Page last updated: 2024-11-05

troglitazone and Lung Neoplasms

troglitazone has been researched along with Lung Neoplasms in 14 studies

Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.

Lung Neoplasms: Tumors or cancer of the LUNG.

Research Excerpts

ExcerptRelevanceReference
"Osteosarcoma often develops micrometastases in the lung prior to diagnosis, causing a fatal outcome."5.36Effect of troglitazone on tumor growth and pulmonary metastasis development of the mouse osteosarcoma cell line LM8. ( Aizawa, J; Kamei, S; Kidani, T; Masuno, H; Norimatsu, Y; Sakayama, K; Yamamoto, H, 2010)
"Pretreatment of troglitazone induced activation of PPARγ in a dose-dependent manner."1.46PPARγ activation by troglitazone enhances human lung cancer cells to TRAIL-induced apoptosis via autophagy flux. ( Lee, YJ; Moon, JH; Nazim, UM; Park, SY; Seol, JW, 2017)
"Troglitazone (TGZ) is a synthetic thiazolidinedione drug belonging to a group of potent peroxisome proliferator-activated receptor gamma (PPAR gamma) agonists known to inhibit proliferation, alter cell cycle regulation, and induce apoptosis in various cancer cell types."1.36The synergistic anticancer effect of troglitazone combined with aspirin causes cell cycle arrest and apoptosis in human lung cancer cells. ( Chang, HY; Cheng, AL; Chuang, SE; Lai, GM; Yan, KH; Yao, CJ, 2010)
"Osteosarcoma often develops micrometastases in the lung prior to diagnosis, causing a fatal outcome."1.36Effect of troglitazone on tumor growth and pulmonary metastasis development of the mouse osteosarcoma cell line LM8. ( Aizawa, J; Kamei, S; Kidani, T; Masuno, H; Norimatsu, Y; Sakayama, K; Yamamoto, H, 2010)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (57.14)29.6817
2010's6 (42.86)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nazim, UM1
Moon, JH1
Lee, YJ1
Seol, JW1
Park, SY1
Chuang, CH1
Yeh, CL1
Yeh, SL1
Lin, ES1
Wang, LY1
Wang, YH1
Reddy, RC2
Srirangam, A1
Reddy, K1
Chen, J1
Gangireddy, S1
Kalemkerian, GP1
Standiford, TJ2
Keshamouni, VG2
Li, MY1
Hsin, MK1
Yip, J1
Mok, TS2
Underwood, MJ1
Chen, GG2
Gras, D1
Chanez, P1
Urbach, V1
Vachier, I1
Godard, P1
Bonnans, C1
Yan, KH1
Yao, CJ2
Chang, HY1
Lai, GM2
Cheng, AL2
Chuang, SE2
Aizawa, J1
Sakayama, K1
Kamei, S1
Kidani, T1
Yamamoto, H1
Norimatsu, Y1
Masuno, H1
Kato, T1
Fujino, H1
Oyama, S1
Kawashima, T1
Murayama, T1
Han, S1
Sidell, N1
Fisher, PB1
Roman, J1
Andela, VB1
Altuwaijri, S1
Wood, J1
Rosier, RN1
Arenberg, DA1
Newstead, MJ1
Anthwal, S1
Chan, CF1
Yang, YY1
Li, M1
Lee, TW1
Warner, TD1
Yim, AP1
Tsubouchi, Y1
Sano, H1
Kawahito, Y1
Mukai, S1
Yamada, R1
Kohno, M1
Inoue, K1
Hla, T1
Kondo, M1

Other Studies

14 other studies available for troglitazone and Lung Neoplasms

ArticleYear
PPARγ activation by troglitazone enhances human lung cancer cells to TRAIL-induced apoptosis via autophagy flux.
    Oncotarget, 2017, Apr-18, Volume: 8, Issue:16

    Topics: Apoptosis; Autophagy; Cell Line, Tumor; Chromans; Humans; Lung Neoplasms; PPAR gamma; Thiazolidinedi

