tryptophan and Diabetes Mellitus, Adult-Onset

tryptophan has been researched along with Diabetes Mellitus, Adult-Onset in 91 studies

Research

Studies (91)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (2.20)	18.7374
1990's	25 (27.47)	18.2507
2000's	9 (9.89)	29.6817
2010's	22 (24.18)	24.3611
2020's	33 (36.26)	2.80

Authors

Authors	Studies
Ashrafian, H; Darzi, A; Holmes, E; Lewis, MR; Penney, N; Purkayastha, S; Whiley, L; Yeung, KTD	1
Han, T; Liu, L; Liu, Z; Sun, C; Wang, W; Wang, X; Yang, X	1
Hu, S; Luo, L; Zeng, L	1
Adamski, J; Copetti, M; De Cosmo, S; Mastroianno, M; Menzaghi, C; Prehn, C; Salvemini, L; Scarale, MG; Trischitta, V	1
Chen, L; Ji, M; Li, C; Li, M; Liu, W; Liu, Y; Pan, C; Sun, S; Xie, Y; Xu, Z; Yang, Y	1
Chen, F; Liao, J; Lu, Q; Niu, C; Wang, H; Wang, S; Yu, Y	1
An, Z; Chen, W; Deng, Y; Gao, Y; He, Z; Hu, Q; Huang, X; Lin, R; Lv, Y; Mo, Z; Qiu, Y; Wang, X; Zhang, H; Zhou, R	1
Armanet, M; Autier, V; Bailbé, D; Carbonne, C; Dairou, J; Domet, T; Gausseres, B; Guillemin, GJ; Kergoat, M; Lim, CK; Liu, J; Movassat, J; Pitasi, CL; Portha, B; Raynal, S; Zhen, D	1
Alshraideh, H; Banimfreg, BH; Semreen, MH; Shamayleh, A; Soares, NC	1
Araki, R; Hada, Y; Hashimoto, K; Iwasaki, H; Kawakami, Y; Matsuda, T; Osaki, Y; Sekiya, M; Shimano, H; Sugano, Y; Suzuki, H; Suzuki, Y; Takahashi, SI; Yahagi, N; Yamanaka, D	1
Anand, BG; Ansari, M; Kar, K; Prajapati, KP; Tiku, AB	1
de Mello, VD; Lindström, J; Männistö, V; Pihlajamäki, J; Sehgal, R; Tuomilehto, J; Uusitupa, M	1
Dai, X; Liu, T; Peng, W; Shi, L; Sun, X; Yan, L; Yan, T; Yang, M; Yang, X; Zhang, X	1
Liu, J; Offei, SD; Scott, EE; Yoshimoto, FK	1
Alves, JTM; Fernandes, GR; Fonseca, DC; Machado, NM; Prudêncio, APA; Sala, P; Torrinhas, RS; Waitzberg, DL	1
Hisamatsu, T; Ida, Y; Kato, Y; Miyoshi, S; Nakamura, H; Ohnishi, H; Okamoto, S; Tokunaga, K; Toue, S; Yoneyama, R	1
Cui, H; Li, H; Lv, S; Pan, B; Su, X; Sun, W; Zhang, H; Zhang, S; Zhang, T; Zhang, Z	1
Cai, Y; Hong, Y; Li, H; Li, P; Li, S; Liao, Q; Liu, D; Shen, B; Xie, Z; Zhang, Q; Zhang, S	1
Abdolghaffari, AH; Hosseini, Y; Lashgari, NA; Momtaz, S; Niazi Shahraki, F; Roudsari, NM; Shayan, M	1
Armad, J; Cui, JY; Gu, H; Jin, Y; Kim, S; Li, H; Mani, S	1
Brunius, C; Hellström, PM; Landberg, R; Nordin, E; Ribbenstedt, A; Vuong, E	1
Gao, J; Lin, X; Ma, X; Ma, Y; Song, B; Wang, H; Yang, T	1
Li, H; Lv, S; Ma, Z; Pan, B; Su, X; Sun, W; Wang, H; Wang, L; Wang, Y; Zhang, H	1
Chan, A; Eliassen, AH; Hu, FB; Hu, Y; Huttenhower, C; Ivey, KL; Lee, KH; Li, J; Li, Y; Qi, Q; Rimm, EB; Sun, Q; Wang, B; Zhu, L	1
Ang, K; Ching, J; Gurung, RL; Kestenbaum, BR; Kovalik, JP; Lee, J; Lee, LS; Lim, SC; Liu, JJ; Liu, S; M, Y; Shao, YM; Sharma, K; Subramaniam, T; Sum, CF; Wee, HN; Zheng, H	1
Iqbal, M; Ismat, F; March, M; McPherson, MJ; Onesti, S; Rahman, M; Shah, MA; Shehzad, A; Ullah, R	1
Benvenga, S; Bolignano, D; Buemi, M; Cernaro, V; Cigala, RM; Crea, F; De Stefano, C; Ferlazzo, VT; Gembillo, G; Genovese, ARR; Loddo, S; Macaione, V; Santoro, D; Vita, R	1
Baydar, T; Efe, B; Girgin, G; Gürcü, S; Kılıçarslan, B; Yorulmaz, G	1
Elovaris, RA; Feinle-Bisset, C; Hajishafiee, M; Heilbronn, LK; Horowitz, M; Jones, KL; Poppitt, SD	1
Akamizu, T; Ihara, Y; Inai, Y; Ino, K; Ito, Y; Iwahashi, N; Kishimoto, S; Manabe, S; Minakata, S; Morita, S	1
Bao, W; Boerwinkle, E; Burk, RD; Cai, J; Chai, JC; Chen, GC; Clish, CB; Daviglus, ML; Dupuis, J; Feofanova, EV; Gerszten, RE; Grove, ML; Hu, FB; Hu, J; Kaplan, RC; Knight, R; Li, J; Manson, JE; Martínez-González, MA; Meigs, JB; Merino, J; Moon, JY; Nguyen, NQ; Perkins, DL; Porneala, BC; Qi, Q; Rebholz, C; Rexrode, KM; Ruiz-Canela, M; Salas-Salvadó, J; Selvin, E; Thyagarajan, B; Usyk, M; Wang, T; Wang, TJ; Wang, W; Wang, Z; Yu, B	1
Cui, W; Guo, R; Shang, J; Wang, L; Xiao, J; Zhang, F; Zhao, Z	1
Gluvic, Z; Isenovic, ER; Obradovic, M; Sudar-Milovanovic, E; Zaric, B	1
Christensen, MHE; Mellgren, G; Midttun, Ø; Njølstad, PR; Nygård, OK; Pedersen, ER; Rebnord, EW; Strand, E; Svingen, GFT; Tell, GS; Ueland, PM	1
Cavanaugh, CR; Hornby, PJ; Jennis, M; Lenhard, J; Leo, GC; Mabus, JR	1
Dettmer, K; Eckardt, KU; Ellmann, L; Gronwald, W; Kastenmüller, G; Köttgen, A; Mohney, RP; Oefner, PJ; Sekula, P; Suhre, K; Vogl, FC	1
Galligan, JJ	1
Aukrust, P; Gaardbo, JC; Gelpi, M; Gerstoft, J; Hoel, H; Holm, K; Hov, JR; Hove-Skovsgaard, M; Kummen, M; Nielsen, SD; Nwosu, F; Rudi, K; Seljeflot, I; Trøseid, M; Ueland, PM; Ullum, H; Valeur, J	1
Arós, F; Clish, CB; Cofán, M; Corella, D; Dennis, C; Estruch, R; Fitó, M; Guasch-Ferre, M; Hu, FB; Lapetra, J; Liang, L; Martinez-Gonzalez, MA; Papandreou, C; Razquin, C; Ros, E; Ruiz-Canela, M; Salas-Salvado, J; Serra-Majem, L; Sorlí, JV; Toledo, E; Yu, E	1
Alzaid, F; Burcelin, R; Callebert, J; Cardellini, M; Chajadine, M; Dairou, J; Denis, RGP; Esposito, B; Federici, M; Fernandez-Real, JM; Haddad, Y; Jegou, S; Launay, JM; Laurans, L; Luquet, SH; Mallat, Z; McQuitty, C; Metghalchi, S; Moreno-Navarrete, JM; Sokol, H; Sovran, B; Straub, M; Taleb, S; Tavitian, B; Tedgui, A; Venteclef, N; Viel, T	1
Hu, FB; Martinez-Gonzalez, MA; Salas-Salvadó, J; Yu, E	1
Farzi, A; Hassan, AM; Holzer, P; Zenz, G	1
Fordyce, J; García, AA; Harrison, ML; Rock, J; Wolfe, AS; Zuñiga, JA	1
Kuusisto, J; Laakso, M; Smith, U; Stancáková, A; Vangipurapu, J	1
Harada, N; Inubushi, T; Ishidoh, K; Kamemura, N; Katunuma, N; Matsunaga, Y; Nakaya, Y; Oda, M; Sakurai, J; Suenaga, M	1
Fitzgerald, RJ; Nongonierma, AB	1
Fu, H; Liu, X; Wang, J; Yu, W; Zheng, D; Zhu, L	1
Oxenkrug, GF	1
Bao, Y; Gao, P; Hong, CS; Jia, W; Luo, P; Tu, Y; Wei, L; Xu, G; Yin, P; Yu, H; Zhang, P; Zhao, X; Zhuang, Z	1
Beavers, LS; Efanov, AM; Fang, X; Gonzalez Valcarcel, IC; Lin, HV; Ma, T; Wang, J; Wang, X	1
Bao, Y; Chen, T; Hu, C; Huang, F; Jia, W; Ma, X; Ni, Y; Rajani, C; Zhao, A; Zheng, X	1
