troglitazone has been researched along with Ovarian Neoplasms in 3 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "CGZ and TGZ cause a decrease in ovarian cancer cell proliferation that is PPARγ independent." | 1.37 | Specific thiazolidinediones inhibit ovarian cancer cell line proliferation and cause cell cycle arrest in a PPARγ independent manner. ( Al-Alem, L; Curry, TE; Kilgore, MW; Southard, RC, 2011) |
| "Troglitazone (TGZ) is a potential anticancer agent." | 1.34 | Inhibition of cell motility by troglitazone in human ovarian carcinoma cell line. ( Chen, SL; Ho, TC; Lai, HY; Tsao, YP; Wu, JY; Yang, YC, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bräutigam, K | 1 |
| Biernath-Wüpping, J | 1 |
| Bauerschlag, DO | 1 |
| von Kaisenberg, CS | 1 |
| Jonat, W | 1 |
| Maass, N | 1 |
| Arnold, N | 1 |
| Meinhold-Heerlein, I | 1 |
| Al-Alem, L | 1 |
| Southard, RC | 1 |
| Kilgore, MW | 1 |
| Curry, TE | 1 |
| Yang, YC | 1 |
| Ho, TC | 1 |
| Chen, SL | 1 |
| Lai, HY | 1 |
| Wu, JY | 1 |
| Tsao, YP | 1 |
3 other studies available for troglitazone and Ovarian Neoplasms
| Article | Year |
|---|---|
Combined treatment with TRAIL and PPARγ ligands overcomes chemoresistance of ovarian cancer cell lines.
Topics: Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 8; Cell Line, Tumor; Chromans; | 2011 |
Specific thiazolidinediones inhibit ovarian cancer cell line proliferation and cause cell cycle arrest in a PPARγ independent manner.
Topics: Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromans; Female; Gene Expression; Humans; Ovarian | 2011 |
Inhibition of cell motility by troglitazone in human ovarian carcinoma cell line.
Topics: Cell Line, Tumor; Cell Movement; Chromans; Dose-Response Relationship, Drug; Female; Humans; Ovarian | 2007 |