Compounds > tryptophan

tryptophan and Disease Exacerbation

tryptophan has been researched along with Disease Exacerbation in 80 studies

Research

Studies (80)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (1.25)18.2507
2000's16 (20.00)29.6817
2010's43 (53.75)24.3611
2020's20 (25.00)2.80

Authors

AuthorsStudies
Agami, R; Altelaar, M; Berkers, CR; Bleijerveld, OB; Blommaert, N; Champagne, J; Faller, WJ; Kenski, J; Nagel, R; Pataskar, A; Peeper, DS; Ramalho, S; Wernaart, D; Zaal, EA1
Guo, W; Liu, Y; Qu, W; Song, W; Sun, LY; Wei, L; Zeng, ZG; Zhang, HM; Zhu, ZJ1
Guan, W; Li, F; Zhang, Y; Zhang, Z; Zhao, Z1
Albóniga-Díez, OE; Barbas, C; Bartolome-Sánchez, S; Blanca-López, N; Blancas, R; Brochado-Kith, O; Ceballos, FC; Cuadros-González, J; Fernández-Rodríguez, A; Jiménez-Sousa, MÁ; Martin-Vicente, M; Martínez, I; Martinez-Acitores, IR; Martínez-González, O; Peréz-García, F; Resino, S; Ryan, P; Vidal-Alcántara, EJ; Virseda-Berdices, A1
Cadnapaphornchai, MA; Chonchol, M; Christians, U; Gitomer, BY; Hopp, K; Jackson, MJ; Klawitter, J; Smith, PH1
Chen, L; Chen, Y; Li, H; Sun, D; Xiang, K; Yang, Y; Zhang, J1
Bäckhed, F; Buffa, JA; Demuth, I; Fischbach, MA; Haghikia, A; Hazen, SL; König, M; Landmesser, U; Li, L; Li, XS; Nemet, I; Romano, KA; Steinhagen-Thiessen, E; Tang, WHW; Wilcox, J; Witkowski, M1
Ang, K; Ching, J; Gurung, RL; Kestenbaum, BR; Kovalik, JP; Lee, J; Lee, LS; Lim, SC; Liu, JJ; Liu, S; M, Y; Shao, YM; Sharma, K; Subramaniam, T; Sum, CF; Wee, HN; Zheng, H1
Hara, T; Kaneda, Y; Kanemura, N; Kitagawa, J; Matsumoto, T; Mizutani, T; Nakamura, H; Nakamura, N; Ninomiya, S; Shimizu, M; Shiraki, M; Tsurumi, H; Yamaguchi, K1
Clauss, D; Pal, A; Schmidt, ME; Steindorf, K; Ulrich, CM; Wiskemann, J; Zimmer, P1
Benkowitz, P; Cheng, Y; Köttgen, A; Lamina, C; Li, Y; Sekula, P1
Brito, RBO; Camacho, CP; Dalmazzo, SV; de Almeida, RJ; Dellê, H; Matheus, LHG; Pereira, LA1
Guddati, AK; Jillella, A; Karim, NA; Kolhe, R; Kota, V; Sobash, PT1
Bastos, VAF; Colli, LM; Corrêa, NCR; da Silva, LS; Ferreira, ICC; Fujimura, PT; Goulart, LR; Goulart, VA; Laus, AC; Leal, LF; Marangoni, K; Martins, MM; Reis, RM; Santos, PS; Souza, AG; Thomé, CH1
Fukaya, K; Ichino, M; Maeda, Y; Muto, Y; Nagakawa, T; Nukaya, T; Saito, K; Sasaki, H; Shiogama, K; Shiroki, R; Sumitomo, M; Takahara, K; Takenaka, M; Yamamoto, Y; Zennami, K1
Beck, J; Daka, K; Delev, D; Grauvogel, J; Heiland, DH; Krüger, MT; Masalha, W; Pompe, N; Schnell, O; Weber, S; Woerner, J1
Cao, T; Li, X; Lin, B; Liu, C; Luo, S; Shi, J; Wang, S; Zhang, X; Zheng, T; Zhou, M1
Lachota, M; Lennikov, A; Malmberg, KJ; Zagozdzon, R1
Bencsik, K; Fricska-Nagy, Z; Sandi, D; Vécsei, L1
Cheng, J; Gao, X; Hou, X; Jin, H; Lv, J; Zheng, G1
Bernasconi, L; Christ-Crain, M; Henzen, C; Hoess, C; Huber, A; Meier, MA; Mueller, B; Ottiger, M; Schuetz, P; Steuer, C; Thomann, R; Vögeli, A; Zimmerli, W1
Chen, IW; Chen, ST; Chiu, DT; Chou, CA; Lin, CN1
Huang, L; Jin, JY; Jolly, S; Kong, FS; Li, L; Mellor, AL; Pi, W; Wang, W; Wu, H; Yan, L; Zang, Y1
Czarny, P; Galecki, P; Sliwinski, T; Wigner, P1
Brunet-Vega, A; Calvet, X; Gombau, L; Junquera, F; Lario, S; Pericay, C; Quintás, G; Ramírez-Lázaro, MJ; Sanjuan-Herráez, D1
Anastos, K; Burk, RD; Clish, CB; Glesby, MJ; Haberlen, SA; Hanna, DB; Hodis, HN; Hua, S; Kaplan, RC; Landay, AL; Lazar, JM; Post, WS; Qi, Q; Scott, JM; Shah, SJ; Wang, T1
Appel, LJ; Arking, DE; Bottinger, E; Coresh, J; Evans, AM; Grams, ME; Inker, LA; Levey, AS; Lipkowitz, MS; Nadkarni, G; Rebholz, CM; Sarnak, MJ; Tin, A; Winkler, CA1
Botticelli, A; Cerbelli, B; Federica, M; Lionetto, L; Marchetti, P; Nuti, M; Pisano, A; Salati, M; Simmaco, M; Zizzari, I1
Amit-Yousif, AJ; Barger, GR; Bosnyák, E; John, F; Juhász, C; Klinger, NV; Michelhaugh, SK; Mittal, S; Robinette, NL; Shah, KD1
Atzler, D; Lacy, M; Nitz, K1
Baldessarini, RJ; Comparelli, A; Corigliano, V; Curto, M; Fazio, F; Ferracuti, S; Lionetto, L; Nicoletti, F; Simmaco, M1
Argyopoulos, CP; Bayliss, GP; Cao, G; Chen, DQ; Chen, H; Chen, L; Cheng, XH; Guo, Y; Kang, H; Li, XR; Liu, D; Ma, SX; Mao, JR; Meng, MX; Samuels, DC; Shang, YQ; Su, W; Vaziri, ND; Wang, M; Ye, F; Yu, H; Yu, XY; Zhang, L; Zhang, Y; Zhao, J; Zhao, S; Zhao, YY; Zhuang, S1
Fan, JG; Zhou, D1
Cheong, IS; Jou, YC; Tsai, HT; Tsai, YS; Tzai, TS1
Arnold, JM; Bader, DA; Cao, Q; Coarfa, C; Devarakonda, V; Donepudi, SR; Dubrulle, J; Jain, AK; Karanam, B; Kavuri, SM; Lotan, Y; Ma, J; Maity, S; McGuire, SE; Putluri, N; Putluri, V; Rajapakshe, K; Sikora, AG; Sreekumar, A; Stossi, F; Vantaku, V; Villanueva, H; von Rundstedt, FC1