Bach, AG; Mühlbauer, E; Peschke, E	1
Bonzo, JA; Gonzalez, FJ; Krausz, KW; Patterson, AD	1
Gong, M; Li, Y; Tang, L; Xu, W; Zhang, J	1
Abilova, SS; Aldashev, AA; Kerimkulova, AS; Lunegova, OS; Mirrakhimov, AE; Mirrakhimov, EM; Moldokeeva, CB; Sovhozova, NA; Zalesskaya, YV	1
Barriga, C; Hernández, R; Morales, I; Paredes, S; Romero de Tejada, A; Sánchez, S; Tormo, MA	1
Babol, K; Blasiak, J; Lukaszek, M; Pertynski, T; Przybylowska, K	1
Blasiak, J; Drzewoski, J; Kasznicki, J; Majsterek, I; Przybyłowska, K	1
Andersen, G; Borch-Johnsen, K; Gjesing, AP; Hansen, T; Jørgensen, T; Pedersen, O	1
Hattori, M; Kotake, Y	1
Iwamoto, K; Kadowaki, H; Kosaka, K; Otabe, S; Shimokawa, K; Silver, K; Walston, J; Yamada, N; Yasuda, K; Yoshinaga, H	1
Fujisawa, T; Fukuda, M; Hamada, Y; Ikegami, H; Nakagawa, Y; Oga, T; Ogihara, T; Shintani, M; Takekawa, K; Ueda, H; Yamato, E	1
Bouchard, C; Mauriège, P	1
Pi-Sunyer, FX	1
Ligere, R; Martinsone, D; Martinsons, A	1
Roth, J; Shuldiner, AR; Silver, K; Walston, J	1
Froguel, P; Strosberg, AD	1
Asano, T; Inoue, H; Kizuki, N; Oka, Y; Oota, Y; Tanizawa, Y; Tsukuda, K; Ueda, K	1
Akanuma, Y; Kadowaki, T; Katakura, T; Kim-Motoyama, H; Ohashi, Y; Shuldiner, AR; Yamada, N; Yamaguchi, T; Yasuda, K; Yazaki, Y	1
Heikkinen, S; Kekäläinen, P; Kuopusjärvi, J; Kuusisto, J; Laakso, M; Pihlajamäki, J; Rissanen, J; Sipiläinen, R; Vanhala, M	1
Arii, K; Hashimoto, K; Ikeda, Y; Ito, H; Nakauchi, Y; Suehiro, T; Yamamoto, M	1
Ferrell, RE; Kuller, LH; Moriarty, M; Wing, RR	1
Biery, AJ; Boyer, BB; Ebbesson, SO; Shuldiner, AR	1
Mitchell, BD; Roth, J; Shuldiner, AR; Silver, K; Sorkin, JD; Stern, MP; Walston, J	1
Strosberg, AD	1
Azuma, N; Hosoda, K; Igaki, T; Itoh, H; Masuzaki, H; Matsuoka, N; Miyamoto, Y; Nakao, K; Nishi, S; Nishimura, H; Satoh, N; Shigemoto, M; Suga, J; Tanaka, T; Yamamoto, Y; Yoshimasa, T; Yoshimasa, Y	1
Kogure, A; Kondo, M; Sakane, N; Umekawa, T; Yoshida, T; Yoshioka, K	1
Fukuo, Y; Gotoda, T; Harada, K; Ishibashi, S; Ohashi, K; Osuga, J; Sun, L; Yamada, N; Yazaki, Y	1
Nakanishi, K; Ohta, H; Shima, Y; Tsukada, T	1
Angelico, F; Cangiano, C; Cascino, A; Del Ben, M; Laviano, A; Preziosa, I; Rossi-Fanelli, F	1
Arndt, H; Büettner, R; Cuk, A; Enger, I; Hügl, S; Nusser, J; Palitzsch, KD; Rogler, G; Schäffler, A; Schölmerich, J; Zietz, B	1
Baba, T; Nakajima, S; Yajima, Y	1
Kogure, A; Kondo, M; Nakamura, Y; Sakane, N; Takakura, Y; Umekawa, T; Yoshida, T; Yoshioka, K	1
Grzeszczak, W; Labuz, B; Lacka, B; Saucha, W; Szydlowska, I; Zukowska-Szczechowska, E; Zychma, MJ	1
Iwamoto, Y; Iwasaki, N; Kanamori, M; Minei, S; Omori, Y; Sanaka, M; Yanagisawa, K	1
Baba, T; Nakajima, S	1
Bon, MA; Oeveren van-Dybicz, AM; van den Bergh, FA; Vermes, I; Vonkeman, HE	1
Carlsson, M; Groop, LC; Hedenbro, J; Orho-Melander, M	1
Daimon, M; Eguchi, H; Igarashi, M; Kameda, W; Kato, T; Manaka, H; Ohnuma, H; Oizumi, T; Saitoh, T; Tominaga, M; Yamaguchi, H	1
Shun, I; Sun, L; Yoko, I	1
Anderson, GH; Jenkins, DJ; Josse, RG; Lee, R; Wolever, TM; Wong, GS	1

Reviews

7 review(s) available for tryptophan and Diabetes Mellitus, Adult-Onset

Article	Year
Indolepropionic Acid, a Gut Bacteria-Produced Tryptophan Metabolite and the Risk of Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease. Nutrients, 2022, Nov-06, Volume: 14, Issue:21 Topics: Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Bacteria; Diabetes Mellitus, Type 2; Humans; Liver; Non-alcoholic Fatty Liver Disease; Tryptophan	2022
IDO/Kynurenine; novel insight for treatment of inflammatory diseases. Cytokine, 2023, Volume: 166 Topics: Animals; Cytokines; Diabetes Mellitus, Type 2; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Mammals; Tryptophan; Tumor Necrosis Factor-alpha	2023
Abnormal tryptophan catabolism in diabetes mellitus and its complications: Opportunities and challenges. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 166 Topics: Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Homeostasis; Humans; Pregnancy; Tryptophan	2023
Tryptophan Metabolism in Atherosclerosis and Diabetes. Current medicinal chemistry, 2022, Volume: 29, Issue:1 Topics: Animals; Atherosclerosis; Diabetes Mellitus, Type 2; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Tryptophan	2022
Beneficial actions of microbiota-derived tryptophan metabolites. Neurogastroenterology and motility, 2018, Volume: 30, Issue:2 Topics: Diabetes Mellitus, Type 2; Gastrointestinal Microbiome; Humans; Obesity; Tryptophan	2018
Diabesity and mood disorders: Multiple links through the microbiota-gut-brain axis. Molecular aspects of medicine, 2019, Volume: 66 Topics: Brain; Diabetes Mellitus, Type 2; Dysbiosis; Endocannabinoids; Fatty Acids, Volatile; Gastrointestinal Microbiome; Humans; Mood Disorders; Obesity; Prevalence; Tryptophan	2019
Association of beta 3-adrenoceptor polymorphism with obesity and diabetes: current status. Trends in pharmacological sciences, 1997, Volume: 18, Issue:12 Topics: Alleles; Animals; Arginine; Diabetes Mellitus; Diabetes Mellitus, Type 2; Electrophoresis, Agar Gel; Female; Gene Frequency; Genotype; Heterozygote; Homozygote; Humans; Male; Mutagenesis; Obesity; Polymerase Chain Reaction; Polymorphism, Genetic; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-3; Sex Factors; Transfection; Tryptophan	1997

Trials

4 trial(s) available for tryptophan and Diabetes Mellitus, Adult-Onset

Article	Year
Effects of Branched-Chain Amino Acids on Skeletal Muscle, Glycemic Control, and Neuropsychological Performance in Elderly Persons with Type 2 Diabetes Mellitus: An Exploratory Randomized Controlled Trial. Nutrients, 2022, Sep-21, Volume: 14, Issue:19 Topics: Aged; Amino Acids, Branched-Chain; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Glycemic Control; Humans; Insulin; Kynurenine; Muscle, Skeletal; Prospective Studies; Soybean Proteins; Tryptophan	2022
