troglitazone has been researched along with Leukemia, Myeloid in 3 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
Leukemia, Myeloid: Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a human eosinophilic leukemia cell line, EoL-1, cell proliferation was suppressed by 2-day treatment with troglitazone." | 1.30 | Troglitazone suppresses cell growth of myeloid leukemia cell lines by induction of p21WAF1/CIP1 cyclin-dependent kinase inhibitor. ( Kiriyama, Y; Nochi, H; Sakurada, Y; Sugimura, A; Tamoto, K; Tokumitsu, Y; Tsuchiya, H; Ui, M, 1999) |
| "Simultaneous treatment of myeloid leukemia cell lines with both troglitazone and a ligand that specifically binds either RXR (LG100268), or retinoic acid receptors (RAR, ATRA, ALART1550), or both (9-cis RA) resulted in additive suppression of clonal growth." | 1.30 | Growth inhibition of myeloid leukemia cells by troglitazone, a ligand for peroxisome proliferator activated receptor gamma, and retinoids. ( Asou, H; Elstner, E; Kamada, N; Koeffler, HP; Kubota, T; Verbeek, W; Williamson, E, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, J | 1 |
| Lu, H | 1 |
| Huang, R | 1 |
| Lin, D | 1 |
| Wu, X | 2 |
| Lin, Q | 1 |
| Zheng, J | 1 |
| Pan, X | 1 |
| Peng, J | 1 |
| Song, Y | 1 |
| Zhang, M | 1 |
| Hou, M | 1 |
| Chen, F | 1 |
| Sugimura, A | 1 |
| Kiriyama, Y | 1 |
| Nochi, H | 1 |
| Tsuchiya, H | 1 |
| Tamoto, K | 1 |
| Sakurada, Y | 1 |
| Ui, M | 1 |
| Tokumitsu, Y | 1 |
| Asou, H | 1 |
| Verbeek, W | 1 |
| Williamson, E | 1 |
| Elstner, E | 1 |
| Kubota, T | 1 |
| Kamada, N | 1 |
| Koeffler, HP | 1 |
3 other studies available for troglitazone and Leukemia, Myeloid
| Article | Year |
|---|---|
Peroxisome proliferator activated receptor-gamma ligands induced cell growth inhibition and its influence on matrix metalloproteinase activity in human myeloid leukemia cells.
Topics: Antineoplastic Agents; Chromans; Extracellular Matrix; Humans; Leukemia, Myeloid; Metalloproteases; | 2005 |
Troglitazone suppresses cell growth of myeloid leukemia cell lines by induction of p21WAF1/CIP1 cyclin-dependent kinase inhibitor.
Topics: Antineoplastic Agents; Cell Cycle; Cell Division; Chromans; Cyclin-Dependent Kinase Inhibitor p21; C | 1999 |
Growth inhibition of myeloid leukemia cells by troglitazone, a ligand for peroxisome proliferator activated receptor gamma, and retinoids.
Topics: Alitretinoin; Antineoplastic Agents; Antioxidants; Cell Cycle; Cell Differentiation; Cell Division; | 1999 |