tryptophan and Alzheimer Disease

tryptophan has been researched along with Alzheimer Disease in 102 studies

Research

Studies (102)

Timeframe	Studies, this research(%)	All Research%
pre-1990	8 (7.84)	18.7374
1990's	10 (9.80)	18.2507
2000's	20 (19.61)	29.6817
2010's	37 (36.27)	24.3611
2020's	27 (26.47)	2.80

Authors

Authors	Studies
Bartolini, M; Benkova, M; Bolognesi, ML; Brazzolotto, X; Caliandro, R; Chalupova, K; Chvojkova, M; Dolezal, R; Gastellier, AJ; Habartova, L; Hepnarova, V; Hrabinova, M; Jarosova, M; Jost, P; Jun, D; Kleteckova, L; Korabecny, J; Kristofikova, Z; Kuca, K; Lamba, D; Mezeiova, E; Misik, J; Monti, B; Muckova, L; Mzik, M; Nachon, F; Nepovimova, E; Pejchal, J; Pesaresi, A; Setnicka, V; Soukup, O; Uliassi, E; Vales, K; Valis, M; Zdarova Karasova, J	1
Dikmen, M; Kaya-Tilki, E	1
Mannan, A; Prabhakar, NK; Sharma, VK; Singh, TG	1
Chaturvedi, S; Panda, JJ; Sharma, M; Shukla, S; Tiwari, V; Wahajuddin, M	1
Al-Hakeim, HK; Almulla, AF; Amrapala, A; Jaleel, AKA; Maes, M; Oxenkrug, G; Supasitthumrong, T; Tunvirachaisakul, C	1
Ano, Y; Nakayama, H; Ohya, R; Takaichi, Y; Takashima, A; Uchida, K	1
Kong, Y; Kumaran Satyanarayanan, S; Liu, J; Su, KP; Sun, J; Ye, T; Yu, Q; Zhang, Y	1
Aranha, CMSQ; Corrêa, MF; Fernandes, GAB; Fernandes, JPS; Junior, NMN; Lopes, FB; Okamoto, DN; Simões, LPM	1
Chen, W; Guo, M; Wang, G; Zhang, H; Zhao, J; Zhu, G	1
Fathi, M; Hajibeygi, R; Jazi, K; Klegeris, A; McElhinney, A; Sayehmiri, F; Shool, S; Sodeifian, F; Tavasol, A; Tavirani, MR; Vakili, K; Yaghoobpoor, S	1
Bain, JR; Cohen, HJ; Faldowski, RA; Hall, KS; Huebner, JL; Huffman, KM; Ilkayeva, OR; Kraus, VB; Kraus, WE; Newby, LK; Parker, DC; Pieper, CF; Smith, PJ; Whitson, HE	1
Salminen, A	1
Fang, C; Huang, H; Niu, H; Ruan, J; Wei, M; Yin, X; Zhou, Y	1
Geng, F; Gu, JM; Jiang, J; Xue, A; Xue, H; Yang, B; Zhang, N; Zhao, JH	1
Bukharov, M; Hua, B; Huang, F; Kharlamova, A; Nazarova, A; Padnya, P; Petrov, K; Stoikov, I; Yusupov, G; Zelenikhin, P	1
Cheng, S; Deng, S; He, C; He, J; Li, Z; Luo, R; Song, Z; Wu, Z; Yang, M; Yu, W	1
Clark, C; Delorenzi, M; Gallart-Ayala, H; Henry, H; Ivanisevic, J; Konz, I; Mehl, F; Oikonomidi, A; Peyratout, G; Popp, J; Teav, T; van der Velpen, V	1
Tanaka, M; Toldi, J; Vécsei, L	1
Antequera, D; Arjona, JAM; Bartolome, F; Bisa, AL; Carro, E; Domínguez, E; González-Sánchez, M; Jiménez, J; Llamas-Velasco, S; Marco, MP; Martín, AH; Munain, AL; Narváez, A; Pérez-Martínez, DA; Rodríguez-Núñez, M; Villarejo-Galende, A	1
Klein, C; Maitre, M; Mensah-Nyagan, AG; Patte-Mensah, C	1
Lee, BY; Leonenko, Z; Robinson, M; Turnbull, S	1
Du, L; Duan, Z; Guo, L; Kuang, C; Liang, H; Shi, L; Takikawa, O; Xing, Z; Yang, Q; Zhang, S	1
Panda, JJ; Sharma, M; Shukla, S; Tiwari, V	1
Brazzolotto, X; Gobec, S; Grošelj, U; Knez, D; Malikowska-Racia, N; Meden, A; Nachon, F; Sałat, K; Svete, J	1
Chappell, KE; D'Hondt, E; Holmes, E; Hye, A; Jiménez, B; Kłoszewska, I; Legido-Quigley, C; Lewis, MR; Lovestone, S; Mecocci, P; Snowden, SG; Soininen, H; Swann, JR; Tsolaki, M; Vellas, B; Whiley, L	1
Chen, J; Han, Y; Li, L; Liu, P; Lv, H; Peng, G; Shao, L; Sheng, Y; Wang, B; Wang, Y; Wu, L; Yue, S; Zheng, Z; Zhu, S	1
Ahn, YH; Kim, TD; Oh, SC; Zhou, S	1
Chalupova, K; Gorecki, L; Hepnarova, V; Hrabinova, M; Hroudova, J; Janockova, J; Jun, D; Korabecny, J; Kristofikova, Z; Kucera, T; Kunes, J; Mezeiova, E; Muckova, L; Prchal, L; Soukup, O	1
Jiaranaikulwanitch, J; Jiranusornkul, S; Saenjum, C; Vajragupta, O; Wongrattanakamon, P; Yooin, W	1
Chu, M; Feng, H; Ge, X; He, M; Lu, C; Wang, Q; Wu, L; Xia, H	1
Alfano, RR; Harvey, G; Harvey, T; Lu, L; Rodríguez-Contreras, A; Shi, L	1
Han, Y; Kong, L; Liu, L; Liu, Z; Sun, H; Wang, X; Yu, J; Zhang, A	1
Advani, R; Giil, LM; Midttun, Ø; Refsum, H; Smith, AD; Ueland, PM; Ulvik, A	1
Adachi, Y; Imaizumi, A; Kageyama, Y; Kumagai, S; Miyake, Y; Mori, M; Nakamura, H; Noguchi, Y; Okabe, Y; Ono, K; Seki, A; Shimodaira, Y	1
Gazit, E; KrishnaKumar, VG; Paul, A; Segal, D	1
