Page last updated: 2024-08-24

trovafloxacin and Acute Liver Injury, Drug-Induced

trovafloxacin has been researched along with Acute Liver Injury, Drug-Induced in 31 studies

Research

Studies (31)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (3.23)	18.2507
2000's	11 (35.48)	29.6817
2010's	17 (54.84)	24.3611
2020's	2 (6.45)	2.80

Authors

Authors	Studies
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Ding, D; Fang, H; Kelly, R; Liu, Z; Shi, Q; Tong, W	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Kang, MG; Park, D; Park, T; Yang, H	1
Barra, M; Bol-Schoenmakers, M; Giustarini, G; Huppelschoten, S; Klingmüller, U; Oppelt, A; Pieters, RHH; Smit, JJ; van de Water, B; Wagenaar, L; Weaver, RJ	1
Bleumink, R; Bol-Schoenmakers, M; Giustarini, G; Kruijssen, L; Pieters, R; Smit, J; van Roest, M; Weaver, RJ	1
Bleumink, R; Bol-Schoenmakers, M; Giustarini, G; Koenderman, L; Kruijssen, L; Pieters, R; Smit, J; van Roest, M; van Staveren, S; Vrisekoop, N; Wagenaar, L; Weaver, RJ	1
Beggs, KM; Fullerton, AM; Ganey, PE; Miyakawa, K; Roth, RA	1
Beggs, KM; Breier, AB; Fullerton, AM; Ganey, PE; Maiuri, AR; Poulsen, KL; Roth, RA	1
Fujiwara, R; Itoh, T; Kutsuno, Y; Sakamoto, M; Sumida, K	1
Deguchi, J; Funabashi, H; Goto, S; Nishio, N; Nomura, N	1
Einhorn, S; LeCluyse, E; Lu, J; Mann, DA; Miller, M; Venkatarangan, L; Watkins, PB	1
Crogan-Grundy, C; Funk, J; Nguyen, DG; Presnell, SC; Robbins, JB; Roth, AB; Singer, T	1
Fujiwara, R; Itoh, T; Mitsugi, R	1
Fujie, Y; Fujiwara, R; Itoh, T; Mitsugi, R; Sumida, K; Tukey, RH	1
Blomme, EA; Ditewig, AC; Ganey, PE; Liguori, MJ; Roth, RA; Shaw, PJ; Waring, JF	1
Ganey, PE; Roth, RA; Shaw, PJ	2
Borlak, J	1
Muller, CD; Peluso, J; Saab, L; Ubeaud-Sequier, G	1
Anderson, MG; Bukofzer, S; Liguori, MJ; McKim, J; Pregenzer, JF; Retief, J; Spear, BB; Waring, JF	1
Ganey, PE; Hopfensperger, MJ; Roth, RA; Shaw, PJ	1
Foss, FW; Macdonald, TL; Sun, Q; Zhu, R	1
Ball, P; Mandell, L; Niki, Y; Tillotson, G	1
Bloch, KJ; Chen, HJ; Maclean, JA	1
Alcantára, R; Alvarez, A; Andrade, RJ; Camargo, R; Lopez-Garrido, MJ; Lucena, MI; Rodrigo, L; Salmerón, J	1
Goldstein, NS; Gordon, SC; Lazarczyk, DA	1
Yagawa, K	1
Moellering, RC; Nicholson, SC; Webb, CD	1

Reviews

4 review(s) available for trovafloxacin and Acute Liver Injury, Drug-Induced

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Idiosyncratic drug-induced liver injury and the role of inflammatory stress with an emphasis on an animal model of trovafloxacin hepatotoxicity. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:1 Topics: Animals; Anti-Infective Agents; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug-Related Side Effects and Adverse Reactions; Fluoroquinolones; Humans; Inflammation; Naphthyridines; Stress, Physiological	2010
Comparative tolerability of the newer fluoroquinolone antibacterials. Drug safety, 1999, Volume: 21, Issue:5 Topics: Animals; Anti-Infective Agents; Cardiovascular System; Chemical and Drug Induced Liver Injury; Fluoroquinolones; Humans; Naphthyridines; Nausea; Product Surveillance, Postmarketing	1999
Latest industry information on the safety profile of levofloxacin in Japan. Chemotherapy, 2001, Volume: 47 Suppl 3 Topics: Adverse Drug Reaction Reporting Systems; Anti-Infective Agents; Central Nervous System; Chemical and Drug Induced Liver Injury; Dermatitis, Phototoxic; Drug Industry; Fluoroquinolones; Heart Diseases; Humans; Japan; Levofloxacin; Naphthyridines; Ofloxacin; Seizures; Substance Withdrawal Syndrome	2001