Albright, RG; Broadhurst, MJ; Deeks, SG; Dunham, RM; Hernandez, RD; Huang, Y; Hunt, PW; Iwai, S; Lederman, MM; Lynch, SV; Maher, MC; McCune, JM; Somsouk, M; Vujkovic-Cvijin, I1
Dijkhuis, A; Johnston, SL; Karlas, JA; Kulik, W; Lutter, R; Molenkamp, R; Smids, BS; Sterk, PJ; van de Pol, MA; van der Sluijs, KF; van der Zee, JS; van Eijk, HW; Wolthers, KC1
Le, V; Lin, S; Liu, J; Que, Z; Tian, J; Zhang, A; Zhang, L; Zheng, Y1
Iida, S; Inagaki, A; Inagaki, H; Ishida, T; Ito, A; Kinoshita, S; Komatsu, H; Kusumoto, S; Maeda, Y; Masaki, A; Narita, T; Niimi, A; Ogura, H; Ri, M; Suzuki, S; Takino, H; Totani, H; Ueda, R; Utsunomiya, A; Yoshida, T1
Boulet, L; Faure, P; Flore, P; Le Gouellec, A; Pépin, JL; Toussaint, B1
Aeinehband, S; Bhat, M; Brenner, P; Engberg, G; Erhardt, S; Fidock, MD; Jokinen, J; Khademi, M; Olsson, T; Piehl, F; Ståhl, S1
Bieber, T; Hinz, T; Novak, N; Staudacher, A; von Bubnoff, D1
Ju, JH; Jung, BH; Jung, SM; Kang, KY; Lee, SH; Park, SH1
Costiniuk, CT; Jenabian, MA; Kema, I; Klein, MB; Mehraj, V; Paulino Ramirez, R; Rollet, K; Routy, JP; Vyboh, K1
Barger, GR; Bosnyák, E; Juhász, C; Kamson, DO; Mittal, S; Robinette, NL1
Dabrowska, M; Jasiewicz, M; Kaminski, KA; Kazimierczyk, R; Knapp, M; Moniuszko, M; Musial, WJ; Pawlak, D; Rusak, M1
Cheng, M; Liu, X; Liu, Y; Xiao, H1
Rodriguez, M; Watzlawik, JO; Wootla, B1
Brunet-Vega, A; Calvet, X; Gombau, L; Junquera, F; Kuligowski, J; Lario, S; Pericay, C; Quintás, G; Ramírez-Lázaro, MJ; Sanjuan-Herráez, D; Vázquez-Sánchez, MA1
Broeckling, CD; Griffin, TJ; Gulcev, M; Hodgson, SW; Reilly, C; Sandri, BJ; Wendt, CH; Witthuhn, BA; Woodruff, PG1
Li, D; Li, M; Liu, Y; Mei, J; Tang, L; Wei, C; Zhu, X1
Devlin, AS; Dodd, D; Fischbach, MA; Marcobal, A; Meyer, T; Nayfach, S; Plummer, N; Pollard, KS; Sonnenburg, JL1
Chida, K; Fujie, M; Furuhashi, K; Hahimoto, D; Inui, N; Nakamura, H; Nakamura, Y; Suda, T; Suzuki, M; Suzuki, Y1
Adams, JR; Ely, EW; Girard, TD; Morandi, A; Pandharipande, PP; Shintani, AK; Thompson, JL1
Akimoto, H; Inaba, T; Ino, K; Kajiyama, H; Kikkawa, F; Nagasaka, T; Nawa, A; Shibata, K; Takikawa, O; Yamamoto, E1
Murray, MF1
Aweeka, F; Barbour, JD; Brenchley, JM; Deeks, SG; Douek, DC; Favre, D; Hecht, FM; Huang, Y; Hunt, PW; Jayawardene, A; Kanwar, B; Loke, P; Lowe, MM; Martin, JN; McCune, JM; Mold, J; Seu, L1
Bergh, A; Ivars, F; Källberg, E; Leanderson, T; Wikström, P1
Mete, G; Ozkan, Y; Sepici, V; Sepici-Dincel, A; Simsek, B1
Begg, DJ; de Silva, K; Earl, J; Plain, KM; Purdie, AC; Whittington, RJ1
Bosire, R; Brown, ER; Choi, RY; Farquhar, C; Fowke, KR; John-Stewart, G; Juno, J; Lohman-Payne, B; Oyugi, JO1
Guillemin, GJ; Jestaedt, L; Jugold, M; Lehmann, I; Litzenburger, UM; Lutz, C; Miller, CL; Opitz, CA; Ott, M; Platten, M; Radlwimmer, B; Sahm, F; Schrenk, D; Schumacher, T; Tritschler, I; Trump, S; von Deimling, A; Weller, M; Wick, W1
Schulman, G1
Ando, T; Andou, A; Hashimoto, M; Hibi, T; Hisamatsu, T; Inoue, N; Iwao, Y; Kanai, T; Kitazume, MT; Matsuoka, K; Muramatsu, T; Ogata, H; Okamoto, S; Ono, N; Sakai, R; Suzuki, M; Uo, M; Yajima, T; Yamakado, M1
Anderson, G; Maes, M1
Sakurai, K; Shearer, GM; Tschetter, JR; Ward, JM; Zou, JP1
Bader, M; Bauer, A; Bauer, I; Grasshoff, U; Holzmann, C; Jones, L; Kask, A; Kobbe, P; Krotova, J; Landwehrmeyer, B; Li, XJ; Lindenberg, KS; Nguyen, HP; Pabst, R; Paul, M; Rathke-Hartlieb, S; Riess, O; Schmidt, T; Schmitt, I; Schulz, JB; Stiller, D; Vaarmann, A; Vieira-Saecker, AM; von Hörsten, S; Walther, T1
Bwanaisa, L; Day, NP; Hunt, NH; Kayira, K; Medana, IM; Njobvu, A; Salahifar-Sabet, H; Smythe, G; Stocker, R; Taylor, TE; Turner, GD1
Hermann, R; Ilonen, J; Kakko, T; Kiviniemi, M; Knip, M; Lipponen, K; Simell, O; Veijola, R1
Burns, TM; Dimberg, EL; Klein, CJ; Phillips, LH; Vaught, BK1
Fuchs, D; Murr, C; Richardsen, L; Weinlich, G; Winkler, C1
Denz, HA; Fiegl, M; Fuchs, D; Prassl, K; Schroecksnadel, K; Winkler, C1
Marmorstein, AD; Marmorstein, LY; McLaughlin, PJ; Peachey, NS; Sasaki, T1
Buchner, A; Castro, M; Eder, M; Hatz, RA; Hofstetter, A; Kammerer, R; Popp, T; Riesenberg, R; Spring, O; Stief, CG; Takikawa, O; Weiler, C; Zimmermann, W1
Fuchs, D; Kemmler, G; Mumelter, B; Sarcletti, M; Schroecksnadel, K; Weiss, G; Winkler, C; Zangerle, R1
Birlouez-Aragon, I; Junes, P; Mondon, H; Moreaux, V; Tessier, F1
Bowering, TA; Grewal, A; Lam, RW; Shiah, IS; Tam, EM; Yatham, LN; Zis, AP1
Baba, T; Nakajima, S1
Fuchs, D; Ledochowski, M; Murr, C; Schubert, C; Sperner-Unterweger, B; Widner, B1
Büssemaker, E; Franz, T; Gross, P; Passauer, J1

