tropisetron and Leukemia

tropisetron has been researched along with Leukemia* in 3 studies

Trials

2 trial(s) available for tropisetron and Leukemia

ArticleYear
Randomized trial of ondansetron, granisetron, and tropisetron in the prevention of acute nausea and vomiting.
    Transplantation proceedings, 2000, Volume: 32, Issue:8

    Topics: Adult; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Granisetron; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppression Therapy; Indoles; Leukemia; Male; Multiple Myeloma; Myelodysplastic Syndromes; Nausea; Ondansetron; Transplantation, Autologous; Transplantation, Homologous; Tropisetron; Vomiting

2000
Navoban (tropisetron, ICS 205-930) and dexamethasone combination in the prevention of vomiting for patients receiving preconditioning high-dose chemotherapy before marrow transplantation.
    Japanese journal of clinical oncology, 1998, Volume: 28, Issue:2

    The anti-emetic efficacy of a combination of tropisetron and dexamethasone was studied in 33 patients who underwent bone marrow transplantation. Another 50 patients receiving conventional anti-emetic therapies in bone marrow transplantation served as control. On the first and second days of preconditioning chemotherapy, 51% and 36% respectively of patients in the tropisetron and dexamethasone group did not experience vomiting, compared with only 12% and 10% of control group patients (P < 0.001). The mean number of episodes of vomiting in the tropisetron and dexamethasone group was also significantly lower than in the control group (0.97+/-1.65 vs 3.50+/-2.45 and 1.30+/-1.40 vs 4.44+/-2.91 respectively, both P < 0.001). Control of vomiting in the two groups was not significantly different during days 3-6. Analysis of patients receiving busulfan and cyclophosphamide as the preconditioning regimen still showed better anti-emetic control in the tropisetron and dexamethasone group than in the control group on the first two days of treatment (total control rate 33.3% vs 6.5% and 44.4% vs 12.9% respectively, P < 0.001). Patients given tropisetron and dexamethasone combination more frequently suffered from dizziness and burning sensation of the chest. However, diarrhea and extrapyramidal symptoms were the most frequent adverse effects seen after using conventional anti-emetic combination. The combination of tropisetron and dexamethasone was thus superior to conventional anti-emetic combinations in preventing vomiting during preconditioning period of bone marrow transplantation. The adverse effects of this combination were minimal and well tolerated by patients.

    Topics: Adolescent; Adult; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Busulfan; Carmustine; Child; Cyclophosphamide; Cytarabine; Dexamethasone; Dizziness; Drug Therapy, Combination; Female; Headache; Heartburn; Humans; Indoles; Leukemia; Male; Melphalan; Middle Aged; Multiple Myeloma; Podophyllotoxin; Transplantation Conditioning; Tropisetron; Vomiting; Whole-Body Irradiation

1998

Other Studies

1 other study(ies) available for tropisetron and Leukemia

ArticleYear
[Experience in using the new antiemetic preparation Navoban in hemoblastosis patients].
    Terapevticheskii arkhiv, 1993, Volume: 65, Issue:10

    Topics: Adolescent; Adult; Antiemetics; Drug Evaluation; Drug Tolerance; Humans; Indoles; Leukemia; Tropisetron; Vomiting

1993