 1995, Volume: 16, Issue:2 Topics: Alcoholism; Animals; Disease Models, Animal; Drinking; Eating; Humans; Indians, North American; Male; Rats; Rats, Sprague-Dawley; Socioeconomic Factors; Tryptophan	1995
Eosinophilia-myalgia syndrome and tryptophan production: a cautionary tale. Trends in biotechnology, 1994, Volume: 12, Issue:9 Topics: Animals; Brassica; Chemical Industry; Disease Models, Animal; Disease Outbreaks; Drug Contamination; Eosinophilia-Myalgia Syndrome; Fatty Acids, Monounsaturated; Humans; Mice; Mice, Inbred C57BL; Plant Oils; Population Surveillance; Rapeseed Oil; Risk Factors; Tryptophan	1994
A murine model of the eosinophilia-myalgia syndrome induced by 1,1'-ethylidenebis (L-tryptophan). The Journal of clinical investigation, 1994, Volume: 93, Issue:4 Topics: Animals; Disease Models, Animal; Eosinophilia-Myalgia Syndrome; Fascia; Female; Mice; Mice, Inbred C57BL; Muscles; Quinolinic Acid; Tryptophan	1994
Eosinophilia-myalgia syndrome: lessons for public health researchers. The Medical journal of Australia, 1993, Jan-04, Volume: 158, Issue:1 Topics: Australia; Case-Control Studies; Centers for Disease Control and Prevention, U.S.; Disease Models, Animal; Disease Outbreaks; Drug Industry; Eosinophilia-Myalgia Syndrome; Epidemiologic Methods; Humans; Information Services; Public Health; Research; Tryptophan; United States	1993
Opposite response to starvation of Trp/LNAA ratio in lean and obese Zucker rats. Biochemistry and molecular biology international, 1993, Volume: 29, Issue:3 Topics: Amino Acids; Amino Acids, Essential; Animals; Body Weight; Disease Models, Animal; Fasting; Male; Obesity; Rats; Rats, Zucker; Starvation; Time Factors; Tryptophan	1993
Subchronic toxicity of 3-phenylamino alanine, an impurity in L-tryptophan reported to be associated with eosinophilia-myalgia syndrome. Archives of toxicology, 1995, Volume: 69, Issue:7 Topics: Administration, Oral; Alanine; Animals; Blood Chemical Analysis; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Eosinophilia-Myalgia Syndrome; Female; Heart; Kidney; Liver; Macrophages, Alveolar; Male; Organ Size; Random Allocation; Rats; Rats, Sprague-Dawley; Testis; Tissue Distribution; Tryptophan	1995
In vivo inhibition of kynurenine aminotransferase activity by isonicotinic acid hydrazide in rats. Bioscience, biotechnology, and biochemistry, 1996, Volume: 60, Issue:5 Topics: Animals; Antitubercular Agents; Disease Models, Animal; Enzyme Inhibitors; Isoniazid; Lyases; Male; Niacin; Pyruvates; Rats; Rats, Wistar; Transaminases; Tryptophan	1996
Evidence of excitotoxicity in the brain of the ornithine carbamoyltransferase deficient sparse fur mouse. Brain research. Developmental brain research, 1995, Dec-21, Volume: 90, Issue:1-2 Topics: Ammonia; Animals; Brain Damage, Chronic; Disease Models, Animal; Glutamine; Hair; Metabolism, Inborn Errors; Mice; Mice, Inbred Strains; Ornithine Carbamoyltransferase; Ornithine Carbamoyltransferase Deficiency Disease; Quinolinic Acid; Tryptophan	1995
A contaminant of L-tryptophan enhances expression of dermal collagen in a murine model of eosinophilia myalgia syndrome. Proceedings of the Association of American Physicians, 1996, Volume: 108, Issue:4 Topics: Animals; Blotting, Northern; Collagen; Disease Models, Animal; Eosinophilia-Myalgia Syndrome; Female; In Situ Hybridization; Mice; Mice, Inbred C57BL; RNA, Messenger; Tryptophan	1996
Brain extracellular quinolinic acid in chronic experimental hepatic encephalopathy as assessed by in vivo microdialysis: acute effects of L-tryptophan. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1996, Volume: 15, Issue:4 Topics: Animals; Brain; Disease Models, Animal; Hepatic Encephalopathy; Male; Microdialysis; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Tryptophan	1996
