Page last updated: 2024-09-03

trypanothione and African Sleeping Sickness

trypanothione has been researched along with African Sleeping Sickness in 11 studies

Research

Studies (11)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (9.09)	18.2507
2000's	8 (72.73)	29.6817
2010's	2 (18.18)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Irsch, T; Krauth-Siegel, RL; Rabbani, N; Thornalley, PJ; Wendler, A	1
McCloskey, DE; Phillips, MA; Xiao, Y	1
Fairlamb, AH; Oza, SL; Patterson, S; Spinks, D; Thompson, S; Wyllie, S	1
Bocedi, A; Dawood, KF; Fabrini, R; Federici, G; Gradoni, L; Pedersen, JZ; Ricci, G	1
Diechtierow, M; Krauth-Siegel, RL	1
Adams, MD; Alsmark, UC; Arrowsmith, C; Aslett, MA; Atkin, RJ; Barrell, BG; Barron, AJ; Barry, JD; Bartholomeu, DC; Berriman, M; Blandin, G; Böhme, U; Bringaud, F; Brooks, K; Caler, E; Carrington, M; Cherevach, I; Chillingworth, TJ; Churcher, C; Clark, LN; Corton, CH; Cronin, A; Davies, RM; Djikeng, A; Doggett, J; Donelson, JE; El-Sayed, NM; Embley, TM; Fairlamb, AH; Feldblyum, T; Field, MC; Fraser, A; Fraser, CM; Ghedin, E; Goodhead, I; Gull, K; Haas, B; Hall, N; Hamlin, NE; Hance, Z; Hannick, L; Harper, D; Harris, BR; Hauser, H; Hertz-Fowler, C; Hostetler, J; Hou, L; Ivens, A; Jagels, K; Johnson, D; Johnson, J; Jones, K; Kerhornou, AX; Koo, H; Landfear, S; Larke, N; Larkin, C; Leech, V; Lennard, NJ; Line, A; Lord, A; Macleod, A; Marcello, L; Martin, DM; Melville, SE; Mooney, PJ; Morgan, GW; Moule, S; Mungall, K; Norbertczak, H; Opperdoes, F; Ormond, D; Pai, G; Peacock, CS; Peterson, J; Quail, MA; Rabbinowitsch, E; Rajandream, MA; Reitter, C; Renauld, H; Salzberg, SL; Sanders, M; Schobel, S; Shallom, J; Sharp, S; Simmonds, M; Simpson, AJ; Tait, A; Tallon, L; Tivey, AR; Turner, CM; Ullu, E; Van Aken, S; Walker, D; Wang, S; Wanless, D; White, B; White, O; Whitehead, S; Wickstead, B; Woodward, J; Wortman, J	1
Araki, N; Asakura, M; Kozaki, S; Nishimura, K; Ohnishi, Y; Samosomsuk, W; Shima, K; Yamasaki, S; Yanase, T	1
Heby, O; Persson, L; Rentala, M	1
Burri, C; Keiser, J; Stich, A	1
D'Silva, C; Daunes, S	1
Bradley, M; Nadeau, K; Walsh, C	1

Reviews

3 review(s) available for trypanothione and African Sleeping Sickness

Article	Year
Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis. Amino acids, 2007, Volume: 33, Issue:2 Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Biogenic Polyamines; Chagas Disease; Eflornithine; Enzyme Inhibitors; Glutathione; Humans; Leishmania; Leishmaniasis; Ornithine Decarboxylase Inhibitors; Robenidine; Spermidine; Spermidine Synthase; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosoma cruzi; Trypanosomiasis, African	2007
The therapeutic potential of inhibitors of the trypanothione cycle. Expert opinion on investigational drugs, 2002, Volume: 11, Issue:2 Topics: Animals; Chagas Disease; Enzyme Inhibitors; Glutathione; Humans; Leishmaniasis; NADH, NADPH Oxidoreductases; Receptors, Peptide; Spermidine; Structure-Activity Relationship; Thioredoxins; Trypanocidal Agents; Trypanosomiasis, African	2002
Molecular studies on trypanothione reductase: an antiparasitic target enzyme. Current topics in cellular regulation, 1992, Volume: 33 Topics: Amino Acid Sequence; Animals; Antiprotozoal Agents; Binding Sites; Chagas Disease; Crithidia; Drug Design; Glutathione; Glutathione Reductase; Leishmania; Molecular Sequence Data; Mutagenesis, Site-Directed; NADH, NADPH Oxidoreductases; Oxidation-Reduction; Prevalence; Protein Engineering; Protozoan Proteins; Spermidine; Substrate Specificity; Trypanosoma; Trypanosoma congolense; Trypanosomiasis, African	1992

