tryptophan and Depressive Disorder, Major

tryptophan has been researched along with Depressive Disorder, Major in 156 studies

Research

Studies (156)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (0.64)	18.7374
1990's	7 (4.49)	18.2507
2000's	52 (33.33)	29.6817
2010's	60 (38.46)	24.3611
2020's	36 (23.08)	2.80

Authors

Authors	Studies
Comai, S; Gobbi, G; Lotfi, G; Manchia, M; Messaoud, A; Najjar, MF; Neffati, F; Rym, M; Valtorta, F; Wahiba, D	1
Bou Khalil, R; El Khoury, R	1
Benedetti, F; Bollettini, I; Colombo, C; Comai, S; Lorenzi, C; Melloni, E; Poletti, S; Vai, B; Valtorta, F; Zanardi, R	1
Chen, W; Chen, Y; Qian, L; Qian, X; Tian, P; Wang, G; Wang, L; Wang, Q; Zhang, H; Zhao, J; Zhu, H; Zou, R	1
Cai, H; Cao, T; Chen, Q; Jiao, S; Wang, L; Wu, X; Yang, C; Yang, D; Yang, P; Zeng, C; Zhang, S; Zhu, Z	1
Badawy, AA; Bano, S; Dawood, S	1
Chang, R; Gong, X; Huang, Z; Tan, S; Zou, J	1
Du, Y; Gong, M; Ma, X; Ni, P; Ni, R; Wei, J; Yang, X; Zhang, Z; Zhao, L	1
Apostolopoulos, V; Davidson, M; Nurgali, K; Rashidi, N	1
Al-Hakeim, HK; Almulla, AF; Maes, M; Oxenkrug, G; Thipakorn, Y; Tunvirachaisakul, C; Vasupanrajit, A	1
Almulla, AF; Maes, M	1
An, H; Bai, L; Fan, H; Ma, B; Ma, T; Qi, S; Wang, Z; Yang, F; Yun, Y; Zhang, Q; Zhao, W	1
Coico, R; Pato, M; Sales, PMG; Schrage, E	1
Allers, KA; Beutel, ME; Borta, A; Koeck, T; Lackner, K; Michal, M; Münzel, T; Niessen, HG; Schulz, A; Schuster, AK; Strauch, K; Süssmuth, SD; Wild, PS; Zahn, D	1
Guo, L; He, H; Li, R; Liu, JC; Shi, QQ; Yu, H; Zhou, CH	1
Bertollo, AG; de Oliveira, T; Ignácio, ZM; Mingoti, MED	1
Hasegawa, M; Kunisawa, K; Mouri, A; Nabeshima, T; Saito, K	1
Chen, Q; Chen, S; Cheng, X; Dong, K; Guo, X; Jin, W; Li, D; Li, P; Li, Q; Li, Z; Lin, P; Lou, X; Shi, Y; Sun, J; Sun, Y	1
Cao, C; Chen, F; Chen, Y; Dai, Y; Liang, X; Su, T; Wang, Q; Wang, S; Wu, P	1
Bi, Y; Chen, Y; Ju, Y; Li, L; Liao, M; Liu, B; Liu, J; Ma, M; Ou, W; Qin, Y; Zhang, Y	1
Maeda, R; Mimura, M; Suematsu, M; Sugiura, Y; Sugiyama, E; Tanaka, KF; Uchida, H; Uchida, T	1
Betancur, C; Callebert, J; Gautron, S; Gruszczynski, C; Guiard, BP; Launay, JM; Louis, F; Manta, S; Orrico-Sanchez, A; Paccard, A; Vialou, V	1
Becquemont, L; Boniface, B; Boursier-Neyret, C; Chanson, P; Colle, R; Corruble, E; David, DJ; Falissard, B; Fève, B; Masson, P; Verstuyft, C; Walther, B; Werner, E	1
Deng, WF; Guo, YY; He, FS; Lai, WT; Li, MZ; Liu, TB; Liu, YH; Rong, H; Wang, MB; Wang, S; Xie, XH; Xu, D; Xu, SX; Yang, QF; Yang, YJ; Ye, SW; Zhang, YL; Zhao, J	1
Chen, X; Chen, Y; Gui, S; Liu, L; Liu, Y; Pu, J; Ran, Y; Song, X; Tian, L; Wang, H; Xie, P; Xu, S; Yang, L; Yu, Y; Zhang, H; Zheng, P; Zhong, X	1
Amini, M; Hosseinzadeh, M; Khosravi, M; Mansoori, A; Raisi, F; Sotoudeh, G	1
Deng, WF; Guo, YY; He, FS; Lai, WT; Li, MZ; Liu, TB; Liu, YH; Rong, H; Tan, ZM; Wang, MB; Wang, S; Xie, XH; Xu, D; Xu, SX; Yang, QF; Yang, YJ; Ye, SW; Zhang, YL; Zhao, J	1
Arolt, V; Arteaga-Henriquez, G; Berghmans, R; Burger, B; Drexhage, HA; Grosse, L; Moll, N; Müller, N; Op de Beeck, G; Schuetze, G; Schwarz, M; Versnel, MA; Weidinger, E; Wijkhuijs, A	1
Bugajska, J; Inglot, M; Janocha-Litwin, J; Malyszczak, K; Marciniak, D; Pawlak, D; Pawlowski, T; Zalewska, M	1
Chamli Hårsmar, S; Lindahl, J; Lindqvist, D; Söderberg, G; Suneson, K	1
Chan, LY; Chiu, YC; Chou, YH; Hu, LY; Liou, YJ; Liu, MN; Yang, BH; Yang, KC	1
Cathomas, F; Guetter, K; Kaiser, S; Klaus, F; Seifritz, E	1
Galea, LAM; Go, KA; Lamers, Y; Qiu, W	1
Choi, H; Joo, EJ; Kang, HG; Lee, J; Lee, KY; Mun, S	1
Kopra, E; Mondelli, V; Nikkheslat, N; Pariante, C	1
Allers, KA; Beekman, ATF; Giltay, EJ; Keller, S; Milaneschi, Y; Niessen, HG; Penninx, BWJH; Schoevers, RA; Süssmuth, SD	1
Miller, BJ; Wang, AK	1
Anderson, G	1
Anderson, G; Carvalho, AF; Duleu, S; Geffard, M; Kanchanatawan, B; Maes, M; Roomruangwong, C; Sirivichayakul, S	1
de Jonge, P; Doornbos, B; Kema, IP; Penninx, BWJH; Sorgdrager, FJH	1
Leonard, BE	1
Duan, KM; Huang, Z; Ma, JH; Wang, SY; Yu, H; Zhou, Y	1
Hayakawa, K; Kanba, S; Kang, D; Kato, TA; Kishimoto, J; Kubo, H; Kuwano, N; Ohgidani, M; Sagata, N; Sato-Kasai, M; Setoyama, D; Shimokawa, N	1
Chen, B; Hu, L; Mai, N; Ning, Y; Shang, D; Wen, Y; Wu, Y; Zhang, M; Zhong, X	1
Benoliel, JJ; Cipriani, A; Coghill, D; Cohen, D; Hetrick, SE; Jiang, X; Lan, X; Liu, L; Ravindran, AV; Xie, P; Yang, L; Yuan, S; Zhang, Y; Zheng, P; Zhou, X	1
Allers, KA; Doolin, K; Farrell, C; Frodl, T; Harkin, A; Liesener, A; O'Hanlon, E; O'Keane, V; Pleiner, S; Roddy, D; Tozzi, L	1
Hood, SD; Moore, JK; Murphy, SE; Rao, P; Runions, KC; Stewart, RM; Wong, JWY; Zepf, FD	1
Amore, M; Baldessarini, RJ; Berardelli, I; Curto, M; Erbuto, D; Forte, A; Girardi, P; Innamorati, M; Lionetto, L; Montebovi, F; Pompili, M; Serafini, G; Seretti, ME; Simmaco, M	1
Barichello, T; Costa, DVDS; da Silva, FER; de Lucena, DF; de Sousa, FCF; de Souza, MRM; Dos Santos, CC; Lima, CNC; Macedo, D; Maes, M; Miyajima, F; Quevedo, J; Rodrigues, FTS; Vasconcelos, SMM	1
Chen, L; Li, H; Liu, W; Ning, Y; Wang, C; Zhan, Y; Zheng, W; Zhou, Y	1
Barone, P	1
Catena-Dell'Osso, M; Dell'Osso, A; Fagiolini, A; Marazziti, D; Rotella, F	1
Baghai, TC; Bondy, B; Eser, D; Müller, N; Myint, AM; Nothdurfter, C; Rupprecht, R; Schüle, C; Schwarz, MJ; Zill, P	1
Badawy, AA	2
Anderson, G; Berk, M; Maes, M	1
Bisserbe, JC; Blais, C; Bowers, H; Ilivitsky, V; Knott, V; Shah, D; Thompson, A	1
von Polier, GG; Zepf, FD	1
Young, SN	1
de Jonge, P; Doornbos, B; Duivis, HE; Kema, IP; Nolen, WA; Penninx, BW; Quak, J; Roest, AM; Vogelzangs, N	1
Bellgowan, PS; Bodurka, J; Dantzer, R; Drevets, WC; Savitz, J; Smith, CM; Teague, TK; Victor, TA; Wurfel, BE	1
Hashimoto, K; Shi, JY; Wang, N; Yang, C; Yang, JJ; Yu, HY	1
Fujii, T; Hattori, K; Higuchi, T; Hori, H; Koga, N; Kunugi, H; Motohashi, N; Noda, T; Ogawa, S; Teraishi, T	1
Andreassen, OA; Brundin, L; Dahl, J; Malt, UF; Ormstad, H; Sandvik, L; Verkerk, R	1
Hu, C; Li, J; Liu, X; Xie, P; Xu, G; Zhang, Y; Zhao, J; Zhao, X; Zheng, P; Zhou, J	1
Alonso, CM; Bradley, KA; Case, JA; Gabbay, V; Hanna, A; Khan, O; Ricart, T	1
Anderson, G; Berk, M; Gałecki, P; Maes, M; Talarowska, M	1
Boyd, BD; Cowan, RL; Rogers, BP; Salomon, RM; Shelton, KM; Taylor, WD; Weinstein, JJ	1
Hattori, K; Higuchi, T; Hori, H; Kajiwara, M; Kunugi, H; Matsuo, J; Ogawa, S; Ota, M; Sasayama, D; Teraishi, T	1
Bodurka, J; Dantzer, R; Drevets, WC; Ford, BN; Meier, TB; Morris, HM; Savitz, J; Teague, TK; Victor, TA; Wurfel, BE	1
aan het Rot, M; Hogenelst, K; Leander, NP; Müller, BC; Sarampalis, A; Schoevers, RA	1
Alyanakian, MA; Aouba, A; Bachmeyer, C; Barète, S; Bonin, B; Chandesris, MO; Chauvet-Gelinier, JC; Côté, F; Damaj, G; Dubreuil, P; Gaillard, R; Georgin-Lavialle, S; Grandpeix-Guyodo, C; Haffen, E; Hermine, O; Launay, JM; Lortholary, O; Moura, DS; Salvador, A; Soucié, E; Teyssier, JR; Trojak, B; Vandel, P	1
Bhat, M; Erhardt, S; Frye, MA; Johansson, AG; Jungholm, O; Landén, M; Samuelsson, M; Schuppe-Koistinen, I; Schwieler, L; Sellgren, CM	1
Andreassen, OA; Dahl, J; Maes, M; Ormstad, H; Verkerk, R	1
Rappaport, J; Velasquez, S	1
Kim, YK; Won, E	1
Bottrel, N; Corum, DG; Drevets, WC; Fiehn, O; Kaddurah-Daouk, R; Motsinger-Reif, A; Rotroff, DM; Salvadore, G; Singh, J	1
Imamura, Y; Mouri, A; Murakami, Y; Nabeshima, T; Saito, K; Tashiro, T; Yamamoto, Y	1
Alves, RC; Pereira, JC; Pradella Hallinan, M	1
Cook, M; Rucker, J	1
Barry, S; Cassidy Eugene, M; Clarke, G; Cryan, J; Dinan Timothy, G; Fitzgerald, P; Quigley Eamonn, MM; Scully, P; Shanahan, F	1
Godinez-Lopez, T; Hernandez-R, J; Manjarrez-Gutierrez, G; Marquez, RH; Mejenes-Alvarez, SA	1
Filteau, MJ; Kennedy, SH; Lam, RW; Lespérance, F; Parikh, SV; Patten, SB; Ravindran, AV	1
Castro, WL; Delgado, PL; El Khoury, A; Mathé, AA; Misiaszek, J; Moreno, FA; Palmer, C; Parkinson, D; Wright, R	1
Barone, PR; Belzung, C; Callebert, J; Laugeray, A; Launay, JM; Surget, A	1
Alonso, CM; Babb, JS; Gabbay, V; Guttman, LE; Hirsch, GS; Katz, Y; Klein, RG; Liebes, L; Mendoza, S	1
Carroll, BJ; Cassidy, F; Cooper, TB; Weiner, RD	1
Diksic, M; Frey, BN; Nishikawa, M; Sakai, Y; Skelin, I	1
Oxenkrug, GF	2
Alleva, E; Anzidei, F; Berry, A; Fiore, M; Laviola, G; Macrì, S; Zoratto, F	1
Fuchs, D; Galfalvy, HC; Grunebaum, MF; Lapidus, M; Mann, JJ; Oquendo, MA; Postolache, TT; Sublette, ME	1
Banga, A; Connor, DF; Handratta, V; Ibrahim, L	1
Bernstein, HG; Bielau, H; Bogerts, B; Brisch, R; Gos, T; Guillemin, GJ; Mawrin, C; Meyer zu Schwabedissen, L; Myint, AM; Sarnyai, Z; Steiner, J; Walter, M	1
Müller, N; Myint, AM; Schwarz, MJ	1
Alhaj, HA; Barton, S; Jervis, V; McAllister-Williams, R; Rodgers, J; Selman, M	1
Ren, YP; Sa, M; Tang, AG; Xiao, LD; Ying, L	1
Drevets, WC; Fromm, SJ; Goldman, D; Hasler, G; Hodgkinson, CA; Levy, J; Roiser, JP; Sahakian, BJ	1
Blinder, S; Erez, J; Lam, RW; Liddle, PF; Sossi, V; Vafai, N; Yatham, LN	1
Amico, F; Carballedo, A; Connor, TJ; Frodl, T; Harkin, A; Hughes, MM; McLoughlin, DM	1
Alcázar-Leyva, S; Alvarado-Vásquez, N; Gaspar, E; González-Trujano, E; Juárez, E; López-Bello, G; Moreno, J; Pavón, L	1
Joyce, PR; Mulder, RT; Porter, RJ	1
Kurup, AR; Kurup, PA	1
Evans, L; Gillin, JC; Golshan, S; Kelsoe, J; Rapaport, M; Resovsky, K; Sutton, L	1
Gillin, JC; Kelsoe, JR; Landolt, HP; Rapaport, MH	1
Gallagher, P; Porter, RJ; Smith, MS; Watson, S; Young, AH	1
Ebert, MH; Gwirtsman, HE; Johnson, BW; Kennedy, JS; Kwentus, J; Salomon, RM; Schmidt, DE	1
Covault, J; Feinn, R; Kranzler, HR; Modesto-Lowe, V; Nellissery, M; Pierucci-Lagha, A; Swift, R	1
Riedel, WJ	1
Kurup, PA; Kurup, RK	1
Bergan, A; Chopra, MP; Crits-Christoph, P; DeRubeis, RJ; Gallop, R; O'Reardon, JP	1
Cowen, PJ; Mannie, ZN; McTavish, SF	1
Bagby, RM; Carella, A; Dunn, E; Houle, S; Hussey, D; Lee, M; Meyer, JH; Praschak-Rieder, N; Willeit, M; Wilson, AA	1
Gillin, JC; Haynes, PL; Kelsoe, J; McQuaid, JR; Rapaport, M	1
