tropisetron and Rheumatic-Diseases

Various rheumatic diseases like fibromyalgia, systemic inflammatory rheumatic disorders and localized diseases, such as arthritides and activated arthroses, tendinopathies and periarthropathies, as well as trigger points can be improved considerably by treatment with the 5-HT3 receptor antagonist tropisetron. Particularly in the latter group of diseases, local injections have done surprisingly rapid analgesic action. This effect matches that of local anesthetics, but lasts considerably longer and is comparable to local injections of local anesthetics combined with corticosteroids. The action of the 5-HT3 receptor antagonists can be attributed to an antinociceptive effect that occurs at the same time as an antiphlogistic and probably also an immunosuppressive effect. Whereas an inhibited release of substance P from the nociceptors, and possibly some other neurokins as well, seems to be the most likely explanation for the antinociceptive action, the antiphlogistic effect is primarily due to an inhibited formation of various different phlogistic substances; in some conditions, like systemic inflammatory rheumatic diseases, for example, the 5-HT3 receptor antagonists may exert an immunosuppressive effect in addition to this.

Topics: Analgesics; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Humans; Indoles; Pain Measurement; Pain Threshold; Rheumatic Diseases; Serotonin 5-HT3 Receptor Antagonists; Serotonin Antagonists; Tropisetron

Local injection of the 5-HT3 receptor antagonist tropisetron manifests a distinct analgesic effect in various local diseases of the locomotor system such as tendinopathies, peri-arthropathies,myofascial pain syndrome, in trigger points, and in inflammatory joint processes.This effect corresponds to that exerted by local anesthetics in general use such as lidocaine and prilocaine among others, but the effect lasts considerably longer. The reason for this finding is found in a simultaneous antiphlogistic effect of the 5-HT3 receptor antagonist as evidenced by animal experiments and clinical data.

Topics: Humans; Indoles; Injections; Rheumatic Diseases; Serotonin Antagonists; Tropisetron

Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Fibromyalgia; Humans; Indoles; Rheumatic Diseases; Serotonin 5-HT3 Receptor Antagonists; Serotonin Antagonists; Tropisetron

Topics: Animals; Clinical Trials as Topic; Fibromyalgia; Humans; Indoles; Pain Measurement; Pain Threshold; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Rheumatic Diseases; Serotonin; Serotonin Antagonists; Treatment Outcome; Tropisetron