troglitazone has been researched along with Leucocythaemia in 2 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present study, two PPAR-gamma agonists, 15-deoxy-delta (12,14)-prostaglandin J2 (15d-PGJ2) and a synthetic PPAR-gamma agonist troglitazone (TGZ), were used to investigate activated PPAR-gamma-induced apoptosis on human monocyte leukemia U937 and Mono Mac 6 cells in vitro." | 3.74 | Downregulation of cyclooxygenase-2 expression and activation of caspase-3 are involved in peroxisome proliferator-activated receptor-gamma agonists induced apoptosis in human monocyte leukemia cells in vitro. ( He, Y; Huang, M; Huang, RW; Li, XD; Lin, DJ; Liu, JJ; Liu, PQ; Xiao, RZ, 2007) |
| "To investigate the effect of etoposide-induced apoptosis by PPARgamma ligands, leukemia cell lines were treated with troglitazone and 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) in the presence of etoposide and studied about various biological responses." | 3.72 | DR1-like element in human topoisomerase IIalpha gene involved in enhancement of etoposide-induced apoptosis by PPARgamma ligand. ( Abe, A; Emi, N; Kanbe, E; Kawabe, T; Saito, H; Towatari, M, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kanbe, E | 1 |
| Abe, A | 1 |
| Towatari, M | 1 |
| Kawabe, T | 1 |
| Saito, H | 1 |
| Emi, N | 1 |
| Liu, JJ | 1 |
| Liu, PQ | 1 |
| Lin, DJ | 1 |
| Xiao, RZ | 1 |
| Huang, M | 1 |
| Li, XD | 1 |
| He, Y | 1 |
| Huang, RW | 1 |
2 other studies available for troglitazone and Leucocythaemia
| Article | Year |
|---|---|
DR1-like element in human topoisomerase IIalpha gene involved in enhancement of etoposide-induced apoptosis by PPARgamma ligand.
Topics: Antigens, Neoplasm; Apoptosis; Chromans; DNA Topoisomerases, Type II; DNA-Binding Proteins; Electrop | 2003 |
Downregulation of cyclooxygenase-2 expression and activation of caspase-3 are involved in peroxisome proliferator-activated receptor-gamma agonists induced apoptosis in human monocyte leukemia cells in vitro.
Topics: Apoptosis; Blotting, Western; Caspase 3; Cell Line, Tumor; Chromans; Cyclooxygenase 2; DNA, Neoplasm | 2007 |