Reviews

9 review(s) available for tryptophan and Disease Exacerbation

ArticleYear
Kynurenine-3-monooxygenase (KMO): From its biological functions to therapeutic effect in diseases progression.
    Journal of cellular physiology, 2022, Volume: 237, Issue:12

    Topics: Disease Progression; Humans; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Neurodegenerative Diseases; Tryptophan

2022
Role of indoleamine 2,3-dioxygenase in acute myeloid leukemia.
    Future oncology (London, England), 2020, Volume: 16, Issue:36

    Topics: Antineoplastic Agents; Cell Differentiation; Dendritic Cells; Disease Progression; Gene Expression Regulation, Leukemic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Leukemia, Myeloid, Acute; Prognosis; Progression-Free Survival; Protein Processing, Post-Translational; Survival Rate; T-Lymphocytes, Regulatory; Tryptophan; Tumor Escape; Tumor Microenvironment; Up-Regulation

2020
Neurodegeneration in Multiple Sclerosis: Symptoms of Silent Progression, Biomarkers and Neuroprotective Therapy-Kynurenines Are Important Players.
    Molecules (Basel, Switzerland), 2021, Jun-05, Volume: 26, Issue:11

    Topics: Animals; Biomarkers; Disease Progression; Humans; Kynurenine; Molecular Targeted Therapy; Multiple Sclerosis; Neurodegenerative Diseases; Signal Transduction; Tryptophan

2021
Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders.
    Psychiatria Danubina, 2017, Volume: 29, Issue:4

    Topics: Antidepressive Agents; Antioxidants; Biomarkers; Depression; Depressive Disorder; Disease Progression; Humans; Inflammation; Kynurenine; Metabolic Networks and Pathways; Nitric Oxide Synthase; Nitrosative Stress; Oxidative Stress; Quality of Life; Quinolinic Acid; Tryptophan

2017
Amino Acids and Their Metabolism in Atherosclerosis.
    Arteriosclerosis, thrombosis, and vascular biology, 2019, Volume: 39, Issue:3

    Topics: Amino Acids; Animals; Arginase; Arginine; Atherosclerosis; Disease Progression; Endothelial Cells; Endothelium, Vascular; Homoarginine; Humans; Hypercholesterolemia; Indoleamine-Pyrrole 2,3,-Dioxygenase; Lymphocyte Subsets; Molecular Targeted Therapy; Nitric Oxide Synthase; Tryptophan; Vasculitis

2019
Microbial metabolites in non-alcoholic fatty liver disease.
    World journal of gastroenterology, 2019, May-07, Volume: 25, Issue:17

    Topics: Bile Acids and Salts; Disease Progression; Ethanol; Fatty Acids, Volatile; Fermentation; Gastrointestinal Microbiome; Humans; Liver; Methylamines; Non-alcoholic Fatty Liver Disease; Prebiotics; Reproducibility of Results; Risk Factors; Signal Transduction; Tryptophan

2019
Tryptophan Catabolites and Their Impact on Multiple Sclerosis Progression.
    Current pharmaceutical design, 2016, Volume: 22, Issue:8

    Topics: Animals; Disease Progression; Humans; Multiple Sclerosis; Tryptophan

2016
A nexus of progression of chronic kidney disease: tryptophan, profibrotic cytokines, and charcoal.
    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 2012, Volume: 22, Issue:1

    Topics: Adsorption; Carbon; Disease Progression; Fibrosis; Humans; Indican; Intestinal Absorption; Kidney Failure, Chronic; Microspheres; Oxides; Renin-Angiotensin System; Transforming Growth Factor beta; Tryptophan

2012
Schizophrenia: linking prenatal infection to cytokines, the tryptophan catabolite (TRYCAT) pathway, NMDA receptor hypofunction, neurodevelopment and neuroprogression.
    Progress in neuro-psychopharmacology & biological psychiatry, 2013, Apr-05, Volume: 42

    Topics: Animals; Brain; Cytokines; Disease Progression; Female; Humans; Infections; Pregnancy; Prenatal Exposure Delayed Effects; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Tryptophan

2013

Trials

3 trial(s) available for tryptophan and Disease Exacerbation

ArticleYear
Resistance Exercise Modulates Kynurenine Pathway in Pancreatic Cancer Patients.
    International journal of sports medicine, 2021, Volume: 42, Issue:1

    Topics: Biomarkers; Disease Progression; Down-Regulation; Humans; Interleukin-6; Kynurenine; Metabolic Networks and Pathways; Middle Aged; Pancreatic Neoplasms; Resistance Training; Tryptophan

2021
Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria.
    The Journal of infectious diseases, 2003, Sep-15, Volume: 188, Issue:6

    Topics: Adult; Child; Child, Preschool; Disease Progression; Humans; Kynurenine; Malaria, Cerebral; Malawi; Picolinic Acids; Quinolinic Acid; Retrospective Studies; Tryptophan; Vietnam

2003
Effects of rapid tryptophan depletion in patients with seasonal affective disorder in natural summer remission.
    Psychological medicine, 2000, Volume: 30, Issue:1

