trypanothione has been researched along with American Trypanosomiasis in 11 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Garg, NJ; Mesías, AC; Zago, MP | 1 |
| González-Chávez, Z; Moreno-Sánchez, R; Saavedra, E; Vázquez, C | 1 |
| Costi, R; Di Santo, R; Saccoliti, F | 1 |
| Beig, M; Garoff, L; Krauth-Siegel, RL; Noack, S; Oellien, F; Selzer, PM | 1 |
| Alberca, LN; Balcazar, D; Benitez, D; Carrillo, C; Comini, M; Fraccaroli, L; Medeiros, A; Sbaraglini, ML; Talevi, A | 1 |
| Campos-Estrada, C; Castro, L; Cortes, L; Díaz, MV; Kemmerling, U; Lapier, M; López-Muñoz, R; Maya, JD; Miranda, MR; Morello, A; Pereira, CA; Reigada, C; Seguel, V | 1 |
| Bocedi, A; Dawood, KF; Fabrini, R; Federici, G; Gradoni, L; Pedersen, JZ; Ricci, G | 1 |
| Campillo, NE; Páez, JA; Sánchez-Sancho, F | 1 |
| Heby, O; Persson, L; Rentala, M | 1 |
| D'Silva, C; Daunes, S | 1 |
| Bradley, M; Nadeau, K; Walsh, C | 1 |
6 review(s) available for trypanothione and American Trypanosomiasis
| Article | Year |
|---|---|
Redox Balance Keepers and Possible Cell Functions Managed by Redox Homeostasis in
Topics: Animals; Antioxidants; Antiparasitic Agents; Chagas Disease; Glutathione; Homeostasis; Humans; Insect Vectors; Nitrosative Stress; Oxidants; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Signal Transduction; Spermidine; Trypanosoma cruzi | 2019 |
Recent Advancement in the Search of Innovative Antiprotozoal Agents Targeting Trypanothione Metabolism.
Topics: Amide Synthases; Amidohydrolases; Animals; Chagas Disease; Enzyme Inhibitors; Glutathione; Humans; Leishmania; Leishmaniasis; NADH, NADPH Oxidoreductases; Protozoan Proteins; Spermidine; Trypanocidal Agents; Trypanosoma | 2020 |
Chagas disease: progress and new perspectives.
Topics: Chagas Disease; Enzyme Inhibitors; Ergosterol; Glutathione; Humans; Hypoxanthine Phosphoribosyltransferase; Spermidine; Trypanosoma cruzi | 2010 |
Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis.
Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Biogenic Polyamines; Chagas Disease; Eflornithine; Enzyme Inhibitors; Glutathione; Humans; Leishmania; Leishmaniasis; Ornithine Decarboxylase Inhibitors; Robenidine; Spermidine; Spermidine Synthase; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosoma cruzi; Trypanosomiasis, African | 2007 |
The therapeutic potential of inhibitors of the trypanothione cycle.
Topics: Animals; Chagas Disease; Enzyme Inhibitors; Glutathione; Humans; Leishmaniasis; NADH, NADPH Oxidoreductases; Receptors, Peptide; Spermidine; Structure-Activity Relationship; Thioredoxins; Trypanocidal Agents; Trypanosomiasis, African | 2002 |
Molecular studies on trypanothione reductase: an antiparasitic target enzyme.
Topics: Amino Acid Sequence; Animals; Antiprotozoal Agents; Binding Sites; Chagas Disease; Crithidia; Drug Design; Glutathione; Glutathione Reductase; Leishmania; Molecular Sequence Data; Mutagenesis, Site-Directed; NADH, NADPH Oxidoreductases; Oxidation-Reduction; Prevalence; Protein Engineering; Protozoan Proteins; Spermidine; Substrate Specificity; Trypanosoma; Trypanosoma congolense; Trypanosomiasis, African | 1992 |
5 other study(ies) available for trypanothione and American Trypanosomiasis
| Article | Year |
|---|---|
Metabolic Control Analysis for Drug Target Prioritization in Trypanosomatids.
Topics: Cell Extracts; Chagas Disease; Computer Simulation; Drug Development; Glutathione; Humans; Kinetics; Metabolic Networks and Pathways; Metabolomics; Models, Biological; Molecular Targeted Therapy; Protozoan Proteins; Recombinant Proteins; Spermidine; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Trypanothione reductase: a target protein for a combined in vitro and in silico screening approach.
Topics: Chagas Disease; Chlorhexidine; Computer Simulation; Drug Evaluation, Preclinical; Enzyme Inhibitors; Glutathione; Inhibitory Concentration 50; Kinetics; Models, Molecular; NADH, NADPH Oxidoreductases; Protozoan Proteins; Quinacrine; Spermidine; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Discovery of novel polyamine analogs with anti-protozoal activity by computer guided drug repositioning.
Topics: Amide Synthases; Antiprotozoal Agents; Chagas Disease; Computer Simulation; Drug Repositioning; Glutathione; Humans; Imidazoles; Nitroimidazoles; Polyamines; Spermidine; Thiophenes; Trypanosoma cruzi; User-Computer Interface | 2016 |
Pentamidine antagonizes the benznidazole's effect in vitro, and lacks of synergy in vivo: Implications about the polyamine transport as an anti-Trypanosoma cruzi target.
Topics: Animals; Chagas Disease; Chlorocebus aethiops; DNA, Protozoan; Dose-Response Relationship, Drug; Glutathione; Macrophages; Male; Mice; Mice, Inbred BALB C; Myocardium; Nitroimidazoles; Parasitemia; Pentamidine; Putrescine; Random Allocation; Spermidine; Thymidine; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2016 |
Trypanothione efficiently intercepts nitric oxide as a harmless iron complex in trypanosomatid parasites.
Topics: Animals; Chagas Disease; Dose-Response Relationship, Drug; Glutathione; Iron; Leishmania infantum; NADH, NADPH Oxidoreductases; Nitric Oxide; Nitrogen Oxides; Protozoan Proteins; Spermidine; Trypanosoma brucei brucei; Trypanosomiasis, African | 2010 |