Bonne, O; Charney, DS; Luckenbaugh, DA; Manji, H; Neumeister, A; Young, TA; Yuan, P	1
Gouda, JF; Gwirtsman, HE; Johnson, BW; Kennedy, JS; Kwentus, J; Salomon, RM; Schmidt, DE; Shiavi, RG; Urbano Blackford, J	1
Joyce, PR; Kennedy, MA; Luty, SE; McKenzie, JM; Miller, AL; Mulder, RT; Porter, RJ	1
Joyce, PR; Luty, SE; Mulder, RT; Porter, RJ	1
Bell, CJ; Hood, SD; Nutt, DJ	1
Gallagher, P; O'Brien, JT; Phipps, AJ; Porter, RJ; Scott, A; Stevenson, PS	1
Huuhka, M; Keränen, T; Leinonen, E; Oja, SS; Palmio, J; Peltola, J; Saransaari, P; Suhonen, J	1
Gallagher, P; Mackin, P	1
Gallagher, P; O'Brien, JT; Porter, RJ	1
Sher, L	1
Booij, L; Brosschot, JF; Haffmans, PM; Swenne, CA; Thayer, JF; Van der Does, AJ	1
Shader, RI	1
Amin, Z; Anderson, GM; Cappiello, A; Czarkowski, KA; Epperson, CN; Krystal, JH; Naftolin, F; Stiklus, S	1
Baruah, S; Corsica, J; Crayton, JW; Doran, N; Gunnarsdottir, D; Hedeker, D; Hitsman, B; McChargue, DE; Pergadia, M; Pingitore, R; Spring, B	1
Bonne, O; Charney, DS; Drevets, WC; Goldman, D; Herscovitch, P; Hu, XZ; Luckenbaugh, DA; Neumeister, A; Nugent, AC; Schwarz, M	1
Ahrens, B; Blank, S; Franke, L; Müller-Oerlinghausen, B; Roggenbach, J; Uebelhack, R	1
Bapatla, KB; Chuai, S; Cristancho, P; O'Reardon, JP; Peshek, AD; Pilania, P	1
Hedeker, D; Hitsman, B; Munafò, M; Pingitore, R; Spring, B	1
Henn, FA; Sartorius, A	1
Landrø, NI; Lappalainen, J; Lunde, H; Magnusson, A; Neumeister, A; Refsum, H; Walderhaug, E	1
Akiskal, HS; Akiskal, KK; Gonda, X; Rihmer, Z	1
Salomon, RM	1
Charney, DS; Czermak, C; Drevets, WC; Geraci, M; Hauger, R; Luckenbaugh, DA; Neumeister, A	1
Robinson, OJ; Sahakian, BJ	1
Isobe, K; Miura, H; Nagatsu, T; Ohta, T; Ozaki, N; Sawada, M	1
Harris, B	1
Alecci, M; Boscati, L; Bravin, S; Ferrara, A; Invernizzi, G; Mauri, MC; Zamberlan, F	1
Aberg-Wistedt, A; Apéria, B; Hasselmark, L; Kjellman, BF; Mathé, AA; Stain-Malmgren, R	1
Alvarez, E; Artigas, F; Bel, N; Celada, P; Ortiz, J; Pérez, V	1
Aubin-Brunet, V; Bouhassira, M; Golmard, JL; Jouvent, R; Launay, JM; Mentré, F	1
Deutz, NE; Klaassen, T; Riedel, WJ; van Praag, HM; van Someren, A	1
Cowen, PJ; Dolan, RJ; Friston, KJ; Morris, JS; Smith, KA	1
Charney, DS; Delgado, PL; Heninger, GR; Krystal, JH; Licinio, J; Miller, HL; Moreno, FA; Salomon, RM	1
Delgado, PL; Heninger, GR; McGahuey, CA; Moreno, FA	1
Driver, HS; Jindal, R; Kennedy, SH; Levitan, RD; Shapiro, CM; Shen, JH	1
Almeida-Montes, LG; Chavez-Balderas, RA; Cortés Sotres, JF; García-Marín, JA; Hheinze-Martin, G; Moreno-Aguilar, J; Valles-Sanchez, V	1
Barsom, MW; Bota, RG; Brody, AL; Saxena, S	1
Van der Does, AJ	1
Bruijn, JA; Fekkes, D; Hoekstra, R; Mulder, PG; Pepplinkhuizen, L; van den Broek, WW	1
Cowen, PJ; Da Roza Davis, JM	1
Chase, D; Delgado, PL; Gelernter, J; Kaiser, B; Michaels, T; Moreno, FA; Rowe, DC	1
Anand, A; Berman, RM; Charney, DS; Fasula, MK; Finkelstein, CO; Heninger, GR; Oren, DA; Roach, LM; Sanacora, G; Wachen, RM	1

Reviews

25 review(s) available for tryptophan and Depressive Disorder, Major

Article	Year
The role and mechanism of tryptophan - kynurenine metabolic pathway in depression. Reviews in the neurosciences, 2023, 04-25, Volume: 34, Issue:3 Topics: Depression; Depressive Disorder, Major; Humans; Inflammation; Kynurenine; Metabolic Networks and Pathways; Tryptophan	2023
The Role of Tryptophan Metabolites in Neuropsychiatric Disorders. International journal of molecular sciences, 2022, Sep-01, Volume: 23, Issue:17 Topics: Depressive Disorder, Major; Humans; Kynurenine; Proteomics; Serotonin; Tryptophan	2022
The Tryptophan Catabolite or Kynurenine Pathway in a Major Depressive Episode with Melancholia, Psychotic Features and Suicidal Behaviors: A Systematic Review and Meta-Analysis. Cells, 2022, 10-02, Volume: 11, Issue:19 Topics: Albumins; Amino Acids; Depressive Disorder, Major; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Quinolinic Acids; Suicidal Ideation; Tryptophan	2022
Linking nervous and immune systems in psychiatric illness: A meta-analysis of the kynurenine pathway. Brain research, 2023, 02-01, Volume: 1800 Topics: Bipolar Disorder; Depressive Disorder, Major; Humans; Immune System; Kynurenic Acid; Kynurenine; Tryptophan	2023
The kynurenine pathway in major depressive disorder under different disease states: A systematic review and meta-analysis. Journal of affective disorders, 2023, 10-15, Volume: 339 Topics: Biomarkers; Depression; Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan	2023
An integrated meta-analysis of peripheral blood metabolites and biological functions in major depressive disorder. Molecular psychiatry, 2021, Volume: 26, Issue:8 Topics: Antidepressive Agents; Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Tryptophan	2021
Inflammatory Depression-Mechanisms and Non-Pharmacological Interventions. International journal of molecular sciences, 2021, Feb-06, Volume: 22, Issue:4 Topics: C-Reactive Protein; Depression; Depressive Disorder, Major; Dopaminergic Neurons; Dysbiosis; Exercise; Exercise Therapy; Fatty Acids, Omega-3; Gastrointestinal Microbiome; Humans; Inflammation; Probiotics; Synaptic Transmission; Tryptophan	2021
Ketamine's effect on inflammation and kynurenine pathway in depression: A systematic review. Journal of psychopharmacology (Oxford, England), 2021, Volume: 35, Issue:8 Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Bipolar Disorder; Cytokines; Depressive Disorder, Major; Humans; Inflammation; Ketamine; Kynurenine; Tryptophan	2021
Meta-analysis of Cerebrospinal Fluid Cytokine and Tryptophan Catabolite Alterations in Psychiatric Patients: Comparisons Between Schizophrenia, Bipolar Disorder, and Depression. Schizophrenia bulletin, 2018, 01-13, Volume: 44, Issue:1 Topics: Bipolar Disorder; Cytokines; Depressive Disorder, Major; Humans; Inflammation; Schizophrenia; Tryptophan	2018
Linking the biological underpinnings of depression: Role of mitochondria interactions with melatonin, inflammation, sirtuins, tryptophan catabolites, DNA repair and oxidative and nitrosative stress, with consequences for classification and cognition. Progress in neuro-psychopharmacology & biological psychiatry, 2018, Jan-03, Volume: 80, Issue:Pt C Topics: Cognition; Cognitive Dysfunction; Depressive Disorder, Major; DNA Repair; Humans; Inflammation; Melatonin; Mitochondria; Nitrosative Stress; Oxidative Stress; Sirtuins; Tryptophan	2018
The role of tryptophan metabolism in postpartum depression. Metabolic brain disease, 2018, Volume: 33, Issue:3 Topics: Depression; Depression, Postpartum; Depressive Disorder, Major; Female; Humans; Kynurenine; Quinolinic Acid; Tryptophan	2018
The 'Yin' and the 'Yang' of the kynurenine pathway: excitotoxicity and neuroprotection imbalance in stress-induced disorders. Behavioural pharmacology, 2019, Volume: 30, Issue:2 and 3-Sp Topics: Animals; Brain; Cytokines; Depressive Disorder, Major; Excitatory Amino Acid Agents; Humans; Hypothalamo-Hypophyseal System; Inflammation; Kynurenine; Neurodegenerative Diseases; Neuroprotection; Pituitary-Adrenal System; Tryptophan	2019
Inflammation, serotonin and major depression. Current drug targets, 2013, May-01, Volume: 14, Issue:5 Topics: Animals; Cytokines; Depressive Disorder, Major; Enzyme Activation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Inflammation Mediators; Serotonin; Stress, Psychological; Tryptophan	2013
Biological phenotypes underpin the physio-somatic symptoms of somatization, depression, and chronic fatigue syndrome. Acta psychiatrica Scandinavica, 2014, Volume: 129, Issue:2 Topics: Autoimmunity; Biomarkers; Depression; Depressive Disorder, Major; Fatigue Syndrome, Chronic; Humans; Immunity, Cellular; Inflammation; Oxidative Stress; Phenotype; Signal Transduction; Somatoform Disorders; Tryptophan	2014
Plasma L-tryptophan concentration in major depressive disorder: new data and meta-analysis. The Journal of clinical psychiatry, 2014, Volume: 75, Issue:9 Topics: Adult; Antidepressive Agents; Case-Control Studies; Depressive Disorder, Major; Female; Humans; Male; Psychiatric Status Rating Scales; Tryptophan	2014
Mechanisms underlying neurocognitive dysfunctions in recurrent major depression. Medical science monitor : international medical journal of experimental and clinical research, 2015, May-27, Volume: 21 Topics: Apoptosis; Attention; Circadian Rhythm; Depressive Disorder, Major; Executive Function; Humans; Hypothalamo-Hypophyseal System; Inflammation; Memory; Neurocognitive Disorders; Neurogenesis; Oxidative Stress; Pituitary-Adrenal System; Psychomotor Performance; Reactive Oxygen Species; Tryptophan	2015
Stress, the Autonomic Nervous System, and the Immune-kynurenine Pathway in the Etiology of Depression. Current neuropharmacology, 2016, Volume: 14, Issue:7 Topics: Animals; Autonomic Nervous System; Depressive Disorder, Major; Humans; Kynurenine; Stress, Psychological; Tryptophan	2016
Tryptophan kynurenine metabolism as a common mediator of genetic and environmental impacts in major depressive disorder: the serotonin hypothesis revisited 40 years later. The Israel journal of psychiatry and related sciences, 2010, Volume: 47, Issue:1 Topics: Adrenal Cortex Hormones; Animals; Biosynthetic Pathways; Cytokines; Depressive Disorder, Major; Environment; Genetic Predisposition to Disease; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Serotonin; Stress, Psychological; Tryptophan; Tryptophan Oxygenase; Tumor Necrosis Factor-alpha; Up-Regulation	2010
The role of the kynurenine metabolism in major depression. Journal of neural transmission (Vienna, Austria : 1996), 2012, Volume: 119, Issue:2 Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; Humans; Inflammation; Kynurenine; Tryptophan	2012
