tryptophan has been researched along with Cataract in 96 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 52 (54.17) | 18.7374 |
1990's | 14 (14.58) | 18.2507 |
2000's | 13 (13.54) | 29.6817 |
2010's | 15 (15.63) | 24.3611 |
2020's | 2 (2.08) | 2.80 |
Authors | Studies |
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Clark, R; Dyba, M; Hejtmancik, JF; Ostrowski, C; Tarasov, SG; Vendra, VPR | 1 |
Butts, CT; Freites, JA; Prytkova, V; Tobias, DJ; Wong, EK | 1 |
Abu-Hussien, M; Gazit, E; Haj, E; Paul, A; Segal, D; Viswanathan, GK | 1 |
Erichsen, JH; Kessel, L; Mensah, A | 1 |
Chen, XJ; Xu, J; Yan, YB; Yao, K; Zhao, WJ | 1 |
Huynh, T; King, JA; Xia, Z; Yang, Z; Zhou, R | 2 |
Srinivasan, K; Suresha, BS | 1 |
King, J; Schafheimer, N; Schey, K; Wang, Z | 1 |
Caceres, MA; Chang, ML; David, LL; Liu, K; Shang, F; Taylor, A; Wawrousek, E; Wilmarth, PA | 1 |
Chaudhury, S; Dasgupta, S; Ghosh, I; Saha, G | 1 |
Davies, MJ; Hawkins, CL; Janmie, JF; Truscott, RJ; Tweeddale, HJ | 1 |
Hemmateenejad, B; Khoshaman, K; Masoudi, R; Yousefi, R; Zm, SZ | 1 |
Buttenschön, KK; Daly, DJ; Dhillon, B; Duncan, RR; Gakamsky, A; Gakamsky, D; Howarth, NM | 1 |
GEIGER, E; SCHAEFFER, AJ | 1 |
Butler, H; Caprara, MH; Doller, C; Howell, S; Mailankot, M; Nagaraj, RH; Reneker, LW; Staniszewska, MM; Wang, B | 1 |
Kanth, VR; Lavanya, K; Raju, TN; Srinivas, J | 1 |
Barton, KA; Bhagyalaxmi, SG; Bhanuprakash Reddy, G; Kumar, KR; Padma, T; Petrash, JM; Srinivas, P; Vidyavathi, M | 1 |
Hu, S; Qi, Y; Zhang, C; Zhao, L; Zhou, G; Zhou, N | 1 |
Babraj, J; Dhillon, B; Gakamsky, DM; Shelton, M; Smith, SD | 1 |
Mamata, M; Nagaraju, T; Padma, T; Reddy, KR; Sridhar, G | 1 |
KAHNEMANN, F | 1 |
DISCHE, Z; ELLIOTT, J; MERRIAM, GR; PEARSON, E | 1 |
KNOX, WE; RIVLIN, RS | 1 |
BARBIROLI, G; CIUSA, W; CRISTINI, G | 1 |
PIKE, RL | 1 |
Fukao, M; Miwa, S; Takikawa, O; Truscott, RJ | 1 |
Fuchs, D; Laganovska, G; Martinsons, A; Pitrans, B; Widner, B | 1 |
MURRAY, JD; SCHAEFFER, AJ | 1 |
Jamie, JF; Streete, IM; Truscott, RJ | 1 |
Backlund, PS; Bityurin, NM; Chelnokov, EV; Hejtmancik, JF; Ostrovsky, MA; Sergeev, YV; Soustov, LV; Wingfield, PT | 1 |
Aquilina, JA; Hains, PG; Korlimbinis, A; Truscott, RJ | 1 |
Korlimbinis, A; Truscott, RJ | 1 |
Kanth, VR; Raju, TN; Reddy, PU | 1 |
Dillon, JP; Gaillard, ER; Garland, DL; Merriam, JC; Paik, DC; Rousseva, LA; Ryzhov, V | 1 |
Cotlier, E; Sharma, YR | 2 |
Allegri, G; Angi, MR | 1 |
Chadwick, C; Phipps, DA; Powell, C | 1 |
Auricchio, G; Libondi, T | 1 |
Dillon, J; Garcia Castineiras, S; Santiago, MA; Spector, A | 1 |
Borkman, RF | 1 |
Auricchio, G; Della Pietra, F; Libondi, T; Menzione, M; Miele, L; Pulcino, D; Rinaldi, E | 1 |
Dillon, J | 1 |
Carreau, JP; Chaudun, E; Counis, MF; Courtois, Y | 1 |
Augusteyn, RC; McNamara, M | 1 |
Bours, J; Dragomirescu, V; Hockwin, O; Koch, HR; Ohrloff, C; Riemann, G | 1 |
Allegri, G; Angi, MR; Costa, C; De Carli, M; Vanzan, S | 1 |
Allegri, G; Angi, MR; Costa, C; Vanzan, S | 1 |
Cotlier, E; Irvine, J; Pucklin, J; Sharma, YR; Teasley, B; Zuckerman, J | 1 |
Cotlier, E | 1 |
Haverkamp, J; Hoenders, HJ; van Haard, PM; Wollensak, J | 1 |
Gafni, A; Schauerte, JA | 1 |
Elderfield, AJ; Truscott, RJ | 3 |
Truscott, RJ; Wood, AM | 1 |
Kamei, A | 1 |
Fukuda, R; Iwase, T; Matsukawa, S; Shirao, E; Shirao, Y | 1 |
Birlouez-Aragon, I; Junes, P; Lecerf, JM; Mondon, H; Moreaux, V; Tessier, F | 1 |
Manabe, S; Takahashi, T; Urban, RC; Yuan, J | 1 |
