troglitazone has been researched along with Sensitivity and Specificity in 7 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recently, it was reported that the intraperitoneal administration of 30 mg/kg/day troglitazone to heterozygous superoxide dismutase 2 gene knockout (Sod2+/-) mice for twenty-eight days caused liver injury, manifested by increased serum ALT activity and hepatic necrosis." | 3.75 | Sensitivity of liver injury in heterozygous Sod2 knockout mice treated with troglitazone or acetaminophen. ( Ando, Y; Arakawa, S; Fujimoto, K; Ito, K; Kumagai, K; Manabe, S; Oda, S; Yamoto, T, 2009) |
| "Stable-isotope trapping combined with mass spectrometry (MS) neutral loss scanning has recently been developed as a high-throughput method for the in vitro screening of major reactive metabolites." | 1.33 | Rapid detection and characterization of minor reactive metabolites using stable-isotope trapping in combination with tandem mass spectrometry. ( Caldwell, GW; Huebert, N; Maher, N; Torres, R; Yan, Z, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 6 (85.71) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, H | 1 |
| Sun, J | 1 |
| Sui, X | 1 |
| Liu, J | 1 |
| Yan, Z | 2 |
| Liu, X | 1 |
| Sun, Y | 1 |
| He, Z | 1 |
| Fujimoto, K | 1 |
| Kumagai, K | 1 |
| Ito, K | 1 |
| Arakawa, S | 1 |
| Ando, Y | 1 |
| Oda, S | 1 |
| Yamoto, T | 1 |
| Manabe, S | 1 |
| Elchalal, U | 1 |
| Humphrey, RG | 1 |
| Smith, SD | 1 |
| Hu, C | 1 |
| Sadovsky, Y | 1 |
| Nelson, DM | 1 |
| Maher, N | 1 |
| Torres, R | 1 |
| Caldwell, GW | 1 |
| Huebert, N | 1 |
| New, LS | 1 |
| Saha, S | 1 |
| Ong, MM | 1 |
| Boelsterli, UA | 1 |
| Chan, EC | 1 |
| Koup, JR | 1 |
| Anderson, GD | 1 |
| Loi, CM | 1 |
| Lambropoulos, J | 1 |
| Bergholdt, AB | 1 |
7 other studies available for troglitazone and Sensitivity and Specificity
| Article | Year |
|---|---|
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metab | 2009 |
Sensitivity of liver injury in heterozygous Sod2 knockout mice treated with troglitazone or acetaminophen.
Topics: Acetaminophen; Adenosine Triphosphate; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartat | 2009 |
Troglitazone attenuates hypoxia-induced injury in cultured term human trophoblasts.
Topics: Apoptosis; Blotting, Western; Cell Hypoxia; Cells, Cultured; Chromans; Female; Gestational Age; Huma | 2004 |
Rapid detection and characterization of minor reactive metabolites using stable-isotope trapping in combination with tandem mass spectrometry.
Topics: Chromans; Clozapine; Glutathione; Humans; Indoles; Isotope Labeling; Isotopes; Mass Spectrometry; Mi | 2005 |
Pharmacokinetic study of intraperitoneally administered troglitazone in mice using ultra-performance liquid chromatography/tandem mass spectrometry.
Topics: Animals; Antineoplastic Agents; Blood Chemical Analysis; Chromans; Chromatography, High Pressure Liq | 2007 |
Effect of troglitazone on urinary excretion of 6beta-hydroxycortisol.
Topics: Aryl Hydrocarbon Hydroxylases; Cardiotonic Agents; Chromans; Cytochrome P-450 CYP3A; Cytochrome P-45 | 1998 |
Method development and validation for the HPLC potency assay of troglitazone tablets.
Topics: Chromans; Chromatography, High Pressure Liquid; Drug Stability; Hypoglycemic Agents; Reproducibility | 2000 |