troglitazone has been researched along with Myocardial Ischemia in 3 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| " We previously demonstrated that chronic pretreatment with a thiazolidinedione peroxisome proliferator-activated receptor (PPAR)-gamma activator, troglitazone, improves recovery of left ventricular (LV) function and substrate metabolism after ischemia and reperfusion, without causing arrhythmias." | 3.72 | Deleterious effects of acute treatment with a peroxisome proliferator-activated receptor-gamma activator in myocardial ischemia and reperfusion in pigs. ( Gen, M; Greyson, C; Kinugawa, K; Lee, J; Long, CS; Lu, L; Schwartz, GG; Xu, Y, 2003) |
| "Troglitazone treatment did not attenuate the insulinopenia and hyperglycemia of diabetic rats, but it partially improved the hypertriglyceridemia." | 1.29 | Cardioprotective effects of troglitazone in streptozotocin-induced diabetic rats. ( Higa, S; Komiya, I; Nagamine, F; Shimabukuro, M; Shinzato, T; Takasu, N, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, Y | 2 |
| Lu, L | 2 |
| Greyson, C | 1 |
| Lee, J | 1 |
| Gen, M | 1 |
| Kinugawa, K | 1 |
| Long, CS | 1 |
| Schwartz, GG | 2 |
| Shimabukuro, M | 1 |
| Higa, S | 1 |
| Shinzato, T | 1 |
| Nagamine, F | 1 |
| Komiya, I | 1 |
| Takasu, N | 1 |
| Zhu, P | 1 |
3 other studies available for troglitazone and Myocardial Ischemia
| Article | Year |
|---|---|
Deleterious effects of acute treatment with a peroxisome proliferator-activated receptor-gamma activator in myocardial ischemia and reperfusion in pigs.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Chromans; Disease Models, Animal; Gene Expression Reg | 2003 |
Cardioprotective effects of troglitazone in streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Cholesterol; Chromans; Diabetes Mellitus, Experimental; Heart; | 1996 |
Troglitazone improves recovery of left ventricular function after regional ischemia in pigs.
Topics: Animals; Blood Pressure; Chromans; Hypoglycemic Agents; Insulin Resistance; Myocardial Ischemia; Oxy | 2000 |