troglitazone and Hirsutism studies

Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.

Hirsutism: A condition observed in WOMEN and CHILDREN when there is excess coarse body hair of an adult male distribution pattern, such as facial and chest areas. It is the result of elevated ANDROGENS from the OVARIES, the ADRENAL GLANDS, or exogenous sources. The concept does not include HYPERTRICHOSIS, which is an androgen-independent excessive hair growth.

Research Excerpts

Excerpt	Relevance	Reference
"We hypothesized that the administration of troglitazone, an insulin-sensitizing agent of the thiazolidinedione class, would improve the ovulatory dysfunction, hirsutism, hyperandrogenemia, and hyperinsulinemia of polycystic ovary syndrome (PCOS) patients."	9.09	Troglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: a multicenter, double blind, placebo-controlled trial. ( Azziz, R; Ehrmann, D; Fereshetian, AG; Ghazzi, MN; Hanley, R; Legro, RS; O'Keefe, M; Whitcomb, RW, 2001)
"We hypothesized that the administration of troglitazone, an insulin-sensitizing agent of the thiazolidinedione class, would improve the ovulatory dysfunction, hirsutism, hyperandrogenemia, and hyperinsulinemia of polycystic ovary syndrome (PCOS) patients."	5.09	Troglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: a multicenter, double blind, placebo-controlled trial. ( Azziz, R; Ehrmann, D; Fereshetian, AG; Ghazzi, MN; Hanley, R; Legro, RS; O'Keefe, M; Whitcomb, RW, 2001)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
Descriptive, Transversal Study of Evaluation of Cardiovascular Risks Factors and Prevalence of Metabolic Syndrome in the Different Phenotypes of Women With Polycystic Ovary Syndrome[NCT00784615]		80 participants (Anticipated)	Observational	2007-12-31	Recruiting
Clinical Metabolic and Endocrine Parameters in Response to Metformin and Lifestyle Intervention in Women With Polycystic Ovary Syndrome: A Phase 4 Randomized, Double- Blind and Placebo Control Trial[NCT00679679]	Phase 4	30 participants (Actual)	Interventional	2003-01-31	Completed
Efficacy and Safety of Furocyst in Patients With Poly Cystic Ovary Syndrome[NCT02789488]	Phase 4	50 participants (Actual)	Interventional	2013-09-30	Completed
Anxiety and Sexual Malfunction in Infertile Polycystic Ovarian Syndrome Patients[NCT05056272]		128 participants (Anticipated)	Observational	2022-01-01	Recruiting
The Impact of Continuous Aerobic Exercise and High-Intensity Interval Training on Reproductive Outcomes in Polycystic Ovary Syndrome: A Pilot Randomized Controlled Trial.[NCT03362918]		60 participants (Actual)	Interventional	2018-01-01	Completed
Adipose Tissue Angiogenesis in Polycystic Ovary Syndrome (PCOS)[NCT01745471]		36 participants (Anticipated)	Observational	2012-12-06	Active, not recruiting
The Effects of Contraceptive Pill and Hormonal Vaginal Ring on Hormonal, Inflammatory and Metabolic Parameters in Women of Reproductive Age With Polycystic Ovary Syndrome (PCOS).[NCT01588873]	Phase 4	42 participants (Anticipated)	Interventional	2012-04-30	Recruiting
Effects of Inositol Alone or Associated With Alpha-lipoic Acid in Polycystic Ovary Syndrome Treatment[NCT04881851]		90 participants (Anticipated)	Interventional	2015-05-07	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabet	2005
[Polycystic ovary syndrome: treatment with insulin-sensitizing agents]. Annales d'endocrinologie, 2002, Volume: 63, Issue:1 Topics: Androgens; Chromans; Female; Hirsutism; Humans; Hypoglycemic Agents; Insulin Resistance; Luteinizing	2002

Article	Year
Troglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: a multicenter, double blind, placebo-controlled trial. The Journal of clinical endocrinology and metabolism, 2001, Volume: 86, Issue:4 Topics: Adult; Androgens; Blood Glucose; Chromans; Dose-Response Relationship, Drug; Double-Blind Method; Fe	2001
Troglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: a multicenter, double blind, placebo-controlled trial. The Journal of clinical endocrinology and metabolism, 2001, Volume: 86, Issue:4 Topics: Adult; Androgens; Blood Glucose; Chromans; Dose-Response Relationship, Drug; Double-Blind Method; Fe	2001
Troglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: a multicenter, double blind, placebo-controlled trial. The Journal of clinical endocrinology and metabolism, 2001, Volume: 86, Issue:4 Topics: Adult; Androgens; Blood Glucose; Chromans; Dose-Response Relationship, Drug; Double-Blind Method; Fe	2001
Troglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: a multicenter, double blind, placebo-controlled trial. The Journal of clinical endocrinology and metabolism, 2001, Volume: 86, Issue:4 Topics: Adult; Androgens; Blood Glucose; Chromans; Dose-Response Relationship, Drug; Double-Blind Method; Fe	2001

troglitazone and Hirsutism

Research Excerpts

Research

Studies (3)

Authors

Clinical Trials (8)

Trial Overview

Reviews

Trials

Authors	Studies
Ehrmann, DA	1
Azziz, R	1
Ehrmann, D	1
Legro, RS	1
Whitcomb, RW	1
Hanley, R	1
Fereshetian, AG	1
O'Keefe, M	1
Ghazzi, MN	1
Laboureau-Soares Barbosa, S	1
Rodien, P	1
Rohmer, V	1