Acute tryptophan depletion. Part II: clinical effects and implications. The Australian and New Zealand journal of psychiatry, 2005, Volume: 39, Issue:7 Topics: Alleles; Alzheimer Disease; Autistic Disorder; Bipolar Disorder; Cognitive Behavioral Therapy; Depressive Disorder, Major; Disruptive, Impulse Control, and Conduct Disorders; Feeding and Eating Disorders; Female; Humans; Hydroxyindoleacetic Acid; Monoamine Oxidase Inhibitors; Premenstrual Syndrome; Promoter Regions, Genetic; Schizophrenia; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Sleep Wake Disorders; Sleep, REM; Surveys and Questionnaires; Tryptophan	2005
Genetic and hormonal regulation of tryptophan kynurenine metabolism: implications for vascular cognitive impairment, major depressive disorder, and aging. Annals of the New York Academy of Sciences, 2007, Volume: 1122 Topics: Aging; Animals; Cognition Disorders; Cytokines; Depressive Disorder, Major; Hormones; Humans; Kynurenine; Models, Biological; Nitric Oxide Synthase Type II; Tryptophan	2007
Recurrence in major depressive disorder: a neurocognitive perspective. Psychological medicine, 2008, Volume: 38, Issue:3 Topics: Cognitive Behavioral Therapy; Depressive Disorder, Major; Humans; Kindling, Neurologic; Models, Neurological; Receptors, Serotonin; Secondary Prevention; Selective Serotonin Reuptake Inhibitors; Serotonin; Tryptophan	2008
A link between stress and depression: shifts in the balance between the kynurenine and serotonin pathways of tryptophan metabolism and the etiology and pathophysiology of depression. Stress (Amsterdam, Netherlands), 2008, Volume: 11, Issue:3 Topics: Animals; Antidepressive Agents; Biogenic Monoamines; Brain; Cytokines; Depression; Depressive Disorder, Major; Humans; Hypothalamo-Hypophyseal System; Kynurenine; Metabolic Networks and Pathways; Models, Biological; Pituitary-Adrenal System; Serotonin; Stress, Psychological; Tryptophan	2008
Prefrontal-subcortical and limbic circuit mediation of major depressive disorder. Seminars in clinical neuropsychiatry, 2001, Volume: 6, Issue:2 Topics: Affect; Brain; Case-Control Studies; Depressive Disorder, Major; Grief; Humans; Limbic System; Neural Pathways; Prefrontal Cortex; Sleep Deprivation; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon; Tryptophan	2001
The effects of tryptophan depletion on mood and psychiatric symptoms. Journal of affective disorders, 2001, Volume: 64, Issue:2-3 Topics: Anorexia Nervosa; Bipolar Disorder; Brain; Bulimia; Cognition Disorders; Depressive Disorder, Major; Humans; Mood Disorders; Obsessive-Compulsive Disorder; Recurrence; Serotonin; Severity of Illness Index; Substance-Related Disorders; Tryptophan	2001

Trials

35 trial(s) available for tryptophan and Depressive Disorder, Major

Article	Year
Bifidobacterium breve CCFM1025 attenuates major depression disorder via regulating gut microbiome and tryptophan metabolism: A randomized clinical trial. Brain, behavior, and immunity, 2022, Volume: 100 Topics: Animals; Bifidobacterium breve; Depression; Depressive Disorder, Major; Double-Blind Method; Gastrointestinal Microbiome; Humans; Mice; Treatment Outcome; Tryptophan	2022
Using acute tryptophan depletion to investigate predictors of treatment response in adolescents with major depressive disorder: study protocol for a randomised controlled trial. Trials, 2018, Aug-10, Volume: 19, Issue:1 Topics: Adolescent; Adolescent Behavior; Affect; Age Factors; Amino Acids; Antidepressive Agents, Second-Generation; Brain; Child; Child Behavior; Combined Modality Therapy; Depressive Disorder, Major; Dietary Supplements; Double-Blind Method; Female; Fluoxetine; Humans; Male; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; Serotonin; Time Factors; Treatment Outcome; Tryptophan; Western Australia	2018
The effects of acute tryptophan depletion on speech and behavioural mimicry in individuals at familial risk for depression. Journal of psychopharmacology (Oxford, England), 2016, Volume: 30, Issue:3 Topics: Adult; Behavior; Brain; Cross-Over Studies; Depression; Depressive Disorder, Major; Double-Blind Method; Female; Humans; Interpersonal Relations; Male; Serotonin; Social Behavior; Speech; Tryptophan; Young Adult	2016
Increased plasma levels of competing amino acids, rather than lowered plasma tryptophan levels, are associated with a non-response to treatment in major depression. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2016, Volume: 26, Issue:8 Topics: Adult; Amino Acids; Antidepressive Agents; Biomarkers; Cytokines; Depressive Disorder, Major; Diagnostic and Statistical Manual of Mental Disorders; Down-Regulation; Drug Resistance; Female; Follow-Up Studies; Humans; Longitudinal Studies; Male; Middle Aged; Norway; Outpatient Clinics, Hospital; Patient Dropouts; Psychiatric Status Rating Scales; Remission Induction; Tryptophan; Up-Regulation	2016
CSF neurochemicals during tryptophan depletion in individuals with remitted depression and healthy controls. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2010, Volume: 20, Issue:1 Topics: Adult; Analysis of Variance; Case-Control Studies; Chromatography, High Pressure Liquid; Circadian Rhythm; Cross-Over Studies; Depressive Disorder, Major; Double-Blind Method; Electrochemistry; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Indoles; Male; Methoxyhydroxyphenylglycol; Middle Aged; Neurochemistry; Neuropeptide Y; Paroxetine; Psychiatric Status Rating Scales; Selective Serotonin Reuptake Inhibitors; Tryptophan; Young Adult	2010
Combined catecholamine and indoleamine depletion following response to ECT. The British journal of psychiatry : the journal of mental science, 2010, Volume: 196, Issue:6 Topics: Adult; Aged; Catecholamines; Cross-Over Studies; Depressive Disorder, Major; Double-Blind Method; Electroconvulsive Therapy; Female; Homovanillic Acid; Humans; Male; Middle Aged; Norepinephrine; Psychiatric Status Rating Scales; Serotonin; Treatment Outcome; Tryptophan	2010
Effect of low-dose acute tryptophan depletion on the specificity of autobiographical memory in healthy subjects with a family history of depression. Psychopharmacology, 2012, Volume: 222, Issue:2 Topics: Analysis of Variance; Cross-Over Studies; Depressive Disorder, Major; Double-Blind Method; Family Health; Female; Humans; Male; Memory, Episodic; Tryptophan; Young Adult	2012
Baseline prolactin and L-tryptophan availability predict response to antidepressant treatment in major depression. Psychopharmacology, 2003, Volume: 165, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Antidepressive Agents, Tricyclic; Biological Availability; Clomipramine; Depressive Disorder, Major; Desipramine; Double-Blind Method; Female; Fenfluramine; Humans; Hydrocortisone; Male; Menstrual Cycle; Middle Aged; Prolactin; Selective Serotonin Reuptake Inhibitors; Time Factors; Tryptophan	2003
Effects of rapid tryptophan depletion on sleep electroencephalogram and mood in subjects with partially remitted depression on bupropion. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2002, Volume: 27, Issue:6 Topics: Adult; Affect; Analysis of Variance; Bupropion; Depressive Disorder, Major; Double-Blind Method; Electroencephalography; Female; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Sleep; Tryptophan	2002
Rapid tryptophan depletion reverses phenelzine-induced suppression of REM sleep. Journal of sleep research, 2003, Volume: 12, Issue:1 Topics: Adult; Depressive Disorder, Major; Double-Blind Method; Electroencephalography; Female; Humans; Male; Monoamine Oxidase Inhibitors; Phenelzine; Sleep, REM; Time Factors; Tryptophan	2003
Elevated prolactin responses to L-tryptophan infusion in medication-free depressed patients. Psychopharmacology, 2003, Volume: 169, Issue:1 Topics: Adolescent; Adult; Dehydroepiandrosterone; Depressive Disorder, Major; Female; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Infusions, Intravenous; Male; Middle Aged; Pituitary-Adrenal System; Prolactin; Receptor, Serotonin, 5-HT1A; Saliva; Tryptophan	2003
Effects of rapid tryptophan depletion on mood and urge to drink in patients with co-morbid major depression and alcohol dependence. Psychopharmacology, 2004, Volume: 171, Issue:3 Topics: Adult; Affect; Alcoholism; Behavior, Addictive; Cross-Over Studies; Depressive Disorder, Major; Diagnosis, Dual (Psychiatry); Double-Blind Method; Female; Genotype; Humans; Male; Middle Aged; Tryptophan	2004
Response to tryptophan depletion in major depression treated with either cognitive therapy or selective serotonin reuptake inhibitor antidepressants. Biological psychiatry, 2004, May-01, Volume: 55, Issue:9 Topics: Cognitive Behavioral Therapy; Cross-Over Studies; Depressive Disorder, Major; Diagnostic and Statistical Manual of Mental Disorders; Double-Blind Method; Drug Administration Schedule; Female; Fluoxetine; Humans; Male; Middle Aged; Paroxetine; Remission Induction; Selective Serotonin Reuptake Inhibitors; Severity of Illness Index; Tryptophan	2004
Tyrosine depletion does not cause depressive relapse in antidepressant-treated patients. Psychopharmacology, 2004, Volume: 175, Issue:1 Topics: Adult; Amino Acids, Neutral; Antidepressive Agents, Tricyclic; Cross-Over Studies; Depressive Disorder, Major; Double-Blind Method; Female; Humans; Middle Aged; Phenylalanine; Prolactin; Secondary Prevention; Selective Serotonin Reuptake Inhibitors; Tryptophan; Tyrosine	2004
Tryptophan depletion and serotonin loss in selective serotonin reuptake inhibitor-treated depression: an [(18)F] MPPF positron emission tomography study. Biological psychiatry, 2004, Oct-15, Volume: 56, Issue:8 Topics: Adult; Aminopyridines; Brain; Brain Mapping; Depressive Disorder, Major; Double-Blind Method; Fluorine Radioisotopes; Humans; Male; Middle Aged; Piperazines; Positron-Emission Tomography; Radiochemistry; Selective Serotonin Reuptake Inhibitors; Serotonin; Tryptophan	2004
