tropisetron and Tendinopathy

A comparison between a local anesthetic drug and the 5-hydroxytryptamine 3 (5-HT3) receptor antagonist tropisetron in treating tendopathies or periarthropathies revealed that tropisetron has a longer effect on resting pain and pain on movement than the local anesthetic drug. The most likely explanation for this effect probably is a blocking of stimulated 5-HT3 receptors at the nociceptors in conjunction with an inhibited release of substance P and other neurokines because of this blockage. Further studies will have to show whether the action of tropisetron in tendopathies is as favorable as that of corticosteroids.

Topics: Anesthetics, Local; Double-Blind Method; Female; Humans; Indoles; Infusions, Intralesional; Injections, Intra-Articular; Male; Middle Aged; Movement; Pain; Pain Measurement; Prilocaine; Serotonin Antagonists; Tendinopathy; Treatment Outcome; Tropisetron

To determine whether local injection of the 5-HT3-receptor antagonist, tropisetron. reduces pain in tendinopathies to the same degree as a local injection of corticosteroids in combination with local anesthetic.. Forty patients with tendinopathies were enrolled in this randomized, observer-blind study. An injection of either 5 mg tropisetron. or 10 mg dexamethasone combined with 60 mg lidocaine was administered around the affected tendon. The effect was measured with a visual analog pain scale before the injection, after 3 hours and on each of the following 7 days, in patients with good effects also 3 months after the injection.. There were no significant differences between the tropisetron and the corticosteroid/anesthetic group in terms of pain at rest or on movement during the study. Both treatments were well tolerated.. Local injection of tropisetron seems to be as safe and as effective as the combination of corticosteroids and local anesthetics in the treatment of painful tendinopathies.

Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Anesthesia, Local; Female; Humans; Indoles; Male; Middle Aged; Pain; Serotonin Antagonists; Severity of Illness Index; Single-Blind Method; Tendinopathy; Treatment Outcome; Tropisetron

Topics: Humans; Indoles; Receptors, Serotonin, 5-HT3; Serotonin 5-HT3 Receptor Antagonists; T-Lymphocytes; Tendinopathy; Tropisetron

Topics: Anti-Inflammatory Agents; Humans; Indoles; Serotonin 5-HT3 Receptor Antagonists; Serotonin Antagonists; Tendinopathy; Tropisetron