Obesity: advances in understanding and treatment. IBC's Second Annual International Symposium on Obesity: Advances in Understanding and Treatment. Washington, DC, USA, 4-6 March 1996. Molecular medicine today, 1996, Volume: 2, Issue:10 Topics: Amyloid; Colipases; Diabetes Mellitus, Type 2; Diet; Disease Models, Animal; Enzyme Precursors; Humans; Islet Amyloid Polypeptide; Leptin; Neuropeptide Y; Neurotransmitter Agents; Obesity; Protein Precursors; Proteins; Serotonin; Tryptophan	1996
Is quinolinic acid involved in the pathogenesis of hepatic encephalopathy? Advances in experimental medicine and biology, 1996, Volume: 398 Topics: Animals; Brain; Cerebral Cortex; Disease Models, Animal; Extracellular Space; Hepatic Encephalopathy; Portacaval Shunt, Surgical; Quinolinic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Reference Values; Time Factors; Tryptophan	1996
Water soluble antioxidants in mammalian aqueous humor: interaction with UV B and hydrogen peroxide. Vision research, 1998, Volume: 38, Issue:19 Topics: Aged; Analysis of Variance; Animals; Antioxidants; Aqueous Humor; Ascorbic Acid; Cataract; Chromatography, High Pressure Liquid; Cysteine; Disease Models, Animal; Female; Glutathione; Humans; Hydrogen Peroxide; Mammals; Oxidants; Rabbits; Rats; Rats, Sprague-Dawley; Tryptophan; Tyrosine; Ultraviolet Rays; Uric Acid	1998
Antithrombin reduces ischemia/reperfusion injury of rat liver by increasing the hepatic level of prostacyclin. Blood, 1999, Jan-01, Volume: 93, Issue:1 Topics: 6-Ketoprostaglandin F1 alpha; Amino Acid Chloromethyl Ketones; Animals; Antithrombin III; Disease Models, Animal; Epoprostenol; Factor Xa; Iloprost; Indomethacin; Injections, Intravenous; Liver; Male; Rats; Rats, Wistar; Reperfusion Injury; Sulfonium Compounds; Tryptophan	1999
Plasma and brain levels of oxindole in experimental chronic hepatic encephalopathy: effects of systemic ammonium acetate and L-tryptophan. Pharmacology & toxicology, 1999, Volume: 85, Issue:3 Topics: Acetates; Administration, Oral; Animals; Brain; Disease Models, Animal; Hepatic Encephalopathy; Indoles; Injections, Intraperitoneal; Liver; Male; Oxindoles; Portacaval Shunt, Surgical; Rats; Rats, Sprague-Dawley; Tryptophan	1999
Differential effects of L-trytophan and buspirone on biogenic amine contents and metabolism in Lurcher mice cerebellum. Neuroscience letters, 2000, Feb-25, Volume: 280, Issue:3 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Amines; Buspirone; Cerebellar Ataxia; Cerebellum; Disease Models, Animal; Dopamine; Female; Heterozygote; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Mice; Mice, Neurologic Mutants; Norepinephrine; Serotonin; Tryptophan	2000
Effects of a tryptophan deficient diet on the morphology of skeletal muscle fibers of the rat. Preliminary observations at neuroendocrinological and submicroscopical levels. Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia, 1995, Volume: 100 Suppl 1 Topics: Animals; Body Weight; Disease Models, Animal; Dwarfism, Pituitary; Female; Food, Formulated; Growth Hormone; Hypothalamo-Hypophyseal System; Microscopy, Electron; Muscle Development; Muscle Fibers, Skeletal; Muscle, Skeletal; Nutritional Physiological Phenomena; Pregnancy; Rats; Rats, Wistar; Serotonin; Tryptophan	1995
Kynurenine production and catabolism in fetal sheep with embolized or nonembolized placentas. American journal of obstetrics and gynecology, 2001, Volume: 185, Issue:4 Topics: Animals; Disease Models, Animal; Embolism; Female; Fetal Blood; Fetal Diseases; Fetal Growth Retardation; Infusions, Intravenous; Kynurenic Acid; Placenta; Placental Insufficiency; Pregnancy; Pregnancy, Animal; Probability; Quinolinic Acid; Reference Values; Sensitivity and Specificity; Sheep; Tryptophan	2001
L-tryptophan-L-kynurenine pathway metabolism accelerated by Toxoplasma gondii infection is abolished in gamma interferon-gene-deficient mice: cross-regulation between inducible nitric oxide synthase and indoleamine-2,3-dioxygenase. Infection and immunity, 2002, Volume: 70, Issue:2 Topics: Animals; Antigens, Protozoan; Antigens, Surface; Brain; Disease Models, Animal; Enzyme Inhibitors; Gene Expression; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Lung; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protozoan Proteins; RNA, Messenger; Toxoplasma; Toxoplasmosis; Tryptophan; Tryptophan Oxygenase	2002