Birlouez-Aragon, I; Junes, P; Mondon, H; Moreaux, V; Tessier, F | 1 |
Richer, SP; Rose, RC | 1 |
Dillon, J; Paik, DC | 1 |
Atwood, CS; Bowden, EF; Bush, AI; Chylack, LT; Faget, KY; Goldstein, LE; Hartshorn, M; Huang, X; Leopold, MC; Lim, JT; Muffat, JA; Saunders, AJ; Scarpa, RC; Tanzi, RE | 1 |
Finch, ED; Weiter, JJ | 1 |
Zigman, S | 2 |
Borkman, RF; Lerman, S | 1 |
Subramanian, S; Weiter, JJ | 1 |
Bours, J; Hockwin, O; Koch, HR; Ohrloff, C; Stoffel, C; Wefers, U | 1 |
Dillon, J; Garcia-Castineiras, S; Spector, A | 2 |
Bunce, GE; Fillnow, GM; Hess, JL | 1 |
Azari, P; Takemoto, LJ | 1 |
van Heyningen, R | 1 |
Bours, J; Hockwin, O; Koch, HR; Ohrloff, C; Stoffel, C | 1 |
Dilley, KJ | 1 |
Bunce, GE; Hess, JL | 1 |
Elderfield, A; Truscott, R | 1 |
Franke, G; Grimm, U; Knapp, A; Mellenthin, R; Seidlitz, G | 1 |
Bazin, M; Cirne de Castro, J; Conte, J; Lawrence, D; Ribeiro, L; Sa e Melo, T; Santus, R | 1 |
Martin, F; Truscott, RJ | 1 |
Hockwin, O; Schmidt, J; Schmitt, C; Wegener, A | 1 |
Chylack, LT; Liang, JN | 1 |
Bessems, GJ; Hoenders, HJ | 1 |
Augusteyn, RC; Boyd, A; Carroll, N; Maclean, H; Merkrebs, J | 1 |
Bender, DA; McCreanor, GM; Salih, MA | 1 |
Nance, WE; Paulson, GW; Son, CD | 1 |
Borkman, RF; Kurzel, RB; Staton, GW; Wolbarsht, M; Yamanashi, BS | 1 |
Kurzel, RB; Wolbarsht, ML; Yamanashi, BS | 1 |
Bunce, GE; Caasi, P; Chaves, N; Hall, B | 1 |
Binazzi, M; Calandra, P | 1 |
Pirie, A | 1 |
Bertelsen, TI; Ehlers, N | 1 |
Barber, GW | 1 |
3 review(s) available for tryptophan and Cataract
Article | Year |
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The physiologic and pharmacologic factors protecting the lens transparency and the update approach to the prevention of experimental cataracts: a review.
Topics: Animals; Cataract; Flavonoids; Humans; Lens, Crystalline; Lysophosphatidylcholines; Osmosis; Oxidation-Reduction; Tryptophan; Ultraviolet Rays; Vitamin E | 1983 |
Ocular hazards and potential uses of near-ultraviolet light.
Topics: Animals; Cataract; Crystallins; Eye; Humans; Keratitis, Dendritic; Lens, Crystalline; Neoplasms, Experimental; Radiation Injuries; Radiation Injuries, Experimental; Radiodermatitis; Simplexvirus; Skin Neoplasms; Tryptophan; Ultraviolet Therapy | 1976 |
Ultraviolet radiation as a risk factor in cataractogenesis.
Topics: Cataract; Epidemiologic Methods; Humans; Risk Factors; Tryptophan; Ultraviolet Rays | 1989 |
93 other study(ies) available for tryptophan and Cataract
Article | Year |
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The Y46D Mutation Destabilizes Dense Packing of the Second Greek Key Pair of Human γC-Crystallin Causing Congenital Nuclear Cataracts.
Topics: Cataract; Escherichia coli; gamma-Crystallins; Humans; Mutation; Tryptophan | 2023 |
Molecular Mechanism of Aggregation of the Cataract-Related γD-Crystallin W42R Variant from Multiscale Atomistic Simulations.
Topics: Amino Acid Substitution; Arginine; Cataract; gamma-Crystallins; Humans; Hydrophobic and Hydrophilic Interactions; Lens, Crystalline; Models, Molecular; Molecular Dynamics Simulation; Mutant Proteins; Protein Aggregates; Protein Aggregation, Pathological; Protein Conformation; Protein Denaturation; Protein Folding; Protein Multimerization; Tryptophan | 2019 |
An amyloidogenic hexapeptide from the cataract-associated γD-crystallin is a model for the full-length protein and is inhibited by naphthoquinone-tryptophan hybrids.