da S Pereira, MC; Del J V Marcano, RG; Gomes, JC; Hosni, AP; Kerppers, II; Khalil, NM; Mainardes, RM; Miri, AL	1
Brazzolotto, X; Gobec, S; Grošelj, U; Gršič, M; Jukič, M; Knez, D; Kos, J; Meden, A; Nachon, F; Pišlar, A; Svete, J; Zahirović, A	1
Chen, X; Geng, F; Lei, X; Li, G; Liu, B; Liu, G; Zhang, N	1
Chalupová, K; Korábečný, J; Mžik, M; Palička, V; Šesták, V; Žďárová-Karasová, J	1
Ano, Y; Nakayama, H; Uchida, K; Yoshino, Y	1
Bao, SS; Brew, BJ; Chung, R; Cullen, KM; Guillemin, GJ; Lim, CK; Nicolazzo, JA; Stankovic, R; Wen, L; Wu, W	1
Du, LF; Han, YG; Lin, T; Liu, J; Luo, Y; Wang, JZ; Xi, L	1
Derreumaux, P; Mu, Y; Xu, W; Zhang, T	1
Anderson, G; Maes, M	1
Fuchs, D; Geisler, S; Leblhuber, F; Schütz, B; Steiner, K	1
Berthoumieu, O; Castillo-Frias, MP; Derreumaux, P; Doig, AJ; Faller, P; Ferre, S; Nasica-Labouze, J; Nguyen, PH; Noël, S; Rampon, C; Saurel, O; Tarus, B	1
Leavitt, BR; Mazarei, G	1
Fuchs, D; Greilberger, J; Greilberger, M; Leblhuber, F; Rommer, PS; Schroth, R; Tafeit, E	1
Gonzalez, J; Ramirez, J; Schwans, JP	1
Abu-Hussien, M; Alyagor, I; Eisenbaum, T; Frenkel-Pinter, M; Gazit, E; Scherzer-Attali, R; Segal, D; Tal, S	1
Bi, L; Chen, W; Guo, L; Qi, H; Qian, Y; Tao, T; Wang, Y; Wu, J; Xu, W	1
Caflisch, A; Convertino, M; Egoz-Matia, N; Frydman-Marom, A; Gazit, E; Levy-Sakin, M; Peled, S; Pellarin, R; Scherzer-Attali, R; Segal, D; Shalev, DE	1
Kincses, ZT; Toldi, J; Vécsei, L	1
Bien, B; Gulaj, E; Pawlak, D; Pawlak, K	1
Fuchs, D; Greilberger, J; Greilberger, M; Leblhuber, F; Tafeit, E; Wintersteiger, R	1
Alberici, A; Archetti, S; Bonvicini, C; Borroni, B; Gennarelli, M; Lupi, A; Padovani, A; Pilotto, A	1
Gallazzi, F; McDonough, RT; Nichols, MR; Paranjape, G	1
Ben-Romano, T; Cooper, I; Farfara, D; Frenkel, D; Gazit, E; Levin, A; Scherzer-Attali, R; Segal, D; Segev-Amzaleg, N; Shalev, DE; Shaltiel-Karyo, R; Trudler, D; Vientrov, M	1
Adalist, YH; Gazit, E; Scherzer-Attali, R; Segal, D; Shaltiel-Karyo, R	1
Elliott, JI; Hata, S; Iijima-Ando, K; Kimura, N; Matsushima, T; Nakaya, T; Nishimura, M; Saito, Y; Suzuki, T; Yamamoto, T	1
Noristani, HN; Rodríguez, JJ; Verkhratsky, A	1
Tan, L; Yu, JT	1
Buerger, K; Guillemin, GJ; Hampel, H; Schwarz, MJ; Teipel, SJ	1
Caflisch, A; Convertino, M; Gazit, E; Pellarin, R; Scherzer-Attali, R; Segal, D	1
Li, L; Mandelkow, E; Mandelkow, EM; von Bergen, M	1
Brew, BJ; Guillemin, GJ	1
Lunn, BS; O'Brien, JT; Porter, RJ	1
Kurup, PA; Kurup, RK	1
LeVine, H	1
Cruts, M; Dermaut, B; Goate, A; Heutink, P; Peeters, K; Rademakers, R; Van Broeckhoven, C	1
Riedel, WJ	1
Elfgren, C; Froelich Fabre, S; Gustafson, L; Lannfelt, L; Nilsson, K; Ostojic, J; Passant, U	1
Bell, CJ; Hood, SD; Nutt, DJ	1
He, Y; Luo, Y; Tang, H; Zhou, H	1
Aykaç-Toker, G; Doğru-Abbasoğlu, S; Emre, M; Gürvit, H; Hanagasi, HA; Uysal, M	1
Batbayli, M; Holm, IE; Law, I; Lindquist, SG; Nielsen, JE; Schwartz, M; Stokholm, J; Waldemar, G	1
Martin-Du Pan, RC; Wurtman, RJ	1
Aguado, EG; de Yebenes, JG; Mena, MA	1
Andersen, J; Arup, P; Bille, A; Jensen, HV; Jørgenson, S; Møller, SE; Olafsson, K	1
Hajba, A; Heinonen, EH; Kotila, M; Savijärvi, M; Scheinin, M	1
Seiler, N	2
Imafuku, I; Kanazawa, I; Kawabata, M; Okazawa, H; Oyama, F; Takeuchi, S; Udagawa, Y; Waragai, M	1
Bonaccorso, S; Bosmans, E; Dossche, A; Kenis, G; Lin, A; Maes, M; Scharpe, S; Song, C; Vandewoude, M; Verkerk, R	1
Goto, S; Kondo, H; Lee, DR; Nakano, K; Semba, R	1
Fuchs, D; Ledochowski, M; Widner, B	1
Demel, U; Fuchs, D; Leblhuber, F; Tilz, GP; Walli, J; Widner, B	2
Ballard, CG; Gray, JM; Lunn, BS; O'Brien, JT; Porter, RJ; Walker, LL	1
Hatters, DM; Howlett, GJ; Lawrence, LJ; MacPhee, CE; Sawyer, WH	1
Liang, JJ	1
Cowen, PJ; Da Roza Davis, JM	1
He, XY; Lin, D; Mehta, P; Merz, G; Schulz, H; Wen, GY; Yang, SY; Yang, YZ	1
Marshall, EF; O'Brien, JT; Porter, RJ	1
Powers, JM; Spicer, SS	1
Beal, MF; Bird, ED; Matson, WR; Milbury, P; Ogawa, T; Ryan, EA; Storey, E	1
Bentham, PW	1
Ericsson, K; Forssell, LG; Hellström, A; Winblad, B	1
Leathwood, PD	2
Carlà, V; Lombardi, G; Moroni, F	1
Slevin, JT; Sparks, DL	1