Monitoring of immune activation using biochemical changes in a porcine model of cardiac arrest. Mediators of inflammation, 2001, Volume: 10, Issue:6 Topics: Animals; Disease Models, Animal; Heart Arrest; Immune System; Kynurenine; Neopterin; Swine; Tryptophan; Tryptophan Oxygenase	2001
Attenuation of hyperalgesia in a rat model of neuropathic pain after intrathecal pre- or post-treatment with a neurokinin-1 antagonist. Pain, 2002, Volume: 95, Issue:3 Topics: Animals; Cold Temperature; Disease Models, Animal; Hyperalgesia; Injections, Spinal; Male; Neurokinin-1 Receptor Antagonists; Nociceptors; Physical Stimulation; Rats; Rats, Long-Evans; Sciatica; Substance P; Tryptophan	2002
Pre- and postsynaptic responses to 1-(1-naphthylpiperazine) following adaptation to stress in rats. Progress in neuro-psychopharmacology & biological psychiatry, 2002, Volume: 26, Issue:1 Topics: Animals; Brain; Disease Models, Animal; Excitatory Postsynaptic Potentials; Hydroxyindoleacetic Acid; Male; Motor Activity; Piperazines; Rats; Rats, Wistar; Restraint, Physical; Serotonin; Stress, Psychological; Synaptic Transmission; Tryptophan	2002
Abundant type 10 17 beta-hydroxysteroid dehydrogenase in the hippocampus of mouse Alzheimer's disease model. Brain research. Molecular brain research, 2002, Feb-28, Volume: 99, Issue:1 Topics: 17-Hydroxysteroid Dehydrogenases; 3-Hydroxyacyl CoA Dehydrogenases; Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Protein Precursor; Animals; Base Sequence; Binding Sites; Cloning, Molecular; Disease Models, Animal; DNA, Complementary; Hippocampus; Humans; Mice; Mice, Transgenic; Mitochondria; Molecular Sequence Data; NAD; Presynaptic Terminals; Protein Isoforms; Protein Structure, Tertiary; Signal Transduction; Steroids; Tryptophan	2002
Mutagenesis of conserved tryptophan residues within the receptor-binding domain of intimin: influence on binding activity and virulence. Microbiology (Reading, England), 2002, Volume: 148, Issue:Pt 3 Topics: Adhesins, Bacterial; Amino Acid Sequence; Animals; Bacterial Adhesion; Carrier Proteins; Cell Line; Citrobacter freundii; Colon; Disease Models, Animal; Enterobacteriaceae Infections; Escherichia coli Proteins; Female; Humans; Mice; Mice, Inbred C3H; Molecular Sequence Data; Mutagenesis, Site-Directed; Receptors, Cell Surface; Tryptophan; Virulence	2002
Biochemical basis of an animal model of depressive illness--a preliminary report--. Folia psychiatrica et neurologica japonica, 1976, Volume: 30, Issue:2 Topics: Adjustment Disorders; Animals; Brain Chemistry; Conditioning, Classical; Disease Models, Animal; Humans; Hydroxyindoleacetic Acid; Liver; Male; Motor Activity; Rats; Serotonin; Tryptophan; Tryptophan Oxygenase; Tyrosine; Tyrosine Transaminase	1976
[Motor activity of tryptophan--xanthommatin metabolic pathway mutants in Drosophila melanogaster]. Doklady Akademii nauk SSSR, 1979, Volume: 246, Issue:2 Topics: Amino Acid Metabolism, Inborn Errors; Animals; Disease Models, Animal; Drosophila melanogaster; Kynurenine; Metamorphosis, Biological; Motor Activity; Mutation; Tryptophan	1979
Effect of lithium and other drugs on the amphetamine chlordiazeposice hyperactivity in mice. Experientia, 1975, Jan-15, Volume: 31, Issue:1 Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Bipolar Disorder; Brain Chemistry; Chlordiazepoxide; Disease Models, Animal; Dopamine beta-Hydroxylase; Enzyme Inhibitors; Female; Fenclonine; Humans; Hyperkinesis; Lithium; Mice; Motor Activity; Norepinephrine; Serotonin; Tryptophan	1975
