trypsinogen and Immune-System-Diseases

Topics: Acute Disease; Alleles; Carrier Proteins; Cytokines; Humans; Immune System Diseases; Inflammation Mediators; Lipopolysaccharide Receptors; Macrophage Migration-Inhibitory Factors; Mutation; Obesity; Pancreatitis; Severity of Illness Index; Toll-Like Receptors; Trypsin; Trypsin Inhibitor, Kazal Pancreatic; Trypsinogen

Type 2 Diabetes (T2D) is characterized by alteration in the circulatory levels of key inflammatory proteins, where our body strives to eliminate the perturbing factor through inflammation as a final resort to restore homeostasis. Plasma proteins play a crucial role to orchestrate this immune response. Over the past two decades, rigorous genetic efforts taken to comprehend T2D physiology have been partially successful and have left behind a dearth of knowledge of its causality. Here, we have investigated how the reported genetic variants of T2D are associated with circulatory levels of key plasma proteins. We identified 99 T2D genetic variants that serve as strong pQTL (protein Quantitative Trait Loci) for 72 plasma proteins, of which 4 proteins namely Small nuclear ribonucleoprotein F [SNRPF] (p = 2.99 × 10

Topics: Adipose Tissue; Blood; Blood Proteins; Diabetes Mellitus, Type 2; Gene Expression; Genetic Variation; Genome-Wide Association Study; Humans; Immune System Diseases; Liver; Pancreas; Platelet Endothelial Cell Adhesion Molecule-1; Protein Interaction Maps; snRNP Core Proteins; Trypsin; Trypsinogen

Topics: Chymotrypsin; Chymotrypsinogen; Enzyme Precursors; Hypersensitivity; Immune System Diseases; Trypsin; Trypsinogen