Topics: Amino Acid Sequence; Amyloid; Cataract; Dose-Response Relationship, Drug; gamma-Crystallins; Humans; Models, Molecular; Molecular Conformation; Naphthalenes; Oligopeptides; Protein Aggregates; Protein Aggregation, Pathological; Recombinant Proteins; Structure-Activity Relationship; Tryptophan | 2020 |
Non-invasive tryptophan fluorescence measurements as a novel method of grading cataract.
Topics: Aged; Aged, 80 and over; Cataract; Diagnostic Techniques, Ophthalmological; Female; Fluorescence; Humans; Male; Middle Aged; Phacoemulsification; Photography; Tryptophan | 2017 |
Introduction of an extra tryptophan fluorophore by cataract-associating mutations destabilizes βB2-crystallin and promotes aggregation.
Topics: beta-Crystallin B Chain; Cataract; Evolution, Molecular; Fluorescence; Humans; Molecular Dynamics Simulation; Protein Denaturation; Protein Stability; Spectrophotometry, Ultraviolet; Tryptophan; Ultraviolet Rays | 2018 |
UV-radiation induced disruption of dry-cavities in human γD-crystallin results in decreased stability and faster unfolding.
Topics: Cataract; gamma-Crystallins; Humans; Hydrophobic and Hydrophilic Interactions; Kynurenine; Molecular Dynamics Simulation; Protein Stability; Protein Unfolding; Tryptophan; Tyrosine; Ultraviolet Rays | 2013 |
Antioxidant potential of fungal metabolite nigerloxin during eye lens abnormalities in galactose-fed rats.
Topics: Aldehyde Reductase; Animals; Antioxidants; Aspergillus niger; Benzoates; Cataract; Diabetes Mellitus, Experimental; Galactose; Glutathione; Lens, Crystalline; Lipid Peroxidation; Male; Oxidative Stress; Polymers; Propane; Rats; Rats, Wistar; Sulfhydryl Compounds; Tryptophan | 2013 |
Dissecting the contributions of β-hairpin tyrosine pairs to the folding and stability of long-lived human γD-crystallins.
Topics: Alanine; Cataract; Cations; gamma-Crystallins; Humans; Hydrophobic and Hydrophilic Interactions; Kynurenine; Models, Molecular; Molecular Dynamics Simulation; Mutation; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Tryptophan; Tyrosine; Ultraviolet Rays | 2014 |
Tyrosine/cysteine cluster sensitizing human γD-crystallin to ultraviolet radiation-induced photoaggregation in vitro.
Topics: Amino Acid Substitution; Cataract; Cysteine; gamma-Crystallins; Humans; Lens, Crystalline; Protein Denaturation; Protein Folding; Protein Structure, Quaternary; Tryptophan; Tyrosine; Ultraviolet Rays | 2014 |
Newborn mouse lens proteome and its alteration by lysine 6 mutant ubiquitin.
Topics: Amino Acid Substitution; Animals; Animals, Newborn; Cataract; Eye Proteins; Gene Expression Profiling; Gene Expression Regulation, Developmental; Lens, Crystalline; Lysine; Mice; Mice, Transgenic; Mutagenesis, Site-Directed; Proteasome Endopeptidase Complex; Proteome; Tryptophan; Ubiquitin | 2014 |
EGCG prevents tryptophan oxidation of cataractous ocular lens human γ-crystallin in presence of H2O2.
Topics: Cataract; Catechin; gamma-Crystallins; Humans; Hydrogen Peroxide; Lens, Crystalline; Middle Aged; Molecular Docking Simulation; Oxidation-Reduction; Protein Conformation; Tryptophan | 2015 |
Cross-linking of lens crystallin proteins induced by tryptophan metabolites and metal ions: implications for cataract development.
Topics: Cataract; Crystallins; Humans; Lens, Crystalline; Tryptophan | 2016 |
The structural alteration and aggregation propensity of glycated lens crystallins in the presence of calcium: Importance of lens calcium homeostasis in development of diabetic cataracts.
Topics: Animals; Benzothiazoles; Calcium; Cataract; Cattle; Chymotrypsin; Circular Dichroism; Cross-Linking Reagents; Crystallins; Diabetes Mellitus; Dynamic Light Scattering; Fluorescence; Glycosylation; Homeostasis; Ions; Kinetics; Lens, Crystalline; Molecular Weight; Protein Aggregates; Protein Conformation; Protein Stability; Proteolysis; Thiazoles; Tryptophan | 2017 |
Tryptophan and Non-Tryptophan Fluorescence of the Eye Lens Proteins Provides Diagnostics of Cataract at the Molecular Level.
Topics: Animals; Cataract; Chromatography, High Pressure Liquid; Crystallins; Fluorescence; Humans; Lens, Crystalline; Mass Spectrometry; Protein Processing, Post-Translational; Spectrometry, Fluorescence; Swine; Tryptophan; Ultraviolet Rays | 2017 |
Cataract development in animals with delayed supplementation of tryptophane.
