troglitazone has been researched along with Weight Gain in 10 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
Weight Gain: Increase in BODY WEIGHT over existing weight.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Troglitazone treatment did not increase ARC NPY gene expression either after a 72 h fast and re-feeding for 2 weeks (Experiment 1) or immediately after a 72 h fast (Experiment 2)." | 5.31 | Troglitazone treatment of aging Brown Norway rats improves food intake and weight gain after fasting without increasing hypothalamic NPY gene expression. ( Marck, BT; Matsumoto, AM; Wolden-Hanson, T, 2002) |
| "To determine the relationship between hypoglycemic activity and body weight gain induced by insulin sensitizers, we compared the effects of thiazolidinedione analogs (troglitazone and pioglitazone) and the oxadiazolidinedione analog (Z)-1,4-bis4[(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)methyl]phen oxy¿but-2-ene (YM440) in diabetic db/db mice." | 3.70 | The novel hypoglycemic agent YM440 normalizes hyperglycemia without changing body fat weight in diabetic db/db mice. ( Hirayama, R; Kurosaki, E; Nakano, R; Shibasaki, M; Shikama, H; Shimaya, A, 2000) |
| " We found that these rats exhibit reduced food intake and body weight gain associated with decreased hypothalamic neuropeptide Y (NPY) gene expression in the arcuate nucleus (ARC), both during ad-libitum feeding and after a 72-h fast." | 3.70 | Aging and the neuroendocrine regulation of reproduction and body weight. ( Gruenewald, DA; Marck, BT; Matsumoto, AM; Naai, MA; Wolden-Hanson, T, 2000) |
| "Troglitazone was given at a dose of 400 mg/day to 20 patients with type 2 diabetes whose diet and sulfonylurea therapy produced unsatisfactory glycemic control (HbA(1c) >7." | 2.69 | Efficacy of troglitazone on body fat distribution in type 2 diabetes. ( Akazawa, S; Eguchi, K; Ito, M; Kawasaki, E; Sun, F, 2000) |
| "Troglitazone treatment did not increase ARC NPY gene expression either after a 72 h fast and re-feeding for 2 weeks (Experiment 1) or immediately after a 72 h fast (Experiment 2)." | 1.31 | Troglitazone treatment of aging Brown Norway rats improves food intake and weight gain after fasting without increasing hypothalamic NPY gene expression. ( Marck, BT; Matsumoto, AM; Wolden-Hanson, T, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 8 (80.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sato, K | 1 |
| Matsushita, K | 1 |
| Matsubara, Y | 1 |
| Kamada, T | 1 |
| Akiba, Y | 1 |
| Kanazawa, A | 1 |
| Kawamori, R | 1 |
| Rusk, MH | 1 |
| Gorson, DM | 1 |
| Kusano, S | 1 |
| Abe, H | 1 |
| Shimaya, A | 1 |
| Kurosaki, E | 1 |
| Nakano, R | 1 |
| Hirayama, R | 1 |
| Shibasaki, M | 1 |
| Shikama, H | 1 |
| Krische, D | 1 |
| Akazawa, S | 1 |
| Sun, F | 1 |
| Ito, M | 1 |
| Kawasaki, E | 1 |
| Eguchi, K | 1 |
| Matsumoto, AM | 2 |
| Marck, BT | 2 |
| Gruenewald, DA | 1 |
| Wolden-Hanson, T | 2 |
| Naai, MA | 1 |
2 reviews available for troglitazone and Weight Gain
| Article | Year |
|---|---|
[Adverse effects of insulin sensitisers and biguanides].
Topics: Acidosis, Lactic; Animals; Biguanides; Capillary Permeability; Chemical and Drug Induced Liver Injur | 2007 |
The glitazones: proceed with caution.
Topics: Chromans; Diabetes Mellitus, Type 2; Drug Evaluation; Humans; Hypoglycemic Agents; Liver; Pioglitazo | 2000 |
1 trial available for troglitazone and Weight Gain
| Article | Year |
|---|---|
Efficacy of troglitazone on body fat distribution in type 2 diabetes.
Topics: Adipose Tissue; Body Mass Index; C-Peptide; Chromans; Diabetes Mellitus; Diabetes Mellitus, Type 2; | 2000 |
7 other studies available for troglitazone and Weight Gain
| Article | Year |
|---|---|
Adipose tissue fat accumulation is reduced by a single intraperitoneal injection of peroxisome proliferator-activated receptor gamma agonist when given to newly hatched chicks.
Topics: Adipose Tissue; Animals; Animals, Newborn; CCAAT-Enhancer-Binding Protein-alpha; Chickens; Chromans; | 2008 |
Effect of troglitazone in type 2 diabetes mellitus.
Topics: Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Humans; Hypoglycemic Agents | 1998 |
Significant weight gain with rezulin therapy.
Topics: Chromans; Diabetes Mellitus, Type 2; Edema; Humans; Hypoglycemic Agents; Male; Middle Aged; Thiazole | 1999 |
Antidiabetic activity of white skinned sweet potato (Ipomoea batatas L.) in obese Zucker fatty rats.
Topics: Animals; Blood Glucose; Chromans; Fatty Acids, Nonesterified; Glucose Tolerance Test; Hyperinsulinis | 2000 |
The novel hypoglycemic agent YM440 normalizes hyperglycemia without changing body fat weight in diabetic db/db mice.
Topics: 3T3 Cells; Adipose Tissue; Animals; Blood Glucose; Cell Differentiation; Chromans; Diabetes Mellitus | 2000 |
Aging and the neuroendocrine regulation of reproduction and body weight.
Topics: Aging; Animals; Arcuate Nucleus of Hypothalamus; Body Composition; Body Weight; Chromans; Eating; Ge | 2000 |
Troglitazone treatment of aging Brown Norway rats improves food intake and weight gain after fasting without increasing hypothalamic NPY gene expression.
Topics: Aging; Animals; Body Composition; Chromans; Eating; Fasting; Gene Expression; Hypoglycemic Agents; H | 2002 |