troglitazone has been researched along with Rheumatoid Arthritis in 8 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "FLS isolated from patients with rheumatoid arthritis (RA) and osteoarthritis (OA) and from normal synovial tissues were incubated with the synthetic PPAR gamma ligand troglitazone to induce adipocyte-like differentiation of the cells." | 3.72 | Cytokines regulate fibroblast-like synovial cell differentiation to adipocyte-like cells. ( Eguchi, K; Ida, H; Kawakami, A; Migita, K; Miyashita, T; Nakashima, T; Origuchi, T; Tanaka, F; Yamasaki, S, 2004) |
| " Whereas high dosage of full agonists may expose RA patients to cardiovascular adverse effects, the proof of concept that PPAR agonists have therapeutical relevance to OA may benefit from an epidemiological follow-up of joint lesions in diabetic or hyperlipidemic patients treated for long periods of time with glitazones or fibrates." | 2.44 | [Pathophysiological relevance of peroxisome proliferators activated receptors (PPAR) to joint diseases - the pro and con of agonists]. ( Bianchi, A; Jouzeau, JY; Koufany, M; Moulin, D; Netter, P; Sebillaud, S, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jouzeau, JY | 1 |
| Moulin, D | 1 |
| Koufany, M | 1 |
| Sebillaud, S | 1 |
| Bianchi, A | 1 |
| Netter, P | 1 |
| Yamasaki, S | 2 |
| Nakashima, T | 2 |
| Kawakami, A | 2 |
| Miyashita, T | 2 |
| Ida, H | 2 |
| Migita, K | 2 |
| Nakata, K | 1 |
| Eguchi, K | 2 |
| Tanaka, F | 1 |
| Origuchi, T | 1 |
| Kim, HJ | 1 |
| Rho, YH | 1 |
| Choi, SJ | 1 |
| Lee, YH | 1 |
| Cheon, H | 1 |
| Um, JW | 1 |
| Sohn, J | 1 |
| Song, GG | 1 |
| Ji, JD | 1 |
| Sakurai, A | 1 |
| Hashizume, K | 1 |
| Kawahito, Y | 3 |
| Kondo, M | 1 |
| Tsubouchi, Y | 2 |
| Hashiramoto, A | 1 |
| Bishop-Bailey, D | 1 |
| Inoue, K | 2 |
| Kohno, M | 2 |
| Yamada, R | 1 |
| Hla, T | 2 |
| Sano, H | 3 |
| Inoue , K | 1 |
1 review available for troglitazone and Rheumatoid Arthritis
| Article | Year |
|---|---|
[Pathophysiological relevance of peroxisome proliferators activated receptors (PPAR) to joint diseases - the pro and con of agonists].
Topics: Animals; Arthritis, Rheumatoid; Chromans; Dimerization; Extracellular Matrix; Humans; Hypoglycemic A | 2008 |
7 other studies available for troglitazone and Rheumatoid Arthritis
| Article | Year |
|---|---|
Functional changes in rheumatoid fibroblast-like synovial cells through activation of peroxisome proliferator-activated receptor gamma-mediated signalling pathway.
Topics: Adipocytes; Arthritis, Rheumatoid; Cell Differentiation; Cells, Cultured; Chromans; DNA; Fibroblasts | 2002 |
Cytokines regulate fibroblast-like synovial cell differentiation to adipocyte-like cells.
Topics: Adipocytes; Arthritis, Rheumatoid; Cell Differentiation; Cells, Cultured; Chromans; Cytokines; Fibro | 2004 |
15-Deoxy-delta12,14-PGJ2 inhibits IL-6-induced Stat3 phosphorylation in lymphocytes.
Topics: Arthritis, Rheumatoid; Chromans; Cycloheximide; Dactinomycin; DNA-Binding Proteins; Gene Expression | 2005 |
Deterioration of rheumatoid arthritis with troglitazone: a rare and unexpected adverse effect.
Topics: Arthritis, Rheumatoid; Chromans; Diabetes Mellitus, Type 2; Disease Progression; Female; Humans; Hyp | 2000 |
15-deoxy-delta(12,14)-PGJ(2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats.
Topics: Animals; Apoptosis; Arthritis; Arthritis, Experimental; Arthritis, Rheumatoid; Cells, Cultured; Chro | 2000 |
Troglitazone as an anti-inflammatory agent.
Topics: Anti-Inflammatory Agents; Antioxidants; Arthritis, Rheumatoid; Chromans; Humans; Thiazoles; Thiazoli | 2000 |
Feedback control of the arachidonate cascade in rheumatoid synoviocytes by 15-deoxy-Delta(12,14)-prostaglandin J2.
Topics: Arachidonic Acid; Arthritis, Rheumatoid; Chromans; Cyclooxygenase 2; Cysteine; Dinoprostone; Feedbac | 2001 |