troglitazone has been researched along with Lung Neoplasms in 14 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
Lung Neoplasms: Tumors or cancer of the LUNG.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Osteosarcoma often develops micrometastases in the lung prior to diagnosis, causing a fatal outcome." | 5.36 | Effect of troglitazone on tumor growth and pulmonary metastasis development of the mouse osteosarcoma cell line LM8. ( Aizawa, J; Kamei, S; Kidani, T; Masuno, H; Norimatsu, Y; Sakayama, K; Yamamoto, H, 2010) |
| "Pretreatment of troglitazone induced activation of PPARγ in a dose-dependent manner." | 1.46 | PPARγ activation by troglitazone enhances human lung cancer cells to TRAIL-induced apoptosis via autophagy flux. ( Lee, YJ; Moon, JH; Nazim, UM; Park, SY; Seol, JW, 2017) |
| "Troglitazone (TGZ) is a synthetic thiazolidinedione drug belonging to a group of potent peroxisome proliferator-activated receptor gamma (PPAR gamma) agonists known to inhibit proliferation, alter cell cycle regulation, and induce apoptosis in various cancer cell types." | 1.36 | The synergistic anticancer effect of troglitazone combined with aspirin causes cell cycle arrest and apoptosis in human lung cancer cells. ( Chang, HY; Cheng, AL; Chuang, SE; Lai, GM; Yan, KH; Yao, CJ, 2010) |
| "Osteosarcoma often develops micrometastases in the lung prior to diagnosis, causing a fatal outcome." | 1.36 | Effect of troglitazone on tumor growth and pulmonary metastasis development of the mouse osteosarcoma cell line LM8. ( Aizawa, J; Kamei, S; Kidani, T; Masuno, H; Norimatsu, Y; Sakayama, K; Yamamoto, H, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (57.14) | 29.6817 |
| 2010's | 6 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nazim, UM | 1 |
| Moon, JH | 1 |
| Lee, YJ | 1 |
| Seol, JW | 1 |
| Park, SY | 1 |
| Chuang, CH | 1 |
| Yeh, CL | 1 |
| Yeh, SL | 1 |
| Lin, ES | 1 |
| Wang, LY | 1 |
| Wang, YH | 1 |
| Reddy, RC | 2 |
| Srirangam, A | 1 |
| Reddy, K | 1 |
| Chen, J | 1 |
| Gangireddy, S | 1 |
| Kalemkerian, GP | 1 |
| Standiford, TJ | 2 |
| Keshamouni, VG | 2 |
| Li, MY | 1 |
| Hsin, MK | 1 |
| Yip, J | 1 |
| Mok, TS | 2 |
| Underwood, MJ | 1 |
| Chen, GG | 2 |
| Gras, D | 1 |
| Chanez, P | 1 |
| Urbach, V | 1 |
| Vachier, I | 1 |
| Godard, P | 1 |
| Bonnans, C | 1 |
| Yan, KH | 1 |
| Yao, CJ | 2 |
| Chang, HY | 1 |
| Lai, GM | 2 |
| Cheng, AL | 2 |
| Chuang, SE | 2 |
| Aizawa, J | 1 |
| Sakayama, K | 1 |
| Kamei, S | 1 |
| Kidani, T | 1 |
| Yamamoto, H | 1 |
| Norimatsu, Y | 1 |
| Masuno, H | 1 |
| Kato, T | 1 |
| Fujino, H | 1 |
| Oyama, S | 1 |
| Kawashima, T | 1 |
| Murayama, T | 1 |
| Han, S | 1 |
| Sidell, N | 1 |
| Fisher, PB | 1 |
| Roman, J | 1 |
| Andela, VB | 1 |
| Altuwaijri, S | 1 |
| Wood, J | 1 |
| Rosier, RN | 1 |
| Arenberg, DA | 1 |
| Newstead, MJ | 1 |
| Anthwal, S | 1 |
| Chan, CF | 1 |
| Yang, YY | 1 |
| Li, M | 1 |
| Lee, TW | 1 |
| Warner, TD | 1 |
| Yim, AP | 1 |
| Tsubouchi, Y | 1 |
| Sano, H | 1 |
| Kawahito, Y | 1 |
| Mukai, S | 1 |
| Yamada, R | 1 |
| Kohno, M | 1 |
| Inoue, K | 1 |
| Hla, T | 1 |
| Kondo, M | 1 |
14 other studies available for troglitazone and Lung Neoplasms
| Article | Year |
|---|---|
PPARγ activation by troglitazone enhances human lung cancer cells to TRAIL-induced apoptosis via autophagy flux.