Other Studies

8 other study(ies) available for trypanothione and African Sleeping Sickness

Article	Year
Glyoxalase II does not support methylglyoxal detoxification but serves as a general trypanothione thioesterase in African trypanosomes. Molecular and biochemical parasitology, 2009, Volume: 163, Issue:1 Topics: Animals; Cell Line; Glutathione; Humans; Kinetics; Protozoan Proteins; Pyruvaldehyde; Spermidine; Substrate Specificity; Thiolester Hydrolases; Trypanosoma brucei brucei; Trypanosomiasis, African	2009
RNA interference-mediated silencing of ornithine decarboxylase and spermidine synthase genes in Trypanosoma brucei provides insight into regulation of polyamine biosynthesis. Eukaryotic cell, 2009, Volume: 8, Issue:5 Topics: Adenosylmethionine Decarboxylase; Animals; Cell Line; Glutathione; Humans; Ornithine Decarboxylase; Polyamines; Protozoan Proteins; RNA Interference; Spermidine; Spermidine Synthase; Trypanosoma brucei brucei; Trypanosomiasis, African	2009
Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods. Molecular microbiology, 2009, Volume: 74, Issue:3 Topics: Amide Synthases; Amidohydrolases; Animals; Enzyme Inhibitors; Gene Knockout Techniques; Glutathione; Mice; Oxidative Stress; Polyamines; Protozoan Proteins; Spermidine; Substrate Specificity; Sulfhydryl Compounds; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi; Trypanosomiasis, African	2009
Trypanothione efficiently intercepts nitric oxide as a harmless iron complex in trypanosomatid parasites. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2010, Volume: 24, Issue:4 Topics: Animals; Chagas Disease; Dose-Response Relationship, Drug; Glutathione; Iron; Leishmania infantum; NADH, NADPH Oxidoreductases; Nitric Oxide; Nitrogen Oxides; Protozoan Proteins; Spermidine; Trypanosoma brucei brucei; Trypanosomiasis, African	2010
A tryparedoxin-dependent peroxidase protects African trypanosomes from membrane damage. Free radical biology & medicine, 2011, Aug-15, Volume: 51, Issue:4 Topics: Antioxidants; Chromans; Gene Knockdown Techniques; Glutathione; Glutathione Peroxidase; Humans; Hydrogen Peroxide; Linoleic Acids; Lipid Peroxidation; Lipid Peroxides; Oxidation-Reduction; Protozoan Proteins; Spermidine; Thioredoxins; Transgenes; Trypanosoma brucei brucei; Trypanosomiasis, African	2011
The genome of the African trypanosome Trypanosoma brucei. Science (New York, N.Y.), 2005, Jul-15, Volume: 309, Issue:5733 Topics: Amino Acids; Animals; Antigenic Variation; Antigens, Protozoan; Carbohydrate Metabolism; Chromosomes; Cytoskeleton; Ergosterol; Genes, Protozoan; Genome, Protozoan; Glutathione; Glycosylphosphatidylinositols; Humans; Lipid Metabolism; Molecular Sequence Data; Protein Transport; Protozoan Proteins; Pseudogenes; Purines; Pyrimidines; Recombination, Genetic; Sequence Analysis, DNA; Spermidine; Trypanosoma brucei brucei; Trypanosomiasis, African	2005
Effects of polyamines on two strains of Trypanosoma brucei in infected rats and in vitro culture. The Journal of parasitology, 2006, Volume: 92, Issue:2 Topics: Amide Synthases; Animals; Culture Media; Eflornithine; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glutathione; Hematocrit; Hydrogen Peroxide; Male; NADH, NADPH Oxidoreductases; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Oxidative Stress; Polyamines; Putrescine; Rats; Rats, Wistar; RNA, Messenger; Spermidine; Spermine; Trypanosoma brucei brucei; Trypanosomiasis, African	2006
New drugs for the treatment of human African trypanosomiasis: research and development. Trends in parasitology, 2001, Volume: 17, Issue:1 Topics: Animals; Drug Combinations; Glutathione; Humans; Spermidine; Thiadiazoles; Trypanocidal Agents; Trypanosoma; Trypanosoma brucei rhodesiense; Trypanosomiasis, African	2001