Topics: Cataract; Dietary Supplements; Tryptophan | 1947 |
Indoleamine 2,3-dioxygenase overexpression causes kynurenine-modification of proteins, fiber cell apoptosis and cataract formation in the mouse lens.
Topics: Animals; Apoptosis; Cataract; Glutathione; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lens, Crystalline; Mice; Mice, Transgenic; Tryptophan | 2009 |
Elevated Expression of indoleamine 2,3-dioxygenase (IDO) and accumulation of kynurenic acid in the pathogenesis of STZ-induced diabetic cataract in Wistar rats.
Topics: Animals; Cataract; Diabetes Mellitus, Experimental; Down-Regulation; Glutathione; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenic Acid; Lens, Crystalline; Male; Oxidative Stress; Oxidoreductases; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tryptophan | 2009 |
A novel mutation (F71L) in alphaA-crystallin with defective chaperone-like function associated with age-related cataract.
Topics: Aging; alpha-Crystallin A Chain; Amino Acid Substitution; Base Sequence; Case-Control Studies; Cataract; Chromatography, Gel; Circular Dichroism; DNA Mutational Analysis; Electrophoresis, Polyacrylamide Gel; Exons; Female; Genetic Predisposition to Disease; Humans; Light; Male; Middle Aged; Molecular Sequence Data; Mutant Proteins; Mutation; Protein Structure, Quaternary; Scattering, Radiation; Spectrometry, Fluorescence; Time Factors; Tryptophan | 2009 |
A missense mutation in CRYBA4 associated with congenital cataract and microcornea.
Topics: Adolescent; Adult; Amino Acid Substitution; Base Sequence; beta-Crystallin A Chain; Cataract; Child; Child, Preschool; Cornea; Eye Abnormalities; Female; Glycine; Guanine; Humans; Male; Models, Chemical; Molecular Biology; Mutation, Missense; Pedigree; Thymine; Tryptophan; Young Adult | 2010 |
Exploring the possibility of early cataract diagnostics based on tryptophan fluorescence.
Topics: Animals; Cataract; Dose-Response Relationship, Radiation; Fluorescence; Humans; Sus scrofa; Tryptophan; Ultraviolet Rays | 2011 |
Is the variant c.422+90G → A in intron 4 of indoleamine 2, 3 -dioxygenase (IDO) gene related to age related cataracts?
Topics: Age of Onset; Aged; Aged, 80 and over; Aging; Body Mass Index; Case-Control Studies; Cataract; Exons; Eye; Eye Proteins; Female; Humans; India; Indoleamine-Pyrrole 2,3,-Dioxygenase; Introns; Lens, Crystalline; Male; Middle Aged; Polymorphism, Restriction Fragment Length; Restriction Mapping; Risk Factors; Sex Factors; Smoking; Tryptophan | 2011 |
[Tryptophan content of human crystalline lens in normal conditions and in cataract demonstrated by the Adams method; histochemical study].
Topics: Cataract; Humans; Lens, Crystalline; Tryptophan | 1957 |
Changes in proteins and protein synthesis; in tryptophane deficiency and radiation cataracts of rats.
Topics: Animals; Cataract; Proteins; Rats; Tryptophan; X-Rays | 1959 |
Effects of age, body size and growth hormone on level of tryptophan peroxidase-oxidase in rat liver.
Topics: Aging; Animals; Body Size; Body Weight; Cataract; Growth Hormone; Human Growth Hormone; Liver; Oxidoreductases; Peroxidase; Peroxidases; Rats; Tryptophan | 1959 |
THE TRANSMETHYLATION PROCESSES IN THE AQUEOUS HUMOUR AND IN THE LENS.
Topics: Aqueous Humor; Cataract; Lens, Crystalline; Metabolism; Niacin; Nicotinic Acids; Research; Tryptophan | 1964 |
Congenital cataract in albino rats fed different amounts of tryphophan and niacin.
Topics: Animals; Cataract; Niacin; Nicotinic Acids; Rats; Tryptophan | 1951 |
Age-related nuclear cataract and indoleamine 2,3-dioxygenase-initiated tryptophan metabolism in the human lens.
Topics: Adult; Aged; Aged, 80 and over; Aging; Blotting, Western; Cataract; Chromatography, High Pressure Liquid; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Lens, Crystalline; Middle Aged; Tryptophan; Tryptophan Oxygenase; Ultraviolet Rays | 2003 |
Kynurenine and neopterin in the aqueous humor of the anterior chamber of the eye and in serum of cataract patients.
Topics: Aged; Aged, 80 and over; Aqueous Humor; Cataract; Exfoliation Syndrome; Humans; Kynurenine; Neopterin; Oxidative Stress; Selenium; Tryptophan | 2003 |
Tryptophan determination in cataract due to deficiency or delayed supplementation of tryptophan.
Topics: Cataract; Dietary Supplements; Humans; Tryptophan | 1950 |
Lenticular levels of amino acids and free UV filters differ significantly between normals and cataract patients.