IBS randomized study: FODMAPs alter bile acids, phenolic- and tryptophan metabolites, while gluten modifies lipids. American journal of physiology. Regulatory, integrative and comparative physiology, 2023, 09-01, Volume: 325, Issue:3 Topics: Bile Acids and Salts; Cross-Over Studies; Diabetes Mellitus, Type 2; Diet, Carbohydrate-Restricted; Disaccharides; Fermentation; Glutens; Humans; Irritable Bowel Syndrome; Lipids; Monosaccharides; Oligosaccharides; Quality of Life; Tryptophan	2023
Effects of intragastric administration of L-tryptophan on the glycaemic response to a nutrient drink in men with type 2 diabetes - impacts on gastric emptying, glucoregulatory hormones and glucose absorption. Nutrition & diabetes, 2021, 01-05, Volume: 11, Issue:1 Topics: 3-O-Methylglucose; Aged; Beverages; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Administration Routes; Gastric Emptying; Glucagon; Glucose; Humans; Insulin; Intestinal Absorption; Male; Middle Aged; Nutrients; Obesity; Postprandial Period; Tryptophan	2021
Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1998, Volume: 22, Issue:7 Topics: 5-Hydroxytryptophan; Administration, Oral; Adult; Aged; Blood Glucose; Body Mass Index; Body Weight; Brain; Diabetes Mellitus, Type 2; Dietary Carbohydrates; Double-Blind Method; Energy Intake; Feeding Behavior; Female; Glycated Hemoglobin; Humans; Insulin; Male; Middle Aged; Tryptophan	1998

Other Studies

80 other study(ies) available for tryptophan and Diabetes Mellitus, Adult-Onset

Article	Year
The impact of bariatric surgery on serum tryptophan-kynurenine pathway metabolites. Scientific reports, 2022, 01-07, Volume: 12, Issue:1 Topics: Adult; Biomarkers; Body Mass Index; Diabetes Mellitus, Type 2; Female; Gastrectomy; Gastric Bypass; Glycated Hemoglobin; Humans; Kynurenine; Longitudinal Studies; Male; Middle Aged; Obesity; Prospective Studies; Time Factors; Treatment Outcome; Tryptophan; Xanthurenates	2022
Dietary tryptophan and the risk of obesity and type 2 diabetes: Total effect and mediation effect of sleep duration. Obesity (Silver Spring, Md.), 2022, Volume: 30, Issue:2 Topics: Cholesterol, LDL; Diabetes Mellitus, Type 2; Humans; Obesity; Risk Factors; Sleep; Tryptophan	2022
Tea combats circadian rhythm disorder syndrome via the gut-liver-brain axis: potential mechanisms speculated. Critical reviews in food science and nutrition, 2023, Volume: 63, Issue:24 Topics: Bile Acids and Salts; Brain; Chronobiology Disorders; Diabetes Mellitus, Type 2; Humans; Liver; Syndrome; Tea; Tryptophan	2023
Circulating Metabolites Associate With and Improve the Prediction of All-Cause Mortality in Type 2 Diabetes. Diabetes, 2022, 06-01, Volume: 71, Issue:6 Topics: Biomarkers; Diabetes Mellitus, Type 2; Humans; Inflammation; Kynurenine; Tryptophan	2022
Indolepropionic acid reduces obesity-induced metabolic dysfunction through colonic barrier restoration mediated via tuft cell-derived IL-25. The FEBS journal, 2022, Volume: 289, Issue:19 Topics: Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Fatty Acids, Nonesterified; Glucose; Indoles; Inflammation; Interleukin-17; Mice; Mice, Inbred C57BL; Obesity; Tight Junction Proteins; Tryptophan	2022
Serum untargeted metabolomics analysis of the mechanisms of evodiamine on type 2 diabetes mellitus model rats. Food & function, 2022, Jun-20, Volume: 13, Issue:12 Topics: Amino Sugars; Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glutathione; Metabolomics; Nucleotides; Proline; Quinazolines; Rats; Streptozocin; Tryptophan	2022
Gut microbiota mediate melatonin signalling in association with type 2 diabetes. Diabetologia, 2022, Volume: 65, Issue:10 Topics: Biomarkers; Case-Control Studies; Chromatography, Liquid; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Gastrointestinal Microbiome; Glucose; Humans; Interleukin-10; Interleukin-17; Interleukin-6; Lipopolysaccharides; Melatonin; RNA, Ribosomal, 16S; Tandem Mass Spectrometry; Tryptophan; Tumor Necrosis Factor-alpha	2022
Kynurenine-3-monooxygenase expression is activated in the pancreatic endocrine cells by diabetes and its blockade improves glucose-stimulated insulin secretion. Biochimica et biophysica acta. Molecular basis of disease, 2022, 11-01, Volume: 1868, Issue:11 Topics: Animals; Blood Glucose; Cytokines; Diabetes Mellitus, Type 2; Glucose; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Kynurenine; Kynurenine 3-Monooxygenase; Morpholinos; Rats; Rats, Wistar; Tryptophan	2022
Untargeted approach to investigating the metabolomics profile of type 2 diabetes emiratis. Journal of proteomics, 2022, 10-30, Volume: 269 Topics: Bile Acids and Salts; Biomarkers; Case-Control Studies; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Glycocholic Acid; Humans; Hydrocortisone; Hydroxyindoleacetic Acid; Metabolomics; Thyroxine; Tryptophan; United Arab Emirates	2022
Tryptophan self-assembly yields cytotoxic nanofibers containing amyloid-mimicking and cross-seeding competent conformers. Nanoscale, 2022, Nov-10, Volume: 14, Issue:43 Topics: Amyloid; Amyloidogenic Proteins; Antineoplastic Agents; Diabetes Mellitus, Type 2; Humans; Nanofibers; Tryptophan	2022
Diet-rich in wheat bran modulates tryptophan metabolism and AhR/IL-22 signalling mediated metabolic health and gut dysbacteriosis: A novel prebiotic-like activity of wheat bran. Food research international (Ottawa, Ont.), 2023, Volume: 163 Topics: Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Dietary Fiber; Dysbiosis; Interleukin-22; Mice; Prebiotics; Receptors, Aryl Hydrocarbon; Tryptophan	2023
Pyridine-containing substrate analogs are restricted from accessing the human cytochrome P450 8B1 active site by tryptophan 281. The Journal of biological chemistry, 2023, Volume: 299, Issue:4 Topics: Catalytic Domain; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Type 2; Heme; Humans; Iron; Pyridines; Steroid 12-alpha-Hydroxylase; Steroids; Tryptophan	2023
