troglitazone has been researched along with Liver Failure, Acute in 10 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
Liver Failure, Acute: A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Data from cases of liver failure associated with troglitazone use were abstracted and analyzed." | 7.72 | Troglitazone-induced liver failure: a case study. ( Graham, DJ; Green, L; Nourjah, P; Senior, JR, 2003) |
| "Data from cases of liver failure associated with troglitazone use were abstracted and analyzed." | 3.72 | Troglitazone-induced liver failure: a case study. ( Graham, DJ; Green, L; Nourjah, P; Senior, JR, 2003) |
| " This is further supported by experimental data that demonstrate that troglitazone, alone among the thiazolidinediones, is toxic in hepatocyte cell culture." | 2.42 | Hepatotoxicity of the thiazolidinediones. ( Chandramouli, J; Tolman, KG, 2003) |
| "Troglitazone use was associated with a marked increase in risk of hospitalized acute idiopathic liver injury and ALF." | 1.32 | Incidence of idiopathic acute liver failure and hospitalized liver injury in patients treated with troglitazone. ( Drinkard, CR; Graham, DJ; Shatin, D, 2003) |
| "Troglitazone is a thiazolidinedione with insulin-sensitizing activities when administered to humans or animals with type 2 diabetes mellitus." | 1.31 | Case of the month. Hepatic and renal failure in a patient taking troglitazone and metformin. ( Chaudhry, MU; Simmons, DL, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Graham, DJ | 4 |
| Drinkard, CR | 2 |
| Shatin, D | 2 |
| Green, L | 1 |
| Senior, JR | 1 |
| Nourjah, P | 1 |
| Tolman, KG | 1 |
| Chandramouli, J | 1 |
| Watkins, PB | 1 |
| Lewis, JH | 1 |
| Shimizu, N | 1 |
| Jagannath, S | 1 |
| Rai, R | 1 |
| Chaudhry, MU | 1 |
| Simmons, DL | 1 |
| Tsong, Y | 1 |
| Burgess, MJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| LabAlert: Enhancing Medication Safety Through Electronic Interventions to Improve Medication Safety[NCT00256386] | 800 participants | Interventional | 2004-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for troglitazone and Liver Failure, Acute
| Article | Year |
|---|---|
Hepatotoxicity of the thiazolidinediones.
Topics: Chemical and Drug Induced Liver Injury; Chromans; Humans; Hypoglycemic Agents; Liver Failure, Acute; | 2003 |
[Proper usage of thiazolidinediones].
Topics: Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin Resistance; Liver Failure, | 2000 |
8 other studies available for troglitazone and Liver Failure, Acute
| Article | Year |
|---|---|
Incidence of idiopathic acute liver failure and hospitalized liver injury in patients treated with troglitazone.
Topics: Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Chromans; Female; Hospitalization; | 2003 |
Troglitazone-induced liver failure: a case study.
Topics: Age Distribution; Aged; Chemical and Drug Induced Liver Injury; Chromans; Chronic Disease; Confidenc | 2003 |
Risk of unexplained acute liver failure in diabetes mellitus.
Topics: Chromans; Diabetes Mellitus; Hepatic Encephalopathy; Humans; Hypoglycemic Agents; Liver Failure, Acu | 2003 |
Idiosyncratic liver injury: challenges and approaches.
Topics: Adaptation, Physiological; Chemical and Drug Induced Liver Injury, Chronic; Chromans; Humans; Hypogl | 2005 |
'Hy's law,' the 'Rezulin Rule,' and other predictors of severe drug-induced hepatotoxicity: putting risk-benefit into perspective.
Topics: Alanine Transaminase; Anticoagulants; Azetidines; Benzylamines; Bilirubin; Biomarkers; Chemical and | 2006 |
Rapid-onset subfulminant liver failure associated with troglitazone.
Topics: Chemical and Drug Induced Liver Injury; Chromans; Humans; Hypoglycemic Agents; Liver Failure, Acute; | 2000 |
Case of the month. Hepatic and renal failure in a patient taking troglitazone and metformin.
Topics: Acute Kidney Injury; Chromans; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Liver Failure | 2001 |
Liver enzyme monitoring in patients treated with troglitazone.
Topics: Chromans; Drug Labeling; Humans; Hypoglycemic Agents; Liver; Liver Failure, Acute; Liver Function Te | 2001 |