Reviews

17 review(s) available for tryptophan and Alzheimer Disease

Article	Year
Kynurenine Metabolism and Alzheimer's Disease: The Potential Targets and Approaches. Neurochemical research, 2022, Volume: 47, Issue:6 Topics: Alzheimer Disease; HIV Infections; Humans; Kynurenine; Oxidative Stress; Tryptophan	2022
The Tryptophan Catabolite or Kynurenine Pathway in Alzheimer's Disease: A Systematic Review and Meta-Analysis. Journal of Alzheimer's disease : JAD, 2022, Volume: 88, Issue:4 Topics: Aged; Alzheimer Disease; Brain; Humans; Kynurenic Acid; Kynurenine; Tryptophan	2022
Dynamic changes in metabolites of the kynurenine pathway in Alzheimer's disease, Parkinson's disease, and Huntington's disease: A systematic Review and meta-analysis. Frontiers in immunology, 2022, Volume: 13 Topics: 3-Hydroxyanthranilic Acid; Adenosine; Alzheimer Disease; Humans; Huntington Disease; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; NAD; Niacinamide; Parkinson Disease; Tryptophan	2022
Activation of aryl hydrocarbon receptor (AhR) in Alzheimer's disease: role of tryptophan metabolites generated by gut host-microbiota. Journal of molecular medicine (Berlin, Germany), 2023, Volume: 101, Issue:3 Topics: Alzheimer Disease; Dysbiosis; Gastrointestinal Microbiome; Humans; Indican; Indoles; Inflammation; Microbiota; Receptors, Aryl Hydrocarbon; Tryptophan	2023
Exploring the Etiological Links behind Neurodegenerative Diseases: Inflammatory Cytokines and Bioactive Kynurenines. International journal of molecular sciences, 2020, Mar-31, Volume: 21, Issue:7 Topics: Alzheimer Disease; Anti-Inflammatory Agents; Biomarkers; Cytokines; Humans; Huntington Disease; Inflammation; Kynurenine; Neurodegenerative Diseases; Parkinson Disease; Reactive Oxygen Species; Tryptophan	2020
Tryptophan metabolites modify brain Aβ peptide degradation: A role in Alzheimer's disease? Progress in neurobiology, 2020, Volume: 190 Topics: Alzheimer Disease; Amyloid beta-Peptides; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Neprilysin; Tryptophan	2020
Tryptophanyl-tRNA Synthetase as a Potential Therapeutic Target. International journal of molecular sciences, 2021, Apr-26, Volume: 22, Issue:9 Topics: Alzheimer Disease; Humans; Interferon-gamma; Neoplasms; Sepsis; Tryptophan; Tryptophan-tRNA Ligase	2021
Overlapping the Tryptophan Catabolite (TRYCAT) and Melatoninergic Pathways in Alzheimer's Disease. Current pharmaceutical design, 2016, Volume: 22, Issue:8 Topics: Alzheimer Disease; Animals; Humans; Melatonin; Metabolic Networks and Pathways; Tryptophan	2016
Indoleamine 2,3 Dioxygenase as a Potential Therapeutic Target in Huntington's Disease. Journal of Huntington's disease, 2015, Volume: 4, Issue:2 Topics: Alzheimer Disease; Animals; Humans; Huntington Disease; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Parkinson Disease; Signal Transduction; Tryptophan	2015
Kynurenines, neurodegeneration and Alzheimer's disease. Journal of cellular and molecular medicine, 2010, Volume: 14, Issue:8 Topics: Alzheimer Disease; Amyloid beta-Peptides; Biosynthetic Pathways; Humans; Kynurenine; Molecular Structure; Nerve Degeneration; Plaque, Amyloid; Quinolinic Acid; Tryptophan	2010
The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations. Journal of the neurological sciences, 2012, Dec-15, Volume: 323, Issue:1-2 Topics: Aging; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Enzyme Inhibitors; Humans; Huntington Disease; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenic Acid; Kynurenine; Microglia; Molecular Targeted Therapy; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Parkinson Disease; Quinolinic Acid; Receptors, G-Protein-Coupled; Receptors, N-Methyl-D-Aspartate; Tryptophan	2012
Implications of the kynurenine pathway and quinolinic acid in Alzheimer's disease. Redox report : communications in free radical research, 2002, Volume: 7, Issue:4 Topics: Alzheimer Disease; Amyloid beta-Peptides; Humans; Kynurenine; Quinolinic Acid; Tryptophan	2002
Acute tryptophan depletion. Part II: clinical effects and implications. The Australian and New Zealand journal of psychiatry, 2005, Volume: 39, Issue:7 Topics: Alleles; Alzheimer Disease; Autistic Disorder; Bipolar Disorder; Cognitive Behavioral Therapy; Depressive Disorder, Major; Disruptive, Impulse Control, and Conduct Disorders; Feeding and Eating Disorders; Female; Humans; Hydroxyindoleacetic Acid; Monoamine Oxidase Inhibitors; Premenstrual Syndrome; Promoter Regions, Genetic; Schizophrenia; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Sleep Wake Disorders; Sleep, REM; Surveys and Questionnaires; Tryptophan	2005
[The role of nutrition in the synthesis of neurotransmitters and in cerebral functions: clinical implications]. Schweizerische medizinische Wochenschrift, 1981, Sep-26, Volume: 111, Issue:39 Topics: Alzheimer Disease; Amino Acids; Choline; Choline O-Acetyltransferase; Diabetes Mellitus; Dopa Decarboxylase; Humans; Intellectual Disability; Memory; Myasthenia Gravis; Neurotransmitter Agents; Nutritional Physiological Phenomena; Serotonin; Tryptophan; Tyrosine	1981
Is ammonia a pathogenetic factor in Alzheimer's disease? Neurochemical research, 1993, Volume: 18, Issue:3 Topics: Alzheimer Disease; Ammonia; Amyloid beta-Protein Precursor; Brain; Humans; Tryptophan	1993
An ammonia hypothesis of Alzheimer disease. Advances in experimental medicine and biology, 1997, Volume: 420 Topics: Alzheimer Disease; Ammonia; Astrocytes; Brain; Glucose; Humans; Neurotoxins; Synaptic Transmission; Tryptophan	1997
Neurotransmitter precursors: from animal experiments to human applications. Nutrition reviews, 1986, Volume: 44 Suppl Topics: Alzheimer Disease; Animals; Behavior, Animal; Brain; Humans; Neurotransmitter Agents; Parkinson Disease; Protein Precursors; Sleep Stages; Tryptophan	1986