Affective state and EEG sleep profile in response to rapid tryptophan depletion in recently recovered nonmedicated depressed individuals. Journal of affective disorders, 2004, Volume: 83, Issue:2-3 Topics: Adult; Affect; Brain; Cognitive Behavioral Therapy; Depression; Depressive Disorder, Major; Double-Blind Method; Female; Humans; Male; Middle Aged; Personality Inventory; Recurrence; Serotonin; Sleep, REM; Treatment Outcome; Tryptophan	2004
Effects of tryptophan depletion on serum levels of brain-derived neurotrophic factor in unmedicated patients with remitted depression and healthy subjects. The American journal of psychiatry, 2005, Volume: 162, Issue:4 Topics: Biomarkers; Brain-Derived Neurotrophic Factor; Cross-Over Studies; Depressive Disorder, Major; Double-Blind Method; Humans; Psychiatric Status Rating Scales; Serotonin; Tryptophan	2005
Treatment enhances ultradian rhythms of CSF monoamine metabolites in patients with major depressive episodes. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:11 Topics: Activity Cycles; Adult; Antidepressive Agents; Area Under Curve; Biogenic Monoamines; Depressive Disorder, Major; Dopamine; Female; Fourier Analysis; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Middle Aged; Psychiatric Status Rating Scales; Serotonin; Spectrum Analysis; Statistics as Topic; Time Factors; Tryptophan	2005
Reversed diurnal variation in depression: associations with a differential antidepressant response, tryptophan: large neutral amino acid ratio and serotonin transporter polymorphisms. Psychological medicine, 2005, Volume: 35, Issue:4 Topics: Adult; Affect; Alleles; Amino Acids; Antidepressive Agents; Bipolar Disorder; Circadian Rhythm; Depressive Disorder, Major; Female; Fluoxetine; Gene Frequency; Genotype; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Nerve Tissue Proteins; Nortriptyline; Polymorphism, Genetic; Prognosis; Promoter Regions, Genetic; Serotonin Plasma Membrane Transport Proteins; Treatment Outcome; Tryptophan	2005
Tryptophan and tyrosine availability and response to antidepressant treatment in major depression. Journal of affective disorders, 2005, Volume: 86, Issue:2-3 Topics: Adrenergic Uptake Inhibitors; Adult; Amino Acids, Neutral; Antidepressive Agents, Tricyclic; Circadian Rhythm; Depressive Disorder, Major; Female; Fluoxetine; Follow-Up Studies; Humans; Hydrocortisone; Male; Nortriptyline; Prolactin; Psychiatric Status Rating Scales; Research Design; Selective Serotonin Reuptake Inhibitors; Treatment Outcome; Tryptophan; Tyrosine	2005
Effects of acute tryptophan depletion on mood and cognitive functioning in older recovered depressed subjects. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2005, Volume: 13, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Beverages; Cognition Disorders; Convalescence; Cross-Over Studies; Depressive Disorder, Major; Disability Evaluation; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neuropsychological Tests; Selective Serotonin Reuptake Inhibitors; Severity of Illness Index; Tryptophan	2005
Effects of rapid tryptophan depletion on salivary cortisol in older people recovered from depression, and the healthy elderly. Journal of psychopharmacology (Oxford, England), 2007, Volume: 21, Issue:1 Topics: Aged; Analysis of Variance; Antidepressive Agents; Convalescence; Cross-Over Studies; Depressive Disorder, Major; Double-Blind Method; Female; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Male; Pituitary-Adrenal System; Reference Values; Saliva; Serotonin; Time Factors; Tryptophan	2007
Tryptophan depletion affects heart rate variability and impulsivity in remitted depressed patients with a history of suicidal ideation. Biological psychiatry, 2006, Sep-01, Volume: 60, Issue:5 Topics: Adult; Amino Acids; Cross-Over Studies; Depressive Disorder, Major; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heart Rate; Humans; Impulsive Behavior; Male; Middle Aged; Neuropsychological Tests; Psychomotor Performance; Serotonin; Suicide; Tryptophan	2006
Effect of tryptophan depletion on smokers and nonsmokers with and without history of major depression. Biological psychiatry, 2007, Jan-01, Volume: 61, Issue:1 Topics: Adolescent; Adult; Aged; Analysis of Variance; Case-Control Studies; Depressive Disorder, Major; Double-Blind Method; Female; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Smoking; Smoking Prevention; Time Factors; Tryptophan	2007
Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls. Archives of general psychiatry, 2006, Volume: 63, Issue:9 Topics: Adult; Ambulatory Care; Amino Acids; Brain; Depressive Disorder, Major; Double-Blind Method; Female; Fluorodeoxyglucose F18; Genotype; Glucose; Humans; Male; Neural Pathways; Placebos; Polymorphism, Single Nucleotide; Positron-Emission Tomography; Prospective Studies; Psychiatric Status Rating Scales; Serotonin; Serotonin Plasma Membrane Transport Proteins; Tissue Distribution; Tryptophan	2006
Effect of tryptophan depletion on the attentional salience of smoking cues. Psychopharmacology, 2007, Volume: 192, Issue:3 Topics: Adult; Affect; Amino Acids; Attention; Cues; Depressive Disorder, Major; Double-Blind Method; Female; Humans; Male; Middle Aged; Multivariate Analysis; Serotonin; Smoking; Smoking Cessation; Tobacco Use Disorder; Tryptophan	2007
Interactive effects of sex and 5-HTTLPR on mood and impulsivity during tryptophan depletion in healthy people. Biological psychiatry, 2007, Sep-15, Volume: 62, Issue:6 Topics: Adult; Affect; Depressive Disorder, Major; Double-Blind Method; Female; Genotype; Humans; Impulsive Behavior; Male; Mood Disorders; Norway; Polymorphism, Genetic; Prevalence; Promoter Regions, Genetic; Serotonin; Serotonin Plasma Membrane Transport Proteins; Tryptophan	2007
Plasma NPY concentrations during tryptophan and sham depletion in medication-free patients with remitted depression. Journal of affective disorders, 2008, Volume: 110, Issue:3 Topics: Adult; Cross-Over Studies; Depressive Disorder, Major; Double-Blind Method; Female; Humans; Male; Neuropeptide Y; Remission Induction; Serotonin; Surveys and Questionnaires; Tryptophan; Young Adult	2008
Prospective trial of L-tryptophan in maternity blues. The British journal of psychiatry : the journal of mental science, 1980, Volume: 137 Topics: Adult; Clinical Trials as Topic; Depressive Disorder, Major; Double-Blind Method; Female; Humans; Psychiatric Status Rating Scales; Tryptophan	1980
Serotonergic 'vulnerability' in affective disorder: a study of the tryptophan depletion test and relationships between peripheral and central serotonin indexes in citalopram-responders. Acta psychiatrica Scandinavica, 1998, Volume: 97, Issue:5 Topics: Adult; Aged; Blood Platelets; Brain; Citalopram; Depressive Disorder, Major; Double-Blind Method; Female; Humans; Hydrocortisone; Male; Middle Aged; Personality Inventory; Prolactin; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin; Tryptophan	1998
Tryptophan depletion in normal volunteers produces selective impairment in memory consolidation. Psychopharmacology, 1999, Volume: 141, Issue:4 Topics: Adolescent; Adult; Amino Acids; Cognition; Cross-Over Studies; Depressive Disorder, Major; Double-Blind Method; Female; Humans; Learning; Male; Memory Disorders; Middle Aged; Sex Characteristics; Tryptophan	1999
Tryptophan-depletion challenge in depressed patients treated with desipramine or fluoxetine: implications for the role of serotonin in the mechanism of antidepressant action. Biological psychiatry, 1999, Jul-15, Volume: 46, Issue:2 Topics: Adult; Aged; Amino Acids; Analysis of Variance; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Brain; Depressive Disorder, Major; Desipramine; Female; Fluoxetine; Humans; Male; Middle Aged; Norepinephrine; Recurrence; Serotonin; Time Factors; Tryptophan	1999
Tryptophan depletion and risk of depression relapse: a prospective study of tryptophan depletion as a potential predictor of depressive episodes. Biological psychiatry, 2000, Aug-15, Volume: 48, Issue:4 Topics: Adult; Cross-Over Studies; Depressive Disorder, Major; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Predictive Value of Tests; Prospective Studies; Recurrence; Risk Factors; Severity of Illness Index; Tryptophan	2000
Preliminary randomized double-blind placebo-controlled trial of tryptophan combined with fluoxetine to treat major depressive disorder: antidepressant and hypnotic effects. Journal of psychiatry & neuroscience : JPN, 2000, Volume: 25, Issue:4 Topics: Adolescent; Adult; Aged; Antidepressive Agents; Depressive Disorder, Major; Double-Blind Method; Drug Therapy, Combination; Female; Fluoxetine; Humans; Hypnotics and Sedatives; Male; Severity of Illness Index; Tryptophan	2000
Monoamine depletion in unmedicated depressed subjects. Biological psychiatry, 2002, Mar-15, Volume: 51, Issue:6 Topics: Adult; alpha-Methyltyrosine; Catecholamines; Depressive Disorder, Major; Diphenhydramine; Dopamine; Double-Blind Method; Female; Humans; Male; Middle Aged; Norepinephrine; Personality Inventory; Serotonin; Tryptophan	2002

Other Studies

96 other study(ies) available for tryptophan and Depressive Disorder, Major

Article	Year
Investigation of the Relationship among Cortisol, Pro-inflammatory Cytokines, and the Degradation of Tryptophan into Kynurenine in Patients with Major Depression and Suicidal Behavior. Current topics in medicinal chemistry, 2022, Volume: 22, Issue:25 Topics: Cytokines; Depressive Disorder, Major; Humans; Hydrocortisone; Interleukin-1; Interleukin-12; Kynurenine; Suicide, Attempted; Tryptophan	2022