Model phenylketonuria (PKU) in the albino rat: behaviroal, biochemical, and neuroanatomical effects. Journal of comparative and physiological psychology, 1975, Volume: 89, Issue:6 Topics: Animals; Axons; Body Weight; Disease Models, Animal; Emotions; Fenclonine; Humans; Learning; Liver; Motor Activity; Myelin Sheath; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Rats; Social Behavior; Tryptophan	1975
Amino acid metabolism in the chronically uremic rat. Clinical nephrology, 1975, Volume: 3, Issue:6 Topics: Amine Oxidase (Copper-Containing); Amines; Amino Acids; Animals; Argininosuccinate Lyase; Argininosuccinate Synthase; Brain; Chronic Disease; Citrulline; Dietary Proteins; Disease Models, Animal; Hydroxyindoleacetic Acid; Kidney; Liver; Monoamine Oxidase; Multienzyme Complexes; Muscles; Myocardium; Ornithine Carbamoyltransferase; Phenylalanine; Phenylalanine Hydroxylase; Rats; Tryptophan; Tryptophan Oxygenase; Tyrosine Transaminase; Uremia	1975
Influences of exogenous intake and nitrogen balance on plasma and brain aromatic amino acid concentrations. Metabolism: clinical and experimental, 1978, Volume: 27, Issue:4 Topics: Amino Acids; Animals; Disease Models, Animal; Female; Liver Diseases; Nitrogen; Octopamine; Parenteral Nutrition; Phenylalanine; Portacaval Shunt, Surgical; Rats; Tryptophan; Tyrosine	1978
Effects of long-term corn consumption on brain serotonin and the response to electric shock. Science (New York, N.Y.), 1975, Nov-14, Volume: 190, Issue:4215 Topics: Animals; Brain; Disease Models, Animal; Male; Pain; Protein-Energy Malnutrition; Rats; Serotonin; Tryptophan	1975
Experimental biharzial bladder cancer: tryptophan metabolism in nonhuman primates experimentally infected with Schistosoma haematobium. Journal of the National Cancer Institute, 1976, Volume: 56, Issue:1 Topics: 3-Hydroxyanthranilic Acid; Animals; Disease Models, Animal; Haplorhini; Kynurenine; Liver; Neoplasms, Experimental; Papio; Schistosomiasis; Tryptophan; Tryptophan Oxygenase	1976
Regional brain indoleamine metabolism following chronic portacaval anastomosis in the rat. Journal of neurochemistry, 1976, Volume: 27, Issue:2 Topics: Animals; Brain; Disease Models, Animal; Fatty Acids; Histidine; Hydroxyindoleacetic Acid; Hypothalamus; Isoleucine; Leucine; Liver Cirrhosis; Phenylalanine; Portacaval Shunt, Surgical; Rats; Serotonin; Tryptophan; Tyrosine; Valine	1976
Reduced central serotonergic activity in mania: implications for the relationship between depression and mania. The British journal of psychiatry : the journal of mental science, 1975, Volume: 126 Topics: Bipolar Disorder; Brain; Depression; Disease Models, Animal; Humans; Hydroxyindoleacetic Acid; Hypnotics and Sedatives; Imipramine; Lithium; Methysergide; Monoamine Oxidase Inhibitors; Phenylalanine; Probenecid; Serotonin; Tryptophan	1975
Tryptophan urinary bladder absorption and bladder cancer. Investigative urology, 1975, Volume: 13, Issue:1 Topics: 2-Acetylaminofluorene; Absorption; Animals; Carbon Isotopes; Disease Models, Animal; Humans; Neoplasms, Experimental; Rabbits; Tryptophan; Urinary Bladder; Urinary Bladder Neoplasms	1975
Copper chelates as possible active forms of the antiarthritic agents. Journal of medicinal chemistry, 1976, Volume: 19, Issue:1 Topics: Acetates; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Chelating Agents; Copper; Disease Models, Animal; Edema; Granuloma; Hydrocortisone; Lethal Dose 50; Mice; ortho-Aminobenzoates; Rats; Salicylates; Tryptophan; Ulcer	1976
Quinolinate in brain and cerebrospinal fluid in rat models of congenital hyperammonemia. Pediatric research, 1992, Volume: 32, Issue:4 Topics: Acetates; Ammonia; Animals; Brain; Disease Models, Animal; Hydroxyindoleacetic Acid; Male; Metabolism, Inborn Errors; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Tryptophan; Urease	1992
Environmental pathology. Mast cell and eosinophil infiltration in intestinal mucosa of Lewis rats treated with L-tryptophan implicated in human eosinophilia myalgia syndrome. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 1991, Volume: 4, Issue:3 Topics: Animals; Colon; Disease Models, Animal; Eosinophilia; Eosinophils; Female; Intestinal Mucosa; Intestine, Small; Mast Cells; Muscular Diseases; Pain; Rats; Rats, Inbred Lew; Syndrome; Tryptophan	1991