Topics: Apoptosis; Autophagy; Cell Line, Tumor; Chromans; Humans; Lung Neoplasms; PPAR gamma; Thiazolidinedi | 2017 |
Quercetin metabolites inhibit MMP-2 expression in A549 lung cancer cells by PPAR-γ associated mechanisms.
Topics: A549 Cells; Anilides; Animals; Anticarcinogenic Agents; Cell Movement; Chromans; Dietary Supplements | 2016 |
Chemotherapeutic drugs induce PPAR-gamma expression and show sequence-specific synergy with PPAR-gamma ligands in inhibition of non-small cell lung cancer.
Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chromans; Gene Exp | 2008 |
PPARgamma activation extinguishes smoking carcinogen by inhibiting NNK-mediated proliferation.
Topics: Carcinogens; Cell Line, Tumor; Cell Proliferation; Chromans; Cyclin-Dependent Kinase Inhibitor p21; | 2010 |
Thiazolidinediones induce proliferation of human bronchial epithelial cells through the GPR40 receptor.
Topics: Adenocarcinoma; Anilides; Bronchi; Calcium Signaling; Cell Division; Cell Line, Transformed; Cell Li | 2009 |
The synergistic anticancer effect of troglitazone combined with aspirin causes cell cycle arrest and apoptosis in human lung cancer cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Aspirin; Blotting, Wester | 2010 |
Effect of troglitazone on tumor growth and pulmonary metastasis development of the mouse osteosarcoma cell line LM8.
Topics: Animals; Antigens, CD34; Cell Line, Tumor; Chromans; Humans; Hypoglycemic Agents; Lung Neoplasms; Ma | 2010 |
Indomethacin induces cellular morphological change and migration via epithelial-mesenchymal transition in A549 human lung cancer cells: a novel cyclooxygenase-inhibition-independent effect.
Topics: Anticarcinogenic Agents; Aspirin; Cadherins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Ch | 2011 |
Ligands of peroxisome proliferator-activated receptor gamma inhibit lung cancer cell growth and induce apoptosis by stimulation of P21 expression.
Topics: Antineoplastic Agents; Apoptosis; Chromans; Cyclin D1; Humans; Lung Neoplasms; Prostaglandin D2; Pro | 2004 |
Inhibition of beta-oxidative respiration is a therapeutic window associated with the cancer chemo-preventive activity of PPARgamma agonists.
Topics: Adenocarcinoma, Bronchiolo-Alveolar; Adenosine Triphosphate; Animals; Antineoplastic Agents; Apoptos | 2005 |
PPAR-gamma activation inhibits angiogenesis by blocking ELR+CXC chemokine production in non-small cell lung cancer.
Topics: Amino Acid Motifs; Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Ce | 2005 |
Dramatic synergistic anticancer effect of clinically achievable doses of lovastatin and troglitazone.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Survival; Chromans; Cyclin A; | 2006 |
Activation of peroxisome proliferator-activated receptor-gamma by troglitazone (TGZ) inhibits human lung cell growth.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromans; Fibroblasts; G | 2005 |
Inhibition of human lung cancer cell growth by the peroxisome proliferator-activated receptor-gamma agonists through induction of apoptosis.
Topics: Apoptosis; Base Sequence; Cell Division; Chromans; DNA Primers; Humans; Lung Neoplasms; Prostaglandi | 2000 |