Trials

8 trial(s) available for tryptophan and Alzheimer Disease

Article	Year
Lowered Levels of Carbonyl Proteins after Vitamin B Supplementation in Patients with Mild Cognitive Impairment and Alzheimer's Disease. Neuro-degenerative diseases, 2016, Volume: 16, Issue:3-4 Topics: Age Factors; Aged; Alzheimer Disease; Biomarkers; Cognitive Dysfunction; Dietary Supplements; Discriminant Analysis; Female; Folic Acid; Humans; Kynurenine; Male; Mental Status Schedule; Middle Aged; ROC Curve; Thiamine; Treatment Outcome; Tryptophan; Vitamin B 12; Vitamin B 6; Vitamin B Complex	2016
Effects of acute tryptophan depletion on cognitive function in Alzheimer's disease and in the healthy elderly. Psychological medicine, 2003, Volume: 33, Issue:1 Topics: Affect; Aged; Alzheimer Disease; Cognition Disorders; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Neuropsychological Tests; Serotonin; Task Performance and Analysis; Tryptophan	2003
Fluvoxamine treatment of dementia: tryptophan levels. Biological psychiatry, 1993, Oct-15, Volume: 34, Issue:8 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acids; Dementia, Multi-Infarct; Female; Fluvoxamine; Humans; Male; Tryptophan	1993
Effects of monoamine oxidase inhibition by selegiline on concentrations of noradrenaline and monoamine metabolites in CSF of patients with Alzheimer's disease. Journal of neural transmission. Parkinson's disease and dementia section, 1993, Volume: 5, Issue:3 Topics: Aged; Alzheimer Disease; Biogenic Monoamines; Double-Blind Method; Female; Humans; Monoamine Oxidase Inhibitors; Norepinephrine; Pilot Projects; Psychiatric Status Rating Scales; Selegiline; Tryptophan	1993
Cognitive deficit induced by acute tryptophan depletion in patients with Alzheimer's disease. The American journal of psychiatry, 2000, Volume: 157, Issue:4 Topics: Aged; Alzheimer Disease; Cognition Disorders; Cross-Over Studies; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Serotonin; Tryptophan	2000
Effects of rapid tryptophan depletion on salivary and plasma cortisol in Alzheimer's disease and the healthy elderly. Journal of psychopharmacology (Oxford, England), 2002, Volume: 16, Issue:1 Topics: Aged; Alzheimer Disease; Area Under Curve; Association Learning; Cross-Over Studies; Double-Blind Method; Female; Humans; Hydrocortisone; Learning; Male; Memory, Short-Term; Neuropsychological Tests; Psychomotor Performance; Saliva; Stress, Psychological; Tryptophan; Verbal Behavior; Verbal Learning	2002
Preliminary communication. A double-blind placebo-controlled trial of L-tryptophan to assess the degree of cognitive and behavioural improvement in patients with Alzheimer-type dementia and to compare differential response in clinical sub-groups. International clinical psychopharmacology, 1990, Volume: 5, Issue:4 Topics: Administration, Oral; Aged; Alzheimer Disease; Behavior; Cognition; Double-Blind Method; Humans; Memory; Neuropsychological Tests; Psychiatric Status Rating Scales; Tryptophan	1990
Early stages of late onset Alzheimer's disease. Diagnostic criteria, protein metabolism, precursor loading effects, neurochemical and neuropsychological applications. Acta neurologica Scandinavica. Supplementum, 1989, Volume: 121 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Choline; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Levodopa; Male; Nerve Tissue Proteins; Neuropsychological Tests; Neurotransmitter Agents; Phosphatidylcholines; Tryptophan	1989

