tryptophan has been researched along with ALS - Amyotrophic Lateral Sclerosis in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (22.73) | 29.6817 |
| 2010's | 13 (59.09) | 24.3611 |
| 2020's | 4 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Monteiro, MJ; Phung, TH; Tatman, M | 1 |
| Chao, WC; Chiang, TH; Chou, PT; Lee, YL; Lin, LJ; Lu, JF; Wang, JS | 1 |
| Ayers, JI; Borchelt, DR; Brown, H; Cashman, NR; Crown, A; Fagerli, E; Galaleldeen, A; McAlary, L; Yerbury, JJ | 1 |
| Kovalenko, A; LeVatte, M; Lipfert, M; Roy, D; Wishart, DS | 1 |
| Chiang, WC; Chou, PC; Huang, JR; Li, HR; Wang, WJ | 1 |
| Bosco, DA; Brown, RH; Hetz, C; MartÃnez Traub, F; Medinas, DB; Rozas, P; Woehlbier, U | 1 |
| Bharath M M, S; Manjula, R; Padmanabhan, B; Unni, S; Wright, GSA | 1 |
| Allison, WT; Blinov, N; Bratvold, J; Cashman, NR; DuVal, MG; Hinge, VK; Kanyo, R; Kovalenko, A; Pokrishevsky, E; Snyder, N | 1 |
| Cai, T; Cai, W; Chen, L; Chen, Z; Cui, F; Huang, X; Mao, F; Sun, Z; Teng, H; Wang, J; Wang, Z; Yu, P | 1 |
| Baranov, S; Chen, Y; Fotinos, A; Kristal, BS; Li, W; Sinha, B; Tu, Y; Wang, X; Wu, Q; Zhou, EW; Zhu, Y | 1 |
| Friedlander, RM; Jiang, J; Li, W; Mao, LL; Sirianni, AC; Sugarbaker, P; Wang, X; Zeng, J; Zhang, X; Zhou, S | 1 |
| Cho, GW; Kim, SH; Oh, YS | 1 |
| Braidy, N; Brew, BJ; Guillemin, GJ; Lee, JM; Lovejoy, D; Rowe, DB; Tan, V | 1 |
| Andres, CR; Baranek, T; Blasco, H; Bruno, C; Corcia, P; Descat, A; Dessein, AF; Goossens, JF; Leman, S; Madji Hounoum, B; Marouillat, S; Nadal-Desbarats, L; Patin, F; Vourc'h, P | 1 |
| Chakrabartty, A; Ho, S; Kerman, A; Mulligan, VK | 1 |
| Brew, BJ; Chen, Y; Coggan, S; Cullen, KM; Garner, B; Grant, R; Guillemin, GJ; Meininger, V; Stankovic, R | 1 |
| Chen, Y; Guillemin, GJ; Meininger, V | 1 |
| Chang, Q; Chestnut, BA; Lesuisse, C; Martin, LJ; Price, A; Wong, M | 1 |
| Tan, L; Yu, JT | 1 |
| Andrekopoulos, C; Chandran, K; Crow, JP; Joseph, J; Kalyanaraman, B; Karoui, H; Zhang, H | 1 |
| Cashman, NR; Chakrabartty, A; Crow, JP; Kondejewski, LH; Lepock, JR; Rakhit, R | 1 |
| Agar, JN; Durham, HD; Gibbs, BF; Kabashi, E; Minotti, S; Taylor, DM | 1 |
2 review(s) available for tryptophan and ALS - Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Involvement of quinolinic acid in the neuropathogenesis of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Humans; Kynurenine; Metabolic Networks and Pathways; Quinolinic Acid; Tryptophan | 2017 |
The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations.
Topics: Aging; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Enzyme Inhibitors; Humans; Huntington Disease; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenic Acid; Kynurenine; Microglia; Molecular Targeted Therapy; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Parkinson Disease; Quinolinic Acid; Receptors, G-Protein-Coupled; Receptors, N-Methyl-D-Aspartate; Tryptophan | 2012 |
20 other study(ies) available for tryptophan and ALS - Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
UBQLN2 undergoes a reversible temperature-induced conformational switch that regulates binding with HSPA1B: ALS/FTD mutations cripple the switch but do not destroy HSPA1B binding.