δ Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2021, Volume: 26, Issue:8 Topics: Biomarkers; Depressive Disorder, Major; Heart Rate; Humans; Kynurenine; Quinolinic Acid; Reproducibility of Results; Sensitivity and Specificity; Stress, Physiological; Tryptophan	2021
Selective association of cytokine levels and kynurenine/tryptophan ratio with alterations in white matter microstructure in bipolar but not in unipolar depression. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2022, Volume: 55 Topics: Biomarkers; Bipolar Disorder; Cytokines; Depressive Disorder, Major; Humans; Kynurenine; Tryptophan; White Matter	2022
Disturbance of neurotransmitter metabolism in drug-naïve, first-episode major depressive disorder: a comparative study on adult and adolescent cohorts. European archives of psychiatry and clinical neuroscience, 2022, Volume: 272, Issue:7 Topics: 3,4-Dihydroxyphenylacetic Acid; Adolescent; Adult; Biomarkers; Depressive Disorder, Major; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Methoxyhydroxyphenylglycol; Neurotransmitter Agents; Norepinephrine; Serotonin; Tryptophan; Vanilmandelic Acid	2022
Inflammation and serotonin deficiency in major depressive disorder: molecular docking of antidepressant and anti-inflammatory drugs to tryptophan and indoleamine 2,3-dioxygenases. Bioscience reports, 2022, 05-27, Volume: 42, Issue:5 Topics: Anti-Inflammatory Agents; Antidepressive Agents; Depressive Disorder, Major; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Molecular Docking Simulation; Salicylates; Serotonin; Tryptophan	2022
A combination of neuroimaging and plasma metabolomic analysis suggests inflammation is associated with white matter structural connectivity in major depressive disorder. Journal of affective disorders, 2022, 12-01, Volume: 318 Topics: Brain; Depressive Disorder, Major; Humans; Inflammation; Kynurenine; Lysophosphatidylcholines; Magnetic Resonance Imaging; Neuroimaging; Tryptophan; White Matter	2022
The Tryptophan Catabolite or Kynurenine Pathway's Role in Major Depression. Current topics in medicinal chemistry, 2022, Volume: 22, Issue:21 Topics: Depression; Depressive Disorder, Major; Humans; Kynurenine; Tryptophan	2022
Relationship between the tryptophan-kynurenine pathway and painful physical symptoms in patients with major depressive disorder. Journal of psychosomatic research, 2022, Volume: 163 Topics: Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Pain; Quinolinic Acid; Serotonin; Tandem Mass Spectrometry; Tryptophan	2022
Tryptophan catabolites and depression in the general population: results from the Gutenberg Health Study. BMC psychiatry, 2023, 01-11, Volume: 23, Issue:1 Topics: Biomarkers; C-Reactive Protein; Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Tryptophan	2023
A Preliminary Comparison of Plasma Tryptophan Metabolites and Medium- and Long-Chain Fatty Acids in Adult Patients with Major Depressive Disorder and Schizophrenia. Medicina (Kaunas, Lithuania), 2023, Feb-20, Volume: 59, Issue:2 Topics: Adult; Depressive Disorder, Major; Fatty Acids; Fatty Acids, Omega-3; Humans; Reproducibility of Results; Schizophrenia; Tryptophan	2023
Stress and Kynurenine-Inflammation Pathway in Major Depressive Disorder. Advances in experimental medicine and biology, 2023, Volume: 1411 Topics: Depressive Disorder, Major; Dioxygenases; Humans; Inflammation; Kynurenine; Quality of Life; Tryptophan	2023
[Diagnoses and new therapeutic strategy focused on physiological alteration of tryptophan metabolism]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2023, May-01, Volume: 158, Issue:3 Topics: alpha7 Nicotinic Acetylcholine Receptor; Antidepressive Agents; Depressive Disorder, Major; Humans; Kynurenine; Serotonin; Tryptophan	2023
Dysbiosis of the Gut Microbiota and Kynurenine (Kyn) Pathway Activity as Potential Biomarkers in Patients with Major Depressive Disorder. Nutrients, 2023, Apr-03, Volume: 15, Issue:7 Topics: Biomarkers; China; Depressive Disorder, Major; Dysbiosis; Gastrointestinal Microbiome; Humans; Kynurenine; Tryptophan	2023
Identification of paeoniflorin from Paeonia lactiflora pall. As an inhibitor of tryptophan 2,3-dioxygenase and assessment of its pharmacological effects on depressive mice. Journal of ethnopharmacology, 2023, Dec-05, Volume: 317 Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; Dioxygenases; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Ligands; Mice; Molecular Docking Simulation; Paeonia; Pilot Projects; Tryptophan; Tryptophan Oxygenase	2023
Metabolites for monitoring symptoms and predicting remission in patients with depression who received electroconvulsive therapy: a pilot study. Scientific reports, 2023, 08-14, Volume: 13, Issue:1 Topics: Biomarkers; Depression; Depressive Disorder, Major; Electroconvulsive Therapy; gamma-Aminobutyric Acid; Humans; Pilot Projects; Treatment Outcome; Tryptophan	2023
Organic cation transporter 2 contributes to SSRI antidepressant efficacy by controlling tryptophan availability in the brain. Translational psychiatry, 2023, 09-29, Volume: 13, Issue:1 Topics: Anhedonia; Animals; Antidepressive Agents; Brain; Corticosterone; Depressive Disorder, Major; Fluoxetine; Kynurenine; Mice; Organic Cation Transporter 2; Selective Serotonin Reuptake Inhibitors; Serotonin; Tryptophan	2023
Peripheral tryptophan, serotonin, kynurenine, and their metabolites in major depression: A case-control study. Psychiatry and clinical neurosciences, 2020, Volume: 74, Issue:2 Topics: 3-Hydroxyanthranilic Acid; Adult; Case-Control Studies; Cohort Studies; Depressive Disorder, Major; Female; Humans; Kynurenine; Male; Middle Aged; Niacinamide; Picolinic Acids; Serotonin; Tryptophan; Xanthurenates	2020
Shotgun metagenomics reveals both taxonomic and tryptophan pathway differences of gut microbiota in major depressive disorder patients. Psychological medicine, 2021, Volume: 51, Issue:1 Topics: Adult; Aged; Depressive Disorder, Major; Female; Gastrointestinal Microbiome; Humans; Male; Metagenomics; Middle Aged; Tryptophan	2021
The relationship between dietary patterns and depression mediated by serum levels of Folate and vitamin B12. BMC psychiatry, 2020, 02-13, Volume: 20, Issue:1 Topics: Adolescent; Adult; Aged; Case-Control Studies; Depression; Depressive Disorder, Major; Female; Folic Acid; Homocysteine; Humans; Iran; Logistic Models; Male; Middle Aged; Tryptophan; Vitamin B 12; Young Adult	2020
Shotgun metagenomics reveals both taxonomic and tryptophan pathway differences of gut microbiota in bipolar disorder with current major depressive episode patients. Journal of affective disorders, 2021, 01-01, Volume: 278 Topics: Bipolar Disorder; Cross-Sectional Studies; Depressive Disorder, Major; Gastrointestinal Microbiome; Humans; Metagenomics; Tryptophan	2021
Activation and deactivation steps in the tryptophan breakdown pathway in major depressive disorder: A link to the monocyte inflammatory state of patients. Progress in neuro-psychopharmacology & biological psychiatry, 2021, 04-20, Volume: 107 Topics: Adult; Cohort Studies; Depressive Disorder, Major; Female; Germany; Humans; Inflammation Mediators; Male; Middle Aged; Monocytes; Signal Transduction; Tryptophan	2021
The role of anthranilic acid in the increase of depressive symptoms and major depressive disorder during treatment for hepatitis C with pegylated interferon-α2a and oral ribavirin. Journal of psychiatry & neuroscience : JPN, 2021, 01-18, Volume: 46, Issue:1 Topics: Adult; Antiviral Agents; Cross-Sectional Studies; Depression; Depressive Disorder, Major; Female; Hepatitis C, Chronic; Humans; Immunologic Factors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-alpha; Kynurenic Acid; Kynurenine; Longitudinal Studies; Male; Middle Aged; ortho-Aminobenzoates; Polyethylene Glycols; Recombinant Proteins; Ribavirin; Tryptophan	2021
A study of tryptophan, kynurenine and serotonin transporter in first-episode drug-naïve major depressive disorder. Psychiatry research. Neuroimaging, 2021, 06-30, Volume: 312 Topics: Depressive Disorder, Major; Humans; Kynurenine; Pharmaceutical Preparations; Serotonin Plasma Membrane Transport Proteins; Tryptophan	2021
Quinolinic acid is associated with cognitive deficits in schizophrenia but not major depressive disorder. Scientific reports, 2021, 05-11, Volume: 11, Issue:1 Topics: Adult; Case-Control Studies; Cognition; Cognitive Dysfunction; Depressive Disorder, Major; Female; Humans; Kynurenine; Male; Middle Aged; Quinolinic Acid; Schizophrenia; Tryptophan; Young Adult	2021
Postpartum corticosterone and fluoxetine shift the tryptophan-kynurenine pathway in dams. Psychoneuroendocrinology, 2021, Volume: 130 Topics: Animals; Corticosterone; Depression, Postpartum; Depressive Disorder, Major; Female; Fluoxetine; Humans; Kynurenine; Postpartum Period; Pregnancy; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Tryptophan	2021
Serum proteomic analysis of major depressive disorder patients and their remission status: Novel biomarker set of zinc-alpha-2-glycoprotein and keratin type II cytoskeletal 1. International journal of biological macromolecules, 2021, Jul-31, Volume: 183 Topics: Adipokines; Adult; Aged; Biomarkers; Case-Control Studies; Chromatography, Liquid; Depressive Disorder, Major; Early Diagnosis; Female; Humans; Keratin-1; Male; Middle Aged; Proteomics; Tandem Mass Spectrometry; Tryptophan; Up-Regulation	2021
The association between plasma tryptophan catabolites and depression: The role of symptom profiles and inflammation. Brain, behavior, and immunity, 2021, Volume: 97 Topics: Depression; Depressive Disorder, Major; Humans; Inflammation; Kynurenic Acid; Kynurenine; Tryptophan	2021
