trypsinogen and Renal-Insufficiency

Screening for cystic fibrosis (CF) was recently added to the neonatal screening programme in the Netherlands. Four patients with renal failure whose heel prick tests were positive for CF as defined by raised levels of immunoreactive trypsinogen (IRT) and pancreatitis-associated protein (PAP) are described. Both cystic fibrosis transmembrane conductance regulator (CFTR) DNA analysis and sweat tests were negative. Limited renal function can be a cause of false positive neonatal screening for CF using IRT and PAP.

Topics: Antigens, Neoplasm; Biomarkers; Biomarkers, Tumor; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; False Positive Reactions; Humans; Infant, Newborn; Lectins, C-Type; Male; Neonatal Screening; Pancreatitis-Associated Proteins; Renal Insufficiency; Trypsinogen