Other Studies

77 other study(ies) available for tryptophan and Alzheimer Disease

Article	Year
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease. European journal of medicinal chemistry, 2019, Apr-15, Volume: 168 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Ligands; Male; Maze Learning; Molecular Structure; Neuroprotective Agents; Protein Aggregates; Rats; Rats, Wistar; Structure-Activity Relationship; Tacrine; Tryptophan	2019
Neuroprotective effects of some epigenetic modifying drugs' on Chlamydia pneumoniae-induced neuroinflammation: A novel model. PloS one, 2021, Volume: 16, Issue:11 Topics: Alzheimer Disease; Amyloid beta-Peptides; Carbamates; Chlamydophila Infections; Chlamydophila pneumoniae; Epigenesis, Genetic; Humans; Hydroxamic Acids; Inflammation; Neuroprotective Agents; Peptide Fragments; Phthalimides; THP-1 Cells; Tryptophan	2021
Self-Fluorescent Lone Tryptophan Nanoparticles as Theranostic Agents Against Alzheimer's Disease. ACS applied materials & interfaces, 2022, Mar-23, Volume: 14, Issue:11 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Nanoparticles; Peptide Fragments; Rats; Theranostic Nanomedicine; Tryptophan	2022
Tryptophan-tyrosine dipeptide improves tau-related symptoms in tauopathy mice. Nutritional neuroscience, 2023, Volume: 26, Issue:8 Topics: Alzheimer Disease; Animals; Dipeptides; Disease Models, Animal; Mice; Mice, Transgenic; tau Proteins; Tauopathies; Tryptophan; Tyrosine	2023
Microbiota-derived metabolite Indoles induced aryl hydrocarbon receptor activation and inhibited neuroinflammation in APP/PS1 mice. Brain, behavior, and immunity, 2022, Volume: 106 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Indoles; Inflammasomes; Interleukin-18; Interleukin-6; Male; Mice; Mice, Transgenic; Microbiota; Neuroinflammatory Diseases; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Presenilin-1; Receptors, Aryl Hydrocarbon; Tryptophan; Tumor Necrosis Factor-alpha	2022
Evaluation of the histamine H Chemical biology & drug design, 2022, Volume: 100, Issue:5 Topics: Acetylcholine; Acetylcholinesterase; Alzheimer Disease; Benzofurans; Butyrylcholinesterase; Cholinesterase Inhibitors; Histamine; Histamine Antagonists; Humans; Ligands; Molecular Docking Simulation; Piperazines; Receptors, Histamine H3; Structure-Activity Relationship; Tryptophan	2022
Frontiers in immunology, 2022, Volume: 13 Topics: Alzheimer Disease; Animals; Bifidobacterium breve; Cognitive Dysfunction; Gastrointestinal Microbiome; Mice; Tryptophan	2022
Tryptophan Metabolism and Neurodegeneration: Longitudinal Associations of Kynurenine Pathway Metabolites with Cognitive Performance and Plasma Alzheimer's Disease and Related Dementias Biomarkers in the Duke Physical Performance Across the LifeSpan Study. Journal of Alzheimer's disease : JAD, 2023, Volume: 91, Issue:3 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Cognition; Humans; Kynurenine; Longevity; Tryptophan	2023
Effects of donepezil treatment on plasma and urine metabolites in amyloid beta-induced Alzheimer's disease rats. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2023, May-30, Volume: 1224 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Donepezil; Fatty Acids; Rats; Tryptophan	2023
[Serum metabolomics study of Psoraleae Fructus in improving learning and memory ability of APP/PS1 mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2023, Volume: 48, Issue:15 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Arachidonic Acid; Disease Models, Animal; Glycerophospholipids; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Tryptophan	2023
Peptidomimetics based on ammonium decasubstituted pillar[5]arenes: Influence of the alpha-amino acid residue nature on cholinesterase inhibition. Bioorganic chemistry, 2023, Volume: 141 Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Humans; Molecular Docking Simulation; Peptidomimetics; Phenylalanine; Structure-Activity Relationship; Tryptophan	2023
Identification of tryptophan metabolism-related genes in immunity and immunotherapy in Alzheimer's disease. Aging, 2023, 11-20, Volume: 15, Issue:22 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Immunotherapy; Mice; Mice, Transgenic; Tryptophan	2023
Systemic and central nervous system metabolic alterations in Alzheimer's disease. Alzheimer's research & therapy, 2019, 11-28, Volume: 11, Issue:1 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Brain; Carnitine; Case-Control Studies; Energy Metabolism; Female; Humans; Male; Metabolomics; Middle Aged; Phosphorylation; tau Proteins; Tryptophan	2019
Kynurenic Acid Levels are Increased in the CSF of Alzheimer's Disease Patients. Biomolecules, 2020, 04-08, Volume: 10, Issue:4 Topics: Aged; Alzheimer Disease; Case-Control Studies; Female; Humans; Kynurenic Acid; Male; Middle Aged; Tryptophan	2020
The effects of melatonin, serotonin, tryptophan and NAS on the biophysical properties of DPPC monolayers. Biochimica et biophysica acta. Biomembranes, 2020, 09-01, Volume: 1862, Issue:9 Topics: 1,2-Dipalmitoylphosphatidylcholine; Alzheimer Disease; Humans; Melatonin; Membrane Fluidity; Membranes, Artificial; Serotonin; Tryptophan	2020
Amyloid β neurotoxicity is IDO1-Kyn-AhR dependent and blocked by IDO1 inhibitor. Signal transduction and targeted therapy, 2020, 06-12, Volume: 5, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Basic Helix-Loop-Helix Transcription Factors; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Neurons; Rats; Receptors, Aryl Hydrocarbon; Tryptophan	2020
Fluorescent Dopamine-Tryptophan Nanocomposites as Dual-Imaging and Antiaggregation Agents: New Generation of Amyloid Theranostics with Trimeric Effects. ACS applied materials & interfaces, 2020, Sep-30, Volume: 12, Issue:39 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Line, Tumor; Disease Models, Animal; Dopamine; Fluorescent Dyes; Humans; Male; Maze Learning; Nanocomposites; Neuroprotective Agents; Particle Size; Protein Aggregates; Rats; Rats, Sprague-Dawley; Streptozocin; Surface Properties; Theranostic Nanomedicine; Tryptophan	2020
Structure-activity relationship study of tryptophan-based butyrylcholinesterase inhibitors. European journal of medicinal chemistry, 2020, Dec-15, Volume: 208 Topics: Alzheimer Disease; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Maze Learning; Memory; Mice; Molecular Structure; Nootropic Agents; Structure-Activity Relationship; Tryptophan	2020
Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer's disease. Alzheimer's research & therapy, 2021, 01-09, Volume: 13, Issue:1 Topics: Alzheimer Disease; Biological Availability; Humans; Kynurenine; Serotonin; Tryptophan	2021
Altered Gut Microbial Metabolites in Amnestic Mild Cognitive Impairment and Alzheimer's Disease: Signals in Host-Microbe Interplay. Nutrients, 2021, Jan-14, Volume: 13, Issue:1 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Bacteria; Cognitive Dysfunction; Fatty Acids, Volatile; Feces; Female; Gastrointestinal Microbiome; Humans; Male; Metabolome; Middle Aged; Tryptophan	2021
Huprine Y - Tryptophan heterodimers with potential implication to Alzheimer's disease treatment. Bioorganic & medicinal chemistry letters, 2021, 07-01, Volume: 43 Topics: Acetylcholinesterase; Alzheimer Disease; Aminoquinolines; Amyloid beta-Peptides; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Heterocyclic Compounds, 4 or More Rings; Humans; Molecular Structure; Neuroprotective Agents; Structure-Activity Relationship; Tryptophan	2021
Potential Anti-Alzheimer Agents from Guanidinyl Tryptophan Derivatives with Activities of Membrane Adhesion and Conformational Transition Inhibitions. Molecules (Basel, Switzerland), 2021, Aug-11, Volume: 26, Issue:16 Topics: Adhesiveness; Adsorption; Alzheimer Disease; Amyloid beta-Peptides; Cell Membrane; Guanidine; Humans; Ligands; Lipid Bilayers; Lipids; Models, Molecular; Molecular Dynamics Simulation; Phosphatidylcholines; Protein Conformation; Protein Structure, Secondary; Tryptophan; Water	2021
