troglitazone has been researched along with Glioblastoma in 5 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The results of the present study show that the anti-diabetic drug troglitazone sensitizes human glioma and neuroblastoma cells to TRAIL-induced apoptosis." | 3.73 | Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin. ( Böck, B; Eckert, A; Oevermann, L; Ramacher, D; Roth, W; Schultze, K; Wiestler, O, 2006) |
| "However, its expression in brain tumors has not been studied." | 1.31 | Expression of PPARgamma and its ligand-dependent growth inhibition in human brain tumor cell lines. ( Fujieda, M; Kato, M; Nagaya, T; Saito, K; Seo, H; Yoshida, J, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hollander, AB | 1 |
| Dorsey, JF | 1 |
| Yao, CJ | 1 |
| Lai, GM | 1 |
| Chan, CF | 1 |
| Cheng, AL | 1 |
| Yang, YY | 1 |
| Chuang, SE | 1 |
| Schultze, K | 1 |
| Böck, B | 1 |
| Eckert, A | 1 |
| Oevermann, L | 1 |
| Ramacher, D | 1 |
| Wiestler, O | 1 |
| Roth, W | 1 |
| Kambe, A | 1 |
| Iguchi, G | 1 |
| Moon, Y | 1 |
| Kamitani, H | 1 |
| Watanabe, T | 1 |
| Eling, TE | 1 |
| Kato, M | 1 |
| Nagaya, T | 1 |
| Fujieda, M | 1 |
| Saito, K | 1 |
| Yoshida, J | 1 |
| Seo, H | 1 |
5 other studies available for troglitazone and Glioblastoma
| Article | Year |
|---|---|
FLIPing the apoptosis switch on in brain tumors using Troglitazone and TRAIL.
Topics: Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Chromans; Glioblastoma; Glioma; Humans; | 2008 |
Dramatic synergistic anticancer effect of clinically achievable doses of lovastatin and troglitazone.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Survival; Chromans; Cyclin A; | 2006 |
Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; CASP8 and FADD-Like Apoptosis Regulating | 2006 |
Regulation of EP4 expression via the Sp-1 transcription factor: inhibition of expression by anti-cancer agents.
Topics: Antineoplastic Agents; Astrocytoma; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; | 2008 |
Expression of PPARgamma and its ligand-dependent growth inhibition in human brain tumor cell lines.
Topics: Antineoplastic Agents; Apoptosis; Astrocytoma; Blotting, Northern; Brain Neoplasms; Cell Division; C | 2002 |