troglitazone has been researched along with Nephritis, Interstitial in 1 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
Nephritis, Interstitial: Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES and/or surrounding interstitium. For primary inflammation of glomerular interstitium, see GLOMERULONEPHRITIS. Infiltration of the inflammatory cells into the interstitial compartment results in EDEMA, increased spaces between the tubules, and tubular renal dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Therefore, we investigated the anti-fibrotic and anti-inflammatory effects of the TZD troglitazone in the mouse model of unilateral ureteral obstruction (UUO)." | 3.75 | PPAR-gamma agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-beta. ( Arakawa, T; Doi, S; Doi, T; Kawai, T; Kohno, N; Masaki, T; Yokoyama, Y; Yorioka, N, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kawai, T | 1 |
| Masaki, T | 1 |
| Doi, S | 1 |
| Arakawa, T | 1 |
| Yokoyama, Y | 1 |
| Doi, T | 1 |
| Kohno, N | 1 |
| Yorioka, N | 1 |
1 other study available for troglitazone and Nephritis, Interstitial
| Article | Year |
|---|---|
PPAR-gamma agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-beta.
Topics: Actins; Animals; Anti-Inflammatory Agents; Arterioles; Blood Glucose; Cell Proliferation; Chromans; | 2009 |