Topics: Adaptor Proteins, Signal Transducing; Amyotrophic Lateral Sclerosis; Autophagy-Related Proteins; Frontotemporal Dementia; HSP70 Heat-Shock Proteins; Humans; Mutation; Temperature; Tryptophan | 2023 |
Unveiling the structural features of nonnative trimers of human superoxide dismutase 1.
Topics: Amyotrophic Lateral Sclerosis; Humans; Models, Molecular; Mutation; Oxidation-Reduction; Protein Folding; Superoxide Dismutase-1; Tryptophan | 2020 |
Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection.
Topics: Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Disease Models, Animal; Female; Humans; Male; Mice; Mice, Transgenic; Mutagenesis, Site-Directed; Prions; Protein Aggregation, Pathological; Recombinant Fusion Proteins; Superoxide Dismutase-1; Tryptophan | 2020 |
Cloning and high-level expression of monomeric human superoxide dismutase 1 (SOD1) and its interaction with pyrimidine analogs.
Topics: Amyotrophic Lateral Sclerosis; Base Sequence; Bromouracil; Cloning, Molecular; Drug Evaluation, Preclinical; Escherichia coli; Humans; Hydrogen Bonding; Molecular Docking Simulation; Molecular Dynamics Simulation; Mutation; Protein Folding; Proton Magnetic Resonance Spectroscopy; Superoxide Dismutase-1; Trifluridine; Tryptophan; Uridine | 2021 |
TAR DNA-binding protein 43 (TDP-43) liquid-liquid phase separation is mediated by just a few aromatic residues.
Topics: Amino Acids, Aromatic; Amyotrophic Lateral Sclerosis; Dementia; DNA-Binding Proteins; Humans; Intrinsically Disordered Proteins; Motor Neuron Disease; Mutation; Nuclear Magnetic Resonance, Biomolecular; Phase Transition; Protein Domains; Tryptophan | 2018 |
Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis.
Topics: Adult; Aged; Aged, 80 and over; Aging; Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Brain; Cell Line; Disease Models, Animal; Endoplasmic Reticulum Stress; Female; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Motor Neurons; Mutation; Oxidation-Reduction; Protein Aggregation, Pathological; Protein Folding; Proteostasis; Spinal Cord; Superoxide Dismutase-1; Tryptophan; Tunicamycin; Unfolded Protein Response | 2018 |
Rational discovery of a SOD1 tryptophan oxidation inhibitor with therapeutic potential for amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Databases, Pharmaceutical; Drug Discovery; Drug Evaluation, Preclinical; Humans; Ligands; Models, Molecular; Molecular Docking Simulation; Molecular Dynamics Simulation; Oxidation-Reduction; Structure-Activity Relationship; Superoxide Dismutase-1; Tryptophan | 2019 |
Tryptophan 32 mediates SOD1 toxicity in a in vivo motor neuron model of ALS and is a promising target for small molecule therapeutics.
Topics: Amyotrophic Lateral Sclerosis; Animals; Humans; Motor Neurons; Nucleic Acid Synthesis Inhibitors; Superoxide Dismutase-1; Telbivudine; Tryptophan; Zebrafish | 2019 |
Identification of a novel missense (C7W) mutation of SOD1 in a large familial amyotrophic lateral sclerosis pedigree.
Topics: Adult; Aged; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; China; Cysteine; Female; Humans; Male; Middle Aged; Mutation, Missense; Pedigree; Superoxide Dismutase; Superoxide Dismutase-1; Tryptophan | 2014 |
N-acetyl-L-tryptophan delays disease onset and extends survival in an amyotrophic lateral sclerosis transgenic mouse model.
Topics: Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Male; Mice; Mice, Transgenic; Mitochondria; Motor Neurons; Neuroglia; Receptors, Neurokinin-1; Spinal Cord; Superoxide Dismutase; Survival Analysis; Tryptophan | 2015 |
N-acetyl-l-tryptophan, but not N-acetyl-d-tryptophan, rescues neuronal cell death in models of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Caspases; Cell Line; Cytochromes c; Drug Evaluation, Preclinical; Hybrid Cells; Interleukin-1beta; Mice; Mitochondria; Motor Neurons; Neurokinin-1 Receptor Antagonists; Neuroprotective Agents; Proteasome Endopeptidase Complex; Receptors, Neurokinin-1; Stereoisomerism; Substance P; Tryptophan | 2015 |
Functional Restoration of Amyotrophic Lateral Sclerosis Patient-Derived Mesenchymal Stromal Cells Through Inhibition of DNA Methyltransferase.