IgM-mediated autoimmune responses to oxidative specific epitopes, but not nitrosylated adducts, are significantly decreased in pregnancy: association with bacterial translocation, perinatal and lifetime major depression and the tryptophan catabolite (TRYC Metabolic brain disease, 2017, Volume: 32, Issue:5 Topics: Adult; Autoimmunity; Bacterial Translocation; Biomarkers; Cytokines; Depression, Postpartum; Depressive Disorder, Major; Epitopes; Female; Gram-Negative Bacteria; Humans; Immunoglobulin M; Inflammation; Kynurenine; Metabolic Networks and Pathways; Nitric Oxide; Pregnancy; Tryptophan; Young Adult	2017
The association between the hypothalamic pituitary adrenal axis and tryptophan metabolism in persons with recurrent major depressive disorder and healthy controls. Journal of affective disorders, 2017, Volume: 222 Topics: Adult; Antidepressive Agents; Chromatography, High Pressure Liquid; Depression; Depressive Disorder, Major; Female; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Kynurenine; Male; Middle Aged; Pituitary-Adrenal System; Recurrence; Tandem Mass Spectrometry; Tryptophan	2017
Major Depression as a Neuroprogressive Prelude to Dementia: What Is the Evidence? Modern trends in pharmacopsychiatry, 2017, Volume: 31 Topics: Brain; Cytokines; Dementia; Depressive Disorder, Major; Humans; Inflammation; Kynurenine; Oxidative Stress; Quinolinic Acid; Tryptophan	2017
Tryptophan-kynurenine and lipid related metabolites as blood biomarkers for first-episode drug-naïve patients with major depressive disorder: An exploratory pilot case-control study. Journal of affective disorders, 2018, 04-15, Volume: 231 Topics: Adult; Biomarkers; Case-Control Studies; Depressive Disorder, Major; Female; Humans; Kynurenine; Lipids; Male; Middle Aged; Pilot Projects; Predictive Value of Tests; Prospective Studies; Severity of Illness Index; Tryptophan	2018
Kynurenine pathway changes in late-life depression. Journal of affective disorders, 2018, 08-01, Volume: 235 Topics: Adult; Age Factors; Aged; Depressive Disorder, Major; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Psychiatric Status Rating Scales; Tryptophan	2018
Polyunsaturated fatty acids metabolism, purine metabolism and inosine as potential independent diagnostic biomarkers for major depressive disorder in children and adolescents. Molecular psychiatry, 2019, Volume: 24, Issue:10 Topics: Adolescent; Biomarkers; Case-Control Studies; Child; China; Chromatography, High Pressure Liquid; Depression; Depressive Disorder, Major; Fatty Acids, Unsaturated; Female; Humans; Inosine; Lipid Metabolism; Male; Mass Spectrometry; Metabolomics; Purines; ROC Curve; Tryptophan	2019
Altered tryptophan catabolite concentrations in major depressive disorder and associated changes in hippocampal subfield volumes. Psychoneuroendocrinology, 2018, Volume: 95 Topics: Adult; Biomarkers; C-Reactive Protein; CA1 Region, Hippocampal; CA2 Region, Hippocampal; CA3 Region, Hippocampal; Chromatography, Liquid; Depressive Disorder, Major; Diagnostic and Statistical Manual of Mental Disorders; Female; Hippocampus; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Male; Middle Aged; Quinolinic Acid; Tandem Mass Spectrometry; Tryptophan	2018
Tryptophan and Kynurenine Metabolites: Are They Related to Depression? Neuropsychobiology, 2019, Volume: 77, Issue:1 Topics: Adult; Bipolar Disorder; Case-Control Studies; Depressive Disorder, Major; Female; Humans; Hydroxyindoleacetic Acid; Kynurenine; Male; ortho-Aminobenzoates; Suicide, Attempted; Tryptophan; Xanthurenates	2019
Major depression model induced by repeated and intermittent lipopolysaccharide administration: Long-lasting behavioral, neuroimmune and neuroprogressive alterations. Journal of psychiatric research, 2018, Volume: 107 Topics: Animals; Behavior, Animal; Depressive Disorder, Major; Disease Models, Animal; Female; Fluoxetine; Lipopolysaccharides; Mice; Selective Serotonin Reuptake Inhibitors; Serotonin; Tryptophan	2018
Cross-sectional relationship between kynurenine pathway metabolites and cognitive function in major depressive disorder. Psychoneuroendocrinology, 2019, Volume: 101 Topics: Adult; Chromatography, Liquid; Cognition; Cross-Sectional Studies; Depression; Depressive Disorder, Major; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Quinolinic Acid; Tryptophan	2019
Tryptophan metabolism and immunogenetics in major depression: a role for interferon-γ gene. Brain, behavior, and immunity, 2013, Volume: 31 Topics: Adult; Aged; Depressive Disorder, Major; Female; Humans; Hydroxyindoleacetic Acid; Immunogenetics; Interferon-gamma; Kynurenine; Male; Middle Aged; Polymorphism, Genetic; Serotonin; Tryptophan	2013
Tryptophan: the key to boosting brain serotonin synthesis in depressive illness. Journal of psychopharmacology (Oxford, England), 2013, Volume: 27, Issue:10 Topics: Animals; Antidepressive Agents; Brain; Depressive Disorder, Major; Humans; Serotonin; Tryptophan; Tryptophan Hydroxylase; Tryptophan Oxygenase	2013
The moderating influence of nicotine and smoking on resting-state mood and EEG changes in remitted depressed patients during tryptophan depletion. Biological psychology, 2013, Volume: 94, Issue:3 Topics: Adult; Affect; Brain; Depressive Disorder, Major; Double-Blind Method; Electroencephalography; Female; Humans; Male; Nicotine; Serotonin; Smoking; Tryptophan	2013
Physiosomatic complaints, immune-inflammatory pathways, and serotonin-related mood symptoms: relevance for tryptophan-related challenge procedures and clinical considerations with respect to the DSM-V. Acta psychiatrica Scandinavica, 2014, Volume: 129, Issue:2 Topics: Depressive Disorder, Major; Fatigue Syndrome, Chronic; Humans; Immunity, Cellular; Somatoform Disorders; Tryptophan	2014
Tryptophan and inhibitors of tryptophan 2,3-dioxygenase as antidepressants. Journal of psychopharmacology (Oxford, England), 2014, Volume: 28, Issue:2 Topics: Animals; Brain; Depressive Disorder, Major; Humans; Serotonin; Tryptophan	2014
Tryptophan and inhibitors of tryptophan 2,3-dioxygenase as antidepressants: reply. Journal of psychopharmacology (Oxford, England), 2014, Volume: 28, Issue:2 Topics: Animals; Brain; Depressive Disorder, Major; Humans; Serotonin; Tryptophan	2014
Does tryptophan degradation along the kynurenine pathway mediate the association between pro-inflammatory immune activity and depressive symptoms? Psychoneuroendocrinology, 2014, Volume: 45 Topics: Adolescent; Adult; Aged; Case-Control Studies; Depression; Depressive Disorder, Major; Female; Humans; Immune System; Inflammation; Inflammation Mediators; Kynurenine; Male; Metabolic Networks and Pathways; Middle Aged; Netherlands; Proteolysis; Tryptophan; Young Adult	2014
Putative neuroprotective and neurotoxic kynurenine pathway metabolites are associated with hippocampal and amygdalar volumes in subjects with major depressive disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015, Volume: 40, Issue:2 Topics: Adult; Amygdala; Anhedonia; Brain-Derived Neurotrophic Factor; C-Reactive Protein; Depressive Disorder, Major; Female; Gray Matter; Hippocampus; Humans; Kynurenic Acid; Kynurenine; Male; Organ Size; Psychiatric Status Rating Scales; Quinolinic Acid; Receptors, Interleukin-1; Signal Transduction; Tryptophan	2015
Serum interleukin-6 is a predictive biomarker for ketamine's antidepressant effect in treatment-resistant patients with major depression. Biological psychiatry, 2015, Feb-01, Volume: 77, Issue:3 Topics: Antidepressive Agents; Biomarkers, Pharmacological; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Humans; Inpatients; Interleukin-1beta; Interleukin-6; Ketamine; Kynurenine; Psychiatric Status Rating Scales; Treatment Outcome; Tryptophan; Tumor Necrosis Factor-alpha	2015
Ongoing episode of major depressive disorder is not associated with elevated plasma levels of kynurenine pathway markers. Psychoneuroendocrinology, 2015, Volume: 56 Topics: Adolescent; Adult; Biomarkers; Chromatography, High Pressure Liquid; Cytokines; Depressive Disorder, Major; Female; Humans; Interview, Psychological; Kynurenine; Male; Middle Aged; Psychiatric Status Rating Scales; Quinolinic Acid; Signal Transduction; Treatment Outcome; Tryptophan; Young Adult	2015
Discovery and validation of plasma biomarkers for major depressive disorder classification based on liquid chromatography-mass spectrometry. Journal of proteome research, 2015, May-01, Volume: 14, Issue:5 Topics: Adult; Biomarkers; Carnitine; Case-Control Studies; Chromatography, Liquid; Depressive Disorder, Major; Female; Humans; Lipid Metabolism; Logistic Models; Lysophosphatidylcholines; Lysophospholipids; Male; Metabolome; Middle Aged; Phosphatidylethanolamines; Quality of Life; Sensitivity and Specificity; Severity of Illness Index; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tryptophan	2015
The role of the kynurenine pathway in suicidality in adolescent major depressive disorder. Psychiatry research, 2015, Jun-30, Volume: 227, Issue:2-3 Topics: Adolescent; Anhedonia; Biomarkers; Depressive Disorder, Major; Female; Humans; Kynurenine; Male; Suicide; Suicide, Attempted; Tryptophan	2015
Effects of acute tryptophan depletion on raphé functional connectivity in depression. Psychiatry research, 2015, Nov-30, Volume: 234, Issue:2 Topics: Adult; Depressive Disorder, Major; Female; Gyrus Cinguli; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nerve Net; Raphe Nuclei; Thalamus; Tryptophan	2015
(13)C-tryptophan breath test detects increased catabolic turnover of tryptophan along the kynurenine pathway in patients with major depressive disorder. Scientific reports, 2015, Nov-03, Volume: 5 Topics: Administration, Oral; Adult; Aged; Analysis of Variance; Antidepressive Agents; Area Under Curve; Breath Tests; Carbon Dioxide; Carbon Isotopes; Depressive Disorder, Major; Exhalation; Female; Humans; Kynurenine; Male; Metabolic Clearance Rate; Metabolic Networks and Pathways; Middle Aged; Regression Analysis; Tryptophan	2015