Red Meat Intake, Indole-3-Acetate, and Nutrients, 2023, Feb-27, Volume: 15, Issue:5 Topics: Acetates; Blood Glucose; Diabetes Mellitus, Type 2; Female; Gastric Bypass; Humans; Indoles; Insulin; Insulin Resistance; Obesity, Morbid; Red Meat; RNA, Ribosomal, 16S; Tryptophan	2023
Plasma free amino acid profiles are associated with serum high molecular weight adiponectin levels in Japanese medical check-up population without type 2 diabetes mellitus. Amino acids, 2023, Volume: 55, Issue:5 Topics: Adiponectin; Amino Acids; Cross-Sectional Studies; Diabetes Mellitus, Type 2; East Asian People; Glutamates; Humans; Insulin Resistance; Lysine; Molecular Weight; Tryptophan	2023
Integrated 16S rRNA Sequencing and Untargeted Metabolomics Analysis to Reveal the Protective Mechanisms of Current drug metabolism, 2023, Volume: 24, Issue:4 Topics: Animals; Anti-Inflammatory Agents; Diabetes Mellitus, Type 2; Metabolomics; Polygonatum; Polysaccharides; Rats; RNA, Ribosomal, 16S; Tryptophan	2023
Indoleacrylic acid produced by Parabacteroides distasonis alleviates type 2 diabetes via activation of AhR to repair intestinal barrier. BMC biology, 2023, 04-18, Volume: 21, Issue:1 Topics: Animals; Bacteroidetes; Diabetes Mellitus, Type 2; Indoles; Inflammation; Rats; Receptors, Aryl Hydrocarbon; Tryptophan	2023
Maternal PBDE exposure disrupts gut microbiome and promotes hepatic proinflammatory signaling in humanized PXR-transgenic mouse offspring over time. Toxicological sciences : an official journal of the Society of Toxicology, 2023, 07-28, Volume: 194, Issue:2 Topics: Animals; Cytokines; Diabetes Mellitus, Type 2; Female; Gastrointestinal Microbiome; Halogenated Diphenyl Ethers; Humans; Indoles; Liver; Male; Maternal Exposure; Mice; Mice, Transgenic; Pregnane X Receptor; RNA, Messenger; Tryptophan	2023
Integrated 16S rRNA sequencing and nontargeted metabolomics analysis to reveal the mechanisms of Yu-Ye Tang on type 2 diabetes mellitus rats. Frontiers in endocrinology, 2023, Volume: 14 Topics: Animals; Diabetes Mellitus, Type 2; Glycerophospholipids; Metabolomics; Rats; RNA, Ribosomal, 16S; Tryptophan	2023
Interplay between diet, circulating indolepropionate concentrations and cardiometabolic health in US populations. Gut, 2023, Nov-24, Volume: 72, Issue:12 Topics: Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diet; Follow-Up Studies; Humans; Kynurenine; Male; Risk Factors; Tryptophan	2023
Plasma Tryptophan-Kynurenine Pathway Metabolites and Risk for Progression to End-Stage Kidney Disease in Patients With Type 2 Diabetes. Diabetes care, 2023, Dec-01, Volume: 46, Issue:12 Topics: Diabetes Mellitus, Type 2; Disease Progression; Humans; Kidney Failure, Chronic; Kynurenic Acid; Kynurenine; Tryptophan	2023
C-Terminal Domain of the Human Zinc Transporter hZnT8 Is Structurally Indistinguishable from Its Disease Risk Variant (R325W). International journal of molecular sciences, 2020, Jan-31, Volume: 21, Issue:3 Topics: Amino Acid Substitution; Arginine; Crystallography, X-Ray; Diabetes Mellitus, Type 2; Humans; Models, Molecular; Protein Domains; Protein Multimerization; Protein Structure, Secondary; Scattering, Small Angle; Tryptophan; X-Ray Diffraction; Zinc; Zinc Transporter 8	2020
RAS inhibition modulates kynurenine levels in a CKD population with and without type 2 diabetes mellitus. International urology and nephrology, 2020, Volume: 52, Issue:6 Topics: Aged; Aged, 80 and over; Angiotensins; Correlation of Data; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Kynurenine; Male; Renal Insufficiency, Chronic; Renin; Tryptophan	2020
Neopterin and biopterin levels and tryptophan degradation in patients with diabetes. Scientific reports, 2020, 10-12, Volume: 10, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biopterins; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Insulin; Kynurenine; Male; Metformin; Middle Aged; Neopterin; Tryptophan; Vildagliptin; Young Adult	2020
Quantification of serum C-mannosyl tryptophan by novel assay to evaluate renal function and vascular complications in patients with type 2 diabetes. Scientific reports, 2021, 01-21, Volume: 11, Issue:1 Topics: Biomarkers; Chromatography, Liquid; Creatine; Cystatin C; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Glomerular Filtration Rate; Humans; Male; Mannose; Middle Aged; Tryptophan	2021
Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies. Gut, 2022, Volume: 71, Issue:6 Topics: Bacteria; Cohort Studies; Diabetes Mellitus, Type 2; Diet; Gastrointestinal Microbiome; Humans; Kynurenine; Lactase; Tryptophan	2022
Untargeted serum metabolomics and tryptophan metabolism profiling in type 2 diabetic patients with diabetic glomerulopathy. Renal failure, 2021, Volume: 43, Issue:1 Topics: Adult; Case-Control Studies; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Linear Models; Male; Metabolic Networks and Pathways; Metabolomics; Middle Aged; Tryptophan	2021
The kynurenine:tryptophan ratio as a predictor of incident type 2 diabetes mellitus in individuals with coronary artery disease. Diabetologia, 2017, Volume: 60, Issue:9 Topics: Aged; Coronary Artery Disease; Diabetes Mellitus, Type 2; Female; Humans; Kynurenine; Male; Middle Aged; Multivariate Analysis; Prospective Studies; Risk Factors; Tryptophan	2017
Microbiota-derived tryptophan indoles increase after gastric bypass surgery and reduce intestinal permeability in vitro and in vivo. Neurogastroenterology and motility, 2018, Volume: 30, Issue:2 Topics: Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Epithelial Cells; Gastric Bypass; Gastrointestinal Microbiome; Indoles; Interferon-gamma; Intestinal Mucosa; Male; Mice, Inbred C57BL; Obesity; Permeability; Tryptophan	2018
