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troglitazone and Liver Neoplasms

troglitazone has been researched along with Liver Neoplasms in 27 studies

Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.

Liver Neoplasms: Tumors or cancer of the LIVER.

Research Excerpts

ExcerptRelevanceReference
"Although the PPARgamma agonist troglitazone has been shown to induce growth inhibition of hepatocellular carcinoma (HCC) cells at high concentration, this study indicates troglitazone does not significantly inhibit the growth of HCC cells at clinically achievable concentrations (1-10 microM), and this lack of activity could not be improved by the addition of 9-cis-retinoic acid."7.72Lack of efficacy of troglitazone at clinically achievable concentrations, with or without 9-cis retinoic acid or cytotoxic agents, for hepatocellular carcinoma cell lines. ( Chen, JY; Cheng, AL; Hsu, C; Shen, YC, 2004)
" The aim of this study is to investigate the mechanisms of cell growth inhibition of hepatocellular carcinoma (HCC) cell lines by the PPARgamma ligand, troglitazone."7.71Peroxisome proliferator-activated receptor gamma ligand troglitazone induces cell cycle arrest and apoptosis of hepatocellular carcinoma cell lines. ( Cioca, DP; Kawa, S; Kiyosawa, K; Tanaka, E; Yoshizawa, K, 2002)
"In our study, we examined whether human hepatocellular carcinoma (HCC) expresses peroxisome proliferator-activated receptor gamma (PPARgamma) and the effects of PPAR gamma activation by its selective ligands on cell growth and cell invasion in HCC cells."5.32Growth arrest by troglitazone is mediated by p27Kip1 accumulation, which results from dual inhibition of proteasome activity and Skp2 expression in human hepatocellular carcinoma cells. ( Kohgo, Y; Motomura, W; Nagamine, M; Okumura, T; Sawamukai, M; Takahashi, N; Tanno, S, 2004)
" In the present study, we examined whether PPARgamma is a possible target molecule for the prevention of cell growth and invasion by treatment with agonists (troglitazone, rosiglitazone) and antagonists (T0070907, GW9662) in four different hepatocellular carcinoma (HCC) cell lines."3.74A peroxisome proliferator-activated receptor gamma antagonist induces vimentin cleavage and inhibits invasion in high-grade hepatocellular carcinoma. ( Baek, HA; Choi, HN; Chung, MJ; Jang, KY; Kim, KR; Lee, HJ; Moon, WS; Park, HS, 2007)
"Although the PPARgamma agonist troglitazone has been shown to induce growth inhibition of hepatocellular carcinoma (HCC) cells at high concentration, this study indicates troglitazone does not significantly inhibit the growth of HCC cells at clinically achievable concentrations (1-10 microM), and this lack of activity could not be improved by the addition of 9-cis-retinoic acid."3.72Lack of efficacy of troglitazone at clinically achievable concentrations, with or without 9-cis retinoic acid or cytotoxic agents, for hepatocellular carcinoma cell lines. ( Chen, JY; Cheng, AL; Hsu, C; Shen, YC, 2004)
" The aim of this study is to investigate the mechanisms of cell growth inhibition of hepatocellular carcinoma (HCC) cell lines by the PPARgamma ligand, troglitazone."3.71Peroxisome proliferator-activated receptor gamma ligand troglitazone induces cell cycle arrest and apoptosis of hepatocellular carcinoma cell lines. ( Cioca, DP; Kawa, S; Kiyosawa, K; Tanaka, E; Yoshizawa, K, 2002)
" In the present study, we investigated: 1) the expression of PPARgamma in both human hepatoma cell lines and 5 resected human hepatocellular carcinoma (HCC) tissues; 2) the growth-inhibitory effect of troglitazone, a PPARgamma ligand, on those hepatoma cells; and 3) the molecular mechanisms of troglitazone-induced cell-cycle arrest."3.71Involvement of p21(WAF1/Cip1), p27(Kip1), and p18(INK4c) in troglitazone-induced cell-cycle arrest in human hepatoma cell lines. ( Hanada, S; Harada, M; Hashimoto, O; Kawaguchi, T; Kimura, R; Koga, H; Kojiro, M; Sakisaka, S; Sasatomi, K; Sata, M; Takagi, T; Taniguchi, E; Ueno, T; Yano, H, 2001)
" In contrast, rosiglitazone (RSG), in the same group of agents, has no significant toxic effects and now is widely used."1.33Chaperone proteins involved in troglitazone-induced toxicity in human hepatoma cell lines. ( Katoh, M; Maniratanachote, R; Minami, K; Nakajima, M; Yokoi, T, 2005)
" Genes that are differentially expressed between the more toxic troglitazone/ciglitazone group and the less toxic rosiglitazone/pioglitazone group are involved in necrotic, apoptotic, and cell proliferative pathways."1.33Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPAR gamma agonists on rat primary hepatocytes and human HepG2 cells. ( Blann, E; Dial, S; Dragan, YP; Guo, L; Muskhelishvili, L; Schroth, G; Shi, L; Sun, Y; Zhang, L, 2006)
"In surgically resected hepatocellular carcinoma (HCC) tissue, an increased expression in Skp2 was found in both the moderately differentiated HCCs and the poorly differentiated HCCs."1.32Troglitazone induces p27Kip1-associated cell-cycle arrest through down-regulating Skp2 in human hepatoma cells. ( Hanada, S; Harada, M; Koga, H; Kumashiro, R; Kumemura, H; Ohtsubo, M; Sata, M; Shishido, S; Taniguchi, E; Ueno, T; Yamashita, K, 2003)
"In our study, we examined whether human hepatocellular carcinoma (HCC) expresses peroxisome proliferator-activated receptor gamma (PPARgamma) and the effects of PPAR gamma activation by its selective ligands on cell growth and cell invasion in HCC cells."1.32Growth arrest by troglitazone is mediated by p27Kip1 accumulation, which results from dual inhibition of proteasome activity and Skp2 expression in human hepatocellular carcinoma cells. ( Kohgo, Y; Motomura, W; Nagamine, M; Okumura, T; Sawamukai, M; Takahashi, N; Tanno, S, 2004)
"The incidence of hepatocellular carcinoma was increased in female mice at 800 mg/kg."1.31Rodent carcinogenicity with the thiazolidinedione antidiabetic agent troglitazone. ( de la Iglesia, FA; Dethloff, LA; Gough, AW; Herman, JR; Masuda, H; McGuire, EJ; Parker, RF; Walsh, KM, 2002)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (3.70)18.2507
2000's23 (85.19)29.6817
2010's1 (3.70)24.3611
2020's2 (7.41)2.80