Relationship between neurotoxic kynurenine metabolites and reductions in right medial prefrontal cortical thickness in major depressive disorder. Brain, behavior, and immunity, 2016, Volume: 53 Topics: Adult; Brain; C-Reactive Protein; Case-Control Studies; Cerebral Cortex; Depressive Disorder, Major; Female; Gray Matter; Humans; Kynurenic Acid; Kynurenine; Magnetic Resonance Imaging; Male; Neurotoxicity Syndromes; Prefrontal Cortex; Quinolinic Acid; Tryptophan	2016
Mast cells' involvement in inflammation pathways linked to depression: evidence in mastocytosis. Molecular psychiatry, 2016, Volume: 21, Issue:11 Topics: Depression; Depressive Disorder, Major; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenic Acid; Kynurenine; Male; Mast Cells; Mastocytosis; Middle Aged; Psychiatric Status Rating Scales; Serotonin; Stress, Psychological; Tryptophan	2016
Electroconvulsive therapy suppresses the neurotoxic branch of the kynurenine pathway in treatment-resistant depressed patients. Journal of neuroinflammation, 2016, Feb-29, Volume: 13, Issue:1 Topics: Adult; Chromatography, High Pressure Liquid; Cohort Studies; Cytokines; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Diagnostic and Statistical Manual of Mental Disorders; Electroconvulsive Therapy; Female; Humans; Interleukin-6; Kynurenine; Luminescence; Male; Metabolic Networks and Pathways; Middle Aged; Psychiatric Status Rating Scales; Treatment Outcome; Tryptophan; Young Adult	2016
Inflammasome Activation in Major Depressive Disorder: A Pivotal Linkage Between Psychological Stress, Purinergic Signaling, and the Kynurenine Pathway. Biological psychiatry, 2016, 07-01, Volume: 80, Issue:1 Topics: Depressive Disorder, Major; Humans; Inflammasomes; Kynurenine; Stress, Psychological; Tryptophan	2016
Metabolomic signatures of drug response phenotypes for ketamine and esketamine in subjects with refractory major depressive disorder: new mechanistic insights for rapid acting antidepressants. Translational psychiatry, 2016, 09-20, Volume: 6, Issue:9 Topics: Adult; Arginine; Citrulline; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Indoleacetic Acids; Infusions, Intravenous; Ketamine; Male; Metabolomics; Methionine; Middle Aged; Ornithine; Phenotype; Phospholipids; Tryptophan; Urea	2016
Kynurenine 3-monooxygenase is implicated in antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions. Behavioural brain research, 2017, 01-15, Volume: 317 Topics: Animals; Antidepressive Agents; Biogenic Monoamines; Depressive Disorder, Major; Disease Models, Animal; Exploratory Behavior; Food Preferences; Hippocampus; Imipramine; Kynurenine; Kynurenine 3-Monooxygenase; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Sertraline; Sucrose; Swimming; Tryptophan	2017
Secondary to excessive melatonin synthesis, the consumption of tryptophan from outside the blood-brain barrier and melatonin over-signaling in the pars tuberalis may be central to the pathophysiology of winter depression. Medical hypotheses, 2017, Volume: 98 Topics: Animals; Blood-Brain Barrier; Central Nervous System; Depressive Disorder, Major; Diet; Humans; Light; Melatonin; Pituitary Gland; Seasonal Affective Disorder; Seasons; Serotonin; Signal Transduction; Thyroid Hormones; Tryptophan	2017
A case of prolonged seizure after ECT in a patient treated with clomipramine, lithium, L-tryptophan, quetiapine, and thyroxine for major depression. The journal of ECT, 2008, Volume: 24, Issue:4 Topics: Affect; Antidepressive Agents; Antidepressive Agents, Tricyclic; Antimanic Agents; Antipsychotic Agents; Clomipramine; Combined Modality Therapy; Depressive Disorder, Major; Dibenzothiazepines; Electroconvulsive Therapy; Electroencephalography; Female; Humans; Lithium Compounds; Middle Aged; Quetiapine Fumarate; Recurrence; Status Epilepticus; Thyroxine; Tryptophan	2008
Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon-gamma, severity of symptoms and psychiatric co-morbidity. Neurogastroenterology and motility, 2008, Volume: 20, Issue:12 Topics: Adult; Anxiety Disorders; Chromatography, High Pressure Liquid; Comorbidity; Depressive Disorder, Major; Female; Humans; Interferon-gamma; Irritable Bowel Syndrome; Kynurenine; Mental Disorders; Tryptophan	2008
Functional change of the auditory cortex related to brain serotonergic neurotransmission in type 1 diabetic adolescents with and without depression. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2009, Volume: 10, Issue:4 Pt 3 Topics: Adolescent; Albumins; Auditory Cortex; Blood Glucose; Brain; Depressive Disorder, Major; Diabetes Mellitus, Type 1; Diagnostic and Statistical Manual of Mental Disorders; Evoked Potentials, Auditory; Female; Glycated Hemoglobin; Humans; Male; Serotonin; Severity of Illness Index; Synaptic Transmission; Tryptophan	2009
Canadian Network for Mood and Anxiety Treatments (CANMAT) Clinical guidelines for the management of major depressive disorder in adults. V. Complementary and alternative medicine treatments. Journal of affective disorders, 2009, Volume: 117 Suppl 1 Topics: Acupuncture Therapy; Adult; Antidepressive Agents; Complementary Therapies; Dehydroepiandrosterone; Depressive Disorder, Major; Dietary Supplements; Exercise Therapy; Fatty Acids, Omega-3; Herbal Medicine; Humans; Hypericum; Phototherapy; Phytotherapy; S-Adenosylmethionine; Sleep Deprivation; Tryptophan; Yoga	2009
Peripheral and cerebral metabolic abnormalities of the tryptophan-kynurenine pathway in a murine model of major depression. Behavioural brain research, 2010, Jun-26, Volume: 210, Issue:1 Topics: Animals; Brain; Chronic Disease; Depressive Disorder, Major; Disease Models, Animal; Hydroxyindoleacetic Acid; Kynurenine; Lung; Male; Metabolic Networks and Pathways; Mice; Mice, Inbred BALB C; Serotonin; Stress, Psychological; Tryptophan	2010
The possible role of the kynurenine pathway in adolescent depression with melancholic features. Journal of child psychology and psychiatry, and allied disciplines, 2010, Volume: 51, Issue:8 Topics: 3-Hydroxyanthranilic Acid; Adolescent; Child; Cytokines; Depressive Disorder; Depressive Disorder, Major; Enzyme Induction; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation Mediators; Kynurenine; Male; Neurotoxins; Reference Values; Tryptophan; Young Adult	2010
Gender differences in alpha-[(11)C]MTrp brain trapping, an index of serotonin synthesis, in medication-free individuals with major depressive disorder: a positron emission tomography study. Psychiatry research, 2010, Aug-30, Volume: 183, Issue:2 Topics: Adult; Brain; Brain Mapping; Depressive Disorder, Major; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Sex Characteristics; Tryptophan; Young Adult	2010
Effects of maternal L-tryptophan depletion and corticosterone administration on neurobehavioral adjustments in mouse dams and their adolescent and adult daughters. Progress in neuro-psychopharmacology & biological psychiatry, 2011, Aug-01, Volume: 35, Issue:6 Topics: Age Factors; Animals; Animals, Newborn; Animals, Outbred Strains; Brain; Brain-Derived Neurotrophic Factor; Conditioning, Operant; Corticosterone; Depressive Disorder, Major; Disease Models, Animal; Exploratory Behavior; Female; Hypothalamic Diseases; Male; Maternal Behavior; Maze Learning; Mice; Pregnancy; Stress, Psychological; Tryptophan	2011
Plasma kynurenine levels are elevated in suicide attempters with major depressive disorder. Brain, behavior, and immunity, 2011, Volume: 25, Issue:6 Topics: Adolescent; Adult; Aged; Antidepressive Agents; Cytokines; Depressive Disorder, Major; Duloxetine Hydrochloride; Female; Humans; Hypericum; Impulsive Behavior; Inflammation; Kynurenine; Male; Middle Aged; Neopterin; Phytotherapy; Recurrence; Serotonin; Smoking; Suicide, Attempted; Thiophenes; Tryptophan; Young Adult	2011
SSRIs and placental dysfunction. Medical hypotheses, 2011, Volume: 77, Issue:2 Topics: Depressive Disorder, Major; Fatty Acids, Unsaturated; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Lipid Peroxidation; Oxidative Stress; Placenta; Pregnancy; Reactive Nitrogen Species; Reactive Oxygen Species; Selective Serotonin Reuptake Inhibitors; Tryptophan	2011
Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission? Journal of neuroinflammation, 2011, Aug-10, Volume: 8 Topics: Adult; Aged; Depressive Disorder, Major; Female; Glutamic Acid; Gyrus Cinguli; Humans; Male; Microglia; Middle Aged; Quinolinic Acid; Serotonin; Synaptic Transmission; Tryptophan	2011
Simultaneous determination of tyrosine, tryptophan and 5-hydroxytryptamine in serum of MDD patients by high performance liquid chromatography with fluorescence detection. Clinica chimica acta; international journal of clinical chemistry, 2012, Jun-14, Volume: 413, Issue:11-12 Topics: Adult; Blood Proteins; Calibration; Chromatography, High Pressure Liquid; Depressive Disorder, Major; Female; Fluorescence; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Reproducibility of Results; Sensitivity and Specificity; Serotonin; Time Factors; Tryptophan; Tyrosine; Young Adult	2012
Serotonin transporter genotype differentially modulates neural responses to emotional words following tryptophan depletion in patients recovered from depression and healthy volunteers. Journal of psychopharmacology (Oxford, England), 2012, Volume: 26, Issue:11 Topics: Adult; Affect; Case-Control Studies; Depressive Disorder, Major; Emotions; Female; Genotype; Gyrus Cinguli; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Polymorphism, Genetic; Serotonin Plasma Membrane Transport Proteins; Tryptophan; Young Adult	2012
