troglitazone has been researched along with Hepatic Encephalopathy in 3 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Graham, DJ | 1 |
| Shibuya, A | 1 |
| Watanabe, M | 1 |
| Fujita, Y | 1 |
| Saigenji, K | 1 |
| Kuwao, S | 1 |
| Takahashi, H | 1 |
| Takeuchi, H | 1 |
| Booth, AM | 1 |
| Caldwell, SH | 1 |
| Iezzoni, JC | 1 |
3 other studies available for troglitazone and Hepatic Encephalopathy
| Article | Year |
|---|---|
Risk of unexplained acute liver failure in diabetes mellitus.
Topics: Chromans; Diabetes Mellitus; Hepatic Encephalopathy; Humans; Hypoglycemic Agents; Liver Failure, Acu | 2003 |
An autopsy case of troglitazone-induced fulminant hepatitis.
Topics: Alanine Transaminase; Autopsy; Bilirubin; Chromans; Diabetes Mellitus, Type 2; Fatal Outcome; Hepati | 1998 |
Troglitazone-associated hepatic failure.
Topics: Aged; Chemical and Drug Induced Liver Injury; Chromans; Diabetes Mellitus, Type 2; Fatal Outcome; Fe | 2000 |