troglitazone has been researched along with Weight Loss in 9 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
Weight Loss: Decrease in existing BODY WEIGHT.
| Excerpt | Relevance | Reference |
|---|---|---|
| "An open study comparing the effects of weight reduction by low-energy diet and treatment with troglitazone, an insulin-sensitizing agent." | 3.70 | Effects of a low-energy diet and an insulin-sensitizing agent on ambulatory blood pressure in overweight hypertensive patients. ( Kawano, Y; Minami, J; Okuda, N; Omae, T; Takishita, S, 2000) |
| "Metformin treatment had no significant impact on GSK-3 protein expression in either adipocytes or skeletal muscle." | 2.72 | Tissue-specific expression and regulation of GSK-3 in human skeletal muscle and adipose tissue. ( Baxi, S; Christiansen, L; Ciaraldi, TP; Henry, RR; Kong, AP; Mudaliar, S; Nikoulina, SE; Oh, DK, 2006) |
| "Treatment with metformin was less effective than lifestyle modifications, resulting in an average reduction of risk for development of type 2 diabetes by 31% compared with placebo." | 2.42 | [Progress in the prevention of type 2 diabetes]. ( Schernthaner, G, 2003) |
| "In contrast, active steatohepatitis, progression of fibrosis, and requirement of antidiabetic medications were seen in patients unable to achieve lifestyle modifications." | 1.35 | Thiazolidinediones for the treatment in NASH: sustained benefit after drug discontinuation? ( Al-Osaimi, AM; Argo, CK; Caldwell, SH; Iezzoni, JC, 2009) |
| "Troglitazone is a new oral antidiabetic agent and has been reported to reduce insulin resistance and improve peripheral hyperinsulinemia in patients with noninsulin-dependent diabetes mellitus." | 1.30 | Effect of troglitazone on blood insulin levels after pancreas transplantation with systemic venous drainage in rats. ( Mitsuo, M; Nakai, I; Oka, T; Shimizu, Y; Uchiyama, K; Yasunami, Y, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 7 (77.78) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Krishnan, V | 1 |
| Baskaran, P | 1 |
| Thyagarajan, B | 1 |
| Venditti, EM | 1 |
| Bray, GA | 1 |
| Carrion-Petersen, ML | 1 |
| Delahanty, LM | 1 |
| Edelstein, SL | 1 |
| Hamman, RF | 1 |
| Hoskin, MA | 1 |
| Knowler, WC | 1 |
| Ma, Y | 1 |
| Argo, CK | 1 |
| Iezzoni, JC | 1 |
| Al-Osaimi, AM | 1 |
| Caldwell, SH | 1 |
| Angulo, P | 1 |
| Pugeat, M | 1 |
| Schernthaner, G | 1 |
| Ciaraldi, TP | 1 |
| Oh, DK | 1 |
| Christiansen, L | 1 |
| Nikoulina, SE | 1 |
| Kong, AP | 1 |
| Baxi, S | 1 |
| Mudaliar, S | 1 |
| Henry, RR | 1 |
| Uchiyama, K | 1 |
| Nakai, I | 1 |
| Shimizu, Y | 1 |
| Mitsuo, M | 1 |
| Yasunami, Y | 1 |
| Oka, T | 1 |
| Kawano, Y | 1 |
| Okuda, N | 1 |
| Minami, J | 1 |
| Takishita, S | 1 |
| Omae, T | 1 |
3 reviews available for troglitazone and Weight Loss
| Article | Year |
|---|---|
Current best treatment for non-alcoholic fatty liver disease.
Topics: Antioxidants; Chromans; Clinical Trials as Topic; Diabetes Complications; Diabetes Mellitus; Fatty L | 2003 |
[Treatment of PCOS without IVF: weight loss, insulin-sensitizing agents].
Topics: Acarbose; Chromans; Enzyme Inhibitors; Female; Glucose Intolerance; Glucosidases; Humans; Hypoglycem | 2003 |
[Progress in the prevention of type 2 diabetes].
Topics: Acarbose; Adult; Alcohol Drinking; Angiotensin-Converting Enzyme Inhibitors; Blood Glucose; Chromans | 2003 |
2 trials available for troglitazone and Weight Loss
| Article | Year |
|---|---|
First versus repeat treatment with a lifestyle intervention program: attendance and weight loss outcomes.
Topics: Behavior Therapy; Caloric Restriction; Chromans; Diabetes Mellitus, Type 2; Diet, Fat-Restricted; Fe | 2008 |
Tissue-specific expression and regulation of GSK-3 in human skeletal muscle and adipose tissue.
Topics: Adult; Aged; Biopsy; Blood Glucose; Caloric Restriction; Chromans; Diabetes Mellitus, Type 2; Female | 2006 |
4 other studies available for troglitazone and Weight Loss
| Article | Year |
|---|---|
Troglitazone activates TRPV1 and causes deacetylation of PPARĪ³ in 3T3-L1 cells.
Topics: 3T3-L1 Cells; Acetylation; Adipogenesis; Adipose Tissue; Animals; Bone Morphogenetic Proteins; Capsa | 2019 |
Thiazolidinediones for the treatment in NASH: sustained benefit after drug discontinuation?
Topics: Biopsy; Chromans; Clinical Trials as Topic; Drug Administration Schedule; Exercise; Fatty Liver; Hum | 2009 |
Effect of troglitazone on blood insulin levels after pancreas transplantation with systemic venous drainage in rats.
Topics: Animals; Blood Glucose; Body Weight; Chromans; Diabetes Mellitus, Type 1; Drainage; Glucose Toleranc | 1997 |
Effects of a low-energy diet and an insulin-sensitizing agent on ambulatory blood pressure in overweight hypertensive patients.
Topics: Adult; Aged; Blood Pressure; Chromans; Diet, Reducing; Female; Humans; Hypertension; Hypoglycemic Ag | 2000 |