    Topics: Adult; Disease Progression; Female; Humans; Male; Phototherapy; Remission, Spontaneous; Seasonal Affective Disorder; Seasons; Tryptophan

2000

Other Studies

68 other study(ies) available for tryptophan and Disease Exacerbation

ArticleYear
Oncogene-dependent sloppiness in mRNA translation.
    Molecular cell, 2021, 11-18, Volume: 81, Issue:22

    Topics: Animals; Carcinogenesis; Cell Membrane; Disease Progression; Drug Resistance, Neoplasm; Frameshift Mutation; Frameshifting, Ribosomal; Humans; Immunotherapy; MAP Kinase Signaling System; Melanoma; Mice; Neoplasms; Oncogenes; Peptides; Protein Biosynthesis; Protein Kinase Inhibitors; Ribosomes; RNA, Messenger; T-Lymphocytes; Tryptophan

2021
Association of Gut Microbiota and Metabolites With Disease Progression in Children With Biliary Atresia.
    Frontiers in immunology, 2021, Volume: 12

    Topics: Bile Acids and Salts; Biliary Atresia; Disease Progression; Dysbiosis; Female; Gastrointestinal Microbiome; Humans; Infant; Infant, Newborn; Male; Tryptophan

2021
Tryptophan metabolism induced by TDO2 promotes prostatic cancer chemotherapy resistance in a AhR/c-Myc dependent manner.
    BMC cancer, 2021, Oct-17, Volume: 21, Issue:1

    Topics: Animals; ATP-Binding Cassette Transporters; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Cell Nucleus; Disease Progression; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Gene Expression; Genes, myc; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Mice, Inbred NOD; Mice, SCID; NF-kappa B; Prostatic Neoplasms; Receptors, Aryl Hydrocarbon; Reverse Transcriptase Polymerase Chain Reaction; Transcriptional Activation; Tryptophan; Up-Regulation

2021
Metabolic Profiling at COVID-19 Onset Shows Disease Severity and Sex-Specific Dysregulation.
    Frontiers in immunology, 2022, Volume: 13

    Topics: COVID-19; Cross-Sectional Studies; Cytokines; Disease Progression; Female; Humans; Kynurenine; Male; Retrospective Studies; SARS-CoV-2; Severity of Illness Index; Tryptophan

2022
Kynurenines in polycystic kidney disease.
    Journal of nephrology, 2023, Volume: 36, Issue:1

    Topics: Adult; Child; Disease Progression; Glomerular Filtration Rate; Humans; Inflammation; Kidney; Kynurenine; Polycystic Kidney, Autosomal Dominant; Tryptophan

2023
Atlas of gut microbe-derived products from aromatic amino acids and risk of cardiovascular morbidity and mortality.
    European heart journal, 2023, 08-22, Volume: 44, Issue:32

    Topics: Amino Acids, Aromatic; Animals; Disease Progression; Gastrointestinal Microbiome; Glucuronides; Glutamine; Humans; Indoles; Mice; Myocardial Infarction; Tryptophan; Tyrosine

2023
Plasma Tryptophan-Kynurenine Pathway Metabolites and Risk for Progression to End-Stage Kidney Disease in Patients With Type 2 Diabetes.
    Diabetes care, 2023, Dec-01, Volume: 46, Issue:12

    Topics: Diabetes Mellitus, Type 2; Disease Progression; Humans; Kidney Failure, Chronic; Kynurenic Acid; Kynurenine; Tryptophan

2023
Low Levels of Serum Tryptophan Underlie Skeletal Muscle Atrophy.
    Nutrients, 2020, Apr-01, Volume: 12, Issue:4

    Topics: Amino Acids; Animals; Cell Proliferation; Cells, Cultured; Citric Acid Cycle; Disease Progression; Glycolysis; Indoleamine-Pyrrole 2,3,-Dioxygenase; Mice, Inbred C57BL; Muscular Atrophy; Myoblasts; Neoplasms; Sarcopenia; Tryptophan

2020
The relationship between blood metabolites of the tryptophan pathway and kidney function: a bidirectional Mendelian randomization analysis.
    Scientific reports, 2020, 07-29, Volume: 10, Issue:1

    Topics: Biomarkers; Disease Progression; Glomerular Filtration Rate; Humans; Indican; Indoles; Kynurenine; Mendelian Randomization Analysis; Renal Insufficiency, Chronic; Tryptophan

2020
1-Methyl-D-tryptophan activates aryl hydrocarbon receptor, a pathway associated with bladder cancer progression.
    BMC cancer, 2020, Sep-09, Volume: 20, Issue:1

    Topics: Aged; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1B1; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Humans; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Receptors, Aryl Hydrocarbon; Signal Transduction; Tryptophan; Urinary Bladder Neoplasms

2020
Cell-free DNA promotes malignant transformation in non-tumor cells.
    Scientific reports, 2020, 12-10, Volume: 10, Issue:1

    Topics: Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Circulating Tumor DNA; Disease Progression; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Hyaluronan Receptors; Male; Matrix Metalloproteinase 9; MicroRNAs; Prostatic Neoplasms; Tryptophan

2020
Tryptophan 2,3-dioxygenase in tumor cells is associated with resistance to immunotherapy in renal cell carcinoma.
    Cancer science, 2021, Volume: 112, Issue:3

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cell Line, Tumor; Chemotherapy, Adjuvant; Disease Progression; Drug Resistance, Neoplasm; Female; Humans; Immune Checkpoint Inhibitors; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kidney; Kidney Neoplasms; Kynurenine; Male; Middle Aged; Nephrectomy; Progression-Free Survival; Tryptophan; Tryptophan Oxygenase

2021
Metabolic alterations in meningioma reflect the clinical course.
    BMC cancer, 2021, Mar-01, Volume: 21, Issue:1

    Topics: Aged; Algorithms; Biomarkers, Tumor; Choline; Cluster Analysis; Disease Progression; Female; Glycine; Humans; Male; Meningeal Neoplasms; Meningioma; Middle Aged; Neoplasm Grading; Nuclear Magnetic Resonance, Biomolecular; Progression-Free Survival; Serine; Treatment Outcome; Tryptophan

2021
STING agonist and IDO inhibitor combination therapy inhibits tumor progression in murine models of colorectal cancer.
    Cellular immunology, 2021, Volume: 366

    Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Carcinogenesis; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Disease Models, Animal; Disease Progression; Female; Humans; Immune Checkpoint Inhibitors; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Membrane Proteins; Mice; Mice, Inbred C57BL; Myeloid-Derived Suppressor Cells; Neoplasm Transplantation; Programmed Cell Death 1 Receptor; Tryptophan

2021
Bioinformatic Analysis Reveals Central Role for Tumor-Infiltrating Immune Cells in Uveal Melanoma Progression.
    Journal of immunology research, 2021, Volume: 2021

