tropisetron has been researched along with Cholestasis* in 2 studies
1 review(s) available for tropisetron and Cholestasis
| Article | Year |
|---|---|
[Pruritus in cancer: uncommon, but sometimes worse than the pain].
Three patients, two females aged 45 and 56 years with metastasized breast carcinoma and one man aged 88 years with inoperable bronchial carcinoma, suffered from severe pruritus. This was only alleviated after treatment with paroxetine, a serotonin re-uptake inhibitor, or with tropisetron, a serotonin antagonist. The youngest woman then could be given chemotherapy, after which clinical recovery occurred, the other patients died, one week and 3 months, respectively, after start of the treatment. Pruritus is a relatively rare symptom in malignancies, but may be worse than pain. In the development and transmission of pruritus signals, in cholestatic icterus as well, serotonin appears to play a more important part than histamine. Topics: Aged; Aged, 80 and over; Breast Neoplasms; Carcinoma, Bronchogenic; Cholestasis; Diagnosis, Differential; Fatal Outcome; Female; Humans; Indoles; Lung Neoplasms; Male; Middle Aged; Paroxetine; Pruritus; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Treatment Outcome; Tropisetron | 1999 |
1 other study(ies) available for tropisetron and Cholestasis
| Article | Year |
|---|---|
Downregulated hypothalamic 5-HT3 receptor expression and enhanced 5-HT3 receptor antagonist-mediated improvement in fatigue-like behaviour in cholestatic rats.
The serotonin neurotransmitter system, including the 5-HT(3) receptor, has been implicated in the genesis of fatigue in patients with liver disease. Therefore, we examined the possible role of 5-HT(3) receptors in cholestasis-associated fatigue. Rats were either bile duct resected (BDR) or sham resected and studied 10 days postsurgery. A significant decrease in hypothalamic 5-HT(3) receptor expression was detected by immunohistochemistry and Western blot in BDR vs sham rats, coupled with increased hypothalamic serotonin turnover identified by an elevated 5-hydroxyindoleacetic acid (5-HIAA) to 5-HT ratio in BDR vs sham rats. To examine fatigue-like behaviour, an activity meter was used. BDR rats exhibited significantly lower locomotor activity than did sham animals. Subcutaneous injection of the 5-HT(3) receptor antagonist tropisetron (0.1 mg kg(-1)) resulted in significantly increased locomotor activity in BDR rats compared to the activity in saline-treated controls, but was without effect in sham rats. However, a 10-fold higher dose of tropisetron significantly increased locomotor activity in both BDR and sham rats compared to saline-injected controls. These findings indicate that cholestasis in the rat is associated with increased hypothalamic serotonin turnover, decreased hypothalamic 5-HT(3) receptor expression, and enhanced sensitivity to locomotor activation induced by 5-HT(3) receptor antagonism, thereby implicating the 5-HT(3) receptor system in cholestasis associated fatigue. Topics: Alanine Transaminase; Animals; Bilirubin; Blotting, Western; Cholestasis; Down-Regulation; Fatigue; Hydroxyindoleacetic Acid; Hypothalamus; Immunohistochemistry; Indoles; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, Serotonin, 5-HT3; RNA, Messenger; Serotonin; Serotonin Antagonists; Tropisetron | 2008 |