Topics: Adult; Aged; Aged, 80 and over; Cataract; Chromatography, High Pressure Liquid; Glucosides; Humans; Kynurenine; Lens, Crystalline; Middle Aged; Phenylbutyrates; Tryptophan; Tyrosine; Ultraviolet Rays; Uric Acid | 2004 |
Increased sensitivity of amino-arm truncated betaA3-crystallin to UV-light-induced photoaggregation.
Topics: Aging; Animals; Baculoviridae; beta-Crystallin A Chain; Blotting, Western; Cataract; Chromatography, Gel; Crystallins; Electrophoresis, Polyacrylamide Gel; Gene Expression; Light; Methionine; Mice; Oxidation-Reduction; Photochemistry; Photolysis; Protein Denaturation; Recombinant Proteins; Scattering, Radiation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tryptophan; Ultraviolet Rays | 2005 |
3-Hydroxykynurenine oxidizes alpha-crystallin: potential role in cataractogenesis.
Topics: alpha-Crystallins; Animals; Catalysis; Cataract; Cattle; Chromatography, High Pressure Liquid; Cysteine; Humans; Kynurenine; Lens, Crystalline; Mass Spectrometry; Methionine; Oxidation-Reduction; Oxidative Stress; Sunscreening Agents; Tryptophan; Ultraviolet Rays | 2006 |
Identification of 3-hydroxykynurenine bound to proteins in the human lens. A possible role in age-related nuclear cataract.
Topics: Aging; Animals; Butterflies; Cataract; Humans; Kynurenine; Lens, Crystalline; Moths; Oxidation-Reduction; Peptides; Pigmentation; Protein Binding; Proteins; Solubility; Sunscreening Agents; Time Factors; Tryptophan; Ultraviolet Rays | 2006 |
Influence of kynurenines in pathogenesis of cataract formation in tryptophan-deficient regimen in Wistar rats.
Topics: Animals; Antioxidants; Cataract; Diet; Kynurenine; Lens, Crystalline; Microscopy, Fluorescence; Oxidative Stress; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Tryptophan | 2007 |
Oxindolealanine in age-related human cataracts.
Topics: Aged; Aged, 80 and over; Alanine; alpha-Crystallins; Animals; Biomarkers; Cataract; Cattle; Chromatography, High Pressure Liquid; Humans; Indoles; Lens Cortex, Crystalline; Lens Nucleus, Crystalline; Lens, Crystalline; Oxidation-Reduction; Oxindoles; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Tryptophan | 2007 |
Plasma tryptophan in senile cataract.
Topics: Aged; Aspirin; Cataract; Humans; Tryptophan | 1980 |
Free and total serum tryptophan in senile cataract.
Topics: Aged; Cataract; Humans; Tryptophan | 1981 |
Senile cataract and plasma tryptophan.
Topics: Aged; Cataract; Humans; Tryptophan | 1981 |
Serum tryptophan and cataract.
Topics: Aged; Cataract; Female; Humans; Male; Middle Aged; Tryptophan | 1981 |
The endopeptidase-resistant protein fraction from human cataractous lenses.
Topics: Amino Acids; Cataract; Chemical Phenomena; Chemistry; Chromatography, Gel; Chromatography, High Pressure Liquid; Crystallins; Endopeptidases; Humans; In Vitro Techniques; Kynurenine; Oxindoles; Spectrophotometry; Tryptophan | 1984 |
Cataracts and photochemical damage in the lens.
Topics: Animals; Cataract; Crystallins; Dose-Response Relationship, Radiation; In Vitro Techniques; Lasers; Lens, Crystalline; Radiation Injuries, Experimental; Rats; Rats, Inbred Strains; Tryptophan; Ultraviolet Rays | 1984 |
Serum tryptophan in humans with senile cataracts.
Topics: Aged; Cataract; Female; Humans; Male; Protein Binding; Tryptophan | 1983 |
Photolytic changes in lens proteins.
Topics: Adolescent; Aged; Aging; Animals; Cataract; Cattle; Crystallins; Glucosides; Humans; In Vitro Techniques; Kynurenine; Lens, Crystalline; Photochemistry; Photolysis; Tryptophan | 1984 |
Changes in the DNA breakage and crystallin synthesis of embryonic chicken lenses cultured in a tryptophan-deficient medium.
Topics: Animals; Cataract; Cells, Cultured; Centrifugation, Density Gradient; Chick Embryo; Crystallins; DNA; Electrophoresis, Polyacrylamide Gel; Lens, Crystalline; Molecular Weight; Tryptophan | 1984 |
The effects of hydrogen peroxide on lens proteins: a possible model for nuclear cataract.
Topics: Amino Acids; Cataract; Crystallins; Humans; Hydrogen Peroxide; In Vitro Techniques; Lens Nucleus, Crystalline; Lens, Crystalline; Methionine; Models, Biological; Peptide Fragments; Protein Conformation; Solubility; Spectrometry, Fluorescence; Spectrophotometry; Sulfhydryl Compounds; Tryptophan | 1984 |
Separation of lens proteins in rats with tryptophan deficiency cataracts.