    Topics: Adult; Aged; Aged, 80 and over; Carcinogenesis; CD8-Positive T-Lymphocytes; Computational Biology; Data Mining; Disease Progression; Female; Humans; Lymphocytes, Tumor-Infiltrating; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Tryptophan; Uveal Neoplasms; Young Adult

2021
Disturbed tryptophan metabolism correlating to progression and metastasis of esophageal squamous cell carcinoma.
    Biochemical and biophysical research communications, 2017, 05-06, Volume: 486, Issue:3

    Topics: 5-Hydroxytryptophan; Aged; Biomarkers, Tumor; Carcinoma, Squamous Cell; Case-Control Studies; Disease Progression; Early Diagnosis; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Female; Humans; Hydroxyindoleacetic Acid; Kynurenine; Lymphatic Metastasis; Male; Metabolome; Middle Aged; Prognosis; Serotonin; Tryptophan

2017
Activation of the Serotonin Pathway is Associated with Poor Outcome in COPD Exacerbation: Results of a Long-Term Cohort Study.
    Lung, 2017, Volume: 195, Issue:3

    Topics: Aged; Aged, 80 and over; Biomarkers; C-Reactive Protein; Calcitonin; Chromatography, Liquid; Disease Progression; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kaplan-Meier Estimate; Kynurenine; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Oxygen; Prognosis; Proportional Hazards Models; Pulmonary Disease, Chronic Obstructive; Randomized Controlled Trials as Topic; Risk Factors; Serotonin; Switzerland; Tandem Mass Spectrometry; Time Factors; Tryptophan; Tryptophan Hydroxylase

2017
Tryptophan as a surrogate prognostic marker for diabetic nephropathy.
    Journal of diabetes investigation, 2018, Volume: 9, Issue:2

    Topics: Adult; Biomarkers; Diabetic Nephropathies; Disease Progression; Female; Humans; Male; Middle Aged; Prognosis; Prospective Studies; Sensitivity and Specificity; Tryptophan

2018
IDO Immune Status after Chemoradiation May Predict Survival in Lung Cancer Patients.
    Cancer research, 2018, 02-01, Volume: 78, Issue:3

    Topics: Adenocarcinoma; Aged; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Chemoradiotherapy; Disease Progression; Female; Follow-Up Studies; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lung Neoplasms; Male; Prognosis; Prospective Studies; Survival Rate; Tryptophan

2018
Plasma sample based analysis of gastric cancer progression using targeted metabolomics.
    Scientific reports, 2017, 12-19, Volume: 7, Issue:1

    Topics: Adult; Aged; Biomarkers, Tumor; Disease Progression; Female; Gastritis; Helicobacter Infections; Humans; Male; Metabolic Networks and Pathways; Metabolome; Metabolomics; Middle Aged; Phenylalanine; Plasma; Stomach; Stomach Neoplasms; Tryptophan

2017
Plasma Tryptophan-Kynurenine Metabolites Are Altered in Human Immunodeficiency Virus Infection and Associated With Progression of Carotid Artery Atherosclerosis.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018, 07-02, Volume: 67, Issue:2

    Topics: Adult; Biomarkers; Carotid Arteries; Carotid Artery Diseases; Disease Progression; Female; HIV Infections; Humans; Kynurenine; Male; Middle Aged; Prospective Studies; Tryptophan

2018
Serum 6-Bromotryptophan Levels Identified as a Risk Factor for CKD Progression.
    Journal of the American Society of Nephrology : JASN, 2018, Volume: 29, Issue:7

    Topics: Adult; Aged; Alleles; Apolipoprotein L1; Biomarkers; Black or African American; Cohort Studies; Disease Progression; Female; Genotype; Humans; Male; Middle Aged; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Renal Insufficiency, Chronic; Risk Factors; Tryptophan; White People

2018
Can IDO activity predict primary resistance to anti-PD-1 treatment in NSCLC?
    Journal of translational medicine, 2018, 08-06, Volume: 16, Issue:1

    Topics: Aged; Carcinoma, Non-Small-Cell Lung; Disease Progression; Drug Resistance, Neoplasm; Female; Humans; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kaplan-Meier Estimate; Kynurenine; Lung Neoplasms; Male; Multivariate Analysis; Programmed Cell Death 1 Receptor; Quinolinic Acid; Tryptophan

2018
Multimodal imaging-defined subregions in newly diagnosed glioblastoma: impact on overall survival.
    Neuro-oncology, 2019, 02-14, Volume: 21, Issue:2

    Topics: Diffusion Magnetic Resonance Imaging; Disease Progression; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Middle Aged; Multimodal Imaging; Neoplasm Recurrence, Local; Positron-Emission Tomography; Prognosis; Survival Rate; Tryptophan

2019
Serum xanthurenic acid levels: Reduced in subjects at ultra high risk for psychosis.
    Schizophrenia research, 2019, Volume: 208

    Topics: Adolescent; Adult; Disease Progression; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Prodromal Symptoms; Psychotic Disorders; Quinolinic Acid; Risk; Schizophrenia; Tryptophan; Xanthurenates; Young Adult

2019
Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan.
    Nature communications, 2019, 04-01, Volume: 10, Issue:1

    Topics: Acetylcarnitine; Animals; Canavanine; Carnitine; Case-Control Studies; Disease Models, Animal; Disease Progression; Fibrosis; Gene Knock-In Techniques; Gene Knockdown Techniques; Humans; I-kappa B Proteins; Inflammation; Kelch-Like ECH-Associated Protein 1; Kidney; Metabolomics; Mice; NF-E2-Related Factor 2; NF-kappa B; Renal Insufficiency, Chronic; Severity of Illness Index; Signal Transduction; Taurine; Tryptophan; Tryptophan Hydroxylase; Ureteral Obstruction

2019
Indoleamine-2,3-dioxygenase-1 expression predicts poorer survival and up-regulates ZEB2 expression in human early stage bladder cancer.
    Urologic oncology, 2019, Volume: 37, Issue:11

    Topics: Aged; Carcinoma, Transitional Cell; Cell Line, Tumor; Disease Progression; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Male; MicroRNAs; Middle Aged; Prognosis; RNA, Messenger; Signal Transduction; Survival Rate; Treatment Outcome; Tryptophan; Urinary Bladder Neoplasms; Zinc Finger E-box Binding Homeobox 2

2019
Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression.
    Oncogene, 2020, Volume: 39, Issue:40