Other Studies

27 other study(ies) available for trovafloxacin and Acute Liver Injury, Drug-Induced

Article	Year
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS computational biology, 2011, Volume: 7, Issue:12 Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Models, Biological; Predictive Value of Tests	2011
Trovafloxacin drives inflammation-associated drug-induced adverse hepatic reaction by changing macrophage polarization. Toxicology in vitro : an international journal published in association with BIBRA, 2022, Volume: 82 Topics: Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Fluoroquinolones; Humans; Inflammation; Liver; Macrophages; Naphthyridines	2022
The hepatotoxic fluoroquinolone trovafloxacin disturbs TNF- and LPS-induced p65 nuclear translocation in vivo and in vitro. Toxicology and applied pharmacology, 2020, 03-15, Volume: 391 Topics: Animals; Anti-Bacterial Agents; Apoptosis; Chemical and Drug Induced Liver Injury; Cytokines; Fluoroquinolones; Humans; I-kappa B Proteins; Lipopolysaccharides; Mice; Mitogen-Activated Protein Kinases; Naphthyridines; RAW 264.7 Cells; Transcription Factor RelA; Translocation, Genetic; Tumor Necrosis Factor-alpha	2020
Tissue influx of neutrophils and monocytes is delayed during development of trovafloxacin-induced tumor necrosis factor-dependent liver injury in mice. Journal of applied toxicology : JAT, 2018, Volume: 38, Issue:5 Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cytokines; Flow Cytometry; Fluoroquinolones; Leukocytes; Levofloxacin; Liver; Male; Mice; Mice, Inbred C57BL; Monocytes; Naphthyridines; Neutrophils; Tumor Necrosis Factor-alpha	2018
Trovafloxacin-Induced Liver Injury: Lack in Regulation of Inflammation by Inhibition of Nucleotide Release and Neutrophil Movement. Toxicological sciences : an official journal of the Society of Toxicology, 2019, 02-01, Volume: 167, Issue:2 Topics: Animals; Anti-Infective Agents; Chemical and Drug Induced Liver Injury; Connexins; Fluoroquinolones; Hep G2 Cells; Humans; Inflammation; Intercellular Adhesion Molecule-1; Male; Mice, Inbred C57BL; Naphthyridines; Nerve Tissue Proteins; Neutrophil Infiltration; Neutrophils; Nucleotides; Tumor Necrosis Factor-alpha	2019
Molecular mechanisms of hepatocellular apoptosis induced by trovafloxacin-tumor necrosis factor-alpha interaction. Toxicological sciences : an official journal of the Society of Toxicology, 2014, Volume: 137, Issue:1 Topics: Animals; Anti-Bacterial Agents; Apoptosis; Caspases; Cell Survival; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Enzyme Activation; Fluoroquinolones; Hep G2 Cells; Hepatocytes; Humans; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Inbred C57BL; Naphthyridines; Phosphorylation; Protein Kinase Inhibitors; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha	2014
Trovafloxacin-induced replication stress sensitizes HepG2 cells to tumor necrosis factor-alpha-induced cytotoxicity mediated by extracellular signal-regulated kinase and ataxia telangiectasia and Rad3-related. Toxicology, 2015, May-04, Volume: 331 Topics: Anti-Bacterial Agents; Ataxia Telangiectasia Mutated Proteins; Caspase 3; Cell Cycle Checkpoints; Cell Proliferation; Chemical and Drug Induced Liver Injury; Cyclin-Dependent Kinase Inhibitor p21; DNA Breaks, Double-Stranded; DNA Replication; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Fluoroquinolones; Hep G2 Cells; Hepatocytes; Humans; Liver; Naphthyridines; Protein Kinase Inhibitors; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53	2015
UDP-glucuronosyltransferase (UGT) 1A1 mainly contributes to the glucuronidation of trovafloxacin. Drug metabolism and pharmacokinetics, 2015, Volume: 30, Issue:1 Topics: Animals; Anti-Bacterial Agents; Chemical and Drug Induced Liver Injury; Fluoroquinolones; Glucuronides; Glucuronosyltransferase; Humans; In Vitro Techniques; Intestinal Mucosa; Intestines; Mice; Microsomes, Liver; Naphthyridines; Polymorphism, Genetic; Rabbits; Rats; Species Specificity	2015