Topics: Amyotrophic Lateral Sclerosis; Cell Differentiation; Cell Movement; Cellular Senescence; DNA Modification Methylases; Humans; Mesenchymal Stem Cells; Neurons; Neuroprotection; Phthalimides; Tryptophan | 2016 |
Omics to Explore Amyotrophic Lateral Sclerosis Evolution: the Central Role of Arginine and Proline Metabolism.
Topics: Amyotrophic Lateral Sclerosis; Animals; Arginine; Disease Models, Animal; Female; Humans; Longitudinal Studies; Male; Metabolomics; Mice, Transgenic; Motor Neurons; Proline; Superoxide Dismutase; Tryptophan | 2017 |
Denaturational stress induces formation of zinc-deficient monomers of Cu,Zn superoxide dismutase: implications for pathogenesis in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Copper; Dimerization; Guanidine; Humans; Kinetics; Models, Molecular; Mutation; Protein Conformation; Protein Denaturation; Superoxide Dismutase; Thermodynamics; Tryptophan; Zinc | 2008 |
The kynurenine pathway and inflammation in amyotrophic lateral sclerosis.
Topics: Adult; Amyotrophic Lateral Sclerosis; Brain; Female; HLA-DR Antigens; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Male; Middle Aged; Picolinic Acids; Quinolinic Acid; Signal Transduction; Spinal Cord; Tryptophan | 2010 |
Recent advances in the treatment of amyotrophic lateral sclerosis. Emphasis on kynurenine pathway inhibitors.
Topics: Adult; Amyotrophic Lateral Sclerosis; Animals; Brain; D-Aspartic Acid; Functional Laterality; Humans; Japan; Kynurenic Acid; Kynurenine; Motor Neurons; N-Methylaspartate; Quinolinic Acid; Riluzole; Signal Transduction; Tryptophan | 2009 |
Epigenetic regulation of motor neuron cell death through DNA methylation.
Topics: 5-Methylcytosine; Age Factors; Amyloid Precursor Protein Secretases; Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Aspartic Acid Endopeptidases; Camptothecin; Caspase 3; Cell Line, Transformed; Central Nervous System; Cytosine; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Enzyme Inhibitors; Epigenomics; Gene Expression Regulation, Developmental; Green Fluorescent Proteins; Humans; Indoles; Mice; Mice, Transgenic; Motor Neurons; Mutation; Phthalimides; Propionates; RNA, Small Interfering; Sciatic Neuropathy; Superoxide Dismutase; Transfection; Tryptophan; Up-Regulation | 2011 |
Bicarbonate-dependent peroxidase activity of human Cu,Zn-superoxide dismutase induces covalent aggregation of protein: intermediacy of tryptophan-derived oxidation products.
Topics: Amyotrophic Lateral Sclerosis; Bicarbonates; Dimerization; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Humans; Models, Chemical; Oxidation-Reduction; Peroxidases; Protein Conformation; Superoxide Dismutase; Tryptophan | 2003 |
Monomeric Cu,Zn-superoxide dismutase is a common misfolding intermediate in the oxidation models of sporadic and familial amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Anilino Naphthalenesulfonates; Calorimetry; Chromatography, Liquid; Circular Dichroism; Dose-Response Relationship, Drug; Erythrocytes; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Light; Mass Spectrometry; Models, Molecular; Mutation; Oxygen; Protein Binding; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Scattering, Radiation; Superoxide Dismutase; Temperature; Tryptophan; Ultracentrifugation | 2004 |
Tryptophan 32 potentiates aggregation and cytotoxicity of a copper/zinc superoxide dismutase mutant associated with familial amyotrophic lateral sclerosis.
Topics: Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Erythrocytes; Humans; Inclusion Bodies; Mice; Mice, Transgenic; Motor Neurons; Mutation, Missense; Oxidation-Reduction; Protein Processing, Post-Translational; Rabbits; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Tryptophan | 2007 |