Topics: Animals; Body Water; Body Weight; Cataract; Crystallins; Isoelectric Focusing; Lens, Crystalline; Organ Size; Rats; Rats, Inbred Strains; Tryptophan | 1982 |
Metabolism and serum levels of tryptophan in senile cataract patients.
Topics: Age Factors; Aged; Cataract; Female; Humans; Kynurenine; Male; Middle Aged; Sex Factors; Tryptophan | 1982 |
Tryptophan lens levels in senile cataract.
Topics: Aged; Cataract; Female; Humans; Kynurenine; Lens, Crystalline; Male; Middle Aged; Oxidation-Reduction; Photochemistry; Tryptophan | 1982 |
Plasma tryptophan in humans with diabetic and senile cataracts.
Topics: Adult; Aged; Aphakia, Postcataract; Cataract; Diabetes Complications; Diabetes Mellitus; Humans; Middle Aged; Tryptophan | 1981 |
Senile cataracts: evidence for acceleration by diabetes and deceleration by salicylate.
Topics: Age Factors; Aged; Aspirin; Cataract; Diabetes Complications; Humans; Middle Aged; Osteoarthritis; Time Factors; Tryptophan | 1981 |
Pyrolysis mass spectra, sulfhydryl and tryptophan content of the embryonic nuclei from adult human normal and nuclear-cataractous lenses.
Topics: Cataract; Computers; Humans; Lens, Crystalline; Mass Spectrometry; Pyrroles; Sulfhydryl Compounds; Tryptophan | 1980 |
Photodegradation of tryptophan residues and attenuation of molecular chaperone activity in alpha-crystallin are correlated.
Topics: Aging; Animals; Cataract; Crystallins; Hot Temperature; Humans; In Vitro Techniques; Molecular Chaperones; Photochemistry; Protein Conformation; Rabbits; Spectrometry, Fluorescence; Tryptophan; Ultraviolet Rays | 1995 |
Serum tryptophan and age-related cataract.
Topics: Age Factors; Aged; Cataract; Chromatography, High Pressure Liquid; Female; Humans; Male; Middle Aged; Tryptophan | 1994 |
Tryptophan metabolism and the reactive metabolite hypothesis for human cataract.
Topics: Cataract; Humans; Lens, Crystalline; Tryptophan | 1994 |
Glutathione levels of the human crystalline lens in aging and its antioxidant effect against the oxidation of lens proteins.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Antioxidants; Cataract; Child; Chromatography, High Pressure Liquid; Circular Dichroism; Crystallins; Glutathione; Glutathione Reductase; Humans; Lens, Crystalline; Middle Aged; Oxidation-Reduction; Protein Binding; Thiobarbituric Acid Reactive Substances; Tryptophan; Tyrosine | 1993 |
Relationship between serum tryptophan and tryptophan metabolite levels after tryptophan ingestion in normal subjects and age-related cataract patients.
Topics: Age Factors; Aged; Aged, 80 and over; Case-Control Studies; Cataract; Fasting; Female; Humans; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Tryptophan; Xanthurenates | 1995 |
[Comparison of free non-tryptophan fluorescent substances in water-soluble fraction of brunescent and non-brunescent human cataract].
Topics: Cataract; Chromatography, High Pressure Liquid; Fluorescence; Glucosides; Humans; Kynurenine; Lens, Crystalline; Solubility; Tryptophan | 1996 |
Is an altered tryptophan metabolism responsible for age-related cataract?
Topics: 3-Hydroxyanthranilic Acid; Aged; Cataract; Chromatography, High Pressure Liquid; Female; Humans; Kynurenine; Male; Reference Values; Sensitivity and Specificity; Tryptophan | 1996 |
Trp oxidation by copper-ascorbate under physiological conditions.
Topics: Adult; Aged; Aged, 80 and over; Ascorbic Acid; Cardiovascular Diseases; Cataract; Copper; Diabetes Mellitus; Diet; Humans; Lens, Crystalline; Middle Aged; Oxidation-Reduction; Peptides; Reference Values; Regression Analysis; Tryptophan | 1996 |
Age-related accumulation of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3- carboxylic acid in human lens.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Carbolines; Cataract; Chromatography, High Pressure Liquid; Glucose; Hot Temperature; Humans; In Vitro Techniques; Lens, Crystalline; Middle Aged; Tryptophan | 1996 |
Decrease in vitamin C concentration in human lenses during cataract progression.
Topics: Ascorbic Acid; Cataract; Disease Progression; Female; Fructose; Humans; Lens Nucleus, Crystalline; Lysine; Male; Sensitivity and Specificity; Tryptophan | 1998 |
Water soluble antioxidants in mammalian aqueous humor: interaction with UV B and hydrogen peroxide.
