troglitazone has been researched along with Sepsis in 2 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sepsis is associated with impaired PMN function, including chemotaxis." | 1.35 | Sepsis-induced inhibition of neutrophil chemotaxis is mediated by activation of peroxisome proliferator-activated receptor-{gamma}. ( Keshamouni, VG; Milam, JE; Narala, VR; Newstead, MW; Reddy, RC; Standiford, TJ, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yuan, Z | 1 |
| Luo, G | 1 |
| Li, X | 1 |
| Chen, J | 1 |
| Wu, J | 1 |
| Peng, Y | 1 |
| Reddy, RC | 1 |
| Narala, VR | 1 |
| Keshamouni, VG | 1 |
| Milam, JE | 1 |
| Newstead, MW | 1 |
| Standiford, TJ | 1 |
2 other studies available for troglitazone and Sepsis
| Article | Year |
|---|---|
PPARĪ³ inhibits HMGB1 expression through upregulation of miR-142-3p in vitro and in vivo.
Topics: 3' Untranslated Regions; Animals; Cells, Cultured; Chromans; HMGB1 Protein; Humans; Interleukin-6; L | 2016 |
Sepsis-induced inhibition of neutrophil chemotaxis is mediated by activation of peroxisome proliferator-activated receptor-{gamma}.
Topics: Actins; Anilides; Animals; Antineoplastic Agents; Cell Adhesion; Chemotaxis; Chromans; Disease Model | 2008 |