From Discovery to Translation: Characterization of C-Mannosyltryptophan and Pseudouridine as Markers of Kidney Function. Scientific reports, 2017, 12-12, Volume: 7, Issue:1 Topics: Adult; Biomarkers; Case-Control Studies; Creatinine; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Glomerular Filtration Rate; Humans; Kidney Function Tests; Male; Middle Aged; Prospective Studies; Pseudouridine; Reference Values; Renal Insufficiency, Chronic; Tryptophan	2017
Impact of HIV and Type 2 diabetes on Gut Microbiota Diversity, Tryptophan Catabolism and Endothelial Dysfunction. Scientific reports, 2018, 04-30, Volume: 8, Issue:1 Topics: Arginine; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Endothelium; Feces; Female; Gastrointestinal Microbiome; HIV Infections; Humans; Inflammation; Kynurenine; Male; Metabolism; Middle Aged; Neopterin; Risk Factors; RNA, Ribosomal, 16S; Tryptophan	2018
Association of Tryptophan Metabolites with Incident Type 2 Diabetes in the PREDIMED Trial: A Case-Cohort Study. Clinical chemistry, 2018, Volume: 64, Issue:8 Topics: Case-Control Studies; Cohort Studies; Diabetes Mellitus, Type 2; Female; Homeostasis; Humans; Insulin Resistance; Male; Tryptophan	2018
Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health. Nature medicine, 2018, Volume: 24, Issue:8 Topics: Animals; Diabetes Mellitus, Type 2; Fatty Liver; Gastrointestinal Microbiome; Health; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Insulin Resistance; Interleukin-22; Interleukins; Intestines; Kynurenine; Lipopolysaccharides; Male; Mice, Inbred C57BL; Obesity; Principal Component Analysis; Tryptophan	2018
Regarding the Robustness of Results for "Association of Tryptophan Metabolites with Incident Type 2 Diabetes in the PREDIMED Trial: A Case-Cohort Study". Clinical chemistry, 2018, Volume: 64, Issue:10 Topics: Cohort Studies; Diabetes Mellitus, Type 2; Diet, Mediterranean; Humans; Risk Factors; Tryptophan	2018
The additive effect of type 2 diabetes on fibrinogen, von Willebrand factor, tryptophan and threonine in people living with HIV. Amino acids, 2019, Volume: 51, Issue:5 Topics: Biomarkers; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Fibrinogen; HIV; HIV Infections; Humans; Male; Middle Aged; Risk Factors; Threonine; Tryptophan; von Willebrand Factor	2019
Nine Amino Acids Are Associated With Decreased Insulin Secretion and Elevated Glucose Levels in a 7.4-Year Follow-up Study of 5,181 Finnish Men. Diabetes, 2019, Volume: 68, Issue:6 Topics: Aged; Alanine; Amino Acids; Aspartic Acid; Blood Glucose; Diabetes Mellitus, Type 2; Finland; Follow-Up Studies; Glutamic Acid; Humans; Insulin Resistance; Insulin Secretion; Isoleucine; Leucine; Male; Metabolomics; Middle Aged; Phenylalanine; Risk Factors; Tryptophan; Tyrosine; Valine	2019
L-tryptophan suppresses rise in blood glucose and preserves insulin secretion in type-2 diabetes mellitus rats. Journal of nutritional science and vitaminology, 2012, Volume: 58, Issue:6 Topics: Adipocytes; Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Energy Metabolism; Glucose Tolerance Test; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; Rats; Rats, Sprague-Dawley; Tryptophan	2012
Inhibition of dipeptidyl peptidase IV (DPP-IV) by tryptophan containing dipeptides. Food & function, 2013, Volume: 4, Issue:12 Topics: Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Humans; Kinetics; Tryptophan	2013
[Screening of urinary biomarkers in patients with type 2 diabetes mellitus]. Wei sheng yan jiu = Journal of hygiene research, 2013, Volume: 42, Issue:6 Topics: Biomarkers; Diabetes Mellitus, Type 2; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Tryptophan	2013
Increased Plasma Levels of Xanthurenic and Kynurenic Acids in Type 2 Diabetes. Molecular neurobiology, 2015, Volume: 52, Issue:2 Topics: 3-Hydroxyanthranilic Acid; Adult; Aged; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenic Acid; Kynurenine; Male; Metformin; Middle Aged; Prediabetic State; Pyridoxal Phosphate; Stress, Physiological; Tryptophan; Tryptophan Oxygenase; Xanthurenates	2015
Metabolomics Study of Roux-en-Y Gastric Bypass Surgery (RYGB) to Treat Type 2 Diabetes Patients Based on Ultraperformance Liquid Chromatography-Mass Spectrometry. Journal of proteome research, 2016, Apr-01, Volume: 15, Issue:4 Topics: Adult; Amino Acids; Bile Acids and Salts; Bilirubin; Biomarkers; Carnitine; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Energy Metabolism; Fatty Acids, Nonesterified; Female; Gastric Bypass; Hippurates; Humans; Indican; Insulin Resistance; Male; Mass Spectrometry; Metabolomics; Middle Aged; Obesity, Morbid; Oxidative Stress; Prognosis; Remission Induction; Treatment Outcome; Tryptophan; Weight Loss	2016
GPR142 Controls Tryptophan-Induced Insulin and Incretin Hormone Secretion to Improve Glucose Metabolism. PloS one, 2016, Volume: 11, Issue:6 Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Glucose; Humans; Incretins; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Mice; Mice, Knockout; Phenylalanine; Receptors, G-Protein-Coupled; Tryptophan	2016
Tryptophan Predicts the Risk for Future Type 2 Diabetes. PloS one, 2016, Volume: 11, Issue:9 Topics: Adult; Aged; Biomarkers; Blood Glucose; Case-Control Studies; China; Diabetes Mellitus, Type 2; Fasting; Female; Humans; Insulin; Insulin Resistance; Isoleucine; Leucine; Longitudinal Studies; Male; Middle Aged; Phenylalanine; Predictive Value of Tests; Prognosis; Risk Factors; Tryptophan; Tyrosine; Valine	2016