Effects of breviscapine on amyloid beta 1-42 induced Alzheimer's disease mice: A HPLC-QTOF-MS based plasma metabonomics study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2017, Jul-01, Volume: 1057 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Biomarkers; Cholesterol; Chromatography, High Pressure Liquid; Disease Models, Animal; Flavonoids; Male; Maze Learning; Metabolic Networks and Pathways; Metabolomics; Mice; Mice, Inbred ICR; Mice, Transgenic; Neuroprotective Agents; Peptide Fragments; Phospholipids; Serotonin; Tandem Mass Spectrometry; Tryptophan	2017
Label-Free Fluorescence Spectroscopy for Detecting Key Biomolecules in Brain Tissue from a Mouse Model of Alzheimer's Disease. Scientific reports, 2017, 06-01, Volume: 7, Issue:1 Topics: Alzheimer Disease; Animals; Brain; Disease Models, Animal; Early Diagnosis; Flavin-Adenine Dinucleotide; Humans; Mice; Mice, Transgenic; NAD; Spectrometry, Fluorescence; Tryptophan	2017
High-Throughput Metabolomics for Discovering Potential Metabolite Biomarkers and Metabolic Mechanism from the APPswe/PS1dE9 Transgenic Model of Alzheimer's Disease. Journal of proteome research, 2017, 09-01, Volume: 16, Issue:9 Topics: Alzheimer Disease; Animals; Arginine; Biomarkers; Chromatography, High Pressure Liquid; Cognitive Dysfunction; Dicarboxylic Acids; Disease Models, Animal; Early Diagnosis; Glucuronic Acid; Glyoxylates; Humans; Male; Metabolome; Metabolomics; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multivariate Analysis; Pentoses; Proline; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Starch; Sucrose; Tryptophan	2017
Kynurenine Pathway Metabolites in Alzheimer's Disease. Journal of Alzheimer's disease : JAD, 2017, Volume: 60, Issue:2 Topics: 3-Hydroxyanthranilic Acid; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Cognition Disorders; Cohort Studies; Female; Humans; Kynurenine; Male; Middle Aged; Neuropsychological Tests; Quinolinic Acid; Signal Transduction; Statistics, Nonparametric; Tryptophan; Xanthurenates	2017
Low plasma tryptophan is associated with olfactory function in healthy elderly community dwellers in Japan. BMC geriatrics, 2017, 10-16, Volume: 17, Issue:1 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Dementia; Female; Humans; Independent Living; Japan; Male; Olfaction Disorders; Smell; Tryptophan	2017
Mechanistic insights into remodeled Tau-derived PHF6 peptide fibrils by Naphthoquinone-Tryptophan hybrids. Scientific reports, 2018, 01-08, Volume: 8, Issue:1 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Circular Dichroism; Humans; Models, Molecular; Molecular Structure; Naphthalenes; Peptide Fragments; Protein Aggregates; Protein Aggregation, Pathological; Protein Binding; Protein Conformation; Protein Interaction Domains and Motifs; Protein Multimerization; tau Proteins; Tryptophan	2018
Study of the Effects of L-tryptophane Nanoparticles on Motor Behavior in Alzheimer's Experimental Models. CNS & neurological disorders drug targets, 2019, Volume: 18, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Infusions, Intraventricular; Nanoparticles; Peptide Fragments; Plaque, Amyloid; Rats; Tryptophan	2019
Tryptophan-derived butyrylcholinesterase inhibitors as promising leads against Alzheimer's disease. Chemical communications (Cambridge, England), 2019, Mar-26, Volume: 55, Issue:26 Topics: Alzheimer Disease; Butyrylcholinesterase; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Crystallography, X-Ray; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Tryptophan	2019
High-throughput metabolomics and ingenuity pathway approach reveals the pharmacological effect and targets of Ginsenoside Rg1 in Alzheimer's disease mice. Scientific reports, 2019, 05-07, Volume: 9, Issue:1 Topics: Alzheimer Disease; Animals; Biomarkers, Pharmacological; Chromatography, High Pressure Liquid; Disease Models, Animal; Ginsenosides; High-Throughput Screening Assays; Hippocampus; Male; Mass Spectrometry; Metabolic Networks and Pathways; Metabolomics; Mice, Transgenic; Neuroprotective Agents; Panax; Proteomics; Sphingolipids; Tryptophan	2019
UHPLC-HRMS study of anti-Alzheimer's drug candidates: metabolism of 7-MEOTA-tryptophan hybrids hampers their passage into brain. Journal of pharmaceutical and biomedical analysis, 2019, Sep-10, Volume: 174 Topics: Alzheimer Disease; Animals; Blood-Brain Barrier; Brain; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Hydrolysis; Male; Rats; Rats, Wistar; Tacrine; Tandem Mass Spectrometry; Tryptophan	2019
Preventive Effects of Tryptophan-Methionine Dipeptide on Neural Inflammation and Alzheimer's Pathology. International journal of molecular sciences, 2019, Jun-29, Volume: 20, Issue:13 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Cytokines; Dietary Supplements; Dipeptides; Female; Methionine; Mice; Microglia; Milk Proteins; Tryptophan	2019
Expression of tryptophan 2,3-dioxygenase and production of kynurenine pathway metabolites in triple transgenic mice and human Alzheimer's disease brain. PloS one, 2013, Volume: 8, Issue:4 Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Aged; Aged, 80 and over; Alzheimer Disease; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Carboxy-Lyases; Case-Control Studies; Cerebellum; Cerebral Cortex; Gene Expression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Metabolic Networks and Pathways; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Organ Specificity; Pentosyltransferases; Real-Time Polymerase Chain Reaction; RNA, Messenger; Tryptophan; Tryptophan Oxygenase	2013
Aluminum(III) interferes with the structure and the activity of the peptidyl-prolyl cis-trans isomerase (Pin1): a new mechanism contributing to the pathogenesis of Alzheimer's disease and cancers? Journal of inorganic biochemistry, 2013, Volume: 126 Topics: Aluminum Chloride; Aluminum Compounds; Alzheimer Disease; Calorimetry, Differential Scanning; Chlorides; Circular Dichroism; Humans; Neoplasms; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase; Protein Binding; Protein Stability; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; Solutions; Spectroscopy, Fourier Transform Infrared; Thermodynamics; Tryptophan	2013
Atomic and dynamic insights into the beneficial effect of the 1,4-naphthoquinon-2-yl-L-tryptophan inhibitor on Alzheimer's Aβ1-42 dimer in terms of aggregation and toxicity. ACS chemical neuroscience, 2014, Feb-19, Volume: 5, Issue:2 Topics: Alzheimer Disease; Amyloid beta-Peptides; Binding Sites; In Vitro Techniques; Molecular Dynamics Simulation; Naphthoquinones; Peptide Fragments; Protein Multimerization; Tryptophan	2014
Elevated fecal calprotectin in patients with Alzheimer's dementia indicates leaky gut. Journal of neural transmission (Vienna, Austria : 1996), 2015, Volume: 122, Issue:9 Topics: Aged; Alzheimer Disease; Feces; Female; Humans; Leukocyte L1 Antigen Complex; Male; Phenylalanine; Tryptophan; Tyrosine	2015
Combined experimental and simulation studies suggest a revised mode of action of the anti-Alzheimer disease drug NQ-Trp. Chemistry (Weinheim an der Bergstrasse, Germany), 2015, Sep-01, Volume: 21, Issue:36 Topics: Alzheimer Disease; Amyloid beta-Peptides; Humans; Magnetic Resonance Spectroscopy; Molecular Dynamics Simulation; Naphthoquinones; Peptide Fragments; Tryptophan	2015
Evaluating Fmoc-amino acids as selective inhibitors of butyrylcholinesterase. Amino acids, 2016, Volume: 48, Issue:12 Topics: Acetylcholinesterase; Alzheimer Disease; Amino Acids; Butyrylcholinesterase; Cholinesterase Inhibitors; Fluorenes; Humans; Leucine; Lysine; Protein Binding; Tryptophan	2016
