troglitazone has been researched along with Melanoma in 3 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Smith, AG | 1 |
| Beaumont, KA | 1 |
| Smit, DJ | 1 |
| Thurber, AE | 1 |
| Cook, AL | 1 |
| Boyle, GM | 1 |
| Parsons, PG | 1 |
| Sturm, RA | 1 |
| Muscat, GE | 1 |
| Paulitschke, V | 1 |
| Gruber, S | 1 |
| Hofstätter, E | 1 |
| Haudek-Prinz, V | 1 |
| Klepeisz, P | 1 |
| Schicher, N | 1 |
| Jonak, C | 1 |
| Petzelbauer, P | 1 |
| Pehamberger, H | 1 |
| Gerner, C | 1 |
| Kunstfeld, R | 1 |
| Mössner, R | 1 |
| Schulz, U | 1 |
| Krüger, U | 1 |
| Middel, P | 1 |
| Schinner, S | 1 |
| Füzesi, L | 1 |
| Neumann, C | 1 |
| Reich, K | 1 |
3 other studies available for troglitazone and Melanoma
| Article | Year |
|---|---|
PPARgamma agonists attenuate proliferation and modulate Wnt/beta-catenin signalling in melanoma cells.
Topics: Animals; Antineoplastic Agents; beta Catenin; Cell Cycle; Cell Growth Processes; Cell Line, Tumor; C | 2009 |
Proteome analysis identified the PPARγ ligand 15d-PGJ2 as a novel drug inhibiting melanoma progression and interfering with tumor-stroma interaction.
Topics: Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromans; Hu | 2012 |
Agonists of peroxisome proliferator-activated receptor gamma inhibit cell growth in malignant melanoma.
Topics: Antineoplastic Agents; Apoptosis; Cell Division; Chromans; Dose-Response Relationship, Drug; Fibrino | 2002 |