Effect of tryptophan on the behavior of nonstressed and stressed mice in Porsolt's swim test. Pharmacology, biochemistry, and behavior, 1990, Volume: 37, Issue:2 Topics: Animals; Antidepressive Agents; Disease Models, Animal; Male; Mice; Motor Activity; Psychological Tests; Stress, Psychological; Swimming; Tryptophan	1990
L-tryptophan implicated in human eosinophilia-myalgia syndrome causes fasciitis and perimyositis in the Lewis rat. The Journal of clinical investigation, 1990, Volume: 86, Issue:5 Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Cortisone; Disease Models, Animal; Eosinophilia; Fasciitis; Female; Humans; Kynurenine; Muscular Diseases; Myositis; Nucleic Acid Hybridization; Rats; Rats, Inbred Lew; RNA, Messenger; Syndrome; Tryptophan	1990
[Serotonin and tryptamine metabolism in the acute hepatic failure model--changes in tryptophan and its metabolites in the liver, brain, kidney and serum]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1990, Volume: 87, Issue:3 Topics: Acute Disease; Animals; Brain; Disease Models, Animal; Guinea Pigs; Kidney; Liver; Liver Diseases; Male; Serotonin; Tryptamines; Tryptophan	1990
Effect of bilateral olfactory bulbectomy in the rat, alone or in combination with antidepressants, on the learned immobility model of depression. Neuropsychobiology, 1985, Volume: 13, Issue:1-2 Topics: Amygdala; Animals; Depressive Disorder; Disease Models, Animal; Humans; Hydroxyindoleacetic Acid; Isoquinolines; Male; Mesencephalon; Nomifensine; Olfactory Bulb; Piperazines; Rats; Rats, Inbred Strains; Serotonin; Trazodone; Tryptophan	1985
5-HT-mediated myoclonus in the guinea pig as a model of brainstem 5-HT and tryptamine receptor action. Advances in neurology, 1986, Volume: 43 Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Brain; Carbidopa; Disease Models, Animal; Guinea Pigs; Hydroxyindoleacetic Acid; Indoles; Monoamine Oxidase Inhibitors; Myoclonus; Pargyline; Piperazine; Piperazines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Tryptamines; Tryptophan	1986
p,p'-DDT-induced myoclonus in the rat and its application as an animal model of 5-HT-sensitive action myoclonus. Advances in neurology, 1986, Volume: 43 Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Brain; Clonazepam; DDT; Disease Models, Animal; Electromyography; Electrophysiology; Hydroxyindoleacetic Acid; Male; Metergoline; Monoamine Oxidase Inhibitors; Myoclonus; Rats; Rats, Inbred Strains; Serotonin; Tryptophan	1986
Content of quinolinic acid and of other tryptophan metabolites increases in brain regions of rats used as experimental models of hepatic encephalopathy. Journal of neurochemistry, 1986, Volume: 46, Issue:3 Topics: Acetates; Animals; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Disease Models, Animal; Hepatic Encephalopathy; Hydroxyindoleacetic Acid; Male; Portacaval Shunt, Surgical; Probenecid; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Serotonin; Tryptophan	1986
Quantitative assay of glycocalyx produced by viridans group streptococci that cause endocarditis. Journal of clinical microbiology, 1989, Volume: 27, Issue:9 Topics: Animals; Disease Models, Animal; Endocarditis, Bacterial; Glycoproteins; Humans; Polysaccharides; Rabbits; Staining and Labeling; Streptococcal Infections; Streptococcus; Tryptophan	1989
Liver tryptophan pyrrolase. A major determinant of the lower brain 5-hydroxytryptamine concentration in alcohol-preferring C57BL mice. The Biochemical journal, 1989, Dec-01, Volume: 264, Issue:2 Topics: Alcoholism; Animals; Brain; Disease Models, Animal; Homeostasis; Hydroxyindoleacetic Acid; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Reference Values; Serotonin; Tryptophan; Tryptophan Oxygenase	1989