Cl-NQTrp Alleviates Tauopathy Symptoms in a Model Organism through the Inhibition of Tau Aggregation-Engendered Toxicity. Neuro-degenerative diseases, 2017, Volume: 17, Issue:2-3 Topics: Alzheimer Disease; Animals; Animals, Genetically Modified; Disease Models, Animal; Drosophila melanogaster; Eye; Naphthalenes; Neuroprotective Agents; Peptide Fragments; tau Proteins; Tauopathies; Tryptophan	2017
Association of polymorphism of DNA repair gene XRCC1 with sporadic late-onset Alzheimer's disease and age of onset in elderly Han Chinese. Journal of the neurological sciences, 2010, Aug-15, Volume: 295, Issue:1-2 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Apolipoproteins E; Arginine; Asian People; DNA-Binding Proteins; Female; Gene Frequency; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Humans; Male; Mental Status Schedule; Polymorphism, Genetic; Tryptophan; X-ray Repair Cross Complementing Protein 1	2010
Complete phenotypic recovery of an Alzheimer's disease model by a quinone-tryptophan hybrid aggregation inhibitor. PloS one, 2010, Jun-14, Volume: 5, Issue:6 Topics: Alzheimer Disease; Circular Dichroism; Humans; Magnetic Resonance Spectroscopy; Models, Biological; Models, Molecular; Naphthoquinones; Phenotype; Quinones; Tryptophan	2010
Kynurenine and its metabolites in Alzheimer's disease patients. Advances in medical sciences, 2010, Volume: 55, Issue:2 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Chromatography, High Pressure Liquid; Female; Humans; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan	2010
Carbonyl proteins as a clinical marker in Alzheimer's disease and its relation to tryptophan degradation and immune activation. Clinical laboratory, 2010, Volume: 56, Issue:9-10 Topics: Aged; Alzheimer Disease; Biomarkers; Cognition Disorders; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Neopterin; Oxidative Stress; Protein Carbonylation; Reference Values; Tryptophan; Vitamin B 12	2010
Atypical presentation of a novel Presenilin 1 R377W mutation: sporadic, late-onset Alzheimer disease with epilepsy and frontotemporal atrophy. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2012, Volume: 33, Issue:2 Topics: Aged; Alzheimer Disease; Arginine; Atrophy; Epilepsy; Fluorodeoxyglucose F18; Frontal Lobe; Humans; Male; Mutation; Positron-Emission Tomography; Presenilin-2; Temporal Lobe; Tomography, X-Ray Computed; Tryptophan	2012
Substituted tryptophans at amyloid-β(1-40) residues 19 and 20 experience different environments after fibril formation. Archives of biochemistry and biophysics, 2011, Volume: 514, Issue:1-2 Topics: Alzheimer Disease; Amyloid beta-Peptides; Fluorescence; Humans; Hydrophobic and Hydrophilic Interactions; Peptide Fragments; Protein Conformation; Tryptophan	2011
Naphthoquinone-tyrptophan reduces neurotoxic Aβ56 levels and improves cognition in Alzheimer's disease animal model. Neurobiology of disease, 2012, Volume: 46, Issue:3* Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Benzothiazoles; Blood-Brain Barrier; Brain Chemistry; Cognition; Drosophila; Fluorescent Dyes; Humans; Longevity; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Models, Molecular; Motor Activity; Naphthalenes; Neurofibrils; Neuroprotective Agents; Psychomotor Performance; Recognition, Psychology; Thiazoles; Tryptophan	2012
Generic inhibition of amyloidogenic proteins by two naphthoquinone-tryptophan hybrid molecules. Proteins, 2012, Volume: 80, Issue:8 Topics: alpha-Synuclein; Alzheimer Disease; Amyloidogenic Proteins; Calcitonin; Humans; Insulin; Islet Amyloid Polypeptide; Muramidase; Naphthoquinones; Tryptophan	2012
Membrane-microdomain localization of amyloid β-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue. The Journal of biological chemistry, 2012, Jun-01, Volume: 287, Issue:23 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Brain; Brain Chemistry; Membrane Microdomains; Mice; Phosphorylation; Protein Structure, Tertiary; Tryptophan	2012
High tryptophan diet reduces CA1 intraneuronal β-amyloid in the triple transgenic mouse model of Alzheimer's disease. Aging cell, 2012, Volume: 11, Issue:5 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; CA1 Region, Hippocampal; Disease Models, Animal; Female; Male; Mice; Mice, Transgenic; Neurons; Serotonin; Serotonin Plasma Membrane Transport Proteins; Tryptophan	2012
Increased 3-hydroxykynurenine serum concentrations differentiate Alzheimer's disease patients from controls. European archives of psychiatry and clinical neuroscience, 2013, Volume: 263, Issue:4 Topics: Aged; Alzheimer Disease; Biomarkers; Blood-Brain Barrier; Brain Chemistry; Chromatography, High Pressure Liquid; Cognition Disorders; Female; Gas Chromatography-Mass Spectrometry; Humans; Kynurenic Acid; Kynurenine; Male; Neuropsychological Tests; Picolinic Acids; Quinolinic Acid; Spectrophotometry, Ultraviolet; Tryptophan	2013
Methylations of tryptophan-modified naphthoquinone affect its inhibitory potential toward Aβ aggregation. The journal of physical chemistry. B, 2013, Feb-14, Volume: 117, Issue:6 Topics: Alzheimer Disease; Amyloid beta-Peptides; Fluorescence Polarization; Humans; Hydrogen Bonding; Molecular Dynamics Simulation; Naphthoquinones; Peptide Fragments; Structure-Activity Relationship; Tryptophan	2013
Structure, stability, and aggregation of paired helical filaments from tau protein and FTDP-17 mutants probed by tryptophan scanning mutagenesis. The Journal of biological chemistry, 2002, Nov-01, Volume: 277, Issue:44 Topics: Alzheimer Disease; Fluorescence Resonance Energy Transfer; Humans; Microtubule-Associated Proteins; Microtubules; Mutagenesis; Neurofibrillary Tangles; Protein Conformation; Protein Structure, Secondary; Repetitive Sequences, Amino Acid; tau Proteins; Tryptophan	2002
Hypothalamic digoxin, hemispheric chemical dominance, and Alzheimer's disease. The International journal of neuroscience, 2003, Volume: 113, Issue:3 Topics: Aged; Albumins; alpha-Tocopherol; Alzheimer Disease; Ceruloplasmin; Digoxin; Dolichols; Dominance, Cerebral; Erythrocyte Membrane; Female; Free Radicals; Functional Laterality; Glycosaminoglycans; Humans; Hydroxymethylglutaryl CoA Reductases; Hypothalamus; Iron; Lysosomes; Magnesium; Male; Matched-Pair Analysis; Middle Aged; Phosphoprotein Phosphatases; Quinolinic Acid; Serotonin; Sodium-Potassium-Exchanging ATPase; Tryptophan	2003
Y10W beta(1-40) fluorescence reflects epitope exposure in conformers of Alzheimer's beta-peptide. Archives of biochemistry and biophysics, 2003, Sep-01, Volume: 417, Issue:1 Topics: Alzheimer Disease; Amino Acid Sequence; Amino Acid Substitution; Amyloid beta-Peptides; Antibodies, Monoclonal; Epitopes; Fluorescence; Humans; Hydrogen-Ion Concentration; Kinetics; Methylamines; Molecular Sequence Data; Oxidants; Peptide Fragments; Propanols; Protein Conformation; Protein Structure, Secondary; Recombinant Proteins; Solutions; Solvents; Time Factors; Tryptophan	2003
Tau (MAPT) mutation Arg406Trp presenting clinically with Alzheimer disease does not share a common founder in Western Europe. Human mutation, 2003, Volume: 22, Issue:5 Topics: Aged; Alzheimer Disease; Arginine; Europe; Founder Effect; Humans; Microsatellite Repeats; Middle Aged; Mutation; Pedigree; tau Proteins; Tryptophan	2003
Cognitive changes after acute tryptophan depletion: what can they tell us? Psychological medicine, 2004, Volume: 34, Issue:1 Topics: Alzheimer Disease; Cognition Disorders; Depressive Disorder, Major; Human Experimentation; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Serotonin; Tryptophan	2004
The tau R406W mutation causes progressive presenile dementia with bitemporal atrophy. Dementia and geriatric cognitive disorders, 2004, Volume: 17, Issue:4 Topics: Age of Onset; Alzheimer Disease; Arginine; Atrophy; Genes, Dominant; Humans; Memory Disorders; Middle Aged; Mutation; Pedigree; tau Proteins; Temporal Lobe; Time Factors; Tryptophan	2004