Adrenoceptor expression and diurnal rhythms of melatonin and its precursors in the pineal gland of type 2 diabetic goto-kakizaki rats. Endocrinology, 2010, Volume: 151, Issue:6 Topics: Animals; Blood Glucose; Body Weight; Chromatography, High Pressure Liquid; Circadian Rhythm; Diabetes Mellitus, Type 2; Insulin; Male; Melatonin; Pineal Gland; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Adrenergic; Reverse Transcriptase Polymerase Chain Reaction; Tryptophan	2010
Metabolomics identifies novel Hnf1alpha-dependent physiological pathways in vivo. Molecular endocrinology (Baltimore, Md.), 2010, Volume: 24, Issue:12 Topics: Adrenal Glands; Amino Acid Transport Systems; Animals; Diabetes Mellitus, Type 2; Hepatocyte Nuclear Factor 1-alpha; Indoles; Kidney; Liver; Male; Metabolomics; Mice; Mice, Knockout; Mutation; Phenylalanine; Tryptophan	2010
A novel GLP-1 analog exhibits potent utility in the treatment of type 2 diabetes with an extended half-life and efficient glucose clearance in vivo. Peptides, 2011, Volume: 32, Issue:7 Topics: Amino Acid Sequence; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Drug Design; Drug Stability; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose Tolerance Test; Glycated Hemoglobin; Half-Life; Humans; Hypoglycemic Agents; Insulin; Kinetics; Male; Molecular Sequence Data; Protein Binding; Rats; Rats, Sprague-Dawley; Rats, Zucker; Receptors, Glucagon; Serum; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tryptophan	2011
An association between TRP64ARG polymorphism of the B3 adrenoreceptor gene and some metabolic disturbances. Cardiovascular diabetology, 2011, Oct-12, Volume: 10 Topics: Adult; Aged; Alleles; Arginine; Diabetes Mellitus, Type 2; Female; Genetic Association Studies; Humans; Kyrgyzstan; Male; Metabolic Syndrome; Middle Aged; Obesity; Polymorphism, Genetic; Receptors, Adrenergic, beta-3; Tryptophan	2011
Orally administered tryptophan and experimental type 2 diabetes. Molecular and cellular biochemistry, 2004, Volume: 261, Issue:1-2 Topics: Administration, Oral; Animals; Antioxidants; Blood Glucose; Body Weight; Catalase; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drinking; Eating; Erythrocytes; Insulin; Male; Melatonin; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Tryptophan	2004
An association between the Trp64Arg polymorphism in the beta3-adrenergic receptor gene and endometrial cancer and obesity. Journal of experimental & clinical cancer research : CR, 2004, Volume: 23, Issue:4 Topics: Adipose Tissue; Adult; Aged; Alleles; Arginine; Body Mass Index; Diabetes Mellitus, Type 2; DNA; DNA Restriction Enzymes; Electrophoresis, Polyacrylamide Gel; Endometrial Neoplasms; Female; Genotype; Humans; Insulin Resistance; Leukocytes; Logistic Models; Middle Aged; Obesity; Odds Ratio; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Postmenopause; Premenopause; Receptors, Adrenergic, beta-3; Tryptophan	2004
The Trp64Arg beta3-adrenergic receptor amino-acid variant is not associated with overweight and type 2 diabetes mellitus in Polish population. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2005, Volume: 113, Issue:10 Topics: Aged; Diabetes Mellitus, Type 2; Female; Genotype; Glucose; Humans; Male; Mutation, Missense; Overweight; Poland; Polymorphism, Genetic; Receptors, Adrenergic, beta-3; Tryptophan	2005
Association of the beta3-adrenergic receptor Trp64Arg polymorphism with common metabolic traits: studies of 7605 middle-aged white people. Molecular genetics and metabolism, 2008, Volume: 94, Issue:1 Topics: Arginine; Denmark; Diabetes Mellitus, Type 2; Female; Genetic Variation; Genotype; Humans; Male; Middle Aged; Obesity; Polymorphism, Single Nucleotide; Receptors, Adrenergic, beta-3; Tryptophan; White People	2008
Studies on the urinary excretion of xanthurenic acid in diabetics. Acta vitaminologica et enzymologica, 1984, Volume: 6, Issue:3 Topics: Adult; Chromatography, High Pressure Liquid; Creatinine; Diabetes Mellitus, Type 2; Humans; Kynurenic Acid; Male; Middle Aged; Tryptophan; Xanthurenates	1984
A mutation in the beta 3-adrenergic receptor gene is associated with obesity and hyperinsulinemia in Japanese subjects. Biochemical and biophysical research communications, 1995, Oct-13, Volume: 215, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Alleles; Amino Acid Sequence; Arginine; Base Sequence; Blood Pressure; Deoxyribonucleases, Type II Site-Specific; Diabetes Mellitus, Type 2; DNA Primers; Female; Gene Frequency; Genetic Carrier Screening; Homozygote; Humans; Hyperinsulinism; Insulin; Male; Middle Aged; Molecular Sequence Data; Obesity; Point Mutation; Polymerase Chain Reaction; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-3; Reference Values; Tryptophan	1995
Association of Trp64Arg mutation of the beta3-adrenergic-receptor with NIDDM and body weight gain. Diabetologia, 1996, Volume: 39, Issue:3 Topics: Age of Onset; Alleles; Arginine; Confidence Intervals; Diabetes Mellitus, Type 2; Finland; France; Genotype; Humans; Indians, North American; Obesity; Point Mutation; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-3; Reference Values; Tryptophan; United States; Weight Gain	1996
Trp64Arg mutation in beta 3-adrenoceptor gene of doubtful significance for obesity and insulin resistance. Lancet (London, England), 1996, Sep-14, Volume: 348, Issue:9029 Topics: Animals; Arginine; Diabetes Mellitus, Type 2; Genetic Predisposition to Disease; Heterozygote; Humans; Insulin Resistance; Mutation; Obesity; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-3; Tryptophan	1996
Obesity: advances in understanding and treatment. IBC's Second Annual International Symposium on Obesity: Advances in Understanding and Treatment. Washington, DC, USA, 4-6 March 1996. Molecular medicine today, 1996, Volume: 2, Issue:10 Topics: Amyloid; Colipases; Diabetes Mellitus, Type 2; Diet; Disease Models, Animal; Enzyme Precursors; Humans; Islet Amyloid Polypeptide; Leptin; Neuropeptide Y; Neurotransmitter Agents; Obesity; Protein Precursors; Proteins; Serotonin; Tryptophan	1996