2017
Quercetin metabolites inhibit MMP-2 expression in A549 lung cancer cells by PPAR-γ associated mechanisms.
    The Journal of nutritional biochemistry, 2016, Volume: 33

    Topics: A549 Cells; Anilides; Animals; Anticarcinogenic Agents; Cell Movement; Chromans; Dietary Supplements

2016
Chemotherapeutic drugs induce PPAR-gamma expression and show sequence-specific synergy with PPAR-gamma ligands in inhibition of non-small cell lung cancer.
    Neoplasia (New York, N.Y.), 2008, Volume: 10, Issue:6

    Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chromans; Gene Exp

2008
PPARgamma activation extinguishes smoking carcinogen by inhibiting NNK-mediated proliferation.
    American journal of respiratory cell and molecular biology, 2010, Volume: 42, Issue:1

    Topics: Carcinogens; Cell Line, Tumor; Cell Proliferation; Chromans; Cyclin-Dependent Kinase Inhibitor p21;

2010
Thiazolidinediones induce proliferation of human bronchial epithelial cells through the GPR40 receptor.
    American journal of physiology. Lung cellular and molecular physiology, 2009, Volume: 296, Issue:6

    Topics: Adenocarcinoma; Anilides; Bronchi; Calcium Signaling; Cell Division; Cell Line, Transformed; Cell Li

2009
The synergistic anticancer effect of troglitazone combined with aspirin causes cell cycle arrest and apoptosis in human lung cancer cells.
    Molecular carcinogenesis, 2010, Volume: 49, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Aspirin; Blotting, Wester

2010
Effect of troglitazone on tumor growth and pulmonary metastasis development of the mouse osteosarcoma cell line LM8.
    BMC cancer, 2010, Feb-22, Volume: 10

    Topics: Animals; Antigens, CD34; Cell Line, Tumor; Chromans; Humans; Hypoglycemic Agents; Lung Neoplasms; Ma

2010
Indomethacin induces cellular morphological change and migration via epithelial-mesenchymal transition in A549 human lung cancer cells: a novel cyclooxygenase-inhibition-independent effect.
    Biochemical pharmacology, 2011, Dec-01, Volume: 82, Issue:11

    Topics: Anticarcinogenic Agents; Aspirin; Cadherins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Ch

2011
Ligands of peroxisome proliferator-activated receptor gamma inhibit lung cancer cell growth and induce apoptosis by stimulation of P21 expression.
    Chest, 2004, Volume: 125, Issue:5 Suppl

    Topics: Antineoplastic Agents; Apoptosis; Chromans; Cyclin D1; Humans; Lung Neoplasms; Prostaglandin D2; Pro

2004
Inhibition of beta-oxidative respiration is a therapeutic window associated with the cancer chemo-preventive activity of PPARgamma agonists.
    FEBS letters, 2005, Mar-14, Volume: 579, Issue:7

    Topics: Adenocarcinoma, Bronchiolo-Alveolar; Adenosine Triphosphate; Animals; Antineoplastic Agents; Apoptos

2005
PPAR-gamma activation inhibits angiogenesis by blocking ELR+CXC chemokine production in non-small cell lung cancer.
    Neoplasia (New York, N.Y.), 2005, Volume: 7, Issue:3

    Topics: Amino Acid Motifs; Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Ce

2005
Dramatic synergistic anticancer effect of clinically achievable doses of lovastatin and troglitazone.
    International journal of cancer, 2006, Feb-01, Volume: 118, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Survival; Chromans; Cyclin A;

2006
Activation of peroxisome proliferator-activated receptor-gamma by troglitazone (TGZ) inhibits human lung cell growth.
    Journal of cellular biochemistry, 2005, Nov-01, Volume: 96, Issue:4

    Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromans; Fibroblasts; G

2005
Inhibition of human lung cancer cell growth by the peroxisome proliferator-activated receptor-gamma agonists through induction of apoptosis.
    Biochemical and biophysical research communications, 2000, Apr-13, Volume: 270, Issue:2

    Topics: Apoptosis; Base Sequence; Cell Division; Chromans; DNA Primers; Humans; Lung Neoplasms; Prostaglandi

2000