Hepatotoxicants induce cytokine imbalance in response to innate immune system. The Journal of toxicological sciences, 2015, Volume: 40, Issue:3 Topics: Acetaminophen; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chemokines; Chromans; Cytokines; Down-Regulation; Fluoroquinolones; Immunity, Innate; Inflammation Mediators; Interleukin-10; Interleukin-1beta; Interleukin-6; Kupffer Cells; Male; Naphthyridines; Nitric Oxide; Rats, Sprague-Dawley; Reactive Oxygen Species; Thiazolidinediones; Troglitazone; Up-Regulation	2015
Morphological and Functional Characterization and Assessment of iPSC-Derived Hepatocytes for In Vitro Toxicity Testing. Toxicological sciences : an official journal of the Society of Toxicology, 2015, Volume: 147, Issue:1 Topics: Acetaminophen; Adult; Bile; Cells, Cultured; Chemical and Drug Induced Liver Injury; Female; Fluoroquinolones; Gene Expression Profiling; Genome-Wide Association Study; Hepatocytes; Humans; Induced Pluripotent Stem Cells; Infant, Newborn; Lipid Metabolism; Lipidoses; Membrane Potential, Mitochondrial; Naphthyridines; Pregnancy; Reproducibility of Results; Toxicity Tests; Transcription, Genetic	2015
Bioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity In Vitro. PloS one, 2016, Volume: 11, Issue:7 Topics: Albumins; Bioprinting; Cell Culture Techniques; Cell Proliferation; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A; Drug-Related Side Effects and Adverse Reactions; Fluoroquinolones; Hepatocytes; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Levofloxacin; Lipopolysaccharides; Liver; Naphthyridines; Platelet Endothelial Cell Adhesion Molecule-1	2016
MicroRNA-877-5p is involved in the trovafloxacin-induced liver injury. Toxicology letters, 2016, Nov-30, Volume: 263 Topics: Animals; Anti-Bacterial Agents; Apoptosis; Cell Line; Chemical and Drug Induced Liver Injury; Fluoroquinolones; Gene Expression Regulation; Humans; Male; Mice; Mice, Inbred C57BL; Microarray Analysis; MicroRNAs; Naphthyridines; Phosphoenolpyruvate Carboxykinase (ATP)	2016
Acyl-glucuronide as a Possible Cause of Trovafloxacin-Induced Liver Toxicity: Induction of Chemokine (C-X-C Motif) Ligand 2 by Trovafloxacin Acyl-glucuronide. Biological & pharmaceutical bulletin, 2016, Volume: 39, Issue:10 Topics: Animals; Chemical and Drug Induced Liver Injury; Chemokine CXCL2; Flavonoids; Fluoroquinolones; Gene Expression Regulation; Glucuronides; Glucuronosyltransferase; Hep G2 Cells; Humans; Mice, Transgenic; Naphthyridines; RNA, Messenger	2016
Coexposure of mice to trovafloxacin and lipopolysaccharide, a model of idiosyncratic hepatotoxicity, results in a unique gene expression profile and interferon gamma-dependent liver injury. Toxicological sciences : an official journal of the Society of Toxicology, 2009, Volume: 107, Issue:1 Topics: Analysis of Variance; Animals; Chemical and Drug Induced Liver Injury; Female; Fluoroquinolones; Gene Expression; Hepatocytes; Inflammation; Interferon-gamma; Interleukin-18; Janus Kinases; Levofloxacin; Lipopolysaccharides; Liver; Liver Diseases; Male; Mice; Mice, Inbred BALB C; Naphthyridines; Necrosis; Ofloxacin; Oligonucleotide Array Sequence Analysis; STAT Transcription Factors; Transcriptional Activation	2009
Trovafloxacin enhances the inflammatory response to a Gram-negative or a Gram-positive bacterial stimulus, resulting in neutrophil-dependent liver injury in mice. The Journal of pharmacology and experimental therapeutics, 2009, Volume: 330, Issue:1 Topics: Animals; Anti-Bacterial Agents; Chemical and Drug Induced Liver Injury; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Bacteria; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naphthyridines; Neutrophils	2009