The effect of L-tryptophan load on endocrine system of pancreas in diabetes mellitus. Advances in experimental medicine and biology, 1996, Volume: 398 Topics: Blood Glucose; Diabetes Mellitus, Type 2; Gastrins; Glucagon; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Reference Values; Tryptophan	1996
Beta 3-adrenoceptor gene variant in obesity and insulin resistance. Lancet (London, England), 1996, Dec-07, Volume: 348, Issue:9041 Topics: Arginine; Diabetes Mellitus, Type 2; Humans; Insulin Resistance; Obesity; Point Mutation; Receptors, Adrenergic, beta; Tryptophan	1996
Beta 3-adrenoceptor gene variant in obesity and insulin resistance. Lancet (London, England), 1996, Dec-07, Volume: 348, Issue:9041 Topics: Arginine; Diabetes Mellitus, Type 2; Disease Susceptibility; Humans; Insulin Resistance; Obesity; Point Mutation; Receptors, Adrenergic, beta; Tryptophan	1996
Prevalence of the Trp64Arg missense mutation of the beta3-adrenergic receptor gene in Japanese subjects. Metabolism: clinical and experimental, 1997, Volume: 46, Issue:2 Topics: Adult; Aged; Alleles; Arginine; Diabetes Mellitus; Diabetes Mellitus, Type 2; Female; Humans; Japan; Male; Middle Aged; Obesity; Point Mutation; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-3; Tryptophan	1997
A mutation of the beta 3-adrenergic receptor is associated with visceral obesity but decreased serum triglyceride. Diabetologia, 1997, Volume: 40, Issue:4 Topics: Adult; Aged; Alleles; Arginine; Body Mass Index; Cholesterol; Deoxyribonucleases, Type II Site-Specific; Diabetes Mellitus, Type 2; Genotype; Glucose Intolerance; Heterozygote; Homozygote; Humans; Insulin; Male; Middle Aged; Obesity; Phenotype; Point Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-3; Reference Values; Triglycerides; Tryptophan	1997
The Trp64Arg polymorphism of the beta 3-Adrenergic receptor gene. Lack of association with NIDDM and features of insulin resistance syndrome. Diabetes care, 1997, Volume: 20, Issue:8 Topics: Adult; Alleles; Arginine; Diabetes Mellitus, Type 2; DNA; DNA Primers; Exons; Female; Finland; Gene Frequency; Genetic Predisposition to Disease; Humans; Insulin Resistance; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-3; Syndrome; Tryptophan	1997
Trp64Arg mutation of beta 3-adrenergic receptor and insulin sensitivity in subjects with glucose intolerance. Internal medicine (Tokyo, Japan), 1997, Volume: 36, Issue:9 Topics: Adipose Tissue; Adult; Aged; Alleles; Arginine; Body Mass Index; Diabetes Mellitus, Type 2; Female; Gene Frequency; Genotype; Glucose Intolerance; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Middle Aged; Point Mutation; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-3; Tryptophan	1997
Trp64Arg substitution in the beta 3-adrenergic receptor does not relate to body weight in healthy, premenopausal women. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1997, Volume: 21, Issue:9 Topics: Alleles; Anthropometry; Base Sequence; Body Weight; Diabetes Mellitus, Type 2; DNA Primers; Female; Gene Frequency; Genotype; Heterozygote; Homozygote; Humans; Middle Aged; Obesity; Point Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Premenopause; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-3; Tryptophan	1997
The beta(3)-adrenergic receptor TRP64ARG polymorphism and obesity in Alaskan Eskimos. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1997, Volume: 21, Issue:12 Topics: Adult; Alaska; Alleles; Arginine; Asian People; Blood Pressure; Body Mass Index; Diabetes Mellitus, Type 2; Female; Gene Frequency; Genotype; Humans; Inuit; Male; Middle Aged; Obesity; Phenotype; Polymorphism, Genetic; Receptors, Adrenergic, beta; Tryptophan	1997
TRP64ARG beta 3-adrenergic receptor and obesity in Mexican Americans. Human genetics, 1997, Volume: 101, Issue:3 Topics: Arginine; Body Mass Index; Diabetes Mellitus, Type 2; Female; Gene Frequency; Genotype; Glucose Tolerance Test; Humans; Insulin; Insulin Resistance; Male; Mexican Americans; Middle Aged; Mutation; Obesity; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-3; Syndrome; Texas; Tryptophan	1997
The significance of the Trp 64 Arg mutation of the beta3-adrenergic receptor gene in impaired glucose tolerance, non-insulin-dependent diabetes mellitus, and insulin resistance in Japanese subjects. Metabolism: clinical and experimental, 1998, Volume: 47, Issue:4 Topics: Adult; Amino Acid Substitution; Arginine; Blood Pressure; Body Mass Index; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Genotype; Glucose Intolerance; Humans; Insulin Resistance; Japan; Lipids; Male; Middle Aged; Point Mutation; Receptors, Adrenergic, beta; Tryptophan	1998
Trp64Arg mutation of beta3-adrenergic receptor and non-insulin dependent diabetes mellitus. Internal medicine (Tokyo, Japan), 1998, Volume: 37, Issue:3 Topics: Adipose Tissue; Alleles; Animals; Arginine; Body Mass Index; Diabetes Mellitus, Type 2; Gene Frequency; Genotype; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Middle Aged; Point Mutation; Rats; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-3; RNA, Messenger; Tryptophan	1998
Clinical features associated with the homozygous Trp64Arg mutation of the beta3-adrenergic receptor: no evidence for its association with obesity in Japanese. Arteriosclerosis, thrombosis, and vascular biology, 1998, Volume: 18, Issue:6 Topics: Arginine; Blood Pressure; Body Mass Index; Cholesterol, LDL; Cohort Studies; Diabetes Mellitus, Type 2; Electrocardiography; Female; Gene Frequency; Genotype; Humans; Japan; Male; Middle Aged; Obesity; Point Mutation; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-3; Triglycerides; Tryptophan	1998