Authors

AuthorsStudies
Chen, S1
Zhang, L2
Chen, Y1
Fu, L1
He, Y2
Li, H1
Lu, C1
Zhu, P1
Li, M1
Duan, J1
Fang, Z1
König, B1
Koch, A1
Spielmann, J1
Hilgenfeld, C1
Hirche, F1
Stangl, GI1
Eder, K1
Saha, S1
Chan, DS1
Lee, CY1
Wong, W1
New, LS1
Chui, WK1
Yap, CW1
Chan, EC1
Ho, HK1
Yoshizawa, K1
Cioca, DP1
Kawa, S1
Tanaka, E1
Kiyosawa, K1
Bae, MA1
Rhee, H1
Song, BJ1
Hilding, A1
Hall, K1
Skogsberg, J1
Ehrenborg, E1
Lewitt, MS1
Koga, H2
Harada, M2
Ohtsubo, M1
Shishido, S1
Kumemura, H1
Hanada, S2
Taniguchi, E2
Yamashita, K1
Kumashiro, R1
Ueno, T2
Sata, M2
Motomura, W1
Takahashi, N1
Nagamine, M1
Sawamukai, M1
Tanno, S1
Kohgo, Y1
Okumura, T1
Shen, YC1
Hsu, C1
Chen, JY1
Cheng, AL1
Maniratanachote, R1
Minami, K1
Katoh, M1
Nakajima, M1
Yokoi, T1
Guo, YT1
Leng, XS1
Li, T1
Zhao, JM1
Lin, XH1
Schaefer, KL1
Wada, K1
Takahashi, H1
Matsuhashi, N1
Ohnishi, S1
Wolfe, MM1
Turner, JR1
Nakajima, A1
Borkan, SC1
Saubermann, LJ1
Bouancheau, D1
Buecher, B1
Jarry, A1
Simon, B1
Masson, D1
Cassagnau, E1
Hamelin, R1
Laboisse, CL1
Bézieau, S1
Denis, MG1
Trubetskoy, O1
Marks, B1
Zielinski, T1
Yueh, MF1
Raucy, J1
Chen, Q1
Xia, Y1
Qiu, Z1
Yu, J1
Qiao, L1
Zimmermann, L1
Ebert, MP1
Zhang, H1
Lin, W1
Röcken, C1
Malfertheiner, P1
Farrell, GC1
Guo, L1
Sun, Y1
Muskhelishvili, L1
Blann, E1
Dial, S1
Shi, L1
Schroth, G1
Dragan, YP1
Kim, KR1
Choi, HN1
Lee, HJ1
Baek, HA1
Park, HS1
Jang, KY1
Chung, MJ1
Moon, WS1
Chung, C1
Doll, JA1
Stellmach, VM1
Gonzales, J1
Surapureddi, S1
Cornwell, M1
Reddy, JK1
Crawford, SE1
Lee, WN1
Lim, S1
Bassilian, S1
Bergner, EA1
Edmond, J1
Nordt, TK1
Peter, K1
Bode, C1
Sobel, BE1
Suzuki, Y1
Urano, T1
Ihara, H1
Nakajima, T1
Nagai, N1
Takada, Y1
Taminato, T1
Takada, A1
Sakisaka, S1
Takagi, T1
Kawaguchi, T1
Sasatomi, K1
Kimura, R1
Hashimoto, O1
Yano, H1
Kojiro, M1
Solomon, SS1
Usdan, LS1
Palazzolo, MR1
Toyoda, M1
Takagi, H1
Horiguchi, N1
Kakizaki, S1
Sato, K1
Takayama, H1
Mori, M1
Herman, JR1
Dethloff, LA1
McGuire, EJ1
Parker, RF1
Walsh, KM1
Gough, AW1
Masuda, H1
de la Iglesia, FA1

