troglitazone has been researched along with Pancreatitis in 5 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
Pancreatitis: INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We determined the influence of troglitazone, a ligand for PPAR-gamma, on pancreatic damage and fibrosis in experimental chronic pancreatitis." | 7.73 | Therapeutic effects of troglitazone in experimental chronic pancreatitis in mice. ( Bruno, MJ; Daalhuisen, J; de Boer, AM; de Vos, AF; Florquin, S; van der Poll, T; van Westerloo, DJ, 2005) |
| "We have previously reported that troglitazone inhibits proinflammatory cytokine production in chronic pancreatitis." | 7.72 | Troglitazone inhibits the progression of chronic pancreatitis and the profibrogenic activity of pancreatic stellate cells via a PPARgamma-independent mechanism. ( Kawamata, H; Kobayashi, M; Shimizu, K; Shiratori, K, 2004) |
| " We determined the influence of troglitazone, a ligand for PPAR-gamma, on pancreatic damage and fibrosis in experimental chronic pancreatitis." | 3.73 | Therapeutic effects of troglitazone in experimental chronic pancreatitis in mice. ( Bruno, MJ; Daalhuisen, J; de Boer, AM; de Vos, AF; Florquin, S; van der Poll, T; van Westerloo, DJ, 2005) |
| " In this study, we investigated the effect of a TZD, troglitazone, on inflammation and fibrogenesis in the pancreas of an experimental model of chronic pancreatitis." | 3.73 | Peroxisome proliferator-activated receptor gamma ligand prevents the development of chronic pancreatitis through modulating NF-kappaB-dependent proinflammatory cytokine production and pancreatic stellate cell activation. ( Hisada, S; Kobayashi, M; Shimizu, K; Shiratori, K, 2005) |
| "We have previously reported that troglitazone inhibits proinflammatory cytokine production in chronic pancreatitis." | 3.72 | Troglitazone inhibits the progression of chronic pancreatitis and the profibrogenic activity of pancreatic stellate cells via a PPARgamma-independent mechanism. ( Kawamata, H; Kobayashi, M; Shimizu, K; Shiratori, K, 2004) |
| "2% troglitazone was administered from 1 month to 7 months of age in WBN/Kob rats with spontaneous chronic pancreatitis." | 3.71 | Thiazolidinedione derivatives as novel therapeutic agents to prevent the development of chronic pancreatitis. ( Fujiwara, T; Hayashi, N; Horikoshi, H; Kobayashi, M; Shimizu, K; Shiratori, K, 2002) |
| "Acute pancreatitis is a severe inflammatory disease of the pancreas." | 1.72 | Lutein inhibits IL‑6 expression by inducing PPAR‑γ activation and SOCS3 expression in cerulein‑stimulated pancreatic acinar cells. ( Ahn, YJ; Kim, H; Lim, JW, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ahn, YJ | 1 |
| Lim, JW | 1 |
| Kim, H | 1 |
| Shimizu, K | 3 |
| Shiratori, K | 3 |
| Kobayashi, M | 3 |
| Kawamata, H | 1 |
| van Westerloo, DJ | 1 |
| Florquin, S | 1 |
| de Boer, AM | 1 |
| Daalhuisen, J | 1 |
| de Vos, AF | 1 |
| Bruno, MJ | 1 |
| van der Poll, T | 1 |
| Hisada, S | 1 |
| Hayashi, N | 1 |
| Fujiwara, T | 1 |
| Horikoshi, H | 1 |
5 other studies available for troglitazone and Pancreatitis
| Article | Year |
|---|---|
Lutein inhibits IL‑6 expression by inducing PPAR‑γ activation and SOCS3 expression in cerulein‑stimulated pancreatic acinar cells.
Topics: Acinar Cells; Acute Disease; Ceruletide; Humans; Interleukin-6; Lutein; Pancreatitis; PPAR gamma; ST | 2022 |
Troglitazone inhibits the progression of chronic pancreatitis and the profibrogenic activity of pancreatic stellate cells via a PPARgamma-independent mechanism.
Topics: Actins; Animals; Cell Division; Cells, Cultured; Chromans; Chronic Disease; Disease Progression; Dru | 2004 |
Therapeutic effects of troglitazone in experimental chronic pancreatitis in mice.
Topics: Actins; Animals; Cell Differentiation; Ceruletide; Chromans; Chronic Disease; Collagen; Disease Mode | 2005 |
Peroxisome proliferator-activated receptor gamma ligand prevents the development of chronic pancreatitis through modulating NF-kappaB-dependent proinflammatory cytokine production and pancreatic stellate cell activation.
Topics: Actins; Animals; Antineoplastic Agents; Chromans; Chronic Disease; Collagen Type I; Collagen Type II | 2005 |
Thiazolidinedione derivatives as novel therapeutic agents to prevent the development of chronic pancreatitis.
Topics: Amylases; Animals; Antineoplastic Agents; Blood Glucose; Chromans; Chronic Disease; Disease Models, | 2002 |