Positron emission tomography study of the effects of tryptophan depletion on brain serotonin(2) receptors in subjects recently remitted from major depression. Archives of general psychiatry, 2012, Volume: 69, Issue:6 Topics: Adult; Antidepressive Agents; Brain; Depressive Disorder, Major; Fluorine Radioisotopes; Humans; Positron-Emission Tomography; Radiography; Receptors, Serotonin, 5-HT2; Recurrence; Selective Serotonin Reuptake Inhibitors; Tryptophan	2012
Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation. Brain, behavior, and immunity, 2012, Volume: 26, Issue:6 Topics: Adult; Biomarkers; C-Reactive Protein; Chromatography, High Pressure Liquid; Cytokines; Depressive Disorder, Major; Female; Humans; Kynurenine; Male; Real-Time Polymerase Chain Reaction; RNA, Messenger; Serotonin Plasma Membrane Transport Proteins; Signal Transduction; Tryptophan	2012
Increase in nitric oxide levels and mitochondrial membrane potential in platelets of untreated patients with major depression. Psychiatry research, 2013, Oct-30, Volume: 209, Issue:3 Topics: Adolescent; Adult; Chromatography, High Pressure Liquid; Depressive Disorder, Major; Female; Flow Cytometry; Humans; Male; Membrane Potential, Mitochondrial; Nitric Oxide; P-Selectin; Psychiatric Status Rating Scales; Serotonin; Tryptophan; Young Adult	2013
Membrane Na(+)-K+ ATPase mediated cascade in bipolar mood disorder, major depressive disorder, and schizophrenia--relationship to hemispheric dominance. The International journal of neuroscience, 2002, Volume: 112, Issue:8 Topics: Adult; Bipolar Disorder; Depressive Disorder, Major; Digoxin; Dominance, Cerebral; Humans; Hydroxymethylglutaryl CoA Reductases; Magnesium; Sampling Studies; Schizophrenia; Sodium-Potassium-Exchanging ATPase; Tryptophan; Tyrosine	2002
Association of a critical CSF tryptophan threshold level with depressive relapse. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2003, Volume: 28, Issue:5 Topics: Adult; Antidepressive Agents; Depressive Disorder, Major; Female; Humans; Male; Middle Aged; Recurrence; Statistics, Nonparametric; Tryptophan	2003
Cognitive changes after acute tryptophan depletion: what can they tell us? Psychological medicine, 2004, Volume: 34, Issue:1 Topics: Alzheimer Disease; Cognition Disorders; Depressive Disorder, Major; Human Experimentation; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Serotonin; Tryptophan	2004
Familial hypothalamic digoxin deficiency syndrome. The Journal of neuropsychiatry and clinical neurosciences, 2004,Winter, Volume: 16, Issue:1 Topics: Body Mass Index; Brain Chemistry; Depressive Disorder, Major; Digoxin; Dolichols; Dominance, Cerebral; Erythrocytes; Family Health; Female; Glycosaminoglycans; Humans; Hydroxymethylglutaryl CoA Reductases; Hypertension; Hypothalamic Diseases; Male; Obsessive-Compulsive Disorder; Osteoporosis; Respiration Disorders; Sexual Dysfunction, Physiological; Sodium-Potassium-Exchanging ATPase; Tics; Tryptophan; Tyrosine	2004
Changes in plasma amino acids after electroconvulsive therapy of depressed patients. Psychiatry research, 2005, Dec-15, Volume: 137, Issue:3 Topics: Adult; Aged; Aspartic Acid; Depressive Disorder, Major; Electroconvulsive Therapy; Electroencephalography; Electromyography; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Male; Middle Aged; Time Factors; Tryptophan	2005
Brain-derived neurotrophic factor in patients with remitted depression. The American journal of psychiatry, 2005, Volume: 162, Issue:12 Topics: Brain-Derived Neurotrophic Factor; Depressive Disorder, Major; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Pituitary-Adrenal System; Research Design; Serotonin; Tryptophan	2005
Tryptophan depletion and alcoholism research. The Australian and New Zealand journal of psychiatry, 2006, Volume: 40, Issue:3 Topics: Alcoholism; Comorbidity; Depressive Disorder, Major; Drive; Genetic Predisposition to Disease; Humans; Research; Tryptophan	2006
Kynurenine--an old pathway retraced. Journal of clinical psychopharmacology, 2006, Volume: 26, Issue:4 Topics: Animals; Depressive Disorder, Major; Humans; Hydrolases; Inflammation; Interferons; Kynurenine; ortho-Aminobenzoates; Rats; Review Literature as Topic; Tryptophan	2006
The resistance to depressive relapse in menopausal women undergoing tryptophan depletion: preliminary findings. Journal of psychopharmacology (Oxford, England), 2007, Volume: 21, Issue:4 Topics: Adult; Affect; Cognition; Depressive Disorder, Major; Drug Therapy, Combination; Estradiol; Female; Fluoxetine; Humans; Menopause; Middle Aged; Pilot Projects; Recurrence; Risk Factors; Selective Serotonin Reuptake Inhibitors; Serotonin; Tryptophan	2007
Peripheral serotonergic markers in acutely suicidal patients. 1. Comparison of serotonergic platelet measures between suicidal individuals, nonsuicidal patients with major depression and healthy subjects. Journal of neural transmission (Vienna, Austria : 1996), 2007, Volume: 114, Issue:4 Topics: Adult; Biomarkers; Blood Platelets; Depressive Disorder, Major; Female; Humans; Male; Mental Disorders; Monoamine Oxidase; Serotonin; Sex Factors; Suicide, Attempted; Tryptophan	2007
Patients with a major depressive episode responding to treatment with repetitive transcranial magnetic stimulation (rTMS) are resistant to the effects of rapid tryptophan depletion. Depression and anxiety, 2007, Volume: 24, Issue:8 Topics: Adult; Demography; Depressive Disorder, Major; Female; Humans; Male; Serotonin; Severity of Illness Index; Surveys and Questionnaires; Time Factors; Transcranial Magnetic Stimulation; Tryptophan	2007
Deep brain stimulation of the lateral habenula in treatment resistant major depression. Medical hypotheses, 2007, Volume: 69, Issue:6 Topics: Animals; Antidepressive Agents; Deep Brain Stimulation; Depression; Depressive Disorder, Major; Electric Stimulation; Electrophysiology; Habenula; Humans; Models, Theoretical; Positron-Emission Tomography; Serotonin; Synaptic Transmission; Tryptophan; Tyrosine	2007
Affective temperament: a mediating variable between environment and clinical depression? Archives of general psychiatry, 2007, Volume: 64, Issue:9 Topics: Depressive Disorder, Major; Female; Genotype; Humans; Irritable Mood; Male; Mood Disorders; Phenotype; Polymorphism, Genetic; Serotonin Plasma Membrane Transport Proteins; Temperament; Tryptophan	2007
Interpreting tryptophan depletion in tobacco smokers. Biological psychiatry, 2008, Feb-15, Volume: 63, Issue:4 Topics: Depressive Disorder, Major; Humans; Tobacco Use Disorder; Tryptophan	2008
Plasma and platelet amino acid concentrations in patients affected by major depression and under fluvoxamine treatment. Neuropsychobiology, 1998, Volume: 37, Issue:3 Topics: Adult; Aged; Amino Acids; Antidepressive Agents, Second-Generation; Blood Platelets; Depressive Disorder, Major; Female; Fluvoxamine; Humans; Male; Middle Aged; Reference Values; Tryptophan	1998
Relationship between blood serotonergic variables, melancholic traits, and response to antidepressant treatments. Journal of clinical psychopharmacology, 1998, Volume: 18, Issue:3 Topics: Adult; Antidepressive Agents; Blood Platelets; Clomipramine; Depressive Disorder; Depressive Disorder, Major; Female; Fluvoxamine; Humans; Male; Middle Aged; Prognosis; Serotonin; Thiazepines; Tryptophan	1998
Relationships between low red blood cell count and clinical response to fluoxetine in depressed elderly patients. Psychiatry research, 1998, Dec-14, Volume: 81, Issue:3 Topics: Aged; Aged, 80 and over; Antidepressive Agents, Second-Generation; Blood Platelets; Carrier Proteins; Depressive Disorder, Major; Erythrocyte Count; Female; Fluoxetine; Humans; Ketanserin; Male; Middle Aged; Personality Inventory; Receptors, Drug; Serotonin; Treatment Outcome; Tryptophan	1998
Covariation of activity in habenula and dorsal raphé nuclei following tryptophan depletion. NeuroImage, 1999, Volume: 10, Issue:2 Topics: Adult; Amygdala; Arousal; Attention; Brain Mapping; Depressive Disorder, Major; Gyrus Cinguli; Habenula; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Raphe Nuclei; Recurrence; Serotonin; Tomography, Emission-Computed; Tryptophan; Verbal Behavior	1999
Relation of serum cholesterol, lipid, serotonin and tryptophan levels to severity of depression and to suicide attempts. Journal of psychiatry & neuroscience : JPN, 2000, Volume: 25, Issue:4 Topics: Adult; Cholesterol; Depressive Disorder, Major; Female; Humans; Lipoproteins; Male; Serotonin; Severity of Illness Index; Suicide, Attempted; Tryptophan	2000
Effect of electroconvulsive therapy on biopterin and large neutral amino acids in severe, medication-resistant depression. Psychiatry research, 2001, Sep-20, Volume: 103, Issue:2-3 Topics: Adult; Aged; Amino Acids, Neutral; Biopterins; Depressive Disorder, Major; Electroconvulsive Therapy; Female; Humans; Isoleucine; Leucine; Male; Middle Aged; Neopterin; Phenylalanine; Psychiatric Status Rating Scales; Psychotic Disorders; Reference Values; Treatment Outcome; Tryptophan; Tyrosine; Valine	2001
Biochemical stress of caring. Psychological medicine, 2001, Volume: 31, Issue:8 Topics: Adult; Aged; Alzheimer Disease; Brain; Caregivers; Depressive Disorder, Major; Female; Humans; Hydrocortisone; Male; Middle Aged; Prevalence; Psychiatric Status Rating Scales; Saliva; Stress, Psychological; Tryptophan	2001
Association between a serotonin transporter promoter region polymorphism and mood response during tryptophan depletion. Molecular psychiatry, 2002, Volume: 7, Issue:2 Topics: Adult; Affect; Aged; Carrier Proteins; Depressive Disorder, Major; Female; Genotype; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Nerve Tissue Proteins; Polymorphism, Genetic; Promoter Regions, Genetic; Serotonin; Serotonin Plasma Membrane Transport Proteins; Tryptophan	2002