troglitazone has been researched along with Leukemia, Erythroblastic, Acute in 3 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
Leukemia, Erythroblastic, Acute: A myeloproliferative disorder characterized by neoplastic proliferation of erythroblastic and myeloblastic elements with atypical erythroblasts and myeloblasts in the peripheral blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Troglitazone (TRG) is an anti-diabetic thiazolidinedione drug previously used to treat insulin-resistance in Type 2 diabetes." | 1.33 | Troglitazone overcomes doxorubicin-resistance in resistant K562 leukemia cells. ( Davies, GF; Harkness, TA; Juurlink, BH; Roesler, WJ, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Davies, GF | 1 |
| Roesler, WJ | 1 |
| Juurlink, BH | 1 |
| Harkness, TA | 1 |
| Coyle, AT | 1 |
| Kinsella, BT | 1 |
| Hishinuma, T | 1 |
| Yamazaki, T | 1 |
| Mizugaki, M | 1 |
3 other studies available for troglitazone and Leukemia, Erythroblastic, Acute
| Article | Year |
|---|---|
Troglitazone overcomes doxorubicin-resistance in resistant K562 leukemia cells.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Northern; Cell Line, Tumor; Cell Survival; Chromans; Dos | 2005 |
Synthetic peroxisome proliferator-activated receptor gamma agonists rosiglitazone and troglitazone suppress transcription by promoter 3 of the human thromboxane A2 receptor gene in human erythroleukemia cells.
Topics: Cell Line; Cell Line, Tumor; Chromans; Genes, Reporter; Humans; Leukemia, Erythroblastic, Acute; Luc | 2006 |
Troglitazone has a reducing effect on thromboxane production.
Topics: Arachidonic Acid; Blood Platelets; Chromans; Diabetes Mellitus, Type 2; Fibrinolytic Agents; Gas Chr | 2000 |