    Topics: Aldehyde Oxidase; Animals; Cell Line, Tumor; Disease Progression; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Kynurenine; Male; Metabolomics; Mice; NADP; Neoplasm Invasiveness; Neoplasm Staging; Nucleotides; Pentose Phosphate Pathway; RNA-Seq; Tissue Array Analysis; Tryptophan; Urinary Bladder; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays

2020
Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism.
    Science translational medicine, 2013, Jul-10, Volume: 5, Issue:193

    Topics: Animals; Antiretroviral Therapy, Highly Active; Bacteria; Biomarkers; Case-Control Studies; Disease Progression; Dysbiosis; Gastrointestinal Tract; HIV Infections; Humans; Mice; Microbiota; Phylogeny; Tryptophan; Viremia

2013
Systemic tryptophan and kynurenine catabolite levels relate to severity of rhinovirus-induced asthma exacerbation: a prospective study with a parallel-group design.
    Thorax, 2013, Volume: 68, Issue:12

    Topics: Adult; Asthma; Biomarkers; Breath Tests; Bronchoalveolar Lavage Fluid; Case-Control Studies; Cytokines; Disease Progression; Eosinophil Cationic Protein; Eosinophils; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Nitric Oxide; ortho-Aminobenzoates; Peroxidase; Picornaviridae Infections; Prospective Studies; Quinolinic Acid; Rhinovirus; Tryptophan; Young Adult

2013
Astragaloside IV inhibits progression of lung cancer by mediating immune function of Tregs and CTLs by interfering with IDO.
    Journal of cancer research and clinical oncology, 2014, Volume: 140, Issue:11

    Topics: Animals; Antineoplastic Agents; Carcinoma, Lewis Lung; Cell Line, Tumor; Coculture Techniques; Disease Progression; Drug Screening Assays, Antitumor; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Mice, Inbred C57BL; Neoplasm Transplantation; Paclitaxel; Saponins; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Regulatory; Triterpenes; Tryptophan; Tumor Burden; Tumor Escape

2014
Prognostic Significance of Tryptophan Catabolism in Adult T-cell Leukemia/Lymphoma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2015, Jun-15, Volume: 21, Issue:12

    Topics: Aged; Aged, 80 and over; Biomarkers; Case-Control Studies; Disease Progression; Female; Human T-lymphotropic virus 1; Humans; Kynurenine; Leukemia-Lymphoma, Adult T-Cell; Lymph Nodes; Male; Middle Aged; Prognosis; Tryptophan

2015
Is tryptophan metabolism involved in sleep apnea-related cardiovascular co-morbidities and cancer progression?
    Medical hypotheses, 2015, Volume: 85, Issue:4

    Topics: Adult; Animals; Cardiovascular Diseases; Comorbidity; Disease Progression; Heme; Humans; Hypoxia; Mice; Models, Theoretical; Neoplasms; Obesity; Rats; Risk Factors; Sleep Apnea, Obstructive; Tryptophan

2015
Cerebrospinal fluid kynurenines in multiple sclerosis; relation to disease course and neurocognitive symptoms.
    Brain, behavior, and immunity, 2016, Volume: 51

    Topics: Adult; Disease Progression; Female; Humans; Kynurenine; Male; Middle Aged; Multiple Sclerosis; Tryptophan

2016
Exaggerated IDO1 expression and activity in Langerhans cells from patients with atopic dermatitis upon viral stimulation: a potential predictive biomarker for high risk of Eczema herpeticum.
    Allergy, 2015, Volume: 70, Issue:11

    Topics: Adult; Biomarkers; Dendritic Cells; Dermatitis, Atopic; Disease Progression; Female; Gene Expression; Humans; Immunoglobulin E; Immunoglobulin G; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kaposi Varicelliform Eruption; Langerhans Cells; Male; Middle Aged; Monocytes; Simplexvirus; Tryptophan; Young Adult

2015
Downregulation of Tryptophan-related Metabolomic Profile in Rheumatoid Arthritis Synovial Fluid.
    The Journal of rheumatology, 2015, Volume: 42, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Blood Sedimentation; C-Reactive Protein; Chromatography, Liquid; Disease Progression; Down-Regulation; Female; Follow-Up Studies; Humans; Male; Mass Spectrometry; Middle Aged; Multivariate Analysis; Osteoarthritis; Sampling Studies; Sensitivity and Specificity; Severity of Illness Index; Statistics, Nonparametric; Synovial Fluid; Tryptophan

2015
Influence of Hepatitis C Virus Sustained Virological Response on Immunosuppressive Tryptophan Catabolism in ART-Treated HIV/HCV Coinfected Patients.
    Journal of acquired immune deficiency syndromes (1999), 2016, Mar-01, Volume: 71, Issue:3

    Topics: Adult; Anti-HIV Agents; Biomarkers; Coinfection; Disease Progression; Female; Hepacivirus; Hepatitis C; HIV Infections; Humans; Inflammation; Insulin; Kynurenine; Male; Middle Aged; Tryptophan

2016
Tryptophan PET predicts spatial and temporal patterns of post-treatment glioblastoma progression detected by contrast-enhanced MRI.
    Journal of neuro-oncology, 2016, Volume: 126, Issue:2

    Topics: Aged; Brain; Brain Neoplasms; Contrast Media; Disease Progression; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multimodal Imaging; Positron-Emission Tomography; Tryptophan

2016
Activity of the kynurenine pathway and its interplay with immunity in patients with pulmonary arterial hypertension.
    Heart (British Cardiac Society), 2016, Volume: 102, Issue:3

    Topics: Adult; Aged; Area Under Curve; Case-Control Studies; Disease Progression; Echocardiography, Doppler; Exercise Test; Female; Flow Cytometry; Humans; Hypertension, Pulmonary; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Prospective Studies; ROC Curve; T-Lymphocytes, Regulatory; Th17 Cells; Tryptophan

2016
Acute nephrotoxicity of aristolochic acid in vitro: metabolomics study for intracellular metabolic time-course changes.
    Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2016, Volume: 21, Issue:3

    Topics: Aristolochia; Aristolochic Acids; Biomarkers; Cell Line; Chromatography, High Pressure Liquid; Disease Progression; Humans; Kidney Diseases; Kidney Tubules, Proximal; Lipid Metabolism; Mass Spectrometry; Metabolic Networks and Pathways; Metabolomics; Tryptophan; Vitamins

2016
Metabolomic Analysis of Gastric Cancer Progression within the Correa's Cascade Using Ultraperformance Liquid Chromatography-Mass Spectrometry.
    Journal of proteome research, 2016, 08-05, Volume: 15, Issue:8

    Topics: Adenocarcinoma; Biomarkers, Tumor; Chromatography, High Pressure Liquid; Disease Progression; Female; Gastritis; Glutamine; Helicobacter Infections; Helicobacter pylori; Humans; Kynurenine; Male; Mass Spectrometry; Metabolomics; Middle Aged; Plasma; Precancerous Conditions; Stomach Neoplasms; Tryptophan