Topics: Aged; Analysis of Variance; Animals; Antioxidants; Aqueous Humor; Ascorbic Acid; Cataract; Chromatography, High Pressure Liquid; Cysteine; Disease Models, Animal; Female; Glutathione; Humans; Hydrogen Peroxide; Mammals; Oxidants; Rabbits; Rats; Rats, Sprague-Dawley; Tryptophan; Tyrosine; Ultraviolet Rays; Uric Acid | 1998 |
The Nitrite/alpha crystallin reaction: a possible mechanism in lens matrix damage.
Topics: Aging; Animals; Cataract; Cattle; Chromatography, High Pressure Liquid; Crystallins; Electrophoresis, Polyacrylamide Gel; Humans; Kynurenine; Lens, Crystalline; Nitrites; Oxidation-Reduction; Smoking; Spectrophotometry, Ultraviolet; Tryptophan; Ultraviolet Rays | 2000 |
3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction.
Topics: 3-Hydroxyanthranilic Acid; Animals; Ascorbic Acid; Cataract; Cattle; Copper; Crystallins; Electrochemistry; Humans; Hydrogen Peroxide; Iron; Kynurenine; Lens, Crystalline; Metals; Oxidation-Reduction; Superoxides; Tryptophan | 2000 |
Paramagnetic species in cataractous human lenses.
Topics: Cataract; Crystallins; Electron Spin Resonance Spectroscopy; Humans; Lens, Crystalline; Tryptophan | 1975 |
Evidence for a free radical mechanism in aging and u.v.-irradiated ocular lenses.
Topics: Aging; Animals; Cataract; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; Lens, Crystalline; Penicillamine; Rats; Tryptophan; Ultraviolet Rays | 1977 |
Free radicals produced in human lenses by a biphotonic process.
Topics: Aged; Cataract; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; Lens, Crystalline; Middle Aged; Spectrophotometry, Ultraviolet; Tryptophan; Ultraviolet Rays | 1978 |
Experimental cataracts in rats due to tryptophan-free diet.
Topics: Animals; Body Weight; Cataract; Deficiency Diseases; Female; Isoelectric Focusing; Lens, Crystalline; Organ Size; Rats; Tryptophan | 1978 |
Effects of reduction on absorption and fluorescence of human lens protein.
Topics: Aging; Cataract; Crystallins; Humans; Oxidation-Reduction; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Tryptophan | 1979 |
Investigation of low tryptophan induced cataract in weanling rats.
Topics: Animals; Cataract; Crystallins; Lens, Crystalline; Male; Rats; Tryptophan; Weaning | 1978 |
Non-tryptophan fluorescence associated with human lens protein; apparent complexity and isolation of bityrosine and anthranilic acid.
Topics: Cataract; Crystallins; Humans; Lens, Crystalline; ortho-Aminobenzoates; Spectrometry, Fluorescence; Tryptophan; Tyrosine | 1978 |
Amino acid composition of normal and cataractous human lens proteins.
Topics: Aged; Amino Acids; Cataract; Crystallins; Cysteine; Cystine; Glutathione; Humans; Middle Aged; Tryptophan | 1976 |
Experimental studies on cataract.
Topics: Aging; Animals; Ascorbic Acid; Cataract; Crystallins; Diabetic Retinopathy; Humans; Lens, Crystalline; Naphthalenes; Naphthoquinones; Peptide Hydrolases; Sorbitol; Tryptophan | 1976 |
Proceedings: Experimental cataracts induced by a tryptophan-free diet.
Topics: Animals; Cataract; Crystallins; Diet; Lens, Crystalline; Rats; Tryptophan | 1975 |
Letter: Ultraviolet light and human cataract.
Topics: Cataract; Free Radicals; Humans; Radiation Effects; Tryptophan; Ultraviolet Rays | 1975 |
Lenticular opacities in young rats as a consequence of maternal diets low in tryptopham and/or vitamin E.
Topics: Animals; Cataract; Female; Lactation; Lens, Crystalline; Maternal-Fetal Exchange; Pregnancy; Pregnancy Complications; Rats; Tryptophan; Vitamin E Deficiency | 1976 |
Tryptophan metabolism in senile cataract patients assessed by high-performance liquid chromatography.
Topics: Aging; Cataract; Chromatography, High Pressure Liquid; Humans; Kynurenic Acid; Kynurenine; Tryptophan | 1991 |
Tryptophan metabolic studies in patients with presenile cataracts.
Topics: Adolescent; Adult; Cataract; Female; Humans; Kynurenine; Male; Pyridoxine; Tryptophan; Xanthurenates | 1990 |
Degradation of crystallins from a psoriatic patient undergoing PUVA therapy.
Topics: Aging; Cataract; Crystallins; Eye Proteins; Humans; Lens, Crystalline; Molecular Weight; Psoriasis; PUVA Therapy; Solubility; Spectrometry, Fluorescence; Tryptophan | 1990 |
The reaction of proteins with 3-hydroxyanthranilic acid as a possible model for senile nuclear cataract in man.
Topics: 3-Hydroxyanthranilic Acid; Animals; Cataract; Cattle; Chromatography, Gel; Color; Crystallins; Humans; Hydrogen Peroxide; Lysine; Methionine; Models, Biological; Molecular Weight; ortho-Aminobenzoates; Oxidation-Reduction; Serum Albumin, Bovine; Sulfhydryl Compounds; Time Factors; Tryptophan | 1989 |
Spectroscopic study on the effects of nonenzymatic glycation in human alpha-crystallin.
