troglitazone has been researched along with Mitochondrial Diseases in 3 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
Mitochondrial Diseases: Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Troglitazone does not cause hepatotoxicity in normal healthy rodents, but it produces mitochondrial injury in vitro at high concentrations." | 5.34 | Troglitazone-induced hepatic necrosis in an animal model of silent genetic mitochondrial abnormalities. ( Boelsterli, UA; Latchoumycandane, C; Ong, MM, 2007) |
| "Troglitazone does not cause hepatotoxicity in normal healthy rodents, but it produces mitochondrial injury in vitro at high concentrations." | 1.34 | Troglitazone-induced hepatic necrosis in an animal model of silent genetic mitochondrial abnormalities. ( Boelsterli, UA; Latchoumycandane, C; Ong, MM, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bavli, D | 1 |
| Prill, S | 1 |
| Ezra, E | 1 |
| Levy, G | 1 |
| Cohen, M | 1 |
| Vinken, M | 1 |
| Vanfleteren, J | 1 |
| Jaeger, M | 1 |
| Nahmias, Y | 1 |
| Ong, MM | 1 |
| Latchoumycandane, C | 1 |
| Boelsterli, UA | 1 |
| Jaeschke, H | 1 |
3 other studies available for troglitazone and Mitochondrial Diseases
| Article | Year |
|---|---|
Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction.
Topics: Chromans; Hep G2 Cells; Humans; Lab-On-A-Chip Devices; Liver; Mitochondria, Liver; Mitochondrial Dis | 2016 |
Troglitazone-induced hepatic necrosis in an animal model of silent genetic mitochondrial abnormalities.
Topics: Aconitate Hydratase; Animals; Chemical and Drug Induced Liver Injury; Chromans; Disease Models, Anim | 2007 |
Troglitazone hepatotoxicity: are we getting closer to understanding idiosyncratic liver injury?
Topics: Animals; Chemical and Drug Induced Liver Injury; Chromans; Disease Models, Animal; Humans; Hypoglyce | 2007 |