troglitazone has been researched along with Neoplasms, Vascular in 2 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hemangiosarcomasare uncommon malignant endothelial cell tumors in humans and experimental animal species." | 1.30 | Spontaneous and thiazolidinedione-induced B6C3F1 mouse hemangiosarcomas exhibit low ras oncogene mutation frequencies. ( Bleavins, MR; de la Iglesia, FA; Duddy, SK; Gorospe, SM, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Duddy, SK | 2 |
| Parker, RF | 1 |
| Bleavins, MR | 2 |
| Gough, AW | 1 |
| Rowse, PE | 1 |
| Gorospe, S | 1 |
| Dethloff, LA | 1 |
| de la Iglesia, FA | 2 |
| Gorospe, SM | 1 |
2 other studies available for troglitazone and Neoplasms, Vascular
| Article | Year |
|---|---|
p53 is not inactivated in B6C3F1 mouse vascular tumors arising spontaneously or associated with long-term administration of the thiazolidinedione troglitazone.
Topics: Animals; Antioxidants; Chromans; DNA, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Gene | 1999 |
Spontaneous and thiazolidinedione-induced B6C3F1 mouse hemangiosarcomas exhibit low ras oncogene mutation frequencies.
Topics: Animals; Carcinogens; Chromans; DNA, Neoplasm; Evolution, Molecular; Female; Genes, ras; Hemangiosar | 1999 |