2016
Tryptophan catabolism in acute exacerbations of chronic obstructive pulmonary disease.
    International journal of chronic obstructive pulmonary disease, 2016, Volume: 11

    Topics: Aged; Aged, 80 and over; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Disease Progression; Down-Regulation; Female; Hospitalization; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Lung; Male; Mass Spectrometry; Metabolomics; Middle Aged; Predictive Value of Tests; Pulmonary Disease, Chronic Obstructive; Time Factors; Tryptophan

2016
1-Methyl-tryptophan attenuates regulatory T cells differentiation due to the inhibition of estrogen-IDO1-MRC2 axis in endometriosis.
    Cell death & disease, 2016, 12-01, Volume: 7, Issue:12

    Topics: Adult; Animals; Cell Differentiation; Disease Progression; Endometriosis; Estrogens; Female; Humans; Immunosuppression Therapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Lectins, C-Type; Lymphocyte Count; Mannose Receptor; Mannose-Binding Lectins; Mice, Inbred C57BL; Middle Aged; Peritoneum; Receptors, Cell Surface; Signal Transduction; T-Lymphocytes, Regulatory; Tryptophan; Up-Regulation; Young Adult

2016
Modulation of a Circulating Uremic Solute via Rational Genetic Manipulation of the Gut Microbiota.
    Cell host & microbe, 2016, Dec-14, Volume: 20, Issue:6

    Topics: Animal Feed; Animals; Bacteria; Bacteroides; Diet; Disease Models, Animal; Disease Progression; Gastrointestinal Microbiome; Gastrointestinal Tract; Genetic Engineering; Germ-Free Life; Humans; Indican; Indoles; Metagenome; Mice; Microbiota; Renal Insufficiency, Chronic; Toxins, Biological; Tryptophan; Tryptophanase

2016
Increased serum kynurenine/tryptophan ratio correlates with disease progression in lung cancer.
    Lung cancer (Amsterdam, Netherlands), 2010, Volume: 67, Issue:3

    Topics: Aged; Disease Progression; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lung Neoplasms; Male; Middle Aged; Prognosis; Tryptophan

2010
Plasma tryptophan and tyrosine levels are independent risk factors for delirium in critically ill patients.
    Intensive care medicine, 2009, Volume: 35, Issue:11

    Topics: Aged; Amino Acid Transport System L; Analysis of Variance; Critical Illness; Delirium; Disease Progression; Female; Humans; Logistic Models; Male; Markov Chains; Middle Aged; Phenylalanine; Pilot Projects; Predictive Value of Tests; Regression Analysis; Risk Assessment; Risk Factors; Severity of Illness Index; Tennessee; Time Factors; Tryptophan; Tyrosine

2009
Role of the immunosuppressive enzyme indoleamine 2,3-dioxygenase in the progression of ovarian carcinoma.
    Gynecologic oncology, 2009, Volume: 115, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Disease Progression; Drug Synergism; Female; Humans; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Lymphocytes, Tumor-Infiltrating; Mice; Mice, Inbred BALB C; Mice, Nude; Ovarian Neoplasms; Paclitaxel; Transfection; Tryptophan; Xenograft Model Antitumor Assays

2009
Insights into therapy: tryptophan oxidation and HIV infection.
    Science translational medicine, 2010, May-19, Volume: 2, Issue:32

    Topics: 3-Hydroxyanthranilic Acid; Anti-Inflammatory Agents; Antiviral Agents; Dendritic Cells; Disease Progression; Enzyme Inhibitors; HIV Infections; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Inflammation Mediators; Interleukin-17; Kynurenine; Oxidation-Reduction; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Tryptophan; Viral Load

2010
Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease.
    Science translational medicine, 2010, May-19, Volume: 2, Issue:32

    Topics: 3-Hydroxyanthranilic Acid; Biopsy; CD4 Lymphocyte Count; CD4-CD8 Ratio; Cells, Cultured; Colon, Sigmoid; Dendritic Cells; Disease Progression; HIV Infections; HIV Seropositivity; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Inflammation Mediators; Interferon-gamma; Interleukin-17; Kynurenine; Lipopolysaccharides; Lymph Nodes; Prospective Studies; Rectum; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Time Factors; Tryptophan; Up-Regulation; Viral Load

2010
Indoleamine 2,3-dioxygenase (IDO) activity influence tumor growth in the TRAMP prostate cancer model.
    The Prostate, 2010, Sep-15, Volume: 70, Issue:13

    Topics: Adenocarcinoma; Animals; Blotting, Western; Disease Progression; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lymph Nodes; Male; Mice; Prostatic Neoplasms; Tryptophan

2010
Tryptophan degradation and neopterin levels in treated rheumatoid arthritis patients.
    Clinical rheumatology, 2012, Volume: 31, Issue:1

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Case-Control Studies; Disease Progression; Female; Humans; Kynurenine; Male; Middle Aged; Neopterin; Tryptophan; Tumor Necrosis Factor-alpha

2012
Indoleamine 2,3-dioxygenase, tryptophan catabolism, and Mycobacterium avium subsp. paratuberculosis: a model for chronic mycobacterial infections.
    Infection and immunity, 2011, Volume: 79, Issue:9

    Topics: Animals; Cattle; Cell Line; Disease Progression; Humans; Ileum; Indoleamine-Pyrrole 2,3,-Dioxygenase; Mycobacterium avium subsp. paratuberculosis; Paratuberculosis; RNA, Messenger; Sheep; Th1 Cells; Tryptophan

2011
C868T single nucleotide polymorphism and HIV type 1 disease progression among postpartum women in Kenya.
    AIDS research and human retroviruses, 2012, Volume: 28, Issue:6

    Topics: Adult; Arginine; CD4 Antigens; CD4 Lymphocyte Count; Cohort Studies; Disease Progression; Female; Genotype; HIV Infections; HIV-1; Humans; Infant, Newborn; Kenya; Polymorphism, Single Nucleotide; Postpartum Period; Pregnancy; Tryptophan; Viral Load; Zidovudine

2012
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor.
    Nature, 2011, Oct-05, Volume: 478, Issue:7368

    Topics: Animals; Autocrine Communication; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Disease Progression; Gene Expression Regulation, Neoplastic; Glioma; Humans; Kynurenine; Ligands; Mice; Mice, Inbred C57BL; Mice, Nude; Neoplasm Transplantation; Paracrine Communication; Receptors, Aryl Hydrocarbon; Tryptophan; Tryptophan Oxygenase

