troglitazone has been researched along with Lung Injury, Acute in 2 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To observe if peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist (troglitazone) was able to alleviate lipopolysaccharide (LPS)-induced acute lung injury (ALI) in rats, and explore the underlying mechanisms." | 3.74 | [The protective effects and mechanisms of peroxisome proliferator-activated receptor-gamma agonist in rats with acute lung injury]. ( Huang, J; Jiang, P; Qian, GS; Wang, JC, 2008) |
| "Fatal influenza (flu) virus infection often activates excessive inflammatory signals, leading to multi-organ failure and death, also referred to as cytokine storm." | 1.72 | Influenza virus causes lung immunopathology through down-regulating PPARĪ³ activity in macrophages. ( Alford, T; Liu, S; Wang, J; Zhang, H; Zhou, D, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, H | 1 |
| Alford, T | 1 |
| Liu, S | 1 |
| Zhou, D | 1 |
| Wang, J | 1 |
| Wang, JC | 1 |
| Jiang, P | 1 |
| Huang, J | 1 |
| Qian, GS | 1 |
2 other studies available for troglitazone and Lung Injury, Acute
| Article | Year |
|---|---|
Influenza virus causes lung immunopathology through down-regulating PPARĪ³ activity in macrophages.
Topics: Acute Lung Injury; Animals; Antiviral Agents; Cytokine Release Syndrome; Humans; Influenza, Human; L | 2022 |
[The protective effects and mechanisms of peroxisome proliferator-activated receptor-gamma agonist in rats with acute lung injury].
Topics: Acute Lung Injury; Animals; Chromans; Lipopolysaccharides; Male; NF-kappa B; PPAR gamma; Rats; Rats, | 2008 |