Reviews

1 review available for troglitazone and Liver Neoplasms

ArticleYear
Inhibiting Sodium Taurocholate Cotransporting Polypeptide in HBV-Related Diseases: From Biological Function to Therapeutic Potential.
    Journal of medicinal chemistry, 2022, 10-13, Volume: 65, Issue:19

    Topics: Carcinoma, Hepatocellular; Hep G2 Cells; Hepatitis B; Hepatitis B virus; Hepatocytes; Humans; Interf

2022

Other Studies

26 other studies available for troglitazone and Liver Neoplasms

ArticleYear
Troglitazone inhibits hepatic oval cell proliferation by inducing cell cycle arrest through Hippo/YAP pathway regulation.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2022, Volume: 54, Issue:6

    Topics: Cell Cycle Checkpoints; Cell Proliferation; Humans; Liver Neoplasms; PPAR gamma; Troglitazone

2022
Activation of PPARalpha and PPARgamma reduces triacylglycerol synthesis in rat hepatoma cells by reduction of nuclear SREBP-1.
    European journal of pharmacology, 2009, Mar-01, Volume: 605, Issue:1-3

    Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Chromans; Fatty Acid Synthases; Glycerol-3-Pho

2009
Pyrrolidinediones reduce the toxicity of thiazolidinediones and modify their anti-diabetic and anti-cancer properties.
    European journal of pharmacology, 2012, Dec-15, Volume: 697, Issue:1-3

    Topics: 3T3-L1 Cells; Animals; Antineoplastic Agents; Biotransformation; Caspase 3; Cell Line, Tumor; Cell P

2012
Peroxisome proliferator-activated receptor gamma ligand troglitazone induces cell cycle arrest and apoptosis of hepatocellular carcinoma cell lines.
    Cancer, 2002, Nov-15, Volume: 95, Issue:10

    Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Chromans; Dose-Response Rel

2002
Troglitazone but not rosiglitazone induces G1 cell cycle arrest and apoptosis in human and rat hepatoma cell lines.
    Toxicology letters, 2003, Mar-20, Volume: 139, Issue:1

    Topics: Animals; Antineoplastic Agents; Apoptosis; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Chro

2003
Troglitazone stimulates IGF-binding protein-1 by a PPAR gamma-independent mechanism.
    Biochemical and biophysical research communications, 2003, Apr-04, Volume: 303, Issue:2

    Topics: Carcinoma, Hepatocellular; Chromans; Gene Expression Regulation, Neoplastic; Humans; Hypoglycemic Ag

2003
Troglitazone induces p27Kip1-associated cell-cycle arrest through down-regulating Skp2 in human hepatoma cells.
    Hepatology (Baltimore, Md.), 2003, Volume: 37, Issue:5

    Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; CDC2-CDC28 Kinases; Cell Cycle Proteins; Chromans;

2003
Growth arrest by troglitazone is mediated by p27Kip1 accumulation, which results from dual inhibition of proteasome activity and Skp2 expression in human hepatocellular carcinoma cells.
    International journal of cancer, 2004, Jan-01, Volume: 108, Issue:1

    Topics: Adenosine Triphosphatases; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Division; Chromans;

2004
Lack of efficacy of troglitazone at clinically achievable concentrations, with or without 9-cis retinoic acid or cytotoxic agents, for hepatocellular carcinoma cell lines.
    British journal of cancer, 2004, Oct-18, Volume: 91, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Hepatocellular; Cell Division;

2004
Chaperone proteins involved in troglitazone-induced toxicity in human hepatoma cell lines.
    Toxicological sciences : an official journal of the Society of Toxicology, 2005, Volume: 83, Issue:2

    Topics: Amino Acid Sequence; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Chromans; Dose-Resp

2005
Peroxisome proliferator-activated receptor gamma ligands suppress liver carcinogenesis induced by diethylnitrosamine in rats.
    World journal of gastroenterology, 2004, Dec-01, Volume: 10, Issue:23