Deficiency of disulfide bonds facilitating fibrillogenesis of endostatin. The Journal of biological chemistry, 2006, Jan-13, Volume: 281, Issue:2 Topics: Alanine; Alzheimer Disease; Animals; Benzothiazoles; Cell Survival; Circular Dichroism; Disulfides; Endostatins; Escherichia coli; Fibril-Associated Collagens; Fluorescent Dyes; Glutathione; Hydrogen-Ion Concentration; Light; Microscopy, Atomic Force; Neovascularization, Pathologic; PC12 Cells; Protein Conformation; Protein Structure, Tertiary; Rats; Scattering, Radiation; Spectroscopy, Fourier Transform Infrared; Temperature; Tetrazolium Salts; Thiazoles; Time Factors; Tryptophan; Ultraviolet Rays	2006
The Arg194Trp polymorphism in DNA repair gene XRCC1 and the risk for sporadic late-onset Alzheimer's disease. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2007, Volume: 28, Issue:1 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Arginine; Case-Control Studies; DNA-Binding Proteins; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Polymorphism, Genetic; Risk; Tryptophan; X-ray Repair Cross Complementing Protein 1	2007
Alzheimer disease-like clinical phenotype in a family with FTDP-17 caused by a MAPT R406W mutation. European journal of neurology, 2008, Volume: 15, Issue:4 Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Arginine; Chromosomes, Human, Pair 17; Dementia; Denmark; Deoxyglucose; Family Health; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Mutation; Neurofibrillary Tangles; Neuropsychological Tests; Peptide Fragments; Phenotype; Positron-Emission Tomography; tau Proteins; Tryptophan	2008
Monoamine metabolites in human cerebrospinal fluid. HPLC/ED method. Acta neurologica Scandinavica, 1984, Volume: 69, Issue:4 Topics: 3,4-Dihydroxyphenylacetic Acid; Alzheimer Disease; Chromatography, High Pressure Liquid; Depression; Dihydroxyphenylalanine; Electrochemistry; Glycols; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Methoxyhydroxyphenylglycol; Parkinson Disease; Phenylacetates; Subarachnoid Hemorrhage; Tryptophan; Tyrosine	1984
Presenilin 1 binds to amyloid precursor protein directly. Biochemical and biophysical research communications, 1997, Oct-20, Volume: 239, Issue:2 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Galactose; Galactosides; Glucose; Hippocampus; Histidine; Humans; Indoles; Membrane Proteins; Plasmids; Presenilin-1; Protein Binding; Rats; Transformation, Genetic; Tryptophan; Uracil	1997
Serotonin-immune interactions in elderly volunteers and in patients with Alzheimer's disease (DAT): lower plasma tryptophan availability to the brain in the elderly and increased serum interleukin-6 in DAT. Aging (Milan, Italy), 1998, Volume: 10, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Brain; Case-Control Studies; Female; Humans; Interleukin-6; Interleukin-8; Male; Middle Aged; Serotonin; Tryptophan	1998
Decrease in the levels of NGF and BDNF in brains of mice fed a tryptophan-deficient diet. Bioscience, biotechnology, and biochemistry, 1999, Volume: 63, Issue:2 Topics: Alzheimer Disease; Animals; Brain; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Entorhinal Cortex; Hippocampus; Male; Mice; Nerve Growth Factors; Neurotrophin 3; Septum Pellucidum; Tryptophan	1999
Sleep disturbances and tryptophan in patients with Alzheimer's disease. Lancet (London, England), 2000, Feb-26, Volume: 355, Issue:9205 Topics: Alzheimer Disease; Humans; Serotonin; Sleep Wake Disorders; Tryptophan	2000
Degradation of tryptophan in neurodegenerative disorders. Advances in experimental medicine and biology, 1999, Volume: 467 Topics: Alzheimer Disease; Biomarkers; Humans; Huntington Disease; Intellectual Disability; Interleukin-2; Kynurenine; Neopterin; Receptors, Interleukin-2; Receptors, Tumor Necrosis Factor; Tryptophan; Tumor Necrosis Factor-alpha	1999
Tryptophan degradation and immune activation in Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996), 2000, Volume: 107, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Brain; Female; Humans; Interferon-gamma; Kynurenine; Male; Middle Aged; Neopterin; Tryptophan	2000
Human apolipoprotein C-II forms twisted amyloid ribbons and closed loops. Biochemistry, 2000, Jul-18, Volume: 39, Issue:28 Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Apolipoprotein C-II; Apolipoproteins C; Benzothiazoles; Chromatography, Gel; Circular Dichroism; Congo Red; Humans; Microscopy, Electron; Protein Conformation; Spectrometry, Fluorescence; Thiazoles; Tryptophan; Ultracentrifugation	2000
Interaction between beta-amyloid and lens alphaB-crystallin. FEBS letters, 2000, Nov-03, Volume: 484, Issue:2 Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Crystallins; Humans; Recombinant Proteins; Spectrometry, Fluorescence; Thiazoles; Tryptophan; Ultraviolet Rays	2000
Biochemical stress of caring. Psychological medicine, 2001, Volume: 31, Issue:8 Topics: Adult; Aged; Alzheimer Disease; Brain; Caregivers; Depressive Disorder, Major; Female; Humans; Hydrocortisone; Male; Middle Aged; Prevalence; Psychiatric Status Rating Scales; Saliva; Stress, Psychological; Tryptophan	2001
Abundant type 10 17 beta-hydroxysteroid dehydrogenase in the hippocampus of mouse Alzheimer's disease model. Brain research. Molecular brain research, 2002, Feb-28, Volume: 99, Issue:1 Topics: 17-Hydroxysteroid Dehydrogenases; 3-Hydroxyacyl CoA Dehydrogenases; Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Protein Precursor; Animals; Base Sequence; Binding Sites; Cloning, Molecular; Disease Models, Animal; DNA, Complementary; Hippocampus; Humans; Mice; Mice, Transgenic; Mitochondria; Molecular Sequence Data; NAD; Presynaptic Terminals; Protein Isoforms; Protein Structure, Tertiary; Signal Transduction; Steroids; Tryptophan	2002
Histochemical similarity of senile plaque amyloid to apudamyloid. Virchows Archiv. A, Pathological anatomy and histology, 1977, Nov-17, Volume: 376, Issue:2 Topics: Aged; Alzheimer Disease; Amyloid; Animals; Brain Chemistry; Dementia; Female; Histocytochemistry; Humans; Male; Mice; Middle Aged; Organ Specificity; Tryptophan; Tyrosine	1977
Kynurenic acid concentrations are reduced in Huntington's disease cerebral cortex. Journal of the neurological sciences, 1992, Volume: 108, Issue:1 Topics: Aged; Alzheimer Disease; Cerebral Cortex; Energy Metabolism; Free Radicals; Humans; Huntington Disease; Kynurenic Acid; Kynurenine; Middle Aged; Parkinson Disease; Purines; Tryptophan; Tyrosine	1992
Neurotransmitter precursors and brain function. Bibliotheca nutritio et dieta, 1986, Issue:38 Topics: Aged; Aging; Alzheimer Disease; Animals; Biological Transport; Brain; Diet; Humans; Learning; Levodopa; Memory; Neurotransmitter Agents; Parkinson Disease; Phosphatidylcholines; Serotonin; Sleep; Tryptophan	1986
The physiopathological role of quinolinic acid in the mammalian central nervous system. Annali dell'Istituto superiore di sanita, 1988, Volume: 24, Issue:3 Topics: Aging; Alzheimer Disease; Animals; Cerebral Cortex; Gas Chromatography-Mass Spectrometry; Hepatic Encephalopathy; Humans; Liver; Liver Cirrhosis; Male; Portacaval Shunt, Surgical; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tryptophan	1988
Determination of tyrosine, tryptophan and their metabolic derivatives by liquid chromatography-electrochemical detection: application to post mortem samples from patients with Parkinson's and Alzheimer's disease. Life sciences, 1985, Feb-04, Volume: 36, Issue:5 Topics: Aged; Alzheimer Disease; Animals; Chromatography, High Pressure Liquid; Electrochemistry; Female; Humans; Male; Middle Aged; Parkinson Disease; Rats; Tryptophan; Tyrosine	1985