2011
Novel, objective, multivariate biomarkers composed of plasma amino acid profiles for the diagnosis and assessment of inflammatory bowel disease.
    PloS one, 2012, Volume: 7, Issue:1

    Topics: Adult; Amino Acids; Biomarkers; Case-Control Studies; Colitis, Ulcerative; Crohn Disease; Disease Progression; Female; Histidine; Humans; Inflammatory Bowel Diseases; Male; Multivariate Analysis; Statistics, Nonparametric; Tryptophan

2012
Effect of indoleamine 2,3-dioxygenase on induction of experimental autoimmune encephalomyelitis.
    Journal of neuroimmunology, 2002, Volume: 129, Issue:1-2

    Topics: Animals; Axons; Cell Division; Cytokines; Disease Models, Animal; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Interleukin-10; Interleukin-4; Kinetics; Kynurenine; Lymph Nodes; Mice; RNA, Messenger; Spinal Cord; T-Lymphocytes; Treatment Outcome; Tryptophan; Tryptophan Oxygenase

2002
Transgenic rat model of Huntington's disease.
    Human molecular genetics, 2003, Mar-15, Volume: 12, Issue:6

    Topics: Animals; Animals, Genetically Modified; Cell Nucleus; Disease Models, Animal; Disease Progression; DNA, Complementary; Glucose; Huntingtin Protein; Huntington Disease; Immunohistochemistry; Magnetic Resonance Imaging; Models, Genetic; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Phenotype; Promoter Regions, Genetic; Rats; Time Factors; Tissue Distribution; Tomography, Emission-Computed; Transgenes; Trinucleotide Repeat Expansion; Tryptophan

2003
Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetes.
    Diabetologia, 2006, Volume: 49, Issue:6

    Topics: Adolescent; Amino Acid Substitution; Arginine; Autoantibodies; Child; Child, Preschool; Diabetes Mellitus, Type 1; Disease Progression; Female; Genetic Variation; Glutamate Decarboxylase; HLA-DQ Antigens; Humans; Infant; Infant, Newborn; Insulin Antibodies; Male; Mass Screening; Nuclear Family; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatase, Non-Receptor Type 22; Protein Tyrosine Phosphatases; Sex Characteristics; Tryptophan

2006
Novel myelin protein zero mutation (Arg36Trp) in a patient with acute onset painful neuropathy.
    Neuromuscular disorders : NMD, 2006, Volume: 16, Issue:5

    Topics: Acute Disease; Amino Acid Substitution; Arginine; Disease Progression; DNA Mutational Analysis; Genetic Predisposition to Disease; Genetic Testing; Hereditary Sensory and Motor Neuropathy; Humans; Inheritance Patterns; Male; Middle Aged; Myelin P0 Protein; Neuralgia; Peripheral Nerves; Peripheral Nervous System Diseases; Point Mutation; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Time Factors; Tryptophan

2006
Decreased serum tryptophan concentration predicts poor prognosis in malignant melanoma patients.
    Dermatology (Basel, Switzerland), 2007, Volume: 214, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Chromatography, High Pressure Liquid; Disease Progression; Female; Follow-Up Studies; Humans; Male; Melanoma; Middle Aged; Neoplasm Staging; Neopterin; Prognosis; Retrospective Studies; Skin Neoplasms; Survival Rate; Tryptophan

2007
Diminished quality of life in patients with cancer correlates with tryptophan degradation.
    Journal of cancer research and clinical oncology, 2007, Volume: 133, Issue:7

    Topics: Aged; Disease Progression; Fatigue; Female; Humans; Immunity, Cellular; Karnofsky Performance Status; Kynurenine; Male; Middle Aged; Neoplasms; Neopterin; Prognosis; Quality of Life; Survival Analysis; Tryptophan

2007
Formation and progression of sub-retinal pigment epithelium deposits in Efemp1 mutation knock-in mice: a model for the early pathogenic course of macular degeneration.
    Human molecular genetics, 2007, Oct-15, Volume: 16, Issue:20

    Topics: Animals; Arginine; Bruch Membrane; Disease Models, Animal; Disease Progression; Extracellular Matrix Proteins; Female; Humans; Macular Degeneration; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Mutagenesis, Site-Directed; Optic Nerve; Pigment Epithelium of Eye; Point Mutation; Retina; Time Factors; Tryptophan

2007
Expression of indoleamine 2,3-dioxygenase in tumor endothelial cells correlates with long-term survival of patients with renal cell carcinoma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Dec-01, Volume: 13, Issue:23

    Topics: Aged; Carcinoma, Renal Cell; Cell Line, Tumor; Disease Progression; Endothelial Cells; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kidney Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Neovascularization, Pathologic; Prognosis; Retrospective Studies; RNA, Messenger; Tryptophan

2007
Quality of life and immune activation in patients with HIV-infection.
    Brain, behavior, and immunity, 2008, Volume: 22, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Adult; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Depression; Disease Progression; Female; Health Status Indicators; Hemoglobins; HIV Infections; Humans; Immunity; Kynurenine; Male; Middle Aged; Neopterin; Predictive Value of Tests; Psychological Tests; Quality of Life; Regression Analysis; Surveys and Questionnaires; Tryptophan; Viral Load

2008
Decrease in vitamin C concentration in human lenses during cataract progression.
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 1998, Volume: 68, Issue:5

    Topics: Ascorbic Acid; Cataract; Disease Progression; Female; Fructose; Humans; Lens Nucleus, Crystalline; Lysine; Male; Sensitivity and Specificity; Tryptophan

1998
Trp64Arg polymorphism of the beta3-adrenergic receptor is not associated with diabetic nephropathy in Japanese patients with type 2 diabetes.
    Diabetes care, 2000, Volume: 23, Issue:6

    Topics: Albuminuria; Amino Acid Substitution; Arginine; Asian People; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Progression; Female; Genotype; Humans; Japan; Male; Middle Aged; Polymorphism, Genetic; Proteinuria; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-3; Tryptophan

2000
Immune reaction links disease progression in cancer patients with depression.
    Medical hypotheses, 2000, Volume: 55, Issue:2

    Topics: Depression; Disease Progression; Humans; Neoplasms; Neopterin; Serotonin; Tryptophan

2000
Tryptophan immunoadsorption strongly reduces proteinuria in recurrent nephrotic syndrome.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2001, Volume: 16, Issue:6

    Topics: Adult; Disease Progression; Humans; Immunoglobulin G; Immunosorbent Techniques; Kidney Failure, Chronic; Kidney Transplantation; Male; Nephrotic Syndrome; Postoperative Complications; Proteinuria; Recurrence; Serum Albumin; Staphylococcal Protein A; Time Factors; Tryptophan

2001