    Topics: Alkylating Agents; Animals; Anticarcinogenic Agents; Chromans; Diethylnitrosamine; Gene Expression;

2004
Peroxisome proliferator-activated receptor gamma inhibition prevents adhesion to the extracellular matrix and induces anoikis in hepatocellular carcinoma cells.
    Cancer research, 2005, Mar-15, Volume: 65, Issue:6

    Topics: Anilides; Anoikis; Benzamides; Carcinoma, Hepatocellular; Cell Adhesion; Cell Growth Processes; Cell

2005
The PPAR(gamma) K422Q mutation does not contribute to troglitazone inefficiency in colon cancer treatment.
    Cancer letters, 2005, Jun-16, Volume: 224, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Chromans; Colonic Neoplasms; DNA Mutational A

2005
A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line.
    The AAPS journal, 2005, Mar-04, Volume: 7, Issue:1

    Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Chromans; Clotrimazole; Cytochrome P-450 CYP1A2; Cytoch

2005
Effect of ecdysterone on glucose metabolism in vitro.
    Life sciences, 2006, Feb-02, Volume: 78, Issue:10

    Topics: Animals; Cell Line, Tumor; Chromans; Dose-Response Relationship, Drug; Ecdysterone; Glucose; Humans;

2006
Troglitazone inhibits tumor growth in hepatocellular carcinoma in vitro and in vivo.
    Hepatology (Baltimore, Md.), 2006, Volume: 43, Issue:1

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Survival; Chromans; Cyclin-Dependent Kin

2006
Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPAR gamma agonists on rat primary hepatocytes and human HepG2 cells.
    Molecular diversity, 2006, Volume: 10, Issue:3

    Topics: Animals; Carcinoma, Hepatocellular; Cells, Cultured; Chromans; Cluster Analysis; Gene Expression Pro

2006
A peroxisome proliferator-activated receptor gamma antagonist induces vimentin cleavage and inhibits invasion in high-grade hepatocellular carcinoma.
    Oncology reports, 2007, Volume: 18, Issue:4

    Topics: Anilides; Benzamides; Blotting, Western; Carcinoma, Hepatocellular; Cell Adhesion; Cell Growth Proce

2007
Pigment epithelium-derived factor is an angiogenesis and lipid regulator that activates peroxisome proliferator-activated receptor alpha.
    Advances in experimental medicine and biology, 2008, Volume: 617

    Topics: Carcinoma, Hepatocellular; Cell Hypoxia; Cell Movement; Chromans; Clofibric Acid; Endothelium, Vascu

2008
Fatty acid cycling in human hepatoma cells and the effects of troglitazone.
    The Journal of biological chemistry, 1998, Aug-14, Volume: 273, Issue:33

    Topics: Carcinoma, Hepatocellular; Chromans; Fatty Acids; Gas Chromatography-Mass Spectrometry; Humans; Live

1998
Differential regulation by troglitazone of plasminogen activator inhibitor type 1 in human hepatic and vascular cells.
    The Journal of clinical endocrinology and metabolism, 2000, Volume: 85, Issue:4

    Topics: Aorta; Carcinoma, Hepatocellular; Cells, Cultured; Chromans; Culture Media, Conditioned; Endothelium

2000
Bezafibrate attenuates the overexpression of plasminogen activator inhibitor-1 messenger RNA by a combination of mono-unsaturated fatty acid and insulin in hepG2 cells.
    Life sciences, 2001, Mar-09, Volume: 68, Issue:16

    Topics: Bezafibrate; Blotting, Northern; Carcinoma, Hepatocellular; Chromans; Culture Media, Conditioned; Do

2001
Involvement of p21(WAF1/Cip1), p27(Kip1), and p18(INK4c) in troglitazone-induced cell-cycle arrest in human hepatoma cell lines.
    Hepatology (Baltimore, Md.), 2001, Volume: 33, Issue:5

    Topics: Carcinoma, Hepatocellular; Carrier Proteins; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Ce

2001
Mechanisms involved in tumor necrosis factor-alpha induction of insulin resistance and its reversal by thiazolidinedione(s).
    The American journal of the medical sciences, 2001, Volume: 322, Issue:2

    Topics: Animals; Autoradiography; Carcinoma, Hepatocellular; Chromans; Diabetes Mellitus, Type 2; Hypoglycem

2001
A ligand for peroxisome proliferator activated receptor gamma inhibits cell growth and induces apoptosis in human liver cancer cells.
    Gut, 2002, Volume: 50, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Caspases; Cell Divis

2002
Rodent carcinogenicity with the thiazolidinedione antidiabetic agent troglitazone.
    Toxicological sciences : an official journal of the Society of Toxicology, 2002, Volume: 68, Issue:1

    Topics: Adipose Tissue, Brown; Administration, Oral; Animals; Area Under Curve; Bone Marrow; Carcinogenicity

2002