Comparative dual-tracer studies of carbon-14 tryptophan and iodine-131 HIPDM in animal models of pancreatic diseases. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1989, Volume: 30, Issue:11 Topics: Animals; Autoradiography; Carbon Radioisotopes; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Iodine Radioisotopes; Iodobenzenes; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C57BL; Pancreatic Diseases; Protein Biosynthesis; Radionuclide Imaging; Tissue Distribution; Tryptophan; Whole-Body Counting	1989
Low doses of L-tryptophan are lethal in rats with adrenal insufficiency. Life sciences, 1987, Jul-20, Volume: 41, Issue:3 Topics: Adrenal Insufficiency; Adrenalectomy; Animals; Corticosterone; Disease Models, Animal; Lethal Dose 50; Liver; Male; Metyrapone; Rats; Rats, Inbred Strains; Tryptophan; Tryptophan Oxygenase	1987
N-3-pyridylmethyl-N'-p-nitrophenylurea ocular toxicity in man and an animal model. Transactions of the American Ophthalmological Society, 1986, Volume: 84 Topics: Adolescent; Adult; Aniline Compounds; Animals; Diabetes Mellitus, Type 1; Disease Models, Animal; Electroretinography; Evoked Potentials, Visual; Eye Diseases; Female; Gentamicins; Humans; Male; Phenylurea Compounds; Rabbits; Rodenticides; Tryptophan	1986
Elevated brain tryptophan and enhanced 5-hydroxytryptamine turnover in acute hepatic heme deficiency: clinical implications. The Journal of pharmacology and experimental therapeutics, 1985, Volume: 232, Issue:2 Topics: Animals; Brain; Cytochrome P-450 Enzyme Inhibitors; Disease Models, Animal; Heme; Liver; Liver Diseases; Male; Morphine; Porphyrias; Rats; Rats, Inbred Strains; Serotonin; Tryptophan	1985
Immunopharmacological disease: a break in tolerance to receptor sites. Lancet (London, England), 1971, Mar-27, Volume: 1, Issue:7700 Topics: Animals; Autoantibodies; Autoimmune Diseases; Cell Membrane; Chemoreceptor Cells; Disease Models, Animal; Encephalomyelitis; Humans; Multiple Sclerosis; Myasthenia Gravis; Tryptophan	1971
Plasma amino acids in dogs with two experimental forms of liver damage. The Journal of surgical research, 1974, Volume: 16, Issue:4 Topics: Amino Acids; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dogs; Fluorometry; Liver; Liver Diseases; Nitrosamines; Portacaval Shunt, Surgical; Tryptophan	1974
Plasma amino acids in experimental acute hepatic failure and their relationship to brain tryptophan. Clinical science and molecular medicine, 1974, Volume: 46, Issue:4 Topics: Acute Disease; Alanine; Amino Acids; Animals; Brain Chemistry; Disease Models, Animal; Glycine; Hepatic Encephalopathy; Liver Diseases; Methionine; Swine; Tryptophan	1974
Indole metabolism and behavior in dog. Biological psychiatry, 1972, Volume: 4, Issue:1 Topics: Amino Acids; Animal Nutritional Physiological Phenomena; Animals; Behavior, Animal; Brain; Brain Chemistry; Depression; Disease Models, Animal; Dogs; Electrodes, Implanted; Electroencephalography; Evaluation Studies as Topic; Female; Housing, Animal; Humans; Indoles; Male; Portacaval Shunt, Surgical; Tranylcypromine; Tryptophan	1972
Alterations of individual free amino acids in brain during acute hepatic coma. Surgery, gynecology & obstetrics, 1970, Volume: 130, Issue:2 Topics: Amino Acids; Animals; Brain Chemistry; Cerebral Cortex; Disease Models, Animal; Dogs; Hepatic Encephalopathy; Histidine; Liver; Models, Biological; Nitrogen; Phenylalanine; Tryptophan; Tyrosine; Water	1970
The effect of penicillamine on seizure threshold. The role of pyridoxine. Archives of neurology, 1970, Volume: 23, Issue:1 Topics: Animals; Disease Models, Animal; Male; Myoclonus; Penicillamine; Pyridoxine; Rats; Seizures; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates	1970
[Some aspects of the metabolism and balance of tryptophan in patients with Far Eastern hemorrhagic fever with renal syndrome]. Terapevticheskii arkhiv, 1970, Volume: 42, Issue:9 Topics: Acute Kidney Injury; Adult; Animals; Disease Models, Animal; Female; Hemorrhagic Fevers, Viral; Humans; Male; Rabbits; Tryptophan	1970