3.3 Trovafloxacin: a case study of idiosyncratic or iatrogenic liver toxicity - molecular mechanisms and lessons for pharmacotoxicity. Human & experimental toxicology, 2009, Volume: 28, Issue:2-3 Topics: Animals; Anti-Bacterial Agents; Chemical and Drug Induced Liver Injury; Fluoroquinolones; Gene Expression Regulation; Genes; Hepatocytes; Humans; Iatrogenic Disease; Naphthyridines	2009
Implication of hepatic transporters (MDR1 and MRP2) in inflammation-associated idiosyncratic drug-induced hepatotoxicity investigated by microvolume cytometry. Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2013, Volume: 83, Issue:4 Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Sub-Family B Member 4; Biological Transport; Chemical and Drug Induced Liver Injury; Flow Cytometry; Fluoroquinolones; Gene Expression Regulation; Hep G2 Cells; Hepatocytes; Humans; Inflammation; Ketolides; Lipopolysaccharides; Liver; Naphthyridines; Piperazines; Sulfonamides; Triazoles; Tumor Necrosis Factor-alpha; Xenobiotics	2013
Microarray analysis in human hepatocytes suggests a mechanism for hepatotoxicity induced by trovafloxacin. Hepatology (Baltimore, Md.), 2005, Volume: 41, Issue:1 Topics: Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Fluoroquinolones; Gene Expression; Glutathione; Hepatocytes; Humans; Male; Microarray Analysis; Mitochondria; Naphthyridines; Oxidative Stress; Rats; Rats, Sprague-Dawley; RNA; Transcription, Genetic	2005
Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha. Toxicological sciences : an official journal of the Society of Toxicology, 2007, Volume: 100, Issue:1 Topics: Alanine Transaminase; Animals; Anti-Infective Agents; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Etanercept; Fluoroquinolones; Immunoglobulin G; Inflammation; Levofloxacin; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; Naphthyridines; Ofloxacin; Pentoxifylline; Receptors, Tumor Necrosis Factor; Time Factors; Transcription, Genetic; Tumor Necrosis Factor-alpha	2007
In vitro metabolism of a model cyclopropylamine to reactive intermediate: insights into trovafloxacin-induced hepatotoxicity. Chemical research in toxicology, 2008, Volume: 21, Issue:3 Topics: Aldehydes; Anti-Bacterial Agents; Chemical and Drug Induced Liver Injury; Cross-Linking Reagents; Cyclopropanes; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 Enzyme System; DNA, Complementary; Fluoroquinolones; Humans; In Vitro Techniques; Liver; Microsomes, Liver; Naphthyridines; Oxidation-Reduction; Peroxidase; Procainamide; Riluzole	2008
Acute eosinophilic hepatitis from trovafloxacin. The New England journal of medicine, 2000, 02-03, Volume: 342, Issue:5 Topics: Aged; Anti-Infective Agents; Chemical and Drug Induced Liver Injury; Chronic Disease; Eosinophilia; Fluoroquinolones; Humans; Liver; Male; Naphthyridines; Sinusitis	2000
Trovafloxacin-induced acute hepatitis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2000, Volume: 30, Issue:2 Topics: Acute Disease; Adult; Aged; Anti-Infective Agents; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Fluoroquinolones; Humans; Liver Function Tests; Male; Middle Aged; Naphthyridines; Pneumonia, Pneumococcal; Prognosis; Respiratory Tract Infections	2000
Trovafloxacin hepatotoxicity. Digestive diseases and sciences, 2001, Volume: 46, Issue:4 Topics: Adult; Anti-Infective Agents; Chemical and Drug Induced Liver Injury; Female; Fluoroquinolones; Humans; Naphthyridines	2001
Antimicrobial-associated acute hepatitis. Pharmacotherapy, 2002, Volume: 22, Issue:6 Topics: Adult; Anti-Infective Agents; Chemical and Drug Induced Liver Injury; Female; Fluoroquinolones; Gatifloxacin; Humans; Liver Function Tests; Naphthyridines	2002