Association of the Trp64Arg mutation of the beta3-adrenergic receptor with fatty liver and mild glucose intolerance in Japanese subjects. Clinica chimica acta; international journal of clinical chemistry, 1998, Jun-22, Volume: 274, Issue:2 Topics: Alleles; Arginine; Diabetes Mellitus, Type 2; Fatty Liver; Gene Frequency; Genotype; Glucose Intolerance; Heterozygote; Homozygote; Humans; Mutation; Obesity; Polymorphism, Restriction Fragment Length; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-3; Tryptophan	1998
The Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is not associated with obesity or type 2 diabetes mellitus in a large population-based Caucasian cohort. The Journal of clinical endocrinology and metabolism, 1998, Volume: 83, Issue:8 Topics: Adult; Aging; Alleles; Arginine; Body Mass Index; Body Temperature Regulation; Body Weight; Cholesterol; Cohort Studies; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Energy Metabolism; Female; Genotype; Humans; Lipolysis; Male; Middle Aged; Obesity; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Random Allocation; Receptors, Adrenergic, beta; Tryptophan	1998
Beta3-adrenergic receptor gene polymorphism is not associated with hypertension in NIDDM patients without nephropathy. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1998, Volume: 30, Issue:10 Topics: Adult; Aged; Arginine; Codon; Diabetes Mellitus, Type 2; Female; Humans; Hypertension; Male; Middle Aged; Mutation; Receptors, Adrenergic, beta; Tryptophan	1998
Trp64Arg mutation of beta3-adrenoceptor gene is associated with diabetic nephropathy in Type II diabetes mellitus. Diabetologia, 1998, Volume: 41, Issue:12 Topics: Aged; Arginine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Male; Middle Aged; Mutation; Receptors, Adrenergic, beta; Tryptophan	1998
Is Trp64Arg polymorphism of beta3-adrenergic receptor a clinically useful marker for the predisposition to diabetic nephropathy in Type II diabetic patients? Diabetologia, 1999, Volume: 42, Issue:5 Topics: Arginine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Genetic Markers; Humans; Receptors, Adrenergic, beta; Tryptophan	1999
Polymorphism of the beta3-adrenergic receptor gene and weight gain in pregnant diabetic women. Diabetes research and clinical practice, 1999, Volume: 44, Issue:1 Topics: Adult; Amino Acid Substitution; Arginine; Body Mass Index; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Genotype; Heterozygote; Homozygote; Humans; Obesity; Polymorphism, Genetic; Pregnancy; Pregnancy in Diabetics; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-3; Tryptophan; Weight Gain	1999
Trp64Arg polymorphism of the beta3-adrenergic receptor is not associated with diabetic nephropathy in Japanese patients with type 2 diabetes. Diabetes care, 2000, Volume: 23, Issue:6 Topics: Albuminuria; Amino Acid Substitution; Arginine; Asian People; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Progression; Female; Genotype; Humans; Japan; Male; Middle Aged; Polymorphism, Genetic; Proteinuria; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-3; Tryptophan	2000
Beta 3-adrenergic receptor gene polymorphism and type 2 diabetes in a Caucasian population. Diabetes, obesity & metabolism, 2001, Volume: 3, Issue:1 Topics: Adult; Aged; Alleles; Arginine; Deoxyribonucleases, Type II Site-Specific; Diabetes Mellitus, Type 2; DNA; Female; Gene Frequency; Heterozygote; Homozygote; Humans; Leukocytes; Male; Middle Aged; Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Receptors, Adrenergic, beta-3; Tryptophan; Weight Gain; White People	2001
Common variants in the beta2-(Gln27Glu) and beta3-(Trp64Arg)--adrenoceptor genes are associated with elevated serum NEFA concentrations and type II diabetes. Diabetologia, 2001, Volume: 44, Issue:5 Topics: Alleles; Amino Acid Substitution; Arginine; Blood Glucose; Blood Pressure; Cholesterol, HDL; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Female; Genetic Variation; Genotype; Glutamic Acid; Glutamine; Homozygote; Humans; Insulin; Male; Middle Aged; Nuclear Family; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Receptors, Adrenergic, beta-2; Receptors, Adrenergic, beta-3; Reference Values; Sweden; Triglycerides; Tryptophan; White People	2001
Genotype Arg/Arg, but not Trp/Arg, of the Trp64Arg polymorphism of the beta(3)-adrenergic receptor is associated with type 2 diabetes and obesity in a large Japanese sample. Diabetes care, 2001, Volume: 24, Issue:9 Topics: Aged; Amino Acid Substitution; Arginine; Asian People; Blood Pressure; Body Mass Index; Cholesterol; Cohort Studies; Diabetes Mellitus; Diabetes Mellitus, Type 2; Female; Genotype; Glucose Intolerance; Humans; Japan; Male; Middle Aged; Obesity; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Receptors, Adrenergic, beta-3; Risk Factors; Tryptophan	2001
[Investigation and comparison of the beta3-adrenergic receptor gene Trp64Arg mutation in the Chinese and Japanese]. Zhonghua yi xue za zhi, 2000, Volume: 80, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Arginine; Asian People; Blood Pressure; Body Mass Index; China; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cohort Studies; Diabetes Mellitus, Type 2; Female; Gene Frequency; Heart Rate; Humans; Hyperlipidemias; Japan; Male; Middle Aged; Mutation; Receptors, Adrenergic, beta-3; Triglycerides; Tryptophan	2000
Relationship between fasting serum tryptophan/large neutral amino acid ratio and reported hunger in subjects with diabetes. Diabetes research (Edinburgh, Scotland), 1988, Volume: 9, Issue:3 Topics: Adult; Aged; Amino Acids; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Fasting; Female; Humans; Hunger; Male; Middle Aged; Reference Values; Tryptophan	1988