Topics: Aged; Aged, 80 and over; Anilino Naphthalenesulfonates; Cataract; Circular Dichroism; Crystallins; Diabetes Complications; Diabetes Mellitus; Fluorometry; Glucose; Glycosylation; Humans; Lens Cortex, Crystalline; Lens, Crystalline; Naphthalenesulfonates; Protein Conformation; Protein Processing, Post-Translational; Spectrophotometry; Tryptophan | 1987 |
Distribution of aromatic and fluorescent compounds within single human lenses.
Topics: Adult; Aged; Aged, 80 and over; Aging; Cataract; Chromatography, High Pressure Liquid; Fluorescence; Humans; Lens, Crystalline; Middle Aged; Tryptophan; Tyrosine; Uric Acid | 1987 |
Serum tryptophan and cataract.
Topics: Adult; Aged; Cataract; Humans; Osmolar Concentration; Reference Values; Tryptophan | 1987 |
Lethal familial pellagra-like skin lesion associated with neurologic and developmental impairment and the development of cataracts.
Topics: Amino Acid Metabolism, Inborn Errors; Cataract; Cerebellar Ataxia; Child, Preschool; Consanguinity; Diagnosis, Differential; Female; Humans; Infant; Intellectual Disability; Male; Pedigree; Pellagra; Skin; Syndrome; Tryptophan | 1985 |
Neurologic aspects of typical and atypical Down's syndrome.
Topics: Cataract; Chromosome Aberrations; Down Syndrome; Gait; Humans; Hydroxyindoleacetic Acid; Intelligence; Mosaicism; Neurologic Manifestations; Seizures; Speech Disorders; Strabismus; Trisomy; Tryptophan; Uric Acid | 1969 |
Tryptophan excited states and cataracts in the human lens.
Topics: Cataract; Crystallins; Humans; Lens, Crystalline; Spectrometry, Fluorescence; Tryptophan | 1973 |
Spectral studies on normal and cataractous intact human lenses.
Topics: Cataract; Crystallins; Humans; Kynurenine; Lens, Crystalline; Pigmentation; Spectrum Analysis; Tryptophan | 1973 |
Prevention of cataract in the progeny of rats fed a maternal diet based on vegetable proteins.
Topics: Abnormalities, Drug-Induced; Animals; Cataract; Dietary Proteins; Female; Maternal-Fetal Exchange; Methionine; Nicotinic Acids; Plant Proteins; Pregnancy; Rats; Tryptophan; Vitamin E | 1972 |
Identification of an error in the tryptophan--niacin pathway in carriers of some dermatoses conditioned or aggravated by sunlight.
Topics: Adult; Aged; Animals; Atrophy; Cataract; Female; Gastric Juice; Humans; Hydrolases; Kynurenine; Light; Lupus Erythematosus, Discoid; Male; Middle Aged; Nicotinic Acids; Pellagra; Pigmentation Disorders; Porphyrias; Rats; Rothmund-Thomson Syndrome; Skin; Skin Diseases; Sunlight; Transaminases; Tryptophan; Urticaria | 1971 |
Formation of N'-formylkynurenine in proteins from lens and other sources by exposure to sunlight.
Topics: Animals; Cataract; Cattle; Chromatography; Crystallins; Electrophoresis; Fluorescence; Humans; In Vitro Techniques; Kynurenine; Muramidase; Oxidation-Reduction; Serum Albumin; Spectrophotometry; Sunlight; Tryptophan | 1971 |
Morphological and histochemical studies on fibrillopathia epitheliocapsularis.
Topics: Aged; Amylases; Arginine; Cataract; Cysteine; Cystine; Endopeptidases; Epithelium; Eye Diseases; Histocytochemistry; Humans; Hyaluronoglucosaminidase; In Vitro Techniques; Lens, Crystalline; Microscopy, Electron; Middle Aged; Ribonucleases; Time Factors; Tryptophan; Tyrosine | 1969 |
Eye lens color: formation and function.
Topics: Aging; Aminobenzoates; Animals; Cataract; Crystallins; Eye Proteins; Fluorescence; Lens, Crystalline; Photochemistry; Pigments, Biological; Radiation Effects; Sharks; Spectrophotometry; Tryptophan; Ultraviolet Rays | 1971 |
Free amino acids in senile cataractous lenses: possible osmotic etiology.
Topics: Adult; Age Factors; Aged; Amino Acids; Animals; Aqueous Humor; Biological Transport, Active; Cataract; Chromatography; Crystallins; Diabetes Mellitus, Experimental; Female; Guinea Pigs; Humans; Lens, Crystalline; Male; Middle Aged; Osmosis; Protein Biosynthesis; Protein Deficiency; Rabbits; Tissue Banks; Tryptophan; Vision, Ocular; Water; Water-Electrolyte Balance; Weights and Measures | 1968 |