troglitazone has been researched along with Heart Disease, Ischemic in 3 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We previously demonstrated that chronic pretreatment with a thiazolidinedione peroxisome proliferator-activated receptor (PPAR)-gamma activator, troglitazone, improves recovery of left ventricular (LV) function and substrate metabolism after ischemia and reperfusion, without causing arrhythmias." | 3.72 | Deleterious effects of acute treatment with a peroxisome proliferator-activated receptor-gamma activator in myocardial ischemia and reperfusion in pigs. ( Gen, M; Greyson, C; Kinugawa, K; Lee, J; Long, CS; Lu, L; Schwartz, GG; Xu, Y, 2003) |
| "Troglitazone treatment did not attenuate the insulinopenia and hyperglycemia of diabetic rats, but it partially improved the hypertriglyceridemia." | 1.29 | Cardioprotective effects of troglitazone in streptozotocin-induced diabetic rats. ( Higa, S; Komiya, I; Nagamine, F; Shimabukuro, M; Shinzato, T; Takasu, N, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, Y | 2 |
| Lu, L | 2 |
| Greyson, C | 1 |
| Lee, J | 1 |
| Gen, M | 1 |
| Kinugawa, K | 1 |
| Long, CS | 1 |
| Schwartz, GG | 2 |
| Shimabukuro, M | 1 |
| Higa, S | 1 |
| Shinzato, T | 1 |
| Nagamine, F | 1 |
| Komiya, I | 1 |
| Takasu, N | 1 |
| Zhu, P | 1 |
3 other studies available for troglitazone and Heart Disease, Ischemic
| Article | Year |
|---|---|
Deleterious effects of acute treatment with a peroxisome proliferator-activated receptor-gamma activator in myocardial ischemia and reperfusion in pigs.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Chromans; Disease Models, Animal; Gene Expression Reg | 2003 |
Cardioprotective effects of troglitazone in streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Cholesterol; Chromans; Diabetes Mellitus, Experimental; Heart; | 1996 |
Troglitazone improves recovery of left ventricular function after regional ischemia in pigs.
Topics: Animals; Blood Pressure; Chromans; Hypoglycemic Agents; Insulin